Amino acid dipepetide frequency for Egaro virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.74AlaAla: 2.74 ± 0.841
0.0AlaCys: 0.0 ± 0.0
1.37AlaAsp: 1.37 ± 1.564
4.11AlaGlu: 4.11 ± 2.169
3.425AlaPhe: 3.425 ± 0.664
6.164AlaGly: 6.164 ± 2.464
0.0AlaHis: 0.0 ± 0.0
0.685AlaIle: 0.685 ± 0.361
6.164AlaLys: 6.164 ± 1.321
4.11AlaLeu: 4.11 ± 1.262
0.685AlaMet: 0.685 ± 0.782
2.055AlaAsn: 2.055 ± 1.084
3.425AlaPro: 3.425 ± 0.48
2.74AlaGln: 2.74 ± 0.841
4.11AlaArg: 4.11 ± 2.169
7.534AlaSer: 7.534 ± 4.028
1.37AlaThr: 1.37 ± 0.421
4.795AlaVal: 4.795 ± 0.243
0.685AlaTrp: 0.685 ± 0.782
3.425AlaTyr: 3.425 ± 1.807
0.0AlaXaa: 0.0 ± 0.0
Cys
2.055CysAla: 2.055 ± 1.203
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.685CysPhe: 0.685 ± 0.361
0.685CysGly: 0.685 ± 0.361
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
2.055CysLys: 2.055 ± 1.084
0.685CysLeu: 0.685 ± 0.782
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.685CysArg: 0.685 ± 0.361
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.685CysTyr: 0.685 ± 0.361
0.0CysXaa: 0.0 ± 0.0
Asp
2.055AspAla: 2.055 ± 0.059
0.685AspCys: 0.685 ± 0.361
1.37AspAsp: 1.37 ± 0.723
2.055AspGlu: 2.055 ± 0.059
4.11AspPhe: 4.11 ± 0.118
3.425AspGly: 3.425 ± 1.623
0.0AspHis: 0.0 ± 0.0
4.795AspIle: 4.795 ± 0.9
2.055AspLys: 2.055 ± 1.203
2.74AspLeu: 2.74 ± 0.302
2.055AspMet: 2.055 ± 1.084
3.425AspAsn: 3.425 ± 1.623
0.685AspPro: 0.685 ± 0.361
1.37AspGln: 1.37 ± 0.421
4.11AspArg: 4.11 ± 0.118
4.11AspSer: 4.11 ± 1.025
3.425AspThr: 3.425 ± 0.48
4.795AspVal: 4.795 ± 0.9
2.055AspTrp: 2.055 ± 0.059
1.37AspTyr: 1.37 ± 0.723
0.0AspXaa: 0.0 ± 0.0
Glu
2.055GluAla: 2.055 ± 0.059
0.0GluCys: 0.0 ± 0.0
4.11GluAsp: 4.11 ± 1.025
2.74GluGlu: 2.74 ± 0.841
4.11GluPhe: 4.11 ± 1.262
3.425GluGly: 3.425 ± 0.48
2.74GluHis: 2.74 ± 1.446
3.425GluIle: 3.425 ± 0.664
2.74GluLys: 2.74 ± 0.841
6.164GluLeu: 6.164 ± 2.11
0.0GluMet: 0.0 ± 0.0
4.795GluAsn: 4.795 ± 0.243
3.425GluPro: 3.425 ± 0.664
1.37GluGln: 1.37 ± 0.723
2.74GluArg: 2.74 ± 1.446
5.479GluSer: 5.479 ± 0.539
3.425GluThr: 3.425 ± 0.664
6.849GluVal: 6.849 ± 0.184
0.0GluTrp: 0.0 ± 0.0
0.685GluTyr: 0.685 ± 0.361
0.0GluXaa: 0.0 ± 0.0
Phe
2.74PheAla: 2.74 ± 0.841
2.055PheCys: 2.055 ± 1.084
2.74PheAsp: 2.74 ± 1.446
1.37PheGlu: 1.37 ± 0.723
0.0PhePhe: 0.0 ± 0.0
3.425PheGly: 3.425 ± 0.664
1.37PheHis: 1.37 ± 0.421
3.425PheIle: 3.425 ± 2.767
3.425PheLys: 3.425 ± 1.807
6.164PheLeu: 6.164 ± 0.966
0.0PheMet: 0.0 ± 0.0
3.425PheAsn: 3.425 ± 0.664
2.055PhePro: 2.055 ± 1.203
0.685PheGln: 0.685 ± 0.361
1.37PheArg: 1.37 ± 0.723
3.425PheSer: 3.425 ± 0.48
1.37PheThr: 1.37 ± 0.723
6.164PheVal: 6.164 ± 0.177
0.685PheTrp: 0.685 ± 0.782
2.055PheTyr: 2.055 ± 1.203
0.0PheXaa: 0.0 ± 0.0
Gly
3.425GlyAla: 3.425 ± 0.664
0.0GlyCys: 0.0 ± 0.0
2.055GlyAsp: 2.055 ± 0.059
3.425GlyGlu: 3.425 ± 0.664
4.795GlyPhe: 4.795 ± 1.387
7.534GlyGly: 7.534 ± 0.546
1.37GlyHis: 1.37 ± 0.421
2.74GlyIle: 2.74 ± 0.841
4.11GlyLys: 4.11 ± 1.025
2.74GlyLeu: 2.74 ± 0.841
0.0GlyMet: 0.0 ± 0.0
2.74GlyAsn: 2.74 ± 0.302
2.74GlyPro: 2.74 ± 1.446
0.685GlyGln: 0.685 ± 0.361
1.37GlyArg: 1.37 ± 0.421
4.795GlySer: 4.795 ± 2.044
3.425GlyThr: 3.425 ± 0.48
4.11GlyVal: 4.11 ± 1.025
0.685GlyTrp: 0.685 ± 0.361
1.37GlyTyr: 1.37 ± 0.421
0.0GlyXaa: 0.0 ± 0.0
His
1.37HisAla: 1.37 ± 0.723
0.0HisCys: 0.0 ± 0.0
1.37HisAsp: 1.37 ± 0.723
1.37HisGlu: 1.37 ± 0.421
0.685HisPhe: 0.685 ± 0.782
0.685HisGly: 0.685 ± 0.361
2.74HisHis: 2.74 ± 0.302
0.685HisIle: 0.685 ± 0.782
0.0HisLys: 0.0 ± 0.0
2.055HisLeu: 2.055 ± 1.084
2.055HisMet: 2.055 ± 1.084
0.685HisAsn: 0.685 ± 0.361
2.055HisPro: 2.055 ± 1.084
0.0HisGln: 0.0 ± 0.0
0.685HisArg: 0.685 ± 0.361
0.0HisSer: 0.0 ± 0.0
0.685HisThr: 0.685 ± 0.361
3.425HisVal: 3.425 ± 1.807
1.37HisTrp: 1.37 ± 0.421
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
2.74IleAla: 2.74 ± 1.985
0.685IleCys: 0.685 ± 0.782
2.055IleAsp: 2.055 ± 0.059
1.37IleGlu: 1.37 ± 0.723
2.74IlePhe: 2.74 ± 0.841
0.685IleGly: 0.685 ± 0.361
2.74IleHis: 2.74 ± 1.446
3.425IleIle: 3.425 ± 0.48
5.479IleLys: 5.479 ± 1.682
4.11IleLeu: 4.11 ± 0.118
0.0IleMet: 0.0 ± 0.299
2.055IleAsn: 2.055 ± 1.084
4.795IlePro: 4.795 ± 0.9
0.0IleGln: 0.0 ± 0.0
0.685IleArg: 0.685 ± 0.361
4.11IleSer: 4.11 ± 0.118
2.055IleThr: 2.055 ± 0.059
5.479IleVal: 5.479 ± 1.682
0.685IleTrp: 0.685 ± 0.782
2.055IleTyr: 2.055 ± 0.059
0.0IleXaa: 0.0 ± 0.0
Lys
5.479LysAla: 5.479 ± 1.682
2.055LysCys: 2.055 ± 0.059
6.164LysAsp: 6.164 ± 1.321
4.11LysGlu: 4.11 ± 1.262
3.425LysPhe: 3.425 ± 0.48
3.425LysGly: 3.425 ± 0.664
0.685LysHis: 0.685 ± 0.361
3.425LysIle: 3.425 ± 0.664
10.274LysLys: 10.274 ± 3.135
10.959LysLeu: 10.959 ± 2.353
2.055LysMet: 2.055 ± 0.839
3.425LysAsn: 3.425 ± 0.664
2.74LysPro: 2.74 ± 1.446
5.479LysGln: 5.479 ± 0.539
5.479LysArg: 5.479 ± 0.539
3.425LysSer: 3.425 ± 0.664
6.849LysThr: 6.849 ± 0.959
4.11LysVal: 4.11 ± 1.025
1.37LysTrp: 1.37 ± 0.421
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
6.164LeuAla: 6.164 ± 2.11
0.0LeuCys: 0.0 ± 0.0
5.479LeuAsp: 5.479 ± 0.539
10.274LeuGlu: 10.274 ± 0.296
2.74LeuPhe: 2.74 ± 0.302
2.74LeuGly: 2.74 ± 0.841
2.74LeuHis: 2.74 ± 0.302
3.425LeuIle: 3.425 ± 1.623
8.904LeuLys: 8.904 ± 1.268
8.904LeuLeu: 8.904 ± 0.125
1.37LeuMet: 1.37 ± 0.421
5.479LeuAsn: 5.479 ± 0.605
6.849LeuPro: 6.849 ± 3.246
4.11LeuGln: 4.11 ± 1.025
2.74LeuArg: 2.74 ± 1.985
8.219LeuSer: 8.219 ± 0.907
6.849LeuThr: 6.849 ± 2.103
6.164LeuVal: 6.164 ± 2.11
2.055LeuTrp: 2.055 ± 0.059
5.479LeuTyr: 5.479 ± 1.748
0.0LeuXaa: 0.0 ± 0.0
Met
0.685MetAla: 0.685 ± 0.782
0.0MetCys: 0.0 ± 0.0
0.685MetAsp: 0.685 ± 0.361
0.685MetGlu: 0.685 ± 0.361
0.0MetPhe: 0.0 ± 0.0
0.685MetGly: 0.685 ± 0.361
1.37MetHis: 1.37 ± 0.421
2.74MetIle: 2.74 ± 1.446
2.055MetLys: 2.055 ± 1.203
0.0MetLeu: 0.0 ± 0.0
0.685MetMet: 0.685 ± 0.361
1.37MetAsn: 1.37 ± 0.723
2.74MetPro: 2.74 ± 0.841
1.37MetGln: 1.37 ± 0.421
1.37MetArg: 1.37 ± 0.723
1.37MetSer: 1.37 ± 0.421
1.37MetThr: 1.37 ± 0.723
0.685MetVal: 0.685 ± 0.361
0.0MetTrp: 0.0 ± 0.0
0.685MetTyr: 0.685 ± 0.782
0.0MetXaa: 0.0 ± 0.0
Asn
3.425AsnAla: 3.425 ± 0.664
0.0AsnCys: 0.0 ± 0.0
0.0AsnAsp: 0.0 ± 0.0
2.055AsnGlu: 2.055 ± 1.084
2.055AsnPhe: 2.055 ± 1.084
0.0AsnGly: 0.0 ± 0.0
0.0AsnHis: 0.0 ± 0.0
2.055AsnIle: 2.055 ± 0.059
10.274AsnLys: 10.274 ± 0.296
5.479AsnLeu: 5.479 ± 1.748
2.74AsnMet: 2.74 ± 1.446
1.37AsnAsn: 1.37 ± 0.421
2.74AsnPro: 2.74 ± 1.446
2.74AsnGln: 2.74 ± 0.302
2.74AsnArg: 2.74 ± 0.302
2.74AsnSer: 2.74 ± 0.841
3.425AsnThr: 3.425 ± 0.48
4.11AsnVal: 4.11 ± 1.025
0.685AsnTrp: 0.685 ± 0.361
0.685AsnTyr: 0.685 ± 0.361
0.0AsnXaa: 0.0 ± 0.0
Pro
2.055ProAla: 2.055 ± 1.203
0.0ProCys: 0.0 ± 0.0
5.479ProAsp: 5.479 ± 2.826
3.425ProGlu: 3.425 ± 1.623
3.425ProPhe: 3.425 ± 1.807
1.37ProGly: 1.37 ± 0.421
0.0ProHis: 0.0 ± 0.0
3.425ProIle: 3.425 ± 1.807
2.74ProLys: 2.74 ± 0.302
4.795ProLeu: 4.795 ± 1.387
2.055ProMet: 2.055 ± 0.059
0.0ProAsn: 0.0 ± 0.0
4.11ProPro: 4.11 ± 1.025
2.055ProGln: 2.055 ± 0.059
2.055ProArg: 2.055 ± 1.203
6.849ProSer: 6.849 ± 0.959
2.055ProThr: 2.055 ± 0.059
6.849ProVal: 6.849 ± 0.184
0.0ProTrp: 0.0 ± 0.0
3.425ProTyr: 3.425 ± 0.664
0.0ProXaa: 0.0 ± 0.0
Gln
3.425GlnAla: 3.425 ± 1.623
0.0GlnCys: 0.0 ± 0.0
1.37GlnAsp: 1.37 ± 0.421
0.685GlnGlu: 0.685 ± 0.361
2.055GlnPhe: 2.055 ± 1.084
0.685GlnGly: 0.685 ± 0.361
1.37GlnHis: 1.37 ± 0.723
2.74GlnIle: 2.74 ± 1.985
2.055GlnLys: 2.055 ± 0.059
4.795GlnLeu: 4.795 ± 2.53
2.055GlnMet: 2.055 ± 1.203
3.425GlnAsn: 3.425 ± 0.664
1.37GlnPro: 1.37 ± 0.421
2.74GlnGln: 2.74 ± 0.302
2.055GlnArg: 2.055 ± 1.203
1.37GlnSer: 1.37 ± 0.421
2.055GlnThr: 2.055 ± 0.059
0.685GlnVal: 0.685 ± 0.782
0.0GlnTrp: 0.0 ± 0.0
1.37GlnTyr: 1.37 ± 0.421
0.0GlnXaa: 0.0 ± 0.0
Arg
2.74ArgAla: 2.74 ± 0.302
0.685ArgCys: 0.685 ± 0.782
2.055ArgAsp: 2.055 ± 1.084
2.055ArgGlu: 2.055 ± 0.059
2.055ArgPhe: 2.055 ± 1.203
2.74ArgGly: 2.74 ± 0.302
0.685ArgHis: 0.685 ± 0.361
2.74ArgIle: 2.74 ± 0.841
5.479ArgLys: 5.479 ± 0.605
6.849ArgLeu: 6.849 ± 1.328
1.37ArgMet: 1.37 ± 0.421
2.74ArgAsn: 2.74 ± 0.302
0.685ArgPro: 0.685 ± 0.361
0.685ArgGln: 0.685 ± 0.782
4.11ArgArg: 4.11 ± 1.262
2.74ArgSer: 2.74 ± 0.841
0.685ArgThr: 0.685 ± 0.361
1.37ArgVal: 1.37 ± 0.421
1.37ArgTrp: 1.37 ± 0.421
1.37ArgTyr: 1.37 ± 0.723
0.0ArgXaa: 0.0 ± 0.0
Ser
4.11SerAla: 4.11 ± 1.262
0.0SerCys: 0.0 ± 0.0
5.479SerAsp: 5.479 ± 0.539
2.74SerGlu: 2.74 ± 0.841
6.164SerPhe: 6.164 ± 1.321
4.795SerGly: 4.795 ± 0.243
0.685SerHis: 0.685 ± 0.361
4.11SerIle: 4.11 ± 1.025
7.534SerLys: 7.534 ± 1.689
10.959SerLeu: 10.959 ± 4.508
0.685SerMet: 0.685 ± 0.361
3.425SerAsn: 3.425 ± 0.48
4.795SerPro: 4.795 ± 3.187
3.425SerGln: 3.425 ± 1.623
1.37SerArg: 1.37 ± 0.421
8.219SerSer: 8.219 ± 3.667
4.795SerThr: 4.795 ± 0.9
3.425SerVal: 3.425 ± 0.664
2.055SerTrp: 2.055 ± 1.084
1.37SerTyr: 1.37 ± 0.421
0.0SerXaa: 0.0 ± 0.0
Thr
4.795ThrAla: 4.795 ± 2.044
0.0ThrCys: 0.0 ± 0.0
2.055ThrAsp: 2.055 ± 0.059
4.11ThrGlu: 4.11 ± 1.025
1.37ThrPhe: 1.37 ± 0.421
4.795ThrGly: 4.795 ± 0.243
0.0ThrHis: 0.0 ± 0.0
1.37ThrIle: 1.37 ± 0.421
2.74ThrLys: 2.74 ± 1.985
5.479ThrLeu: 5.479 ± 1.682
0.0ThrMet: 0.0 ± 0.0
2.055ThrAsn: 2.055 ± 1.084
4.795ThrPro: 4.795 ± 0.243
0.685ThrGln: 0.685 ± 0.361
4.11ThrArg: 4.11 ± 1.025
6.849ThrSer: 6.849 ± 2.103
3.425ThrThr: 3.425 ± 0.664
4.795ThrVal: 4.795 ± 0.243
0.685ThrTrp: 0.685 ± 0.361
1.37ThrTyr: 1.37 ± 0.723
0.0ThrXaa: 0.0 ± 0.0
Val
4.11ValAla: 4.11 ± 1.025
0.685ValCys: 0.685 ± 0.361
6.849ValAsp: 6.849 ± 0.959
8.904ValGlu: 8.904 ± 3.555
2.055ValPhe: 2.055 ± 1.084
3.425ValGly: 3.425 ± 1.807
0.685ValHis: 0.685 ± 0.361
1.37ValIle: 1.37 ± 0.421
5.479ValLys: 5.479 ± 0.605
8.904ValLeu: 8.904 ± 5.592
1.37ValMet: 1.37 ± 0.723
4.11ValAsn: 4.11 ± 1.025
4.11ValPro: 4.11 ± 1.025
4.11ValGln: 4.11 ± 1.025
0.685ValArg: 0.685 ± 0.782
4.11ValSer: 4.11 ± 0.118
4.795ValThr: 4.795 ± 0.243
4.11ValVal: 4.11 ± 2.169
0.0ValTrp: 0.0 ± 0.0
2.74ValTyr: 2.74 ± 0.302
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
2.055TrpGlu: 2.055 ± 1.203
0.0TrpPhe: 0.0 ± 0.0
0.685TrpGly: 0.685 ± 0.361
0.685TrpHis: 0.685 ± 0.361
0.685TrpIle: 0.685 ± 0.361
0.0TrpLys: 0.0 ± 0.0
2.055TrpLeu: 2.055 ± 0.059
0.685TrpMet: 0.685 ± 0.782
2.055TrpAsn: 2.055 ± 1.084
0.0TrpPro: 0.0 ± 0.0
0.685TrpGln: 0.685 ± 0.782
2.055TrpArg: 2.055 ± 0.059
2.055TrpSer: 2.055 ± 0.059
0.685TrpThr: 0.685 ± 0.361
0.0TrpVal: 0.0 ± 0.0
0.685TrpTrp: 0.685 ± 0.782
1.37TrpTyr: 1.37 ± 0.421
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.425TyrAla: 3.425 ± 1.807
0.685TyrCys: 0.685 ± 0.361
0.0TyrAsp: 0.0 ± 0.0
2.74TyrGlu: 2.74 ± 1.446
2.055TyrPhe: 2.055 ± 0.059
2.74TyrGly: 2.74 ± 1.446
2.055TyrHis: 2.055 ± 1.084
1.37TyrIle: 1.37 ± 0.421
1.37TyrLys: 1.37 ± 0.421
2.74TyrLeu: 2.74 ± 0.302
0.0TyrMet: 0.0 ± 0.0
0.685TyrAsn: 0.685 ± 0.361
2.055TyrPro: 2.055 ± 0.059
1.37TyrGln: 1.37 ± 1.564
0.685TyrArg: 0.685 ± 0.782
2.74TyrSer: 2.74 ± 0.302
2.74TyrThr: 2.74 ± 0.841
0.685TyrVal: 0.685 ± 0.361
1.37TyrTrp: 1.37 ± 0.723
0.685TyrTyr: 0.685 ± 0.361
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (1461 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski