Amino acid dipepetide frequency for Selenomonas sp. mPRGC5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.135AlaAla: 11.135 ± 0.166
1.127AlaCys: 1.127 ± 0.038
5.53AlaAsp: 5.53 ± 0.091
6.944AlaGlu: 6.944 ± 0.116
3.288AlaPhe: 3.288 ± 0.07
7.961AlaGly: 7.961 ± 0.165
1.584AlaHis: 1.584 ± 0.049
5.801AlaIle: 5.801 ± 0.096
5.969AlaLys: 5.969 ± 0.104
8.043AlaLeu: 8.043 ± 0.124
3.199AlaMet: 3.199 ± 0.074
3.201AlaAsn: 3.201 ± 0.082
2.796AlaPro: 2.796 ± 0.078
3.277AlaGln: 3.277 ± 0.07
4.159AlaArg: 4.159 ± 0.088
4.754AlaSer: 4.754 ± 0.082
3.767AlaThr: 3.767 ± 0.066
7.404AlaVal: 7.404 ± 0.106
0.817AlaTrp: 0.817 ± 0.036
2.798AlaTyr: 2.798 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.86CysAla: 0.86 ± 0.037
0.195CysCys: 0.195 ± 0.016
0.59CysAsp: 0.59 ± 0.025
0.705CysGlu: 0.705 ± 0.03
0.508CysPhe: 0.508 ± 0.026
1.245CysGly: 1.245 ± 0.049
0.281CysHis: 0.281 ± 0.022
0.728CysIle: 0.728 ± 0.032
0.57CysLys: 0.57 ± 0.029
1.134CysLeu: 1.134 ± 0.041
0.314CysMet: 0.314 ± 0.021
0.415CysAsn: 0.415 ± 0.026
0.61CysPro: 0.61 ± 0.03
0.457CysGln: 0.457 ± 0.023
0.708CysArg: 0.708 ± 0.029
0.659CysSer: 0.659 ± 0.028
0.506CysThr: 0.506 ± 0.023
0.729CysVal: 0.729 ± 0.032
0.136CysTrp: 0.136 ± 0.013
0.448CysTyr: 0.448 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
4.878AspAla: 4.878 ± 0.095
0.7AspCys: 0.7 ± 0.025
3.023AspAsp: 3.023 ± 0.071
4.355AspGlu: 4.355 ± 0.089
2.741AspPhe: 2.741 ± 0.053
4.444AspGly: 4.444 ± 0.083
0.974AspHis: 0.974 ± 0.038
4.417AspIle: 4.417 ± 0.09
3.953AspLys: 3.953 ± 0.069
4.419AspLeu: 4.419 ± 0.075
1.934AspMet: 1.934 ± 0.046
2.195AspAsn: 2.195 ± 0.058
1.694AspPro: 1.694 ± 0.044
1.198AspGln: 1.198 ± 0.034
2.48AspArg: 2.48 ± 0.052
2.917AspSer: 2.917 ± 0.064
2.979AspThr: 2.979 ± 0.074
4.202AspVal: 4.202 ± 0.082
0.675AspTrp: 0.675 ± 0.029
2.475AspTyr: 2.475 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
6.632GluAla: 6.632 ± 0.111
0.634GluCys: 0.634 ± 0.027
3.609GluAsp: 3.609 ± 0.067
5.564GluGlu: 5.564 ± 0.111
2.24GluPhe: 2.24 ± 0.06
4.196GluGly: 4.196 ± 0.069
1.416GluHis: 1.416 ± 0.04
4.617GluIle: 4.617 ± 0.079
5.455GluLys: 5.455 ± 0.089
6.731GluLeu: 6.731 ± 0.112
2.16GluMet: 2.16 ± 0.059
3.243GluAsn: 3.243 ± 0.062
2.052GluPro: 2.052 ± 0.056
3.072GluGln: 3.072 ± 0.076
3.551GluArg: 3.551 ± 0.076
3.097GluSer: 3.097 ± 0.069
3.288GluThr: 3.288 ± 0.066
4.503GluVal: 4.503 ± 0.086
0.57GluTrp: 0.57 ± 0.025
2.306GluTyr: 2.306 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.631PheAla: 3.631 ± 0.069
0.654PheCys: 0.654 ± 0.032
2.432PheAsp: 2.432 ± 0.055
2.017PheGlu: 2.017 ± 0.058
1.846PhePhe: 1.846 ± 0.055
3.069PheGly: 3.069 ± 0.067
0.903PheHis: 0.903 ± 0.033
2.459PheIle: 2.459 ± 0.058
1.728PheLys: 1.728 ± 0.045
3.762PheLeu: 3.762 ± 0.087
1.235PheMet: 1.235 ± 0.045
1.376PheAsn: 1.376 ± 0.035
1.257PhePro: 1.257 ± 0.044
1.229PheGln: 1.229 ± 0.036
1.767PheArg: 1.767 ± 0.046
2.525PheSer: 2.525 ± 0.057
2.217PheThr: 2.217 ± 0.054
2.782PheVal: 2.782 ± 0.071
0.436PheTrp: 0.436 ± 0.024
1.38PheTyr: 1.38 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
6.331GlyAla: 6.331 ± 0.126
1.086GlyCys: 1.086 ± 0.047
3.912GlyAsp: 3.912 ± 0.114
4.482GlyGlu: 4.482 ± 0.082
3.219GlyPhe: 3.219 ± 0.073
5.515GlyGly: 5.515 ± 0.128
1.589GlyHis: 1.589 ± 0.043
5.781GlyIle: 5.781 ± 0.092
5.236GlyLys: 5.236 ± 0.104
6.337GlyLeu: 6.337 ± 0.087
2.589GlyMet: 2.589 ± 0.064
2.908GlyAsn: 2.908 ± 0.109
1.557GlyPro: 1.557 ± 0.045
2.566GlyGln: 2.566 ± 0.059
3.882GlyArg: 3.882 ± 0.071
4.334GlySer: 4.334 ± 0.123
4.471GlyThr: 4.471 ± 0.108
5.398GlyVal: 5.398 ± 0.092
0.918GlyTrp: 0.918 ± 0.029
2.716GlyTyr: 2.716 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.488HisAla: 1.488 ± 0.044
0.308HisCys: 0.308 ± 0.02
1.14HisAsp: 1.14 ± 0.035
1.324HisGlu: 1.324 ± 0.045
0.882HisPhe: 0.882 ± 0.033
1.599HisGly: 1.599 ± 0.047
0.555HisHis: 0.555 ± 0.03
1.47HisIle: 1.47 ± 0.039
1.07HisLys: 1.07 ± 0.037
1.681HisLeu: 1.681 ± 0.044
0.574HisMet: 0.574 ± 0.027
0.833HisAsn: 0.833 ± 0.032
1.021HisPro: 1.021 ± 0.036
0.668HisGln: 0.668 ± 0.029
0.98HisArg: 0.98 ± 0.035
1.004HisSer: 1.004 ± 0.038
1.116HisThr: 1.116 ± 0.039
1.318HisVal: 1.318 ± 0.037
0.24HisTrp: 0.24 ± 0.018
0.788HisTyr: 0.788 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
6.089IleAla: 6.089 ± 0.098
0.901IleCys: 0.901 ± 0.033
4.011IleAsp: 4.011 ± 0.073
4.192IleGlu: 4.192 ± 0.075
2.438IlePhe: 2.438 ± 0.062
4.99IleGly: 4.99 ± 0.075
1.379IleHis: 1.379 ± 0.04
4.018IleIle: 4.018 ± 0.09
3.623IleLys: 3.623 ± 0.064
5.8IleLeu: 5.8 ± 0.118
1.867IleMet: 1.867 ± 0.048
2.584IleAsn: 2.584 ± 0.07
2.746IlePro: 2.746 ± 0.061
2.116IleGln: 2.116 ± 0.051
3.367IleArg: 3.367 ± 0.064
3.779IleSer: 3.779 ± 0.078
3.817IleThr: 3.817 ± 0.077
4.676IleVal: 4.676 ± 0.088
0.519IleTrp: 0.519 ± 0.026
2.068IleTyr: 2.068 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
5.928LysAla: 5.928 ± 0.096
0.522LysCys: 0.522 ± 0.025
3.833LysAsp: 3.833 ± 0.076
4.947LysGlu: 4.947 ± 0.081
1.948LysPhe: 1.948 ± 0.057
3.91LysGly: 3.91 ± 0.077
1.083LysHis: 1.083 ± 0.033
4.045LysIle: 4.045 ± 0.072
4.867LysLys: 4.867 ± 0.105
5.539LysLeu: 5.539 ± 0.086
1.98LysMet: 1.98 ± 0.052
2.932LysAsn: 2.932 ± 0.077
2.134LysPro: 2.134 ± 0.053
2.339LysGln: 2.339 ± 0.053
2.871LysArg: 2.871 ± 0.062
3.012LysSer: 3.012 ± 0.067
3.187LysThr: 3.187 ± 0.069
4.301LysVal: 4.301 ± 0.072
0.598LysTrp: 0.598 ± 0.024
2.224LysTyr: 2.224 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
9.375LeuAla: 9.375 ± 0.139
1.146LeuCys: 1.146 ± 0.043
5.11LeuAsp: 5.11 ± 0.079
5.559LeuGlu: 5.559 ± 0.088
3.398LeuPhe: 3.398 ± 0.082
6.732LeuGly: 6.732 ± 0.113
1.859LeuHis: 1.859 ± 0.049
4.931LeuIle: 4.931 ± 0.09
5.27LeuLys: 5.27 ± 0.084
9.282LeuLeu: 9.282 ± 0.166
2.753LeuMet: 2.753 ± 0.061
3.253LeuAsn: 3.253 ± 0.063
4.266LeuPro: 4.266 ± 0.075
3.61LeuGln: 3.61 ± 0.067
4.53LeuArg: 4.53 ± 0.099
5.901LeuSer: 5.901 ± 0.101
5.466LeuThr: 5.466 ± 0.094
6.187LeuVal: 6.187 ± 0.099
0.793LeuTrp: 0.793 ± 0.035
2.796LeuTyr: 2.796 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
3.182MetAla: 3.182 ± 0.066
0.238MetCys: 0.238 ± 0.018
1.914MetAsp: 1.914 ± 0.052
2.194MetGlu: 2.194 ± 0.053
1.014MetPhe: 1.014 ± 0.035
2.223MetGly: 2.223 ± 0.059
0.506MetHis: 0.506 ± 0.023
1.699MetIle: 1.699 ± 0.057
2.153MetLys: 2.153 ± 0.048
2.952MetLeu: 2.952 ± 0.063
1.048MetMet: 1.048 ± 0.039
1.397MetAsn: 1.397 ± 0.04
1.377MetPro: 1.377 ± 0.041
1.262MetGln: 1.262 ± 0.038
1.562MetArg: 1.562 ± 0.048
1.742MetSer: 1.742 ± 0.041
1.895MetThr: 1.895 ± 0.048
2.14MetVal: 2.14 ± 0.056
0.175MetTrp: 0.175 ± 0.014
0.713MetTyr: 0.713 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.224AsnAla: 3.224 ± 0.092
0.461AsnCys: 0.461 ± 0.023
2.099AsnAsp: 2.099 ± 0.06
2.269AsnGlu: 2.269 ± 0.058
1.52AsnPhe: 1.52 ± 0.043
3.27AsnGly: 3.27 ± 0.089
0.851AsnHis: 0.851 ± 0.034
2.963AsnIle: 2.963 ± 0.076
2.07AsnLys: 2.07 ± 0.056
3.695AsnLeu: 3.695 ± 0.073
1.296AsnMet: 1.296 ± 0.035
1.597AsnAsn: 1.597 ± 0.071
2.019AsnPro: 2.019 ± 0.048
1.331AsnGln: 1.331 ± 0.044
1.932AsnArg: 1.932 ± 0.053
1.966AsnSer: 1.966 ± 0.06
2.078AsnThr: 2.078 ± 0.066
2.823AsnVal: 2.823 ± 0.101
0.45AsnTrp: 0.45 ± 0.026
1.542AsnTyr: 1.542 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
3.549ProAla: 3.549 ± 0.089
0.38ProCys: 0.38 ± 0.025
2.338ProAsp: 2.338 ± 0.055
3.372ProGlu: 3.372 ± 0.072
1.529ProPhe: 1.529 ± 0.051
2.518ProGly: 2.518 ± 0.052
0.725ProHis: 0.725 ± 0.03
2.191ProIle: 2.191 ± 0.059
1.994ProLys: 1.994 ± 0.051
3.183ProLeu: 3.183 ± 0.071
1.059ProMet: 1.059 ± 0.036
1.288ProAsn: 1.288 ± 0.042
1.045ProPro: 1.045 ± 0.041
1.576ProGln: 1.576 ± 0.046
1.4ProArg: 1.4 ± 0.041
1.73ProSer: 1.73 ± 0.044
1.648ProThr: 1.648 ± 0.041
3.157ProVal: 3.157 ± 0.062
0.392ProTrp: 0.392 ± 0.02
1.291ProTyr: 1.291 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
3.819GlnAla: 3.819 ± 0.072
0.281GlnCys: 0.281 ± 0.017
1.927GlnAsp: 1.927 ± 0.052
3.136GlnGlu: 3.136 ± 0.077
1.119GlnPhe: 1.119 ± 0.032
2.53GlnGly: 2.53 ± 0.062
0.74GlnHis: 0.74 ± 0.03
2.098GlnIle: 2.098 ± 0.054
2.584GlnLys: 2.584 ± 0.061
3.631GlnLeu: 3.631 ± 0.071
1.063GlnMet: 1.063 ± 0.035
1.598GlnAsn: 1.598 ± 0.056
1.384GlnPro: 1.384 ± 0.054
2.369GlnGln: 2.369 ± 0.078
1.841GlnArg: 1.841 ± 0.052
1.841GlnSer: 1.841 ± 0.058
1.757GlnThr: 1.757 ± 0.05
2.429GlnVal: 2.429 ± 0.053
0.335GlnTrp: 0.335 ± 0.02
1.204GlnTyr: 1.204 ± 0.038
0.0GlnXaa: 0.0 ± 0.0
Arg
3.574ArgAla: 3.574 ± 0.066
0.564ArgCys: 0.564 ± 0.03
2.55ArgAsp: 2.55 ± 0.056
4.045ArgGlu: 4.045 ± 0.081
1.896ArgPhe: 1.896 ± 0.055
2.971ArgGly: 2.971 ± 0.059
1.098ArgHis: 1.098 ± 0.04
3.53ArgIle: 3.53 ± 0.073
3.229ArgLys: 3.229 ± 0.066
4.738ArgLeu: 4.738 ± 0.088
1.568ArgMet: 1.568 ± 0.043
2.02ArgAsn: 2.02 ± 0.051
1.682ArgPro: 1.682 ± 0.043
2.478ArgGln: 2.478 ± 0.068
2.815ArgArg: 2.815 ± 0.068
2.247ArgSer: 2.247 ± 0.052
2.33ArgThr: 2.33 ± 0.048
3.034ArgVal: 3.034 ± 0.055
0.546ArgTrp: 0.546 ± 0.026
1.877ArgTyr: 1.877 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
4.71SerAla: 4.71 ± 0.107
0.668SerCys: 0.668 ± 0.028
2.813SerAsp: 2.813 ± 0.061
3.068SerGlu: 3.068 ± 0.063
2.444SerPhe: 2.444 ± 0.052
4.533SerGly: 4.533 ± 0.11
1.126SerHis: 1.126 ± 0.032
3.537SerIle: 3.537 ± 0.072
2.813SerLys: 2.813 ± 0.064
5.397SerLeu: 5.397 ± 0.081
1.629SerMet: 1.629 ± 0.046
1.97SerAsn: 1.97 ± 0.049
1.825SerPro: 1.825 ± 0.051
2.006SerGln: 2.006 ± 0.056
2.805SerArg: 2.805 ± 0.064
3.143SerSer: 3.143 ± 0.095
2.731SerThr: 2.731 ± 0.071
4.063SerVal: 4.063 ± 0.07
0.632SerTrp: 0.632 ± 0.026
1.995SerTyr: 1.995 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
5.387ThrAla: 5.387 ± 0.09
0.545ThrCys: 0.545 ± 0.028
2.92ThrAsp: 2.92 ± 0.062
3.275ThrGlu: 3.275 ± 0.062
2.033ThrPhe: 2.033 ± 0.051
4.765ThrGly: 4.765 ± 0.102
0.947ThrHis: 0.947 ± 0.032
3.561ThrIle: 3.561 ± 0.071
2.932ThrLys: 2.932 ± 0.064
4.758ThrLeu: 4.758 ± 0.082
1.544ThrMet: 1.544 ± 0.048
1.946ThrAsn: 1.946 ± 0.07
2.357ThrPro: 2.357 ± 0.062
1.558ThrGln: 1.558 ± 0.04
2.167ThrArg: 2.167 ± 0.053
2.722ThrSer: 2.722 ± 0.07
2.893ThrThr: 2.893 ± 0.08
4.29ThrVal: 4.29 ± 0.097
0.469ThrTrp: 0.469 ± 0.024
1.689ThrTyr: 1.689 ± 0.056
0.0ThrXaa: 0.0 ± 0.0
Val
6.313ValAla: 6.313 ± 0.104
0.875ValCys: 0.875 ± 0.034
4.159ValAsp: 4.159 ± 0.072
4.636ValGlu: 4.636 ± 0.083
2.802ValPhe: 2.802 ± 0.077
4.867ValGly: 4.867 ± 0.098
1.304ValHis: 1.304 ± 0.039
4.671ValIle: 4.671 ± 0.078
4.369ValLys: 4.369 ± 0.076
6.788ValLeu: 6.788 ± 0.099
2.331ValMet: 2.331 ± 0.056
2.823ValAsn: 2.823 ± 0.078
2.907ValPro: 2.907 ± 0.067
2.317ValGln: 2.317 ± 0.054
3.529ValArg: 3.529 ± 0.055
4.316ValSer: 4.316 ± 0.09
4.23ValThr: 4.23 ± 0.077
5.422ValVal: 5.422 ± 0.105
0.652ValTrp: 0.652 ± 0.029
2.293ValTyr: 2.293 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.688TrpAla: 0.688 ± 0.036
0.128TrpCys: 0.128 ± 0.011
0.475TrpAsp: 0.475 ± 0.026
0.617TrpGlu: 0.617 ± 0.026
0.385TrpPhe: 0.385 ± 0.022
0.709TrpGly: 0.709 ± 0.035
0.271TrpHis: 0.271 ± 0.019
0.525TrpIle: 0.525 ± 0.024
0.59TrpLys: 0.59 ± 0.026
1.094TrpLeu: 1.094 ± 0.039
0.322TrpMet: 0.322 ± 0.02
0.498TrpAsn: 0.498 ± 0.027
0.299TrpPro: 0.299 ± 0.018
0.72TrpGln: 0.72 ± 0.035
0.556TrpArg: 0.556 ± 0.028
0.52TrpSer: 0.52 ± 0.024
0.456TrpThr: 0.456 ± 0.024
0.483TrpVal: 0.483 ± 0.026
0.139TrpTrp: 0.139 ± 0.013
0.364TrpTyr: 0.364 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.762TyrAla: 2.762 ± 0.056
0.383TyrCys: 0.383 ± 0.022
2.266TyrAsp: 2.266 ± 0.06
2.237TyrGlu: 2.237 ± 0.06
1.455TyrPhe: 1.455 ± 0.05
2.781TyrGly: 2.781 ± 0.057
0.868TyrHis: 0.868 ± 0.034
1.937TyrIle: 1.937 ± 0.047
1.727TyrLys: 1.727 ± 0.052
3.252TyrLeu: 3.252 ± 0.068
0.919TyrMet: 0.919 ± 0.036
1.381TyrAsn: 1.381 ± 0.045
1.336TyrPro: 1.336 ± 0.048
1.536TyrGln: 1.536 ± 0.046
1.889TyrArg: 1.889 ± 0.052
1.698TyrSer: 1.698 ± 0.048
1.928TyrThr: 1.928 ± 0.055
2.263TyrVal: 2.263 ± 0.054
0.348TyrTrp: 0.348 ± 0.021
1.311TyrTyr: 1.311 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2656 proteins (875554 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski