Amino acid dipepetide frequency for Pseudaminobacter arsenicus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.658AlaAla: 16.658 ± 0.169	1.045AlaCys: 1.045 ± 0.027	6.747AlaAsp: 6.747 ± 0.068	7.777AlaGlu: 7.777 ± 0.09	4.592AlaPhe: 4.592 ± 0.053	10.813AlaGly: 10.813 ± 0.1	2.223AlaHis: 2.223 ± 0.044	6.869AlaIle: 6.869 ± 0.079	4.232AlaLys: 4.232 ± 0.062	12.672AlaLeu: 12.672 ± 0.12	3.552AlaMet: 3.552 ± 0.056	3.068AlaAsn: 3.068 ± 0.045	4.897AlaPro: 4.897 ± 0.07	3.69AlaGln: 3.69 ± 0.044	8.262AlaArg: 8.262 ± 0.085	6.485AlaSer: 6.485 ± 0.078	5.826AlaThr: 5.826 ± 0.057	8.592AlaVal: 8.592 ± 0.083	1.426AlaTrp: 1.426 ± 0.034	2.664AlaTyr: 2.664 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.96CysAla: 0.96 ± 0.026	0.12CysCys: 0.12 ± 0.01	0.498CysAsp: 0.498 ± 0.018	0.469CysGlu: 0.469 ± 0.019	0.334CysPhe: 0.334 ± 0.014	0.904CysGly: 0.904 ± 0.028	0.248CysHis: 0.248 ± 0.014	0.423CysIle: 0.423 ± 0.018	0.209CysLys: 0.209 ± 0.012	0.8CysLeu: 0.8 ± 0.023	0.186CysMet: 0.186 ± 0.012	0.203CysAsn: 0.203 ± 0.012	0.441CysPro: 0.441 ± 0.018	0.236CysGln: 0.236 ± 0.012	0.66CysArg: 0.66 ± 0.023	0.484CysSer: 0.484 ± 0.019	0.429CysThr: 0.429 ± 0.017	0.635CysVal: 0.635 ± 0.02	0.124CysTrp: 0.124 ± 0.008	0.239CysTyr: 0.239 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.3AspAla: 6.3 ± 0.065	0.497AspCys: 0.497 ± 0.018	2.971AspAsp: 2.971 ± 0.052	3.637AspGlu: 3.637 ± 0.051	2.237AspPhe: 2.237 ± 0.044	4.99AspGly: 4.99 ± 0.061	1.289AspHis: 1.289 ± 0.032	3.255AspIle: 3.255 ± 0.048	1.846AspLys: 1.846 ± 0.036	5.465AspLeu: 5.465 ± 0.061	1.448AspMet: 1.448 ± 0.04	1.36AspAsn: 1.36 ± 0.036	3.284AspPro: 3.284 ± 0.051	1.648AspGln: 1.648 ± 0.035	4.28AspArg: 4.28 ± 0.067	2.119AspSer: 2.119 ± 0.033	2.55AspThr: 2.55 ± 0.043	3.95AspVal: 3.95 ± 0.051	0.893AspTrp: 0.893 ± 0.024	1.486AspTyr: 1.486 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.827GluAla: 7.827 ± 0.088	0.397GluCys: 0.397 ± 0.017	2.762GluAsp: 2.762 ± 0.047	3.436GluGlu: 3.436 ± 0.056	1.99GluPhe: 1.99 ± 0.038	4.309GluGly: 4.309 ± 0.062	1.227GluHis: 1.227 ± 0.033	3.95GluIle: 3.95 ± 0.056	2.742GluLys: 2.742 ± 0.048	5.621GluLeu: 5.621 ± 0.065	1.617GluMet: 1.617 ± 0.033	1.818GluAsn: 1.818 ± 0.032	2.826GluPro: 2.826 ± 0.059	2.197GluGln: 2.197 ± 0.044	5.081GluArg: 5.081 ± 0.068	2.479GluSer: 2.479 ± 0.047	3.468GluThr: 3.468 ± 0.052	3.905GluVal: 3.905 ± 0.046	0.74GluTrp: 0.74 ± 0.024	1.058GluTyr: 1.058 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.617PheAla: 4.617 ± 0.052	0.413PheCys: 0.413 ± 0.017	2.646PheAsp: 2.646 ± 0.041	2.262PheGlu: 2.262 ± 0.038	1.535PhePhe: 1.535 ± 0.038	3.9PheGly: 3.9 ± 0.052	0.812PheHis: 0.812 ± 0.022	1.904PheIle: 1.904 ± 0.036	1.033PheLys: 1.033 ± 0.029	3.615PheLeu: 3.615 ± 0.064	0.847PheMet: 0.847 ± 0.026	1.057PheAsn: 1.057 ± 0.026	1.625PhePro: 1.625 ± 0.031	1.13PheGln: 1.13 ± 0.028	2.384PheArg: 2.384 ± 0.04	2.536PheSer: 2.536 ± 0.038	1.957PheThr: 1.957 ± 0.037	2.921PheVal: 2.921 ± 0.048	0.56PheTrp: 0.56 ± 0.02	0.95PheTyr: 0.95 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	8.909GlyAla: 8.909 ± 0.087	0.861GlyCys: 0.861 ± 0.023	4.245GlyAsp: 4.245 ± 0.054	5.002GlyGlu: 5.002 ± 0.067	3.81GlyPhe: 3.81 ± 0.056	7.281GlyGly: 7.281 ± 0.091	1.884GlyHis: 1.884 ± 0.035	5.033GlyIle: 5.033 ± 0.057	3.692GlyLys: 3.692 ± 0.063	8.723GlyLeu: 8.723 ± 0.077	2.476GlyMet: 2.476 ± 0.044	2.312GlyAsn: 2.312 ± 0.046	3.294GlyPro: 3.294 ± 0.05	2.673GlyGln: 2.673 ± 0.046	5.959GlyArg: 5.959 ± 0.069	4.843GlySer: 4.843 ± 0.052	4.55GlyThr: 4.55 ± 0.053	5.917GlyVal: 5.917 ± 0.065	1.309GlyTrp: 1.309 ± 0.031	2.296GlyTyr: 2.296 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.31HisAla: 2.31 ± 0.043	0.264HisCys: 0.264 ± 0.014	1.248HisAsp: 1.248 ± 0.034	1.224HisGlu: 1.224 ± 0.028	0.853HisPhe: 0.853 ± 0.021	1.923HisGly: 1.923 ± 0.047	0.582HisHis: 0.582 ± 0.023	1.068HisIle: 1.068 ± 0.028	0.572HisLys: 0.572 ± 0.018	2.051HisLeu: 2.051 ± 0.042	0.537HisMet: 0.537 ± 0.02	0.484HisAsn: 0.484 ± 0.016	1.244HisPro: 1.244 ± 0.028	0.61HisGln: 0.61 ± 0.022	1.429HisArg: 1.429 ± 0.034	0.996HisSer: 0.996 ± 0.026	0.817HisThr: 0.817 ± 0.022	1.503HisVal: 1.503 ± 0.032	0.318HisTrp: 0.318 ± 0.016	0.578HisTyr: 0.578 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.556IleAla: 7.556 ± 0.078	0.561IleCys: 0.561 ± 0.019	3.77IleAsp: 3.77 ± 0.05	3.898IleGlu: 3.898 ± 0.046	1.968IlePhe: 1.968 ± 0.04	5.313IleGly: 5.313 ± 0.069	1.006IleHis: 1.006 ± 0.023	2.659IleIle: 2.659 ± 0.049	1.563IleLys: 1.563 ± 0.035	4.694IleLeu: 4.694 ± 0.075	1.152IleMet: 1.152 ± 0.028	1.509IleAsn: 1.509 ± 0.03	2.427IlePro: 2.427 ± 0.038	1.223IleGln: 1.223 ± 0.028	3.588IleArg: 3.588 ± 0.052	3.206IleSer: 3.206 ± 0.049	2.729IleThr: 2.729 ± 0.048	4.795IleVal: 4.795 ± 0.072	0.623IleTrp: 0.623 ± 0.02	1.22IleTyr: 1.22 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.703LysAla: 4.703 ± 0.059	0.175LysCys: 0.175 ± 0.01	1.801LysAsp: 1.801 ± 0.044	1.856LysGlu: 1.856 ± 0.042	1.03LysPhe: 1.03 ± 0.028	2.768LysGly: 2.768 ± 0.053	0.63LysHis: 0.63 ± 0.022	1.882LysIle: 1.882 ± 0.039	1.47LysLys: 1.47 ± 0.037	3.579LysLeu: 3.579 ± 0.051	0.906LysMet: 0.906 ± 0.03	0.998LysAsn: 0.998 ± 0.029	2.292LysPro: 2.292 ± 0.045	1.12LysGln: 1.12 ± 0.025	2.552LysArg: 2.552 ± 0.046	2.063LysSer: 2.063 ± 0.042	2.101LysThr: 2.101 ± 0.04	2.601LysVal: 2.601 ± 0.048	0.428LysTrp: 0.428 ± 0.016	0.689LysTyr: 0.689 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.317LeuAla: 13.317 ± 0.122	0.901LeuCys: 0.901 ± 0.026	5.781LeuAsp: 5.781 ± 0.065	5.386LeuGlu: 5.386 ± 0.063	3.791LeuPhe: 3.791 ± 0.062	8.105LeuGly: 8.105 ± 0.085	1.858LeuHis: 1.858 ± 0.035	5.11LeuIle: 5.11 ± 0.07	3.836LeuLys: 3.836 ± 0.051	9.365LeuLeu: 9.365 ± 0.118	2.318LeuMet: 2.318 ± 0.043	2.477LeuAsn: 2.477 ± 0.043	5.356LeuPro: 5.356 ± 0.057	2.639LeuGln: 2.639 ± 0.042	6.41LeuArg: 6.41 ± 0.081	6.499LeuSer: 6.499 ± 0.073	5.366LeuThr: 5.366 ± 0.063	7.473LeuVal: 7.473 ± 0.083	1.124LeuTrp: 1.124 ± 0.031	2.101LeuTyr: 2.101 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.26MetAla: 3.26 ± 0.045	0.169MetCys: 0.169 ± 0.011	1.177MetAsp: 1.177 ± 0.03	1.279MetGlu: 1.279 ± 0.029	0.753MetPhe: 0.753 ± 0.024	1.86MetGly: 1.86 ± 0.042	0.463MetHis: 0.463 ± 0.019	1.448MetIle: 1.448 ± 0.031	1.11MetLys: 1.11 ± 0.028	2.638MetLeu: 2.638 ± 0.049	0.738MetMet: 0.738 ± 0.026	0.852MetAsn: 0.852 ± 0.023	1.508MetPro: 1.508 ± 0.034	0.844MetGln: 0.844 ± 0.023	1.9MetArg: 1.9 ± 0.032	1.639MetSer: 1.639 ± 0.035	1.868MetThr: 1.868 ± 0.038	1.887MetVal: 1.887 ± 0.038	0.203MetTrp: 0.203 ± 0.012	0.317MetTyr: 0.317 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.172AsnAla: 3.172 ± 0.045	0.264AsnCys: 0.264 ± 0.014	1.432AsnAsp: 1.432 ± 0.033	1.387AsnGlu: 1.387 ± 0.034	1.024AsnPhe: 1.024 ± 0.024	2.512AsnGly: 2.512 ± 0.046	0.527AsnHis: 0.527 ± 0.017	1.505AsnIle: 1.505 ± 0.037	0.747AsnLys: 0.747 ± 0.024	2.616AsnLeu: 2.616 ± 0.046	0.664AsnMet: 0.664 ± 0.021	0.681AsnAsn: 0.681 ± 0.023	1.887AsnPro: 1.887 ± 0.038	0.756AsnGln: 0.756 ± 0.024	1.881AsnArg: 1.881 ± 0.036	1.323AsnSer: 1.323 ± 0.029	1.271AsnThr: 1.271 ± 0.028	1.992AsnVal: 1.992 ± 0.04	0.437AsnTrp: 0.437 ± 0.019	0.681AsnTyr: 0.681 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.023ProAla: 6.023 ± 0.081	0.337ProCys: 0.337 ± 0.012	3.409ProAsp: 3.409 ± 0.051	3.621ProGlu: 3.621 ± 0.06	1.984ProPhe: 1.984 ± 0.037	4.264ProGly: 4.264 ± 0.05	1.04ProHis: 1.04 ± 0.025	2.427ProIle: 2.427 ± 0.04	1.674ProLys: 1.674 ± 0.035	4.598ProLeu: 4.598 ± 0.054	1.147ProMet: 1.147 ± 0.029	1.297ProAsn: 1.297 ± 0.028	2.184ProPro: 2.184 ± 0.046	1.719ProGln: 1.719 ± 0.035	2.84ProArg: 2.84 ± 0.046	2.776ProSer: 2.776 ± 0.045	2.331ProThr: 2.331 ± 0.037	4.155ProVal: 4.155 ± 0.055	0.661ProTrp: 0.661 ± 0.024	1.241ProTyr: 1.241 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	4.0GlnAla: 4.0 ± 0.051	0.208GlnCys: 0.208 ± 0.011	1.411GlnAsp: 1.411 ± 0.035	1.668GlnGlu: 1.668 ± 0.037	1.1GlnPhe: 1.1 ± 0.025	2.283GlnGly: 2.283 ± 0.038	0.602GlnHis: 0.602 ± 0.018	1.848GlnIle: 1.848 ± 0.035	1.251GlnLys: 1.251 ± 0.03	2.702GlnLeu: 2.702 ± 0.044	0.916GlnMet: 0.916 ± 0.027	0.866GlnAsn: 0.866 ± 0.023	1.693GlnPro: 1.693 ± 0.04	1.17GlnGln: 1.17 ± 0.033	2.346GlnArg: 2.346 ± 0.046	1.713GlnSer: 1.713 ± 0.033	1.639GlnThr: 1.639 ± 0.032	2.162GlnVal: 2.162 ± 0.037	0.381GlnTrp: 0.381 ± 0.016	0.599GlnTyr: 0.599 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.39ArgAla: 7.39 ± 0.079	0.475ArgCys: 0.475 ± 0.018	3.872ArgAsp: 3.872 ± 0.052	4.212ArgGlu: 4.212 ± 0.071	2.907ArgPhe: 2.907 ± 0.039	4.548ArgGly: 4.548 ± 0.051	1.748ArgHis: 1.748 ± 0.039	4.268ArgIle: 4.268 ± 0.056	2.716ArgLys: 2.716 ± 0.044	7.733ArgLeu: 7.733 ± 0.074	1.88ArgMet: 1.88 ± 0.032	2.07ArgAsn: 2.07 ± 0.04	3.431ArgPro: 3.431 ± 0.057	2.698ArgGln: 2.698 ± 0.057	5.63ArgArg: 5.63 ± 0.081	3.917ArgSer: 3.917 ± 0.06	3.234ArgThr: 3.234 ± 0.051	4.402ArgVal: 4.402 ± 0.053	0.902ArgTrp: 0.902 ± 0.025	1.737ArgTyr: 1.737 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.339SerAla: 6.339 ± 0.072	0.486SerCys: 0.486 ± 0.019	3.02SerAsp: 3.02 ± 0.048	2.97SerGlu: 2.97 ± 0.044	2.362SerPhe: 2.362 ± 0.038	5.789SerGly: 5.789 ± 0.062	1.171SerHis: 1.171 ± 0.031	2.997SerIle: 2.997 ± 0.049	1.728SerLys: 1.728 ± 0.035	5.473SerLeu: 5.473 ± 0.068	1.502SerMet: 1.502 ± 0.036	1.402SerAsn: 1.402 ± 0.025	2.754SerPro: 2.754 ± 0.047	1.699SerGln: 1.699 ± 0.038	3.763SerArg: 3.763 ± 0.059	3.184SerSer: 3.184 ± 0.045	2.759SerThr: 2.759 ± 0.043	4.131SerVal: 4.131 ± 0.058	0.76SerTrp: 0.76 ± 0.022	1.375SerTyr: 1.375 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.037ThrAla: 6.037 ± 0.062	0.401ThrCys: 0.401 ± 0.016	2.704ThrAsp: 2.704 ± 0.042	2.68ThrGlu: 2.68 ± 0.043	2.005ThrPhe: 2.005 ± 0.038	4.964ThrGly: 4.964 ± 0.06	1.033ThrHis: 1.033 ± 0.026	3.142ThrIle: 3.142 ± 0.052	1.515ThrLys: 1.515 ± 0.033	5.535ThrLeu: 5.535 ± 0.068	1.274ThrMet: 1.274 ± 0.03	1.292ThrAsn: 1.292 ± 0.032	3.029ThrPro: 3.029 ± 0.048	1.379ThrGln: 1.379 ± 0.033	3.188ThrArg: 3.188 ± 0.048	2.829ThrSer: 2.829 ± 0.036	2.804ThrThr: 2.804 ± 0.049	4.347ThrVal: 4.347 ± 0.055	0.619ThrTrp: 0.619 ± 0.02	1.14ThrTyr: 1.14 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.108ValAla: 9.108 ± 0.099	0.634ValCys: 0.634 ± 0.02	3.968ValAsp: 3.968 ± 0.059	4.759ValGlu: 4.759 ± 0.061	2.907ValPhe: 2.907 ± 0.049	5.497ValGly: 5.497 ± 0.066	1.417ValHis: 1.417 ± 0.036	4.064ValIle: 4.064 ± 0.068	2.514ValLys: 2.514 ± 0.047	7.404ValLeu: 7.404 ± 0.084	1.944ValMet: 1.944 ± 0.035	1.987ValAsn: 1.987 ± 0.037	3.728ValPro: 3.728 ± 0.053	1.868ValGln: 1.868 ± 0.038	4.727ValArg: 4.727 ± 0.063	4.538ValSer: 4.538 ± 0.061	4.373ValThr: 4.373 ± 0.055	5.875ValVal: 5.875 ± 0.077	0.9ValTrp: 0.9 ± 0.026	1.451ValTyr: 1.451 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.186TrpAla: 1.186 ± 0.026	0.141TrpCys: 0.141 ± 0.009	0.59TrpAsp: 0.59 ± 0.02	0.605TrpGlu: 0.605 ± 0.019	0.528TrpPhe: 0.528 ± 0.02	0.859TrpGly: 0.859 ± 0.024	0.339TrpHis: 0.339 ± 0.016	0.633TrpIle: 0.633 ± 0.023	0.517TrpLys: 0.517 ± 0.019	1.623TrpLeu: 1.623 ± 0.042	0.339TrpMet: 0.339 ± 0.015	0.463TrpAsn: 0.463 ± 0.017	0.716TrpPro: 0.716 ± 0.023	0.566TrpGln: 0.566 ± 0.02	1.08TrpArg: 1.08 ± 0.029	0.8TrpSer: 0.8 ± 0.022	0.705TrpThr: 0.705 ± 0.021	0.769TrpVal: 0.769 ± 0.026	0.197TrpTrp: 0.197 ± 0.012	0.297TrpTyr: 0.297 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.416TyrAla: 2.416 ± 0.042	0.252TyrCys: 0.252 ± 0.013	1.453TyrAsp: 1.453 ± 0.035	1.322TyrGlu: 1.322 ± 0.032	0.992TyrPhe: 0.992 ± 0.028	2.186TyrGly: 2.186 ± 0.039	0.513TyrHis: 0.513 ± 0.018	0.975TyrIle: 0.975 ± 0.028	0.679TyrLys: 0.679 ± 0.02	2.306TyrLeu: 2.306 ± 0.038	0.472TyrMet: 0.472 ± 0.018	0.564TyrAsn: 0.564 ± 0.022	1.112TyrPro: 1.112 ± 0.026	0.692TyrGln: 0.692 ± 0.02	1.809TyrArg: 1.809 ± 0.036	1.234TyrSer: 1.234 ± 0.031	1.14TyrThr: 1.14 ± 0.027	1.653TyrVal: 1.653 ± 0.033	0.349TyrTrp: 0.349 ± 0.014	0.609TyrTyr: 0.609 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4868 proteins (1502345 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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