Amino acid dipepetide frequency for Crassaminicella sp. SY095

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.462AlaAla: 4.462 ± 0.088
0.723AlaCys: 0.723 ± 0.035
2.699AlaAsp: 2.699 ± 0.062
3.658AlaGlu: 3.658 ± 0.079
2.715AlaPhe: 2.715 ± 0.059
4.187AlaGly: 4.187 ± 0.088
0.93AlaHis: 0.93 ± 0.034
6.231AlaIle: 6.231 ± 0.096
5.296AlaLys: 5.296 ± 0.085
6.043AlaLeu: 6.043 ± 0.094
1.905AlaMet: 1.905 ± 0.047
2.624AlaAsn: 2.624 ± 0.059
1.521AlaPro: 1.521 ± 0.049
1.66AlaGln: 1.66 ± 0.049
2.114AlaArg: 2.114 ± 0.052
3.333AlaSer: 3.333 ± 0.072
3.027AlaThr: 3.027 ± 0.069
4.458AlaVal: 4.458 ± 0.079
0.353AlaTrp: 0.353 ± 0.02
2.255AlaTyr: 2.255 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
0.607CysAla: 0.607 ± 0.028
0.175CysCys: 0.175 ± 0.015
0.547CysAsp: 0.547 ± 0.026
0.676CysGlu: 0.676 ± 0.03
0.42CysPhe: 0.42 ± 0.024
0.924CysGly: 0.924 ± 0.04
0.175CysHis: 0.175 ± 0.015
1.168CysIle: 1.168 ± 0.039
0.895CysLys: 0.895 ± 0.033
0.794CysLeu: 0.794 ± 0.028
0.284CysMet: 0.284 ± 0.017
0.539CysAsn: 0.539 ± 0.023
0.467CysPro: 0.467 ± 0.03
0.225CysGln: 0.225 ± 0.016
0.406CysArg: 0.406 ± 0.022
0.62CysSer: 0.62 ± 0.03
0.517CysThr: 0.517 ± 0.025
0.665CysVal: 0.665 ± 0.033
0.075CysTrp: 0.075 ± 0.01
0.374CysTyr: 0.374 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
2.965AspAla: 2.965 ± 0.073
0.52AspCys: 0.52 ± 0.028
2.494AspAsp: 2.494 ± 0.063
4.512AspGlu: 4.512 ± 0.081
2.629AspPhe: 2.629 ± 0.054
3.164AspGly: 3.164 ± 0.07
0.767AspHis: 0.767 ± 0.028
6.161AspIle: 6.161 ± 0.094
5.103AspLys: 5.103 ± 0.077
4.947AspLeu: 4.947 ± 0.079
1.538AspMet: 1.538 ± 0.045
2.326AspAsn: 2.326 ± 0.063
1.54AspPro: 1.54 ± 0.043
1.209AspGln: 1.209 ± 0.037
1.92AspArg: 1.92 ± 0.047
2.346AspSer: 2.346 ± 0.049
2.61AspThr: 2.61 ± 0.052
3.596AspVal: 3.596 ± 0.061
0.391AspTrp: 0.391 ± 0.022
2.373AspTyr: 2.373 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
4.504GluAla: 4.504 ± 0.09
0.563GluCys: 0.563 ± 0.025
4.138GluAsp: 4.138 ± 0.08
7.302GluGlu: 7.302 ± 0.12
2.646GluPhe: 2.646 ± 0.054
4.454GluGly: 4.454 ± 0.081
1.021GluHis: 1.021 ± 0.036
8.012GluIle: 8.012 ± 0.099
8.79GluLys: 8.79 ± 0.129
6.462GluLeu: 6.462 ± 0.096
2.174GluMet: 2.174 ± 0.048
5.054GluAsn: 5.054 ± 0.092
1.387GluPro: 1.387 ± 0.042
2.014GluGln: 2.014 ± 0.053
2.899GluArg: 2.899 ± 0.063
3.122GluSer: 3.122 ± 0.064
2.874GluThr: 2.874 ± 0.069
5.076GluVal: 5.076 ± 0.083
0.48GluTrp: 0.48 ± 0.025
2.891GluTyr: 2.891 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
2.309PheAla: 2.309 ± 0.057
0.538PheCys: 0.538 ± 0.024
2.396PheAsp: 2.396 ± 0.055
2.921PheGlu: 2.921 ± 0.062
1.976PhePhe: 1.976 ± 0.064
2.926PheGly: 2.926 ± 0.066
0.767PheHis: 0.767 ± 0.032
4.594PheIle: 4.594 ± 0.094
3.469PheLys: 3.469 ± 0.066
3.808PheLeu: 3.808 ± 0.07
1.169PheMet: 1.169 ± 0.035
2.05PheAsn: 2.05 ± 0.047
1.269PhePro: 1.269 ± 0.044
1.064PheGln: 1.064 ± 0.031
1.374PheArg: 1.374 ± 0.039
2.719PheSer: 2.719 ± 0.059
2.275PheThr: 2.275 ± 0.061
2.957PheVal: 2.957 ± 0.065
0.324PheTrp: 0.324 ± 0.02
1.721PheTyr: 1.721 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
4.456GlyAla: 4.456 ± 0.099
0.817GlyCys: 0.817 ± 0.038
3.093GlyAsp: 3.093 ± 0.069
4.205GlyGlu: 4.205 ± 0.08
3.088GlyPhe: 3.088 ± 0.071
4.435GlyGly: 4.435 ± 0.087
1.075GlyHis: 1.075 ± 0.041
7.421GlyIle: 7.421 ± 0.101
5.998GlyLys: 5.998 ± 0.088
6.005GlyLeu: 6.005 ± 0.099
2.04GlyMet: 2.04 ± 0.044
3.038GlyAsn: 3.038 ± 0.066
1.446GlyPro: 1.446 ± 0.041
1.617GlyGln: 1.617 ± 0.051
2.456GlyArg: 2.456 ± 0.056
3.229GlySer: 3.229 ± 0.068
3.42GlyThr: 3.42 ± 0.063
4.804GlyVal: 4.804 ± 0.09
0.504GlyTrp: 0.504 ± 0.025
2.956GlyTyr: 2.956 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
0.903HisAla: 0.903 ± 0.033
0.18HisCys: 0.18 ± 0.015
0.687HisAsp: 0.687 ± 0.029
1.041HisGlu: 1.041 ± 0.036
0.704HisPhe: 0.704 ± 0.028
1.026HisGly: 1.026 ± 0.035
0.322HisHis: 0.322 ± 0.02
1.67HisIle: 1.67 ± 0.051
1.299HisLys: 1.299 ± 0.04
1.391HisLeu: 1.391 ± 0.045
0.454HisMet: 0.454 ± 0.022
0.795HisAsn: 0.795 ± 0.033
0.76HisPro: 0.76 ± 0.033
0.43HisGln: 0.43 ± 0.024
0.625HisArg: 0.625 ± 0.029
0.867HisSer: 0.867 ± 0.032
0.841HisThr: 0.841 ± 0.034
0.98HisVal: 0.98 ± 0.03
0.128HisTrp: 0.128 ± 0.012
0.608HisTyr: 0.608 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.497IleAla: 6.497 ± 0.095
1.173IleCys: 1.173 ± 0.037
6.168IleAsp: 6.168 ± 0.087
7.973IleGlu: 7.973 ± 0.1
4.439IlePhe: 4.439 ± 0.088
7.084IleGly: 7.084 ± 0.106
1.711IleHis: 1.711 ± 0.045
9.724IleIle: 9.724 ± 0.142
9.432IleLys: 9.432 ± 0.106
9.435IleLeu: 9.435 ± 0.122
2.489IleMet: 2.489 ± 0.059
5.337IleAsn: 5.337 ± 0.078
3.808IlePro: 3.808 ± 0.074
2.864IleGln: 2.864 ± 0.059
3.393IleArg: 3.393 ± 0.073
5.974IleSer: 5.974 ± 0.097
4.954IleThr: 4.954 ± 0.099
6.48IleVal: 6.48 ± 0.086
0.554IleTrp: 0.554 ± 0.029
3.499IleTyr: 3.499 ± 0.065
0.0IleXaa: 0.0 ± 0.0
Lys
5.348LysAla: 5.348 ± 0.096
0.709LysCys: 0.709 ± 0.034
5.831LysAsp: 5.831 ± 0.102
9.662LysGlu: 9.662 ± 0.111
3.02LysPhe: 3.02 ± 0.064
5.458LysGly: 5.458 ± 0.079
1.387LysHis: 1.387 ± 0.039
9.504LysIle: 9.504 ± 0.097
9.738LysLys: 9.738 ± 0.137
7.75LysLeu: 7.75 ± 0.11
2.766LysMet: 2.766 ± 0.056
6.41LysAsn: 6.41 ± 0.09
2.374LysPro: 2.374 ± 0.051
2.496LysGln: 2.496 ± 0.053
3.588LysArg: 3.588 ± 0.068
4.456LysSer: 4.456 ± 0.082
3.982LysThr: 3.982 ± 0.068
6.101LysVal: 6.101 ± 0.1
0.648LysTrp: 0.648 ± 0.028
4.051LysTyr: 4.051 ± 0.072
0.0LysXaa: 0.0 ± 0.0
Leu
5.438LeuAla: 5.438 ± 0.081
1.005LeuCys: 1.005 ± 0.032
5.058LeuAsp: 5.058 ± 0.081
6.76LeuGlu: 6.76 ± 0.093
3.724LeuPhe: 3.724 ± 0.078
6.436LeuGly: 6.436 ± 0.107
1.206LeuHis: 1.206 ± 0.036
7.927LeuIle: 7.927 ± 0.121
8.946LeuLys: 8.946 ± 0.103
8.048LeuLeu: 8.048 ± 0.112
2.423LeuMet: 2.423 ± 0.055
4.967LeuAsn: 4.967 ± 0.082
2.97LeuPro: 2.97 ± 0.064
2.262LeuGln: 2.262 ± 0.057
3.314LeuArg: 3.314 ± 0.064
5.834LeuSer: 5.834 ± 0.085
4.165LeuThr: 4.165 ± 0.074
5.307LeuVal: 5.307 ± 0.095
0.554LeuTrp: 0.554 ± 0.029
3.066LeuTyr: 3.066 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
2.018MetAla: 2.018 ± 0.052
0.226MetCys: 0.226 ± 0.016
1.649MetAsp: 1.649 ± 0.045
1.901MetGlu: 1.901 ± 0.048
1.022MetPhe: 1.022 ± 0.032
2.027MetGly: 2.027 ± 0.052
0.464MetHis: 0.464 ± 0.023
2.677MetIle: 2.677 ± 0.06
2.976MetLys: 2.976 ± 0.058
2.302MetLeu: 2.302 ± 0.055
0.824MetMet: 0.824 ± 0.032
1.715MetAsn: 1.715 ± 0.041
0.936MetPro: 0.936 ± 0.033
0.786MetGln: 0.786 ± 0.034
0.969MetArg: 0.969 ± 0.034
1.478MetSer: 1.478 ± 0.04
1.261MetThr: 1.261 ± 0.039
1.781MetVal: 1.781 ± 0.049
0.139MetTrp: 0.139 ± 0.012
0.838MetTyr: 0.838 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
2.89AsnAla: 2.89 ± 0.057
0.598AsnCys: 0.598 ± 0.026
2.456AsnAsp: 2.456 ± 0.058
3.71AsnGlu: 3.71 ± 0.078
2.223AsnPhe: 2.223 ± 0.049
3.192AsnGly: 3.192 ± 0.063
0.924AsnHis: 0.924 ± 0.031
6.617AsnIle: 6.617 ± 0.098
5.35AsnLys: 5.35 ± 0.081
4.82AsnLeu: 4.82 ± 0.078
1.635AsnMet: 1.635 ± 0.046
3.271AsnAsn: 3.271 ± 0.076
2.18AsnPro: 2.18 ± 0.051
1.527AsnGln: 1.527 ± 0.047
2.054AsnArg: 2.054 ± 0.045
2.532AsnSer: 2.532 ± 0.07
2.627AsnThr: 2.627 ± 0.062
3.382AsnVal: 3.382 ± 0.062
0.444AsnTrp: 0.444 ± 0.024
2.084AsnTyr: 2.084 ± 0.052
0.0AsnXaa: 0.0 ± 0.0
Pro
1.609ProAla: 1.609 ± 0.049
0.319ProCys: 0.319 ± 0.019
1.599ProAsp: 1.599 ± 0.047
2.18ProGlu: 2.18 ± 0.049
1.49ProPhe: 1.49 ± 0.042
1.937ProGly: 1.937 ± 0.054
0.555ProHis: 0.555 ± 0.026
3.203ProIle: 3.203 ± 0.071
2.644ProLys: 2.644 ± 0.053
2.607ProLeu: 2.607 ± 0.056
0.803ProMet: 0.803 ± 0.033
1.598ProAsn: 1.598 ± 0.047
0.785ProPro: 0.785 ± 0.036
0.872ProGln: 0.872 ± 0.033
0.9ProArg: 0.9 ± 0.031
1.731ProSer: 1.731 ± 0.048
1.621ProThr: 1.621 ± 0.047
2.307ProVal: 2.307 ± 0.061
0.252ProTrp: 0.252 ± 0.017
1.405ProTyr: 1.405 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
1.63GlnAla: 1.63 ± 0.046
0.25GlnCys: 0.25 ± 0.017
1.187GlnAsp: 1.187 ± 0.042
2.034GlnGlu: 2.034 ± 0.054
1.05GlnPhe: 1.05 ± 0.037
1.479GlnGly: 1.479 ± 0.042
0.379GlnHis: 0.379 ± 0.02
2.611GlnIle: 2.611 ± 0.049
2.674GlnLys: 2.674 ± 0.059
2.409GlnLeu: 2.409 ± 0.053
0.853GlnMet: 0.853 ± 0.032
1.58GlnAsn: 1.58 ± 0.041
0.687GlnPro: 0.687 ± 0.028
0.819GlnGln: 0.819 ± 0.034
1.068GlnArg: 1.068 ± 0.037
1.333GlnSer: 1.333 ± 0.042
1.158GlnThr: 1.158 ± 0.042
1.663GlnVal: 1.663 ± 0.046
0.206GlnTrp: 0.206 ± 0.015
1.136GlnTyr: 1.136 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
1.955ArgAla: 1.955 ± 0.045
0.43ArgCys: 0.43 ± 0.023
1.794ArgAsp: 1.794 ± 0.043
3.016ArgGlu: 3.016 ± 0.066
1.576ArgPhe: 1.576 ± 0.044
2.189ArgGly: 2.189 ± 0.052
0.521ArgHis: 0.521 ± 0.023
3.549ArgIle: 3.549 ± 0.071
3.806ArgLys: 3.806 ± 0.068
3.199ArgLeu: 3.199 ± 0.065
1.081ArgMet: 1.081 ± 0.038
2.026ArgAsn: 2.026 ± 0.047
1.061ArgPro: 1.061 ± 0.037
1.057ArgGln: 1.057 ± 0.042
1.57ArgArg: 1.57 ± 0.046
1.634ArgSer: 1.634 ± 0.045
1.557ArgThr: 1.557 ± 0.041
2.355ArgVal: 2.355 ± 0.054
0.275ArgTrp: 0.275 ± 0.016
1.471ArgTyr: 1.471 ± 0.047
0.0ArgXaa: 0.0 ± 0.0
Ser
2.814SerAla: 2.814 ± 0.065
0.572SerCys: 0.572 ± 0.026
2.46SerAsp: 2.46 ± 0.053
3.279SerGlu: 3.279 ± 0.064
2.697SerPhe: 2.697 ± 0.057
3.611SerGly: 3.611 ± 0.062
0.87SerHis: 0.87 ± 0.033
5.856SerIle: 5.856 ± 0.099
5.039SerLys: 5.039 ± 0.087
4.968SerLeu: 4.968 ± 0.086
1.571SerMet: 1.571 ± 0.045
2.864SerAsn: 2.864 ± 0.07
1.612SerPro: 1.612 ± 0.041
1.48SerGln: 1.48 ± 0.044
1.889SerArg: 1.889 ± 0.045
3.165SerSer: 3.165 ± 0.074
2.651SerThr: 2.651 ± 0.068
3.459SerVal: 3.459 ± 0.059
0.428SerTrp: 0.428 ± 0.022
2.081SerTyr: 2.081 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
3.052ThrAla: 3.052 ± 0.068
0.464ThrCys: 0.464 ± 0.027
2.308ThrAsp: 2.308 ± 0.048
2.879ThrGlu: 2.879 ± 0.064
2.104ThrPhe: 2.104 ± 0.048
3.773ThrGly: 3.773 ± 0.071
0.75ThrHis: 0.75 ± 0.032
5.001ThrIle: 5.001 ± 0.084
3.892ThrLys: 3.892 ± 0.073
4.378ThrLeu: 4.378 ± 0.081
1.084ThrMet: 1.084 ± 0.041
2.489ThrAsn: 2.489 ± 0.06
1.869ThrPro: 1.869 ± 0.05
1.189ThrGln: 1.189 ± 0.037
1.558ThrArg: 1.558 ± 0.047
2.74ThrSer: 2.74 ± 0.063
2.507ThrThr: 2.507 ± 0.065
3.261ThrVal: 3.261 ± 0.075
0.343ThrTrp: 0.343 ± 0.022
1.876ThrTyr: 1.876 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
4.243ValAla: 4.243 ± 0.075
0.764ValCys: 0.764 ± 0.034
3.909ValAsp: 3.909 ± 0.072
4.78ValGlu: 4.78 ± 0.08
2.961ValPhe: 2.961 ± 0.069
4.666ValGly: 4.666 ± 0.086
1.052ValHis: 1.052 ± 0.034
6.381ValIle: 6.381 ± 0.092
5.683ValLys: 5.683 ± 0.083
5.966ValLeu: 5.966 ± 0.09
1.68ValMet: 1.68 ± 0.044
3.239ValAsn: 3.239 ± 0.067
2.162ValPro: 2.162 ± 0.058
1.529ValGln: 1.529 ± 0.045
2.321ValArg: 2.321 ± 0.062
3.908ValSer: 3.908 ± 0.073
3.182ValThr: 3.182 ± 0.068
4.755ValVal: 4.755 ± 0.089
0.387ValTrp: 0.387 ± 0.023
2.482ValTyr: 2.482 ± 0.052
0.0ValXaa: 0.0 ± 0.0
Trp
0.434TrpAla: 0.434 ± 0.026
0.075TrpCys: 0.075 ± 0.011
0.395TrpAsp: 0.395 ± 0.025
0.441TrpGlu: 0.441 ± 0.024
0.304TrpPhe: 0.304 ± 0.019
0.483TrpGly: 0.483 ± 0.026
0.134TrpHis: 0.134 ± 0.012
0.745TrpIle: 0.745 ± 0.033
0.582TrpLys: 0.582 ± 0.025
0.556TrpLeu: 0.556 ± 0.025
0.196TrpMet: 0.196 ± 0.014
0.413TrpAsn: 0.413 ± 0.022
0.186TrpPro: 0.186 ± 0.016
0.182TrpGln: 0.182 ± 0.016
0.245TrpArg: 0.245 ± 0.017
0.311TrpSer: 0.311 ± 0.021
0.355TrpThr: 0.355 ± 0.022
0.438TrpVal: 0.438 ± 0.022
0.091TrpTrp: 0.091 ± 0.01
0.275TrpTyr: 0.275 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.06TyrAla: 2.06 ± 0.048
0.452TyrCys: 0.452 ± 0.024
2.244TyrAsp: 2.244 ± 0.058
2.932TyrGlu: 2.932 ± 0.068
1.841TyrPhe: 1.841 ± 0.055
2.655TyrGly: 2.655 ± 0.057
0.7TyrHis: 0.7 ± 0.03
3.934TyrIle: 3.934 ± 0.071
3.669TyrLys: 3.669 ± 0.06
3.52TyrLeu: 3.52 ± 0.07
1.018TyrMet: 1.018 ± 0.041
2.178TyrAsn: 2.178 ± 0.055
1.396TyrPro: 1.396 ± 0.043
0.922TyrGln: 0.922 ± 0.038
1.458TyrArg: 1.458 ± 0.045
2.034TyrSer: 2.034 ± 0.049
1.937TyrThr: 1.937 ± 0.048
2.225TyrVal: 2.225 ± 0.057
0.268TyrTrp: 0.268 ± 0.019
1.681TyrTyr: 1.681 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2867 proteins (861284 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski