Amino acid dipepetide frequency for Luteibacter rhizovicinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.21AlaAla: 15.21 ± 0.167	1.084AlaCys: 1.084 ± 0.034	6.888AlaAsp: 6.888 ± 0.085	5.879AlaGlu: 5.879 ± 0.096	4.187AlaPhe: 4.187 ± 0.063	10.232AlaGly: 10.232 ± 0.131	2.615AlaHis: 2.615 ± 0.043	5.914AlaIle: 5.914 ± 0.066	3.619AlaLys: 3.619 ± 0.075	13.374AlaLeu: 13.374 ± 0.142	3.245AlaMet: 3.245 ± 0.05	3.43AlaAsn: 3.43 ± 0.075	5.669AlaPro: 5.669 ± 0.076	4.289AlaGln: 4.289 ± 0.063	8.419AlaArg: 8.419 ± 0.119	7.291AlaSer: 7.291 ± 0.088	7.006AlaThr: 7.006 ± 0.108	8.576AlaVal: 8.576 ± 0.097	1.829AlaTrp: 1.829 ± 0.045	2.666AlaTyr: 2.666 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.938CysAla: 0.938 ± 0.025	0.092CysCys: 0.092 ± 0.008	0.466CysAsp: 0.466 ± 0.019	0.399CysGlu: 0.399 ± 0.017	0.3CysPhe: 0.3 ± 0.014	0.791CysGly: 0.791 ± 0.027	0.219CysHis: 0.219 ± 0.013	0.361CysIle: 0.361 ± 0.019	0.172CysLys: 0.172 ± 0.01	0.749CysLeu: 0.749 ± 0.026	0.182CysMet: 0.182 ± 0.012	0.193CysAsn: 0.193 ± 0.012	0.383CysPro: 0.383 ± 0.017	0.208CysGln: 0.208 ± 0.012	0.516CysArg: 0.516 ± 0.022	0.437CysSer: 0.437 ± 0.018	0.442CysThr: 0.442 ± 0.02	0.626CysVal: 0.626 ± 0.023	0.102CysTrp: 0.102 ± 0.009	0.226CysTyr: 0.226 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.036AspAla: 8.036 ± 0.099	0.384AspCys: 0.384 ± 0.019	3.757AspAsp: 3.757 ± 0.056	3.468AspGlu: 3.468 ± 0.061	2.188AspPhe: 2.188 ± 0.041	5.699AspGly: 5.699 ± 0.105	1.243AspHis: 1.243 ± 0.033	3.071AspIle: 3.071 ± 0.052	1.719AspLys: 1.719 ± 0.042	5.576AspLeu: 5.576 ± 0.069	1.301AspMet: 1.301 ± 0.03	1.564AspAsn: 1.564 ± 0.041	3.323AspPro: 3.323 ± 0.059	1.642AspGln: 1.642 ± 0.034	4.039AspArg: 4.039 ± 0.07	2.797AspSer: 2.797 ± 0.053	3.25AspThr: 3.25 ± 0.065	4.873AspVal: 4.873 ± 0.061	0.982AspTrp: 0.982 ± 0.029	1.647AspTyr: 1.647 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.16GluAla: 6.16 ± 0.097	0.337GluCys: 0.337 ± 0.017	2.246GluAsp: 2.246 ± 0.043	2.22GluGlu: 2.22 ± 0.054	1.57GluPhe: 1.57 ± 0.037	3.918GluGly: 3.918 ± 0.055	1.39GluHis: 1.39 ± 0.035	2.341GluIle: 2.341 ± 0.05	1.759GluLys: 1.759 ± 0.042	5.533GluLeu: 5.533 ± 0.079	1.018GluMet: 1.018 ± 0.032	1.383GluAsn: 1.383 ± 0.031	2.31GluPro: 2.31 ± 0.049	2.1GluGln: 2.1 ± 0.044	4.69GluArg: 4.69 ± 0.084	2.647GluSer: 2.647 ± 0.053	2.704GluThr: 2.704 ± 0.051	3.51GluVal: 3.51 ± 0.061	0.701GluTrp: 0.701 ± 0.024	1.176GluTyr: 1.176 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.498PheAla: 4.498 ± 0.062	0.313PheCys: 0.313 ± 0.016	2.792PheAsp: 2.792 ± 0.046	1.835PheGlu: 1.835 ± 0.04	1.324PhePhe: 1.324 ± 0.033	3.539PheGly: 3.539 ± 0.062	0.778PheHis: 0.778 ± 0.028	1.353PheIle: 1.353 ± 0.035	0.859PheLys: 0.859 ± 0.028	3.001PheLeu: 3.001 ± 0.054	0.705PheMet: 0.705 ± 0.026	1.147PheAsn: 1.147 ± 0.033	1.494PhePro: 1.494 ± 0.039	0.986PheGln: 0.986 ± 0.028	2.239PheArg: 2.239 ± 0.048	2.18PheSer: 2.18 ± 0.046	1.917PheThr: 1.917 ± 0.047	3.004PheVal: 3.004 ± 0.051	0.468PheTrp: 0.468 ± 0.02	0.89PheTyr: 0.89 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	8.969GlyAla: 8.969 ± 0.175	0.816GlyCys: 0.816 ± 0.029	4.969GlyAsp: 4.969 ± 0.081	4.347GlyGlu: 4.347 ± 0.065	3.362GlyPhe: 3.362 ± 0.045	7.432GlyGly: 7.432 ± 0.187	2.074GlyHis: 2.074 ± 0.044	4.457GlyIle: 4.457 ± 0.069	3.448GlyLys: 3.448 ± 0.061	7.927GlyLeu: 7.927 ± 0.099	2.371GlyMet: 2.371 ± 0.046	2.828GlyAsn: 2.828 ± 0.094	3.058GlyPro: 3.058 ± 0.047	3.056GlyGln: 3.056 ± 0.062	5.599GlyArg: 5.599 ± 0.08	5.325GlySer: 5.325 ± 0.116	5.287GlyThr: 5.287 ± 0.14	6.659GlyVal: 6.659 ± 0.082	1.466GlyTrp: 1.466 ± 0.037	2.727GlyTyr: 2.727 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.977HisAla: 2.977 ± 0.044	0.213HisCys: 0.213 ± 0.013	1.397HisAsp: 1.397 ± 0.033	1.13HisGlu: 1.13 ± 0.029	0.876HisPhe: 0.876 ± 0.029	2.201HisGly: 2.201 ± 0.04	0.549HisHis: 0.549 ± 0.021	0.996HisIle: 0.996 ± 0.028	0.478HisLys: 0.478 ± 0.022	2.123HisLeu: 2.123 ± 0.048	0.525HisMet: 0.525 ± 0.02	0.505HisAsn: 0.505 ± 0.021	1.438HisPro: 1.438 ± 0.032	0.593HisGln: 0.593 ± 0.025	1.616HisArg: 1.616 ± 0.042	1.079HisSer: 1.079 ± 0.033	1.142HisThr: 1.142 ± 0.031	1.8HisVal: 1.8 ± 0.038	0.411HisTrp: 0.411 ± 0.017	0.683HisTyr: 0.683 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.868IleAla: 6.868 ± 0.078	0.39IleCys: 0.39 ± 0.017	3.806IleAsp: 3.806 ± 0.058	3.038IleGlu: 3.038 ± 0.059	1.397IlePhe: 1.397 ± 0.032	4.688IleGly: 4.688 ± 0.074	0.987IleHis: 0.987 ± 0.029	1.401IleIle: 1.401 ± 0.035	1.145IleLys: 1.145 ± 0.034	3.376IleLeu: 3.376 ± 0.061	0.672IleMet: 0.672 ± 0.025	1.341IleAsn: 1.341 ± 0.036	2.265IlePro: 2.265 ± 0.039	1.208IleGln: 1.208 ± 0.03	2.945IleArg: 2.945 ± 0.052	2.481IleSer: 2.481 ± 0.047	2.317IleThr: 2.317 ± 0.047	4.265IleVal: 4.265 ± 0.061	0.531IleTrp: 0.531 ± 0.021	1.104IleTyr: 1.104 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.688LysAla: 3.688 ± 0.066	0.127LysCys: 0.127 ± 0.01	1.703LysAsp: 1.703 ± 0.044	1.328LysGlu: 1.328 ± 0.038	0.77LysPhe: 0.77 ± 0.027	2.357LysGly: 2.357 ± 0.045	0.715LysHis: 0.715 ± 0.025	1.377LysIle: 1.377 ± 0.032	1.191LysLys: 1.191 ± 0.047	3.149LysLeu: 3.149 ± 0.052	0.614LysMet: 0.614 ± 0.021	0.906LysAsn: 0.906 ± 0.031	1.985LysPro: 1.985 ± 0.05	1.137LysGln: 1.137 ± 0.033	2.224LysArg: 2.224 ± 0.047	1.65LysSer: 1.65 ± 0.038	1.796LysThr: 1.796 ± 0.043	2.303LysVal: 2.303 ± 0.043	0.315LysTrp: 0.315 ± 0.014	0.689LysTyr: 0.689 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.297LeuAla: 13.297 ± 0.134	0.891LeuCys: 0.891 ± 0.027	6.367LeuAsp: 6.367 ± 0.075	4.622LeuGlu: 4.622 ± 0.081	3.342LeuPhe: 3.342 ± 0.059	8.479LeuGly: 8.479 ± 0.109	2.208LeuHis: 2.208 ± 0.047	4.541LeuIle: 4.541 ± 0.072	3.222LeuLys: 3.222 ± 0.056	10.283LeuLeu: 10.283 ± 0.142	2.096LeuMet: 2.096 ± 0.04	2.592LeuAsn: 2.592 ± 0.063	6.028LeuPro: 6.028 ± 0.085	2.863LeuGln: 2.863 ± 0.054	7.687LeuArg: 7.687 ± 0.103	6.239LeuSer: 6.239 ± 0.087	5.704LeuThr: 5.704 ± 0.1	7.303LeuVal: 7.303 ± 0.079	1.209LeuTrp: 1.209 ± 0.034	2.161LeuTyr: 2.161 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.608MetAla: 2.608 ± 0.047	0.149MetCys: 0.149 ± 0.01	1.146MetAsp: 1.146 ± 0.037	0.929MetGlu: 0.929 ± 0.029	0.694MetPhe: 0.694 ± 0.022	1.623MetGly: 1.623 ± 0.04	0.558MetHis: 0.558 ± 0.024	0.97MetIle: 0.97 ± 0.024	0.865MetLys: 0.865 ± 0.026	2.508MetLeu: 2.508 ± 0.056	0.438MetMet: 0.438 ± 0.02	0.814MetAsn: 0.814 ± 0.022	1.449MetPro: 1.449 ± 0.036	0.849MetGln: 0.849 ± 0.028	1.814MetArg: 1.814 ± 0.036	1.673MetSer: 1.673 ± 0.035	1.587MetThr: 1.587 ± 0.033	1.482MetVal: 1.482 ± 0.033	0.212MetTrp: 0.212 ± 0.013	0.451MetTyr: 0.451 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.608AsnAla: 3.608 ± 0.075	0.177AsnCys: 0.177 ± 0.012	1.774AsnAsp: 1.774 ± 0.046	1.396AsnGlu: 1.396 ± 0.032	0.996AsnPhe: 0.996 ± 0.03	3.009AsnGly: 3.009 ± 0.091	0.569AsnHis: 0.569 ± 0.02	1.324AsnIle: 1.324 ± 0.041	0.733AsnLys: 0.733 ± 0.029	2.696AsnLeu: 2.696 ± 0.06	0.533AsnMet: 0.533 ± 0.021	0.881AsnAsn: 0.881 ± 0.044	1.77AsnPro: 1.77 ± 0.043	0.866AsnGln: 0.866 ± 0.03	1.76AsnArg: 1.76 ± 0.037	1.338AsnSer: 1.338 ± 0.044	1.533AsnThr: 1.533 ± 0.049	2.331AsnVal: 2.331 ± 0.059	0.408AsnTrp: 0.408 ± 0.017	0.887AsnTyr: 0.887 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	6.303ProAla: 6.303 ± 0.088	0.324ProCys: 0.324 ± 0.016	3.59ProAsp: 3.59 ± 0.053	3.03ProGlu: 3.03 ± 0.053	1.779ProPhe: 1.779 ± 0.039	4.649ProGly: 4.649 ± 0.067	1.045ProHis: 1.045 ± 0.028	2.062ProIle: 2.062 ± 0.04	1.517ProLys: 1.517 ± 0.039	4.919ProLeu: 4.919 ± 0.061	1.291ProMet: 1.291 ± 0.036	1.392ProAsn: 1.392 ± 0.038	2.586ProPro: 2.586 ± 0.075	1.557ProGln: 1.557 ± 0.037	3.093ProArg: 3.093 ± 0.048	3.016ProSer: 3.016 ± 0.047	2.676ProThr: 2.676 ± 0.044	4.437ProVal: 4.437 ± 0.057	0.776ProTrp: 0.776 ± 0.023	1.312ProTyr: 1.312 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.063GlnAla: 4.063 ± 0.069	0.201GlnCys: 0.201 ± 0.013	1.388GlnAsp: 1.388 ± 0.036	1.188GlnGlu: 1.188 ± 0.03	1.072GlnPhe: 1.072 ± 0.031	2.577GlnGly: 2.577 ± 0.044	0.798GlnHis: 0.798 ± 0.024	1.597GlnIle: 1.597 ± 0.039	1.0GlnLys: 1.0 ± 0.028	3.44GlnLeu: 3.44 ± 0.051	0.742GlnMet: 0.742 ± 0.024	0.905GlnAsn: 0.905 ± 0.026	1.912GlnPro: 1.912 ± 0.041	1.5GlnGln: 1.5 ± 0.04	2.804GlnArg: 2.804 ± 0.053	1.932GlnSer: 1.932 ± 0.041	1.817GlnThr: 1.817 ± 0.045	2.587GlnVal: 2.587 ± 0.049	0.531GlnTrp: 0.531 ± 0.02	0.817GlnTyr: 0.817 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.513ArgAla: 7.513 ± 0.102	0.49ArgCys: 0.49 ± 0.019	4.463ArgAsp: 4.463 ± 0.061	4.266ArgGlu: 4.266 ± 0.075	2.934ArgPhe: 2.934 ± 0.048	4.904ArgGly: 4.904 ± 0.072	1.869ArgHis: 1.869 ± 0.045	3.851ArgIle: 3.851 ± 0.062	2.065ArgLys: 2.065 ± 0.045	7.696ArgLeu: 7.696 ± 0.109	1.929ArgMet: 1.929 ± 0.041	1.871ArgAsn: 1.871 ± 0.037	3.18ArgPro: 3.18 ± 0.05	2.565ArgGln: 2.565 ± 0.047	5.599ArgArg: 5.599 ± 0.103	3.819ArgSer: 3.819 ± 0.057	3.593ArgThr: 3.593 ± 0.06	5.224ArgVal: 5.224 ± 0.078	1.255ArgTrp: 1.255 ± 0.036	2.271ArgTyr: 2.271 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	6.42SerAla: 6.42 ± 0.074	0.423SerCys: 0.423 ± 0.019	3.12SerAsp: 3.12 ± 0.05	2.519SerGlu: 2.519 ± 0.043	2.196SerPhe: 2.196 ± 0.037	5.606SerGly: 5.606 ± 0.115	1.311SerHis: 1.311 ± 0.034	2.786SerIle: 2.786 ± 0.045	1.603SerLys: 1.603 ± 0.036	6.049SerLeu: 6.049 ± 0.082	1.438SerMet: 1.438 ± 0.033	1.617SerAsn: 1.617 ± 0.049	2.981SerPro: 2.981 ± 0.048	1.817SerGln: 1.817 ± 0.038	3.878SerArg: 3.878 ± 0.062	3.545SerSer: 3.545 ± 0.069	3.386SerThr: 3.386 ± 0.067	4.482SerVal: 4.482 ± 0.077	0.888SerTrp: 0.888 ± 0.026	1.626SerTyr: 1.626 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	6.206ThrAla: 6.206 ± 0.098	0.405ThrCys: 0.405 ± 0.021	3.242ThrAsp: 3.242 ± 0.064	2.272ThrGlu: 2.272 ± 0.044	2.066ThrPhe: 2.066 ± 0.047	5.328ThrGly: 5.328 ± 0.126	1.282ThrHis: 1.282 ± 0.03	2.619ThrIle: 2.619 ± 0.049	1.385ThrLys: 1.385 ± 0.036	6.381ThrLeu: 6.381 ± 0.115	1.167ThrMet: 1.167 ± 0.031	1.538ThrAsn: 1.538 ± 0.059	3.567ThrPro: 3.567 ± 0.058	1.856ThrGln: 1.856 ± 0.045	3.62ThrArg: 3.62 ± 0.058	3.241ThrSer: 3.241 ± 0.059	3.271ThrThr: 3.271 ± 0.08	4.672ThrVal: 4.672 ± 0.088	0.831ThrTrp: 0.831 ± 0.029	1.479ThrTyr: 1.479 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	9.82ValAla: 9.82 ± 0.103	0.649ValCys: 0.649 ± 0.023	5.08ValAsp: 5.08 ± 0.059	4.129ValGlu: 4.129 ± 0.066	2.641ValPhe: 2.641 ± 0.047	5.911ValGly: 5.911 ± 0.085	1.62ValHis: 1.62 ± 0.035	3.492ValIle: 3.492 ± 0.051	2.066ValLys: 2.066 ± 0.042	7.942ValLeu: 7.942 ± 0.102	1.65ValMet: 1.65 ± 0.038	2.327ValAsn: 2.327 ± 0.057	4.036ValPro: 4.036 ± 0.067	2.242ValGln: 2.242 ± 0.042	5.446ValArg: 5.446 ± 0.069	4.719ValSer: 4.719 ± 0.08	4.593ValThr: 4.593 ± 0.078	6.498ValVal: 6.498 ± 0.09	0.931ValTrp: 0.931 ± 0.026	1.776ValTyr: 1.776 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.186TrpAla: 1.186 ± 0.033	0.131TrpCys: 0.131 ± 0.009	0.677TrpAsp: 0.677 ± 0.023	0.492TrpGlu: 0.492 ± 0.02	0.594TrpPhe: 0.594 ± 0.021	0.874TrpGly: 0.874 ± 0.03	0.405TrpHis: 0.405 ± 0.02	0.731TrpIle: 0.731 ± 0.024	0.511TrpLys: 0.511 ± 0.02	1.963TrpLeu: 1.963 ± 0.047	0.438TrpMet: 0.438 ± 0.019	0.555TrpAsn: 0.555 ± 0.021	0.693TrpPro: 0.693 ± 0.024	0.67TrpGln: 0.67 ± 0.025	1.24TrpArg: 1.24 ± 0.036	0.889TrpSer: 0.889 ± 0.03	0.911TrpThr: 0.911 ± 0.029	0.906TrpVal: 0.906 ± 0.026	0.261TrpTrp: 0.261 ± 0.016	0.369TrpTyr: 0.369 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.053TyrAla: 3.053 ± 0.05	0.207TyrCys: 0.207 ± 0.011	1.69TyrAsp: 1.69 ± 0.046	1.227TyrGlu: 1.227 ± 0.035	1.033TyrPhe: 1.033 ± 0.029	2.359TyrGly: 2.359 ± 0.058	0.499TyrHis: 0.499 ± 0.018	0.98TyrIle: 0.98 ± 0.025	0.668TyrLys: 0.668 ± 0.023	2.45TyrLeu: 2.45 ± 0.044	0.464TyrMet: 0.464 ± 0.018	0.798TyrAsn: 0.798 ± 0.034	1.227TyrPro: 1.227 ± 0.038	0.864TyrGln: 0.864 ± 0.029	2.131TyrArg: 2.131 ± 0.045	1.391TyrSer: 1.391 ± 0.035	1.495TyrThr: 1.495 ± 0.047	2.032TyrVal: 2.032 ± 0.038	0.387TyrTrp: 0.387 ± 0.018	0.761TyrTyr: 0.761 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3849 proteins (1339777 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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