Amino acid dipepetide frequency for Algoriphagus kandeliae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.872AlaAla: 4.872 ± 0.096	0.58AlaCys: 0.58 ± 0.025	3.419AlaAsp: 3.419 ± 0.057	4.647AlaGlu: 4.647 ± 0.069	3.654AlaPhe: 3.654 ± 0.054	5.023AlaGly: 5.023 ± 0.075	1.171AlaHis: 1.171 ± 0.031	4.954AlaIle: 4.954 ± 0.074	4.309AlaLys: 4.309 ± 0.082	6.448AlaLeu: 6.448 ± 0.092	1.655AlaMet: 1.655 ± 0.039	2.91AlaAsn: 2.91 ± 0.045	2.285AlaPro: 2.285 ± 0.056	2.657AlaGln: 2.657 ± 0.051	2.541AlaArg: 2.541 ± 0.057	4.228AlaSer: 4.228 ± 0.059	3.005AlaThr: 3.005 ± 0.055	4.095AlaVal: 4.095 ± 0.063	0.858AlaTrp: 0.858 ± 0.032	2.472AlaTyr: 2.472 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.375CysAla: 0.375 ± 0.018	0.071CysCys: 0.071 ± 0.008	0.36CysAsp: 0.36 ± 0.024	0.445CysGlu: 0.445 ± 0.023	0.358CysPhe: 0.358 ± 0.019	0.585CysGly: 0.585 ± 0.025	0.175CysHis: 0.175 ± 0.013	0.393CysIle: 0.393 ± 0.019	0.345CysLys: 0.345 ± 0.015	0.553CysLeu: 0.553 ± 0.022	0.136CysMet: 0.136 ± 0.01	0.284CysAsn: 0.284 ± 0.017	0.321CysPro: 0.321 ± 0.019	0.273CysGln: 0.273 ± 0.017	0.247CysArg: 0.247 ± 0.015	0.454CysSer: 0.454 ± 0.021	0.343CysThr: 0.343 ± 0.018	0.318CysVal: 0.318 ± 0.018	0.074CysTrp: 0.074 ± 0.007	0.223CysTyr: 0.223 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.193AspAla: 3.193 ± 0.054	0.359AspCys: 0.359 ± 0.018	2.27AspAsp: 2.27 ± 0.048	3.873AspGlu: 3.873 ± 0.06	3.947AspPhe: 3.947 ± 0.068	3.874AspGly: 3.874 ± 0.079	1.029AspHis: 1.029 ± 0.033	3.496AspIle: 3.496 ± 0.059	2.819AspLys: 2.819 ± 0.055	6.01AspLeu: 6.01 ± 0.083	1.146AspMet: 1.146 ± 0.032	2.005AspAsn: 2.005 ± 0.05	2.784AspPro: 2.784 ± 0.052	2.608AspGln: 2.608 ± 0.051	2.506AspArg: 2.506 ± 0.048	3.304AspSer: 3.304 ± 0.054	2.071AspThr: 2.071 ± 0.043	2.918AspVal: 2.918 ± 0.056	0.967AspTrp: 0.967 ± 0.03	2.507AspTyr: 2.507 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.948GluAla: 4.948 ± 0.071	0.296GluCys: 0.296 ± 0.017	3.765GluAsp: 3.765 ± 0.058	6.333GluGlu: 6.333 ± 0.088	3.534GluPhe: 3.534 ± 0.064	4.73GluGly: 4.73 ± 0.07	1.048GluHis: 1.048 ± 0.032	5.986GluIle: 5.986 ± 0.094	6.463GluLys: 6.463 ± 0.082	7.178GluLeu: 7.178 ± 0.082	1.789GluMet: 1.789 ± 0.043	4.47GluAsn: 4.47 ± 0.063	2.031GluPro: 2.031 ± 0.043	2.422GluGln: 2.422 ± 0.05	3.002GluArg: 3.002 ± 0.049	4.103GluSer: 4.103 ± 0.064	3.2GluThr: 3.2 ± 0.061	4.931GluVal: 4.931 ± 0.072	0.874GluTrp: 0.874 ± 0.027	2.325GluTyr: 2.325 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.325PheAla: 3.325 ± 0.056	0.388PheCys: 0.388 ± 0.017	3.318PheAsp: 3.318 ± 0.055	4.003PheGlu: 4.003 ± 0.063	3.317PhePhe: 3.317 ± 0.072	4.163PheGly: 4.163 ± 0.069	1.05PheHis: 1.05 ± 0.029	3.454PheIle: 3.454 ± 0.062	2.839PheLys: 2.839 ± 0.047	5.801PheLeu: 5.801 ± 0.082	1.07PheMet: 1.07 ± 0.034	2.476PheAsn: 2.476 ± 0.049	2.234PhePro: 2.234 ± 0.048	2.272PheGln: 2.272 ± 0.047	2.286PheArg: 2.286 ± 0.05	4.355PheSer: 4.355 ± 0.065	2.809PheThr: 2.809 ± 0.051	2.889PheVal: 2.889 ± 0.049	0.79PheTrp: 0.79 ± 0.029	2.075PheTyr: 2.075 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.585GlyAla: 4.585 ± 0.072	0.516GlyCys: 0.516 ± 0.029	3.616GlyAsp: 3.616 ± 0.07	4.613GlyGlu: 4.613 ± 0.065	4.166GlyPhe: 4.166 ± 0.086	5.284GlyGly: 5.284 ± 0.096	1.198GlyHis: 1.198 ± 0.036	5.971GlyIle: 5.971 ± 0.087	5.443GlyLys: 5.443 ± 0.066	6.88GlyLeu: 6.88 ± 0.094	1.986GlyMet: 1.986 ± 0.042	3.638GlyAsn: 3.638 ± 0.075	2.05GlyPro: 2.05 ± 0.045	2.376GlyGln: 2.376 ± 0.049	2.749GlyArg: 2.749 ± 0.054	4.355GlySer: 4.355 ± 0.064	3.797GlyThr: 3.797 ± 0.055	4.618GlyVal: 4.618 ± 0.072	0.989GlyTrp: 0.989 ± 0.03	2.806GlyTyr: 2.806 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.119HisAla: 1.119 ± 0.033	0.156HisCys: 0.156 ± 0.012	0.825HisAsp: 0.825 ± 0.025	1.097HisGlu: 1.097 ± 0.031	1.208HisPhe: 1.208 ± 0.031	1.325HisGly: 1.325 ± 0.038	0.566HisHis: 0.566 ± 0.024	1.156HisIle: 1.156 ± 0.038	0.797HisLys: 0.797 ± 0.03	2.026HisLeu: 2.026 ± 0.04	0.358HisMet: 0.358 ± 0.017	0.652HisAsn: 0.652 ± 0.025	1.124HisPro: 1.124 ± 0.034	0.899HisGln: 0.899 ± 0.027	0.831HisArg: 0.831 ± 0.028	1.075HisSer: 1.075 ± 0.028	0.816HisThr: 0.816 ± 0.026	1.059HisVal: 1.059 ± 0.029	0.299HisTrp: 0.299 ± 0.014	0.783HisTyr: 0.783 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	4.933IleAla: 4.933 ± 0.082	0.547IleCys: 0.547 ± 0.021	3.954IleAsp: 3.954 ± 0.057	4.931IleGlu: 4.931 ± 0.073	3.678IlePhe: 3.678 ± 0.062	5.099IleGly: 5.099 ± 0.081	1.627IleHis: 1.627 ± 0.039	4.558IleIle: 4.558 ± 0.076	4.098IleLys: 4.098 ± 0.066	7.375IleLeu: 7.375 ± 0.096	1.294IleMet: 1.294 ± 0.032	3.518IleAsn: 3.518 ± 0.06	3.823IlePro: 3.823 ± 0.061	3.576IleGln: 3.576 ± 0.064	3.512IleArg: 3.512 ± 0.049	5.498IleSer: 5.498 ± 0.069	3.615IleThr: 3.615 ± 0.06	3.748IleVal: 3.748 ± 0.058	0.931IleTrp: 0.931 ± 0.032	2.537IleTyr: 2.537 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.665LysAla: 4.665 ± 0.065	0.221LysCys: 0.221 ± 0.016	3.504LysAsp: 3.504 ± 0.057	5.47LysGlu: 5.47 ± 0.081	2.547LysPhe: 2.547 ± 0.051	4.381LysGly: 4.381 ± 0.068	0.984LysHis: 0.984 ± 0.028	5.126LysIle: 5.126 ± 0.074	5.333LysLys: 5.333 ± 0.087	5.784LysLeu: 5.784 ± 0.084	1.662LysMet: 1.662 ± 0.044	3.759LysAsn: 3.759 ± 0.067	2.562LysPro: 2.562 ± 0.04	2.019LysGln: 2.019 ± 0.041	2.61LysArg: 2.61 ± 0.049	4.273LysSer: 4.273 ± 0.067	3.38LysThr: 3.38 ± 0.052	4.234LysVal: 4.234 ± 0.066	0.724LysTrp: 0.724 ± 0.025	2.235LysTyr: 2.235 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	7.104LeuAla: 7.104 ± 0.081	0.573LeuCys: 0.573 ± 0.022	5.722LeuAsp: 5.722 ± 0.072	7.555LeuGlu: 7.555 ± 0.082	5.228LeuPhe: 5.228 ± 0.076	7.281LeuGly: 7.281 ± 0.1	1.588LeuHis: 1.588 ± 0.034	7.574LeuIle: 7.574 ± 0.091	6.484LeuLys: 6.484 ± 0.082	9.284LeuLeu: 9.284 ± 0.127	2.223LeuMet: 2.223 ± 0.05	4.805LeuAsn: 4.805 ± 0.071	4.25LeuPro: 4.25 ± 0.075	3.464LeuGln: 3.464 ± 0.065	3.886LeuArg: 3.886 ± 0.064	6.906LeuSer: 6.906 ± 0.079	4.822LeuThr: 4.822 ± 0.072	6.224LeuVal: 6.224 ± 0.073	1.015LeuTrp: 1.015 ± 0.03	2.965LeuTyr: 2.965 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.853MetAla: 1.853 ± 0.049	0.098MetCys: 0.098 ± 0.009	1.426MetAsp: 1.426 ± 0.034	1.797MetGlu: 1.797 ± 0.039	0.706MetPhe: 0.706 ± 0.028	1.789MetGly: 1.789 ± 0.046	0.426MetHis: 0.426 ± 0.019	1.65MetIle: 1.65 ± 0.038	2.001MetLys: 2.001 ± 0.042	1.952MetLeu: 1.952 ± 0.042	0.644MetMet: 0.644 ± 0.024	1.268MetAsn: 1.268 ± 0.031	0.97MetPro: 0.97 ± 0.029	0.748MetGln: 0.748 ± 0.025	1.044MetArg: 1.044 ± 0.03	1.268MetSer: 1.268 ± 0.035	1.143MetThr: 1.143 ± 0.035	1.441MetVal: 1.441 ± 0.038	0.189MetTrp: 0.189 ± 0.013	0.576MetTyr: 0.576 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.919AsnAla: 2.919 ± 0.05	0.328AsnCys: 0.328 ± 0.019	2.143AsnAsp: 2.143 ± 0.047	3.024AsnGlu: 3.024 ± 0.057	2.79AsnPhe: 2.79 ± 0.05	3.439AsnGly: 3.439 ± 0.067	0.999AsnHis: 0.999 ± 0.03	2.99AsnIle: 2.99 ± 0.055	2.44AsnLys: 2.44 ± 0.057	5.337AsnLeu: 5.337 ± 0.078	1.034AsnMet: 1.034 ± 0.03	2.041AsnAsn: 2.041 ± 0.05	3.239AsnPro: 3.239 ± 0.065	2.58AsnGln: 2.58 ± 0.052	2.378AsnArg: 2.378 ± 0.051	3.347AsnSer: 3.347 ± 0.062	2.346AsnThr: 2.346 ± 0.049	2.516AsnVal: 2.516 ± 0.051	0.855AsnTrp: 0.855 ± 0.029	2.183AsnTyr: 2.183 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	2.6ProAla: 2.6 ± 0.051	0.187ProCys: 0.187 ± 0.014	2.743ProAsp: 2.743 ± 0.055	3.996ProGlu: 3.996 ± 0.062	2.254ProPhe: 2.254 ± 0.048	2.936ProGly: 2.936 ± 0.054	0.74ProHis: 0.74 ± 0.028	3.039ProIle: 3.039 ± 0.052	2.564ProLys: 2.564 ± 0.051	3.508ProLeu: 3.508 ± 0.057	0.908ProMet: 0.908 ± 0.032	2.228ProAsn: 2.228 ± 0.047	1.08ProPro: 1.08 ± 0.037	1.421ProGln: 1.421 ± 0.036	1.304ProArg: 1.304 ± 0.036	2.789ProSer: 2.789 ± 0.054	1.995ProThr: 1.995 ± 0.042	2.88ProVal: 2.88 ± 0.058	0.539ProTrp: 0.539 ± 0.025	1.537ProTyr: 1.537 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.837GlnAla: 2.837 ± 0.049	0.155GlnCys: 0.155 ± 0.014	2.063GlnAsp: 2.063 ± 0.041	3.252GlnGlu: 3.252 ± 0.058	1.898GlnPhe: 1.898 ± 0.045	2.38GlnGly: 2.38 ± 0.053	0.597GlnHis: 0.597 ± 0.021	3.131GlnIle: 3.131 ± 0.055	2.961GlnLys: 2.961 ± 0.057	3.917GlnLeu: 3.917 ± 0.064	0.947GlnMet: 0.947 ± 0.028	2.056GlnAsn: 2.056 ± 0.046	1.361GlnPro: 1.361 ± 0.035	1.425GlnGln: 1.425 ± 0.037	1.589GlnArg: 1.589 ± 0.039	2.305GlnSer: 2.305 ± 0.046	1.922GlnThr: 1.922 ± 0.044	2.831GlnVal: 2.831 ± 0.054	0.419GlnTrp: 0.419 ± 0.019	1.233GlnTyr: 1.233 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.474ArgAla: 2.474 ± 0.055	0.199ArgCys: 0.199 ± 0.015	2.18ArgAsp: 2.18 ± 0.043	3.118ArgGlu: 3.118 ± 0.062	2.472ArgPhe: 2.472 ± 0.055	2.51ArgGly: 2.51 ± 0.051	0.684ArgHis: 0.684 ± 0.023	3.476ArgIle: 3.476 ± 0.059	3.168ArgLys: 3.168 ± 0.056	4.006ArgLeu: 4.006 ± 0.06	1.188ArgMet: 1.188 ± 0.035	2.193ArgAsn: 2.193 ± 0.052	1.512ArgPro: 1.512 ± 0.038	1.49ArgGln: 1.49 ± 0.038	1.772ArgArg: 1.772 ± 0.044	2.366ArgSer: 2.366 ± 0.046	2.035ArgThr: 2.035 ± 0.048	2.675ArgVal: 2.675 ± 0.05	0.534ArgTrp: 0.534 ± 0.02	1.657ArgTyr: 1.657 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	3.744SerAla: 3.744 ± 0.056	0.55SerCys: 0.55 ± 0.024	3.383SerAsp: 3.383 ± 0.061	4.485SerGlu: 4.485 ± 0.061	3.972SerPhe: 3.972 ± 0.053	5.144SerGly: 5.144 ± 0.081	1.186SerHis: 1.186 ± 0.03	4.79SerIle: 4.79 ± 0.075	4.165SerLys: 4.165 ± 0.067	6.768SerLeu: 6.768 ± 0.09	1.464SerMet: 1.464 ± 0.036	3.163SerAsn: 3.163 ± 0.049	2.749SerPro: 2.749 ± 0.051	2.708SerGln: 2.708 ± 0.053	2.659SerArg: 2.659 ± 0.056	4.372SerSer: 4.372 ± 0.08	3.14SerThr: 3.14 ± 0.056	3.688SerVal: 3.688 ± 0.065	0.945SerTrp: 0.945 ± 0.029	2.431SerTyr: 2.431 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	3.232ThrAla: 3.232 ± 0.061	0.329ThrCys: 0.329 ± 0.019	2.662ThrAsp: 2.662 ± 0.05	3.148ThrGlu: 3.148 ± 0.05	2.651ThrPhe: 2.651 ± 0.049	4.016ThrGly: 4.016 ± 0.067	0.928ThrHis: 0.928 ± 0.028	3.598ThrIle: 3.598 ± 0.057	2.519ThrLys: 2.519 ± 0.052	4.888ThrLeu: 4.888 ± 0.068	0.908ThrMet: 0.908 ± 0.028	2.18ThrAsn: 2.18 ± 0.055	2.347ThrPro: 2.347 ± 0.046	1.808ThrGln: 1.808 ± 0.037	1.79ThrArg: 1.79 ± 0.038	3.058ThrSer: 3.058 ± 0.055	2.358ThrThr: 2.358 ± 0.054	3.155ThrVal: 3.155 ± 0.063	0.748ThrTrp: 0.748 ± 0.03	2.016ThrTyr: 2.016 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	4.029ValAla: 4.029 ± 0.069	0.456ValCys: 0.456 ± 0.021	3.525ValAsp: 3.525 ± 0.056	4.252ValGlu: 4.252 ± 0.067	3.413ValPhe: 3.413 ± 0.058	4.227ValGly: 4.227 ± 0.065	1.126ValHis: 1.126 ± 0.035	4.506ValIle: 4.506 ± 0.075	3.853ValLys: 3.853 ± 0.052	5.954ValLeu: 5.954 ± 0.077	1.414ValMet: 1.414 ± 0.036	3.01ValAsn: 3.01 ± 0.055	2.45ValPro: 2.45 ± 0.052	2.132ValGln: 2.132 ± 0.048	2.504ValArg: 2.504 ± 0.044	4.122ValSer: 4.122 ± 0.066	3.058ValThr: 3.058 ± 0.069	3.908ValVal: 3.908 ± 0.068	0.75ValTrp: 0.75 ± 0.025	2.159ValTyr: 2.159 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.782TrpAla: 0.782 ± 0.03	0.076TrpCys: 0.076 ± 0.008	0.782TrpAsp: 0.782 ± 0.031	0.993TrpGlu: 0.993 ± 0.033	0.633TrpPhe: 0.633 ± 0.026	0.902TrpGly: 0.902 ± 0.034	0.24TrpHis: 0.24 ± 0.015	1.035TrpIle: 1.035 ± 0.035	0.987TrpLys: 0.987 ± 0.028	1.172TrpLeu: 1.172 ± 0.03	0.471TrpMet: 0.471 ± 0.017	0.703TrpAsn: 0.703 ± 0.025	0.383TrpPro: 0.383 ± 0.019	0.458TrpGln: 0.458 ± 0.02	0.58TrpArg: 0.58 ± 0.023	0.747TrpSer: 0.747 ± 0.026	0.695TrpThr: 0.695 ± 0.026	0.898TrpVal: 0.898 ± 0.029	0.216TrpTrp: 0.216 ± 0.015	0.48TrpTyr: 0.48 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.195TyrAla: 2.195 ± 0.044	0.248TyrCys: 0.248 ± 0.014	2.023TyrAsp: 2.023 ± 0.039	2.396TyrGlu: 2.396 ± 0.043	2.488TyrPhe: 2.488 ± 0.049	2.55TyrGly: 2.55 ± 0.048	0.811TyrHis: 0.811 ± 0.025	1.967TyrIle: 1.967 ± 0.045	1.883TyrLys: 1.883 ± 0.04	4.113TyrLeu: 4.113 ± 0.066	0.69TyrMet: 0.69 ± 0.026	1.567TyrAsn: 1.567 ± 0.036	1.69TyrPro: 1.69 ± 0.043	1.944TyrGln: 1.944 ± 0.039	1.92TyrArg: 1.92 ± 0.042	2.58TyrSer: 2.58 ± 0.046	1.794TyrThr: 1.794 ± 0.044	1.822TyrVal: 1.822 ± 0.042	0.517TyrTrp: 0.517 ± 0.02	1.499TyrTyr: 1.499 ± 0.041	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3350 proteins (1196724 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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