Amino acid dipepetide frequency for Patagioenas fasciata monilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.1AlaAla: 7.1 ± 0.046	1.327AlaCys: 1.327 ± 0.011	3.12AlaAsp: 3.12 ± 0.016	5.249AlaGlu: 5.249 ± 0.027	2.428AlaPhe: 2.428 ± 0.016	4.723AlaGly: 4.723 ± 0.029	1.388AlaHis: 1.388 ± 0.009	2.791AlaIle: 2.791 ± 0.017	3.709AlaLys: 3.709 ± 0.023	6.737AlaLeu: 6.737 ± 0.033	1.543AlaMet: 1.543 ± 0.013	2.142AlaAsn: 2.142 ± 0.014	3.671AlaPro: 3.671 ± 0.029	3.071AlaGln: 3.071 ± 0.021	3.432AlaArg: 3.432 ± 0.018	5.537AlaSer: 5.537 ± 0.028	3.533AlaThr: 3.533 ± 0.021	4.985AlaVal: 4.985 ± 0.028	0.746AlaTrp: 0.746 ± 0.009	1.458AlaTyr: 1.458 ± 0.011	0.008AlaXaa: 0.008 ± 0.001
Cys	1.243CysAla: 1.243 ± 0.012	0.626CysCys: 0.626 ± 0.009	1.066CysAsp: 1.066 ± 0.014	1.327CysGlu: 1.327 ± 0.016	0.83CysPhe: 0.83 ± 0.009	1.477CysGly: 1.477 ± 0.016	0.656CysHis: 0.656 ± 0.008	1.006CysIle: 1.006 ± 0.014	1.226CysLys: 1.226 ± 0.011	2.083CysLeu: 2.083 ± 0.017	0.434CysMet: 0.434 ± 0.007	0.834CysAsn: 0.834 ± 0.01	1.289CysPro: 1.289 ± 0.019	1.071CysGln: 1.071 ± 0.012	1.298CysArg: 1.298 ± 0.012	2.024CysSer: 2.024 ± 0.017	1.161CysThr: 1.161 ± 0.011	1.273CysVal: 1.273 ± 0.014	0.292CysTrp: 0.292 ± 0.006	0.597CysTyr: 0.597 ± 0.007	0.002CysXaa: 0.002 ± 0.0
Asp	3.052AspAla: 3.052 ± 0.016	1.075AspCys: 1.075 ± 0.013	2.809AspAsp: 2.809 ± 0.022	3.707AspGlu: 3.707 ± 0.022	2.096AspPhe: 2.096 ± 0.013	3.474AspGly: 3.474 ± 0.028	1.124AspHis: 1.124 ± 0.01	2.706AspIle: 2.706 ± 0.015	2.714AspLys: 2.714 ± 0.017	4.928AspLeu: 4.928 ± 0.022	1.15AspMet: 1.15 ± 0.011	1.855AspAsn: 1.855 ± 0.016	2.768AspPro: 2.768 ± 0.018	1.85AspGln: 1.85 ± 0.012	2.455AspArg: 2.455 ± 0.017	4.282AspSer: 4.282 ± 0.022	2.683AspThr: 2.683 ± 0.018	3.227AspVal: 3.227 ± 0.02	0.603AspTrp: 0.603 ± 0.009	1.528AspTyr: 1.528 ± 0.012	0.002AspXaa: 0.002 ± 0.0
Glu	4.98GluAla: 4.98 ± 0.028	1.267GluCys: 1.267 ± 0.015	4.622GluAsp: 4.622 ± 0.024	8.439GluGlu: 8.439 ± 0.053	2.047GluPhe: 2.047 ± 0.014	4.127GluGly: 4.127 ± 0.025	1.572GluHis: 1.572 ± 0.011	3.405GluIle: 3.405 ± 0.028	5.814GluLys: 5.814 ± 0.034	6.635GluLeu: 6.635 ± 0.04	1.836GluMet: 1.836 ± 0.013	3.391GluAsn: 3.391 ± 0.022	3.14GluPro: 3.14 ± 0.038	3.476GluGln: 3.476 ± 0.032	4.205GluArg: 4.205 ± 0.026	4.723GluSer: 4.723 ± 0.024	3.712GluThr: 3.712 ± 0.021	4.252GluVal: 4.252 ± 0.03	0.711GluTrp: 0.711 ± 0.008	1.681GluTyr: 1.681 ± 0.023	0.005GluXaa: 0.005 ± 0.001
Phe	2.018PheAla: 2.018 ± 0.015	0.885PheCys: 0.885 ± 0.01	1.649PheAsp: 1.649 ± 0.011	1.986PheGlu: 1.986 ± 0.014	1.457PhePhe: 1.457 ± 0.015	2.151PheGly: 2.151 ± 0.016	1.0PheHis: 1.0 ± 0.011	1.76PheIle: 1.76 ± 0.017	1.802PheLys: 1.802 ± 0.013	3.742PheLeu: 3.742 ± 0.029	0.742PheMet: 0.742 ± 0.008	1.317PheAsn: 1.317 ± 0.012	1.889PhePro: 1.889 ± 0.015	1.724PheGln: 1.724 ± 0.012	1.844PheArg: 1.844 ± 0.02	3.224PheSer: 3.224 ± 0.019	1.993PheThr: 1.993 ± 0.016	2.129PheVal: 2.129 ± 0.016	0.462PheTrp: 0.462 ± 0.006	1.136PheTyr: 1.136 ± 0.01	0.003PheXaa: 0.003 ± 0.0
Gly	4.149GlyAla: 4.149 ± 0.027	1.286GlyCys: 1.286 ± 0.013	3.311GlyAsp: 3.311 ± 0.023	4.099GlyGlu: 4.099 ± 0.03	2.313GlyPhe: 2.313 ± 0.021	4.483GlyGly: 4.483 ± 0.032	1.579GlyHis: 1.579 ± 0.014	2.775GlyIle: 2.775 ± 0.017	3.814GlyLys: 3.814 ± 0.023	5.309GlyLeu: 5.309 ± 0.03	1.334GlyMet: 1.334 ± 0.013	2.468GlyAsn: 2.468 ± 0.016	3.394GlyPro: 3.394 ± 0.049	2.703GlyGln: 2.703 ± 0.019	3.631GlyArg: 3.631 ± 0.022	5.734GlySer: 5.734 ± 0.03	3.741GlyThr: 3.741 ± 0.021	3.486GlyVal: 3.486 ± 0.022	0.782GlyTrp: 0.782 ± 0.01	1.761GlyTyr: 1.761 ± 0.015	0.01GlyXaa: 0.01 ± 0.001
His	1.339HisAla: 1.339 ± 0.012	0.7HisCys: 0.7 ± 0.009	0.933HisAsp: 0.933 ± 0.009	1.366HisGlu: 1.366 ± 0.012	1.002HisPhe: 1.002 ± 0.009	1.556HisGly: 1.556 ± 0.011	0.879HisHis: 0.879 ± 0.01	1.243HisIle: 1.243 ± 0.011	1.295HisLys: 1.295 ± 0.01	2.707HisLeu: 2.707 ± 0.019	0.571HisMet: 0.571 ± 0.008	0.92HisAsn: 0.92 ± 0.01	1.553HisPro: 1.553 ± 0.016	1.253HisGln: 1.253 ± 0.012	1.544HisArg: 1.544 ± 0.013	2.232HisSer: 2.232 ± 0.015	1.282HisThr: 1.282 ± 0.012	1.477HisVal: 1.477 ± 0.011	0.327HisTrp: 0.327 ± 0.006	0.808HisTyr: 0.808 ± 0.009	0.001HisXaa: 0.001 ± 0.0
Ile	2.749IleAla: 2.749 ± 0.018	1.085IleCys: 1.085 ± 0.011	2.09IleAsp: 2.09 ± 0.015	2.734IleGlu: 2.734 ± 0.023	1.806IlePhe: 1.806 ± 0.016	2.244IleGly: 2.244 ± 0.016	1.258IleHis: 1.258 ± 0.012	2.396IleIle: 2.396 ± 0.017	2.778IleLys: 2.778 ± 0.02	4.409IleLeu: 4.409 ± 0.022	0.998IleMet: 0.998 ± 0.008	1.951IleAsn: 1.951 ± 0.015	2.68IlePro: 2.68 ± 0.018	2.318IleGln: 2.318 ± 0.017	2.393IleArg: 2.393 ± 0.015	3.903IleSer: 3.903 ± 0.02	2.716IleThr: 2.716 ± 0.031	2.591IleVal: 2.591 ± 0.023	0.506IleTrp: 0.506 ± 0.007	1.362IleTyr: 1.362 ± 0.012	0.002IleXaa: 0.002 ± 0.0
Lys	4.036LysAla: 4.036 ± 0.021	1.141LysCys: 1.141 ± 0.011	3.364LysAsp: 3.364 ± 0.022	5.588LysGlu: 5.588 ± 0.038	1.68LysPhe: 1.68 ± 0.012	3.416LysGly: 3.416 ± 0.031	1.482LysHis: 1.482 ± 0.012	2.911LysIle: 2.911 ± 0.019	5.034LysLys: 5.034 ± 0.032	5.399LysLeu: 5.399 ± 0.027	1.572LysMet: 1.572 ± 0.012	2.546LysAsn: 2.546 ± 0.016	3.178LysPro: 3.178 ± 0.035	2.944LysGln: 2.944 ± 0.024	3.512LysArg: 3.512 ± 0.021	4.233LysSer: 4.233 ± 0.024	3.334LysThr: 3.334 ± 0.019	3.584LysVal: 3.584 ± 0.035	0.649LysTrp: 0.649 ± 0.01	1.661LysTyr: 1.661 ± 0.018	0.002LysXaa: 0.002 ± 0.0
Leu	6.347LeuAla: 6.347 ± 0.028	2.164LeuCys: 2.164 ± 0.02	4.674LeuAsp: 4.674 ± 0.022	7.249LeuGlu: 7.249 ± 0.044	3.149LeuPhe: 3.149 ± 0.022	5.259LeuGly: 5.259 ± 0.033	2.655LeuHis: 2.655 ± 0.016	3.756LeuIle: 3.756 ± 0.023	6.066LeuLys: 6.066 ± 0.03	10.053LeuLeu: 10.053 ± 0.061	1.981LeuMet: 1.981 ± 0.015	3.601LeuAsn: 3.601 ± 0.022	5.651LeuPro: 5.651 ± 0.03	5.798LeuGln: 5.798 ± 0.048	5.596LeuArg: 5.596 ± 0.027	7.813LeuSer: 7.813 ± 0.036	4.786LeuThr: 4.786 ± 0.024	5.185LeuVal: 5.185 ± 0.024	1.069LeuTrp: 1.069 ± 0.011	2.503LeuTyr: 2.503 ± 0.018	0.008LeuXaa: 0.008 ± 0.001
Met	1.779MetAla: 1.779 ± 0.013	0.412MetCys: 0.412 ± 0.006	1.279MetAsp: 1.279 ± 0.012	1.991MetGlu: 1.991 ± 0.015	0.745MetPhe: 0.745 ± 0.009	1.314MetGly: 1.314 ± 0.013	0.49MetHis: 0.49 ± 0.006	0.856MetIle: 0.856 ± 0.009	1.559MetLys: 1.559 ± 0.014	1.999MetLeu: 1.999 ± 0.014	0.599MetMet: 0.599 ± 0.012	0.923MetAsn: 0.923 ± 0.01	1.068MetPro: 1.068 ± 0.011	1.041MetGln: 1.041 ± 0.01	1.116MetArg: 1.116 ± 0.009	1.626MetSer: 1.626 ± 0.013	1.106MetThr: 1.106 ± 0.01	1.388MetVal: 1.388 ± 0.013	0.248MetTrp: 0.248 ± 0.004	0.574MetTyr: 0.574 ± 0.006	0.001MetXaa: 0.001 ± 0.0
Asn	2.278AsnAla: 2.278 ± 0.014	0.89AsnCys: 0.89 ± 0.012	1.628AsnAsp: 1.628 ± 0.014	2.441AsnGlu: 2.441 ± 0.016	1.444AsnPhe: 1.444 ± 0.012	2.633AsnGly: 2.633 ± 0.02	0.939AsnHis: 0.939 ± 0.009	2.226AsnIle: 2.226 ± 0.016	2.412AsnLys: 2.412 ± 0.016	3.742AsnLeu: 3.742 ± 0.023	0.958AsnMet: 0.958 ± 0.011	1.688AsnAsn: 1.688 ± 0.015	2.133AsnPro: 2.133 ± 0.015	1.689AsnGln: 1.689 ± 0.016	1.95AsnArg: 1.95 ± 0.013	3.312AsnSer: 3.312 ± 0.023	2.147AsnThr: 2.147 ± 0.014	2.356AsnVal: 2.356 ± 0.019	0.449AsnTrp: 0.449 ± 0.005	1.14AsnTyr: 1.14 ± 0.01	0.001AsnXaa: 0.001 ± 0.0
Pro	4.766ProAla: 4.766 ± 0.031	1.128ProCys: 1.128 ± 0.014	2.684ProAsp: 2.684 ± 0.016	4.213ProGlu: 4.213 ± 0.038	1.799ProPhe: 1.799 ± 0.015	4.775ProGly: 4.775 ± 0.077	1.352ProHis: 1.352 ± 0.012	1.874ProIle: 1.874 ± 0.024	2.826ProLys: 2.826 ± 0.024	4.822ProLeu: 4.822 ± 0.025	0.998ProMet: 0.998 ± 0.009	1.809ProAsn: 1.809 ± 0.014	5.357ProPro: 5.357 ± 0.062	2.593ProGln: 2.593 ± 0.021	3.009ProArg: 3.009 ± 0.019	5.359ProSer: 5.359 ± 0.035	2.84ProThr: 2.84 ± 0.019	3.956ProVal: 3.956 ± 0.028	0.616ProTrp: 0.616 ± 0.009	1.358ProTyr: 1.358 ± 0.011	0.01ProXaa: 0.01 ± 0.001
Gln	3.256GlnAla: 3.256 ± 0.018	0.942GlnCys: 0.942 ± 0.012	2.35GlnAsp: 2.35 ± 0.016	3.932GlnGlu: 3.932 ± 0.034	1.395GlnPhe: 1.395 ± 0.012	2.654GlnGly: 2.654 ± 0.019	1.387GlnHis: 1.387 ± 0.013	2.085GlnIle: 2.085 ± 0.013	3.139GlnLys: 3.139 ± 0.025	4.79GlnLeu: 4.79 ± 0.035	1.137GlnMet: 1.137 ± 0.011	2.0GlnAsn: 2.0 ± 0.016	2.731GlnPro: 2.731 ± 0.02	3.292GlnGln: 3.292 ± 0.04	2.916GlnArg: 2.916 ± 0.022	3.349GlnSer: 3.349 ± 0.026	2.399GlnThr: 2.399 ± 0.017	2.696GlnVal: 2.696 ± 0.015	0.529GlnTrp: 0.529 ± 0.008	1.192GlnTyr: 1.192 ± 0.01	0.003GlnXaa: 0.003 ± 0.001
Arg	3.643ArgAla: 3.643 ± 0.021	1.263ArgCys: 1.263 ± 0.014	2.802ArgAsp: 2.802 ± 0.017	3.986ArgGlu: 3.986 ± 0.024	1.806ArgPhe: 1.806 ± 0.011	3.422ArgGly: 3.422 ± 0.029	1.482ArgHis: 1.482 ± 0.012	2.471ArgIle: 2.471 ± 0.013	3.767ArgLys: 3.767 ± 0.019	5.069ArgLeu: 5.069 ± 0.022	1.236ArgMet: 1.236 ± 0.011	2.199ArgAsn: 2.199 ± 0.013	2.802ArgPro: 2.802 ± 0.019	2.66ArgGln: 2.66 ± 0.021	4.297ArgArg: 4.297 ± 0.029	4.439ArgSer: 4.439 ± 0.03	2.851ArgThr: 2.851 ± 0.015	3.044ArgVal: 3.044 ± 0.025	0.702ArgTrp: 0.702 ± 0.007	1.501ArgTyr: 1.501 ± 0.011	0.007ArgXaa: 0.007 ± 0.001
Ser	5.645SerAla: 5.645 ± 0.025	1.92SerCys: 1.92 ± 0.015	4.135SerAsp: 4.135 ± 0.026	5.38SerGlu: 5.38 ± 0.026	2.956SerPhe: 2.956 ± 0.018	5.356SerGly: 5.356 ± 0.029	2.039SerHis: 2.039 ± 0.016	3.383SerIle: 3.383 ± 0.018	4.387SerLys: 4.387 ± 0.024	7.952SerLeu: 7.952 ± 0.042	1.637SerMet: 1.637 ± 0.012	2.897SerAsn: 2.897 ± 0.021	5.921SerPro: 5.921 ± 0.039	3.831SerGln: 3.831 ± 0.028	4.483SerArg: 4.483 ± 0.03	9.725SerSer: 9.725 ± 0.058	4.703SerThr: 4.703 ± 0.027	5.097SerVal: 5.097 ± 0.021	1.01SerTrp: 1.01 ± 0.011	2.065SerTyr: 2.065 ± 0.016	0.005SerXaa: 0.005 ± 0.001
Thr	4.074ThrAla: 4.074 ± 0.024	1.345ThrCys: 1.345 ± 0.017	2.712ThrAsp: 2.712 ± 0.017	3.866ThrGlu: 3.866 ± 0.02	2.021ThrPhe: 2.021 ± 0.016	3.58ThrGly: 3.58 ± 0.021	1.168ThrHis: 1.168 ± 0.009	2.429ThrIle: 2.429 ± 0.02	2.856ThrLys: 2.856 ± 0.022	5.05ThrLeu: 5.05 ± 0.023	1.138ThrMet: 1.138 ± 0.01	1.873ThrAsn: 1.873 ± 0.014	3.386ThrPro: 3.386 ± 0.023	2.192ThrGln: 2.192 ± 0.014	2.473ThrArg: 2.473 ± 0.014	4.854ThrSer: 4.854 ± 0.027	3.085ThrThr: 3.085 ± 0.023	4.036ThrVal: 4.036 ± 0.037	0.692ThrTrp: 0.692 ± 0.014	1.415ThrTyr: 1.415 ± 0.012	0.004ThrXaa: 0.004 ± 0.001
Val	4.155ValAla: 4.155 ± 0.023	1.435ValCys: 1.435 ± 0.013	2.876ValAsp: 2.876 ± 0.018	3.999ValGlu: 3.999 ± 0.029	2.337ValPhe: 2.337 ± 0.019	3.211ValGly: 3.211 ± 0.018	1.506ValHis: 1.506 ± 0.012	2.903ValIle: 2.903 ± 0.023	3.682ValLys: 3.682 ± 0.03	6.173ValLeu: 6.173 ± 0.026	1.34ValMet: 1.34 ± 0.011	2.393ValAsn: 2.393 ± 0.02	3.812ValPro: 3.812 ± 0.038	2.871ValGln: 2.871 ± 0.018	2.965ValArg: 2.965 ± 0.018	4.992ValSer: 4.992 ± 0.029	4.012ValThr: 4.012 ± 0.047	4.002ValVal: 4.002 ± 0.031	0.691ValTrp: 0.691 ± 0.008	1.622ValTyr: 1.622 ± 0.012	0.006ValXaa: 0.006 ± 0.001
Trp	0.677TrpAla: 0.677 ± 0.008	0.251TrpCys: 0.251 ± 0.005	0.657TrpAsp: 0.657 ± 0.01	0.778TrpGlu: 0.778 ± 0.009	0.432TrpPhe: 0.432 ± 0.008	0.656TrpGly: 0.656 ± 0.012	0.301TrpHis: 0.301 ± 0.005	0.577TrpIle: 0.577 ± 0.009	0.834TrpLys: 0.834 ± 0.008	1.192TrpLeu: 1.192 ± 0.011	0.305TrpMet: 0.305 ± 0.005	0.528TrpAsn: 0.528 ± 0.007	0.466TrpPro: 0.466 ± 0.007	0.545TrpGln: 0.545 ± 0.007	0.714TrpArg: 0.714 ± 0.007	0.903TrpSer: 0.903 ± 0.011	0.643TrpThr: 0.643 ± 0.01	0.651TrpVal: 0.651 ± 0.008	0.179TrpTrp: 0.179 ± 0.004	0.345TrpTyr: 0.345 ± 0.008	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.403TyrAla: 1.403 ± 0.011	0.673TyrCys: 0.673 ± 0.008	1.325TyrAsp: 1.325 ± 0.012	1.707TyrGlu: 1.707 ± 0.016	1.168TyrPhe: 1.168 ± 0.011	1.646TyrGly: 1.646 ± 0.012	0.724TyrHis: 0.724 ± 0.008	1.411TyrIle: 1.411 ± 0.015	1.548TyrLys: 1.548 ± 0.018	2.57TyrLeu: 2.57 ± 0.017	0.603TyrMet: 0.603 ± 0.007	1.12TyrAsn: 1.12 ± 0.011	1.245TyrPro: 1.245 ± 0.012	1.245TyrGln: 1.245 ± 0.013	1.611TyrArg: 1.611 ± 0.012	2.255TyrSer: 2.255 ± 0.016	1.521TyrThr: 1.521 ± 0.018	1.565TyrVal: 1.565 ± 0.014	0.368TyrTrp: 0.368 ± 0.008	0.951TyrTyr: 0.951 ± 0.011	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.009XaaAla: 0.009 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.003XaaAsp: 0.003 ± 0.0	0.004XaaGlu: 0.004 ± 0.0	0.002XaaPhe: 0.002 ± 0.0	0.007XaaGly: 0.007 ± 0.001	0.003XaaHis: 0.003 ± 0.001	0.001XaaIle: 0.001 ± 0.0	0.003XaaLys: 0.003 ± 0.0	0.008XaaLeu: 0.008 ± 0.001	0.002XaaMet: 0.002 ± 0.0	0.002XaaAsn: 0.002 ± 0.0	0.01XaaPro: 0.01 ± 0.001	0.002XaaGln: 0.002 ± 0.0	0.006XaaArg: 0.006 ± 0.001	0.006XaaSer: 0.006 ± 0.001	0.003XaaThr: 0.003 ± 0.0	0.005XaaVal: 0.005 ± 0.001	0.002XaaTrp: 0.002 ± 0.0	0.003XaaTyr: 0.003 ± 0.0	1.21XaaXaa: 1.21 ± 0.06

Statistics based on 24737 proteins (14120877 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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