Amino acid dipepetide frequency for Streptococcus satellite phage Javan756

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.113AlaAla: 1.113 ± 0.736
1.113AlaCys: 1.113 ± 0.586
3.34AlaAsp: 3.34 ± 0.819
5.937AlaGlu: 5.937 ± 1.654
3.711AlaPhe: 3.711 ± 1.188
2.226AlaGly: 2.226 ± 0.897
0.742AlaHis: 0.742 ± 0.584
2.968AlaIle: 2.968 ± 0.753
7.05AlaLys: 7.05 ± 1.167
5.566AlaLeu: 5.566 ± 1.315
2.226AlaMet: 2.226 ± 1.333
2.226AlaAsn: 2.226 ± 0.76
1.113AlaPro: 1.113 ± 0.498
0.742AlaGln: 0.742 ± 0.478
2.226AlaArg: 2.226 ± 0.753
1.855AlaSer: 1.855 ± 0.971
2.597AlaThr: 2.597 ± 1.03
2.968AlaVal: 2.968 ± 1.033
0.742AlaTrp: 0.742 ± 0.402
2.597AlaTyr: 2.597 ± 0.949
0.0AlaXaa: 0.0 ± 0.0
Cys
0.371CysAla: 0.371 ± 0.368
0.0CysCys: 0.0 ± 0.0
0.742CysAsp: 0.742 ± 0.474
0.371CysGlu: 0.371 ± 0.479
0.0CysPhe: 0.0 ± 0.0
0.371CysGly: 0.371 ± 0.354
0.0CysHis: 0.0 ± 0.0
0.371CysIle: 0.371 ± 0.354
0.371CysLys: 0.371 ± 0.354
0.0CysLeu: 0.0 ± 0.0
0.742CysMet: 0.742 ± 0.427
0.371CysAsn: 0.371 ± 0.291
0.371CysPro: 0.371 ± 0.351
0.371CysGln: 0.371 ± 0.382
0.371CysArg: 0.371 ± 0.316
0.371CysSer: 0.371 ± 0.403
0.371CysThr: 0.371 ± 0.351
0.371CysVal: 0.371 ± 0.291
0.0CysTrp: 0.0 ± 0.0
0.742CysTyr: 0.742 ± 0.436
0.0CysXaa: 0.0 ± 0.0
Asp
1.113AspAla: 1.113 ± 0.56
0.371AspCys: 0.371 ± 0.354
1.855AspAsp: 1.855 ± 1.082
2.597AspGlu: 2.597 ± 0.802
3.34AspPhe: 3.34 ± 0.74
2.597AspGly: 2.597 ± 0.722
0.371AspHis: 0.371 ± 0.372
6.679AspIle: 6.679 ± 1.325
6.679AspLys: 6.679 ± 1.235
8.163AspLeu: 8.163 ± 1.921
0.742AspMet: 0.742 ± 0.449
4.082AspAsn: 4.082 ± 1.337
2.226AspPro: 2.226 ± 1.156
1.484AspGln: 1.484 ± 0.714
2.226AspArg: 2.226 ± 0.674
4.082AspSer: 4.082 ± 1.334
2.597AspThr: 2.597 ± 1.05
2.597AspVal: 2.597 ± 0.714
0.0AspTrp: 0.0 ± 0.0
3.711AspTyr: 3.711 ± 1.431
0.0AspXaa: 0.0 ± 0.0
Glu
5.937GluAla: 5.937 ± 1.615
0.742GluCys: 0.742 ± 0.461
5.566GluAsp: 5.566 ± 1.496
8.534GluGlu: 8.534 ± 2.15
1.855GluPhe: 1.855 ± 0.645
3.34GluGly: 3.34 ± 1.025
1.855GluHis: 1.855 ± 0.616
7.421GluIle: 7.421 ± 1.878
7.421GluLys: 7.421 ± 1.382
11.874GluLeu: 11.874 ± 1.538
1.484GluMet: 1.484 ± 0.712
6.308GluAsn: 6.308 ± 1.06
1.484GluPro: 1.484 ± 0.829
4.453GluGln: 4.453 ± 1.288
4.824GluArg: 4.824 ± 1.671
6.679GluSer: 6.679 ± 1.011
4.453GluThr: 4.453 ± 1.165
4.082GluVal: 4.082 ± 0.903
0.0GluTrp: 0.0 ± 0.0
2.597GluTyr: 2.597 ± 0.763
0.0GluXaa: 0.0 ± 0.0
Phe
0.371PheAla: 0.371 ± 0.351
0.0PheCys: 0.0 ± 0.0
1.855PheAsp: 1.855 ± 0.863
3.34PheGlu: 3.34 ± 1.234
2.597PhePhe: 2.597 ± 0.846
1.113PheGly: 1.113 ± 0.542
1.113PheHis: 1.113 ± 0.5
4.453PheIle: 4.453 ± 1.208
4.453PheLys: 4.453 ± 1.238
3.34PheLeu: 3.34 ± 1.026
1.855PheMet: 1.855 ± 0.774
1.113PheAsn: 1.113 ± 0.589
0.371PhePro: 0.371 ± 0.291
1.484PheGln: 1.484 ± 0.543
1.855PheArg: 1.855 ± 0.82
3.34PheSer: 3.34 ± 0.702
2.226PheThr: 2.226 ± 0.869
2.226PheVal: 2.226 ± 0.965
0.371PheTrp: 0.371 ± 0.354
1.855PheTyr: 1.855 ± 0.726
0.0PheXaa: 0.0 ± 0.0
Gly
1.855GlyAla: 1.855 ± 0.905
0.371GlyCys: 0.371 ± 0.316
0.0GlyAsp: 0.0 ± 0.0
1.855GlyGlu: 1.855 ± 0.786
1.113GlyPhe: 1.113 ± 0.663
2.597GlyGly: 2.597 ± 0.951
1.855GlyHis: 1.855 ± 0.713
4.082GlyIle: 4.082 ± 0.759
4.453GlyLys: 4.453 ± 1.186
3.34GlyLeu: 3.34 ± 1.321
1.484GlyMet: 1.484 ± 0.598
2.226GlyAsn: 2.226 ± 0.983
0.0GlyPro: 0.0 ± 0.0
1.855GlyGln: 1.855 ± 0.748
1.484GlyArg: 1.484 ± 0.582
1.484GlySer: 1.484 ± 0.653
3.711GlyThr: 3.711 ± 1.609
3.34GlyVal: 3.34 ± 1.002
0.371GlyTrp: 0.371 ± 0.351
4.082GlyTyr: 4.082 ± 1.031
0.0GlyXaa: 0.0 ± 0.0
His
1.855HisAla: 1.855 ± 0.728
0.0HisCys: 0.0 ± 0.0
1.484HisAsp: 1.484 ± 0.845
0.742HisGlu: 0.742 ± 0.454
1.484HisPhe: 1.484 ± 0.703
1.484HisGly: 1.484 ± 0.577
0.0HisHis: 0.0 ± 0.0
1.113HisIle: 1.113 ± 0.496
1.113HisLys: 1.113 ± 0.62
2.597HisLeu: 2.597 ± 0.664
0.0HisMet: 0.0 ± 0.0
1.113HisAsn: 1.113 ± 0.53
1.113HisPro: 1.113 ± 0.679
0.742HisGln: 0.742 ± 0.514
1.484HisArg: 1.484 ± 0.86
1.484HisSer: 1.484 ± 0.625
0.742HisThr: 0.742 ± 0.457
0.371HisVal: 0.371 ± 0.316
0.0HisTrp: 0.0 ± 0.0
0.742HisTyr: 0.742 ± 0.402
0.0HisXaa: 0.0 ± 0.0
Ile
2.226IleAla: 2.226 ± 0.722
0.742IleCys: 0.742 ± 0.474
6.679IleAsp: 6.679 ± 2.179
8.534IleGlu: 8.534 ± 2.408
2.226IlePhe: 2.226 ± 0.772
3.34IleGly: 3.34 ± 0.709
1.113IleHis: 1.113 ± 0.7
4.824IleIle: 4.824 ± 1.014
7.792IleLys: 7.792 ± 1.316
5.566IleLeu: 5.566 ± 1.308
1.484IleMet: 1.484 ± 0.681
4.453IleAsn: 4.453 ± 1.109
2.968IlePro: 2.968 ± 1.029
2.226IleGln: 2.226 ± 0.713
2.226IleArg: 2.226 ± 0.901
6.308IleSer: 6.308 ± 1.753
5.195IleThr: 5.195 ± 1.349
2.226IleVal: 2.226 ± 1.024
0.742IleTrp: 0.742 ± 0.571
4.082IleTyr: 4.082 ± 1.385
0.0IleXaa: 0.0 ± 0.0
Lys
7.792LysAla: 7.792 ± 1.928
0.371LysCys: 0.371 ± 0.354
4.824LysAsp: 4.824 ± 1.407
10.761LysGlu: 10.761 ± 2.18
2.968LysPhe: 2.968 ± 0.824
3.34LysGly: 3.34 ± 1.115
2.226LysHis: 2.226 ± 1.067
7.792LysIle: 7.792 ± 1.344
8.163LysLys: 8.163 ± 1.473
7.05LysLeu: 7.05 ± 1.603
1.855LysMet: 1.855 ± 0.913
4.824LysAsn: 4.824 ± 0.858
2.968LysPro: 2.968 ± 0.808
5.937LysGln: 5.937 ± 1.461
7.421LysArg: 7.421 ± 1.18
4.824LysSer: 4.824 ± 1.314
6.679LysThr: 6.679 ± 1.711
5.195LysVal: 5.195 ± 1.186
1.113LysTrp: 1.113 ± 0.702
1.855LysTyr: 1.855 ± 0.765
0.0LysXaa: 0.0 ± 0.0
Leu
6.308LeuAla: 6.308 ± 1.41
1.113LeuCys: 1.113 ± 0.736
7.792LeuAsp: 7.792 ± 1.452
9.276LeuGlu: 9.276 ± 2.083
4.453LeuPhe: 4.453 ± 1.336
3.34LeuGly: 3.34 ± 1.083
1.855LeuHis: 1.855 ± 0.778
6.679LeuIle: 6.679 ± 1.531
11.503LeuLys: 11.503 ± 1.556
9.276LeuLeu: 9.276 ± 1.962
2.226LeuMet: 2.226 ± 0.649
7.421LeuAsn: 7.421 ± 1.499
1.855LeuPro: 1.855 ± 0.722
3.34LeuGln: 3.34 ± 1.115
5.195LeuArg: 5.195 ± 1.168
5.937LeuSer: 5.937 ± 1.231
7.421LeuThr: 7.421 ± 1.61
4.082LeuVal: 4.082 ± 1.095
0.742LeuTrp: 0.742 ± 0.454
3.34LeuTyr: 3.34 ± 1.134
0.0LeuXaa: 0.0 ± 0.0
Met
2.968MetAla: 2.968 ± 0.888
0.0MetCys: 0.0 ± 0.0
1.855MetAsp: 1.855 ± 0.581
2.968MetGlu: 2.968 ± 0.876
0.742MetPhe: 0.742 ± 0.532
1.484MetGly: 1.484 ± 0.82
0.0MetHis: 0.0 ± 0.0
0.371MetIle: 0.371 ± 0.368
2.597MetLys: 2.597 ± 0.76
2.597MetLeu: 2.597 ± 0.828
0.0MetMet: 0.0 ± 0.0
1.855MetAsn: 1.855 ± 0.752
0.371MetPro: 0.371 ± 0.374
1.113MetGln: 1.113 ± 0.492
1.113MetArg: 1.113 ± 0.54
1.113MetSer: 1.113 ± 0.576
3.34MetThr: 3.34 ± 1.192
1.484MetVal: 1.484 ± 0.623
0.0MetTrp: 0.0 ± 0.0
0.371MetTyr: 0.371 ± 0.372
0.0MetXaa: 0.0 ± 0.0
Asn
3.34AsnAla: 3.34 ± 0.873
0.0AsnCys: 0.0 ± 0.0
3.34AsnAsp: 3.34 ± 0.94
5.195AsnGlu: 5.195 ± 1.504
1.484AsnPhe: 1.484 ± 0.556
2.597AsnGly: 2.597 ± 0.891
1.113AsnHis: 1.113 ± 0.552
1.855AsnIle: 1.855 ± 0.77
4.453AsnLys: 4.453 ± 1.547
6.679AsnLeu: 6.679 ± 1.291
1.113AsnMet: 1.113 ± 0.706
2.597AsnAsn: 2.597 ± 0.725
2.597AsnPro: 2.597 ± 0.879
2.226AsnGln: 2.226 ± 0.736
2.968AsnArg: 2.968 ± 0.974
4.082AsnSer: 4.082 ± 1.167
4.453AsnThr: 4.453 ± 1.385
1.113AsnVal: 1.113 ± 0.507
1.113AsnTrp: 1.113 ± 0.511
1.484AsnTyr: 1.484 ± 0.508
0.0AsnXaa: 0.0 ± 0.0
Pro
1.113ProAla: 1.113 ± 0.576
0.0ProCys: 0.0 ± 0.0
1.484ProAsp: 1.484 ± 0.696
1.484ProGlu: 1.484 ± 0.645
0.371ProPhe: 0.371 ± 0.354
1.113ProGly: 1.113 ± 0.615
0.371ProHis: 0.371 ± 0.374
1.855ProIle: 1.855 ± 0.654
2.968ProLys: 2.968 ± 0.943
2.597ProLeu: 2.597 ± 0.84
0.742ProMet: 0.742 ± 0.448
1.484ProAsn: 1.484 ± 0.653
0.742ProPro: 0.742 ± 0.586
0.742ProGln: 0.742 ± 0.498
1.113ProArg: 1.113 ± 0.55
2.226ProSer: 2.226 ± 0.849
1.855ProThr: 1.855 ± 0.703
1.855ProVal: 1.855 ± 0.69
0.0ProTrp: 0.0 ± 0.0
1.855ProTyr: 1.855 ± 0.698
0.0ProXaa: 0.0 ± 0.0
Gln
5.937GlnAla: 5.937 ± 1.67
0.0GlnCys: 0.0 ± 0.0
2.597GlnAsp: 2.597 ± 0.663
3.711GlnGlu: 3.711 ± 0.938
0.742GlnPhe: 0.742 ± 0.461
0.742GlnGly: 0.742 ± 0.498
0.371GlnHis: 0.371 ± 0.362
2.597GlnIle: 2.597 ± 0.796
5.937GlnLys: 5.937 ± 1.5
3.34GlnLeu: 3.34 ± 0.878
0.0GlnMet: 0.0 ± 0.0
1.484GlnAsn: 1.484 ± 0.588
1.484GlnPro: 1.484 ± 0.928
2.597GlnGln: 2.597 ± 1.416
2.597GlnArg: 2.597 ± 0.879
1.855GlnSer: 1.855 ± 1.091
2.226GlnThr: 2.226 ± 0.808
1.484GlnVal: 1.484 ± 0.733
0.0GlnTrp: 0.0 ± 0.0
2.597GlnTyr: 2.597 ± 1.061
0.0GlnXaa: 0.0 ± 0.0
Arg
2.226ArgAla: 2.226 ± 0.829
0.0ArgCys: 0.0 ± 0.0
2.597ArgAsp: 2.597 ± 1.044
7.05ArgGlu: 7.05 ± 1.325
0.371ArgPhe: 0.371 ± 0.291
1.855ArgGly: 1.855 ± 0.823
1.113ArgHis: 1.113 ± 0.533
6.308ArgIle: 6.308 ± 1.274
3.711ArgLys: 3.711 ± 0.754
6.679ArgLeu: 6.679 ± 1.662
1.113ArgMet: 1.113 ± 0.545
3.711ArgAsn: 3.711 ± 1.141
0.0ArgPro: 0.0 ± 0.0
3.34ArgGln: 3.34 ± 0.81
0.742ArgArg: 0.742 ± 0.494
1.855ArgSer: 1.855 ± 0.755
1.484ArgThr: 1.484 ± 0.519
1.855ArgVal: 1.855 ± 0.892
0.0ArgTrp: 0.0 ± 0.0
3.711ArgTyr: 3.711 ± 1.2
0.0ArgXaa: 0.0 ± 0.0
Ser
3.34SerAla: 3.34 ± 1.346
0.0SerCys: 0.0 ± 0.0
5.566SerAsp: 5.566 ± 0.895
4.082SerGlu: 4.082 ± 0.995
2.597SerPhe: 2.597 ± 0.651
2.226SerGly: 2.226 ± 0.698
2.226SerHis: 2.226 ± 0.642
4.453SerIle: 4.453 ± 1.114
4.082SerLys: 4.082 ± 1.396
5.937SerLeu: 5.937 ± 1.361
2.597SerMet: 2.597 ± 0.853
1.855SerAsn: 1.855 ± 0.562
2.597SerPro: 2.597 ± 0.827
2.226SerGln: 2.226 ± 0.737
2.968SerArg: 2.968 ± 0.993
2.597SerSer: 2.597 ± 0.89
4.453SerThr: 4.453 ± 1.311
2.597SerVal: 2.597 ± 0.869
0.371SerTrp: 0.371 ± 0.316
1.855SerTyr: 1.855 ± 0.68
0.0SerXaa: 0.0 ± 0.0
Thr
2.226ThrAla: 2.226 ± 0.841
0.371ThrCys: 0.371 ± 0.354
2.597ThrAsp: 2.597 ± 1.003
6.308ThrGlu: 6.308 ± 1.711
4.082ThrPhe: 4.082 ± 1.808
3.711ThrGly: 3.711 ± 0.975
1.855ThrHis: 1.855 ± 0.647
3.34ThrIle: 3.34 ± 1.023
4.453ThrLys: 4.453 ± 1.258
8.905ThrLeu: 8.905 ± 1.517
3.34ThrMet: 3.34 ± 1.39
2.597ThrAsn: 2.597 ± 0.928
1.484ThrPro: 1.484 ± 0.635
2.597ThrGln: 2.597 ± 1.269
2.968ThrArg: 2.968 ± 0.79
2.597ThrSer: 2.597 ± 0.764
3.711ThrThr: 3.711 ± 1.009
3.711ThrVal: 3.711 ± 0.823
0.0ThrTrp: 0.0 ± 0.0
1.855ThrTyr: 1.855 ± 0.843
0.0ThrXaa: 0.0 ± 0.0
Val
1.855ValAla: 1.855 ± 1.269
0.371ValCys: 0.371 ± 0.479
1.484ValAsp: 1.484 ± 0.525
4.453ValGlu: 4.453 ± 1.456
1.484ValPhe: 1.484 ± 0.598
2.226ValGly: 2.226 ± 1.295
0.371ValHis: 0.371 ± 0.316
4.082ValIle: 4.082 ± 1.576
5.566ValLys: 5.566 ± 1.814
3.711ValLeu: 3.711 ± 1.238
1.484ValMet: 1.484 ± 0.608
1.113ValAsn: 1.113 ± 0.641
1.484ValPro: 1.484 ± 0.548
2.597ValGln: 2.597 ± 0.913
2.597ValArg: 2.597 ± 0.743
3.711ValSer: 3.711 ± 1.404
3.711ValThr: 3.711 ± 1.282
2.597ValVal: 2.597 ± 1.128
0.0ValTrp: 0.0 ± 0.0
1.484ValTyr: 1.484 ± 0.736
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.742TrpGlu: 0.742 ± 0.478
0.0TrpPhe: 0.0 ± 0.0
0.371TrpGly: 0.371 ± 0.362
0.0TrpHis: 0.0 ± 0.0
0.742TrpIle: 0.742 ± 0.483
1.113TrpLys: 1.113 ± 0.612
0.742TrpLeu: 0.742 ± 0.429
0.0TrpMet: 0.0 ± 0.0
0.371TrpAsn: 0.371 ± 0.369
0.0TrpPro: 0.0 ± 0.0
0.371TrpGln: 0.371 ± 0.351
0.371TrpArg: 0.371 ± 0.354
0.371TrpSer: 0.371 ± 0.316
0.0TrpThr: 0.0 ± 0.0
0.371TrpVal: 0.371 ± 0.351
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.484TyrAla: 1.484 ± 0.673
1.113TyrCys: 1.113 ± 0.51
1.855TyrAsp: 1.855 ± 0.823
2.968TyrGlu: 2.968 ± 0.807
3.711TyrPhe: 3.711 ± 1.55
1.484TyrGly: 1.484 ± 0.763
1.113TyrHis: 1.113 ± 0.594
2.968TyrIle: 2.968 ± 1.076
4.082TyrLys: 4.082 ± 1.546
5.195TyrLeu: 5.195 ± 1.013
1.484TyrMet: 1.484 ± 0.756
2.597TyrAsn: 2.597 ± 0.809
0.742TyrPro: 0.742 ± 0.402
1.855TyrGln: 1.855 ± 0.863
2.968TyrArg: 2.968 ± 1.204
1.855TyrSer: 1.855 ± 0.665
1.484TyrThr: 1.484 ± 0.639
1.855TyrVal: 1.855 ± 1.05
0.0TyrTrp: 0.0 ± 0.0
2.968TyrTyr: 2.968 ± 1.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 17 proteins (2696 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski