Amino acid dipepetide frequency for Flavobacterium urocaniciphilum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.07AlaAla: 4.07 ± 0.118	0.598AlaCys: 0.598 ± 0.037	3.053AlaAsp: 3.053 ± 0.065	3.904AlaGlu: 3.904 ± 0.092	3.262AlaPhe: 3.262 ± 0.074	4.231AlaGly: 4.231 ± 0.144	0.93AlaHis: 0.93 ± 0.035	5.25AlaIle: 5.25 ± 0.09	4.807AlaLys: 4.807 ± 0.105	5.441AlaLeu: 5.441 ± 0.084	1.35AlaMet: 1.35 ± 0.046	3.931AlaAsn: 3.931 ± 0.076	1.905AlaPro: 1.905 ± 0.08	2.386AlaGln: 2.386 ± 0.061	1.641AlaArg: 1.641 ± 0.051	4.046AlaSer: 4.046 ± 0.101	4.488AlaThr: 4.488 ± 0.175	3.746AlaVal: 3.746 ± 0.077	0.545AlaTrp: 0.545 ± 0.029	2.256AlaTyr: 2.256 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.493CysAla: 0.493 ± 0.024	0.114CysCys: 0.114 ± 0.012	0.528CysAsp: 0.528 ± 0.034	0.498CysGlu: 0.498 ± 0.025	0.464CysPhe: 0.464 ± 0.03	0.775CysGly: 0.775 ± 0.053	0.198CysHis: 0.198 ± 0.021	0.629CysIle: 0.629 ± 0.029	0.496CysLys: 0.496 ± 0.024	0.649CysLeu: 0.649 ± 0.031	0.154CysMet: 0.154 ± 0.015	0.553CysAsn: 0.553 ± 0.031	0.386CysPro: 0.386 ± 0.025	0.295CysGln: 0.295 ± 0.032	0.177CysArg: 0.177 ± 0.014	0.711CysSer: 0.711 ± 0.046	0.541CysThr: 0.541 ± 0.029	0.52CysVal: 0.52 ± 0.024	0.087CysTrp: 0.087 ± 0.011	0.304CysTyr: 0.304 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.444AspAla: 3.444 ± 0.071	0.397AspCys: 0.397 ± 0.024	2.43AspAsp: 2.43 ± 0.067	3.521AspGlu: 3.521 ± 0.072	3.647AspPhe: 3.647 ± 0.076	3.427AspGly: 3.427 ± 0.086	0.644AspHis: 0.644 ± 0.028	4.127AspIle: 4.127 ± 0.072	4.263AspLys: 4.263 ± 0.089	4.808AspLeu: 4.808 ± 0.074	1.019AspMet: 1.019 ± 0.037	3.271AspAsn: 3.271 ± 0.067	1.252AspPro: 1.252 ± 0.041	1.17AspGln: 1.17 ± 0.038	1.507AspArg: 1.507 ± 0.04	2.941AspSer: 2.941 ± 0.067	2.77AspThr: 2.77 ± 0.071	3.485AspVal: 3.485 ± 0.076	0.664AspTrp: 0.664 ± 0.031	2.61AspTyr: 2.61 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	3.846GluAla: 3.846 ± 0.08	0.365GluCys: 0.365 ± 0.025	3.06GluAsp: 3.06 ± 0.061	4.74GluGlu: 4.74 ± 0.095	3.201GluPhe: 3.201 ± 0.06	3.094GluGly: 3.094 ± 0.066	0.973GluHis: 0.973 ± 0.038	6.176GluIle: 6.176 ± 0.1	6.669GluLys: 6.669 ± 0.108	5.853GluLeu: 5.853 ± 0.106	1.641GluMet: 1.641 ± 0.049	5.568GluAsn: 5.568 ± 0.095	1.405GluPro: 1.405 ± 0.05	2.175GluGln: 2.175 ± 0.057	2.049GluArg: 2.049 ± 0.052	3.204GluSer: 3.204 ± 0.068	3.51GluThr: 3.51 ± 0.072	4.26GluVal: 4.26 ± 0.072	0.527GluTrp: 0.527 ± 0.023	2.409GluTyr: 2.409 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	3.22PheAla: 3.22 ± 0.066	0.539PheCys: 0.539 ± 0.029	3.316PheAsp: 3.316 ± 0.067	3.759PheGlu: 3.759 ± 0.071	2.946PhePhe: 2.946 ± 0.069	3.664PheGly: 3.664 ± 0.072	0.891PheHis: 0.891 ± 0.032	4.31PheIle: 4.31 ± 0.089	3.936PheLys: 3.936 ± 0.081	4.73PheLeu: 4.73 ± 0.095	1.162PheMet: 1.162 ± 0.045	3.848PheAsn: 3.848 ± 0.081	1.707PhePro: 1.707 ± 0.049	1.745PheGln: 1.745 ± 0.05	1.402PheArg: 1.402 ± 0.043	4.324PheSer: 4.324 ± 0.083	3.593PheThr: 3.593 ± 0.091	3.355PheVal: 3.355 ± 0.073	0.541PheTrp: 0.541 ± 0.029	2.442PheTyr: 2.442 ± 0.058	0.0PheXaa: 0.0 ± 0.0
Gly	4.113GlyAla: 4.113 ± 0.109	0.677GlyCys: 0.677 ± 0.045	2.877GlyAsp: 2.877 ± 0.06	3.214GlyGlu: 3.214 ± 0.058	3.607GlyPhe: 3.607 ± 0.072	4.564GlyGly: 4.564 ± 0.141	1.046GlyHis: 1.046 ± 0.04	5.209GlyIle: 5.209 ± 0.086	4.919GlyLys: 4.919 ± 0.089	5.398GlyLeu: 5.398 ± 0.076	1.477GlyMet: 1.477 ± 0.045	4.014GlyAsn: 4.014 ± 0.094	1.255GlyPro: 1.255 ± 0.045	1.753GlyGln: 1.753 ± 0.052	1.698GlyArg: 1.698 ± 0.057	3.996GlySer: 3.996 ± 0.101	4.938GlyThr: 4.938 ± 0.2	3.953GlyVal: 3.953 ± 0.087	0.64GlyTrp: 0.64 ± 0.033	2.674GlyTyr: 2.674 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	0.902HisAla: 0.902 ± 0.035	0.188HisCys: 0.188 ± 0.016	0.806HisAsp: 0.806 ± 0.035	0.936HisGlu: 0.936 ± 0.035	1.149HisPhe: 1.149 ± 0.037	0.964HisGly: 0.964 ± 0.039	0.404HisHis: 0.404 ± 0.023	1.27HisIle: 1.27 ± 0.045	1.158HisLys: 1.158 ± 0.041	1.587HisLeu: 1.587 ± 0.051	0.304HisMet: 0.304 ± 0.022	1.023HisAsn: 1.023 ± 0.034	0.715HisPro: 0.715 ± 0.029	0.628HisGln: 0.628 ± 0.029	0.55HisArg: 0.55 ± 0.028	0.981HisSer: 0.981 ± 0.033	0.893HisThr: 0.893 ± 0.035	0.883HisVal: 0.883 ± 0.035	0.139HisTrp: 0.139 ± 0.013	0.734HisTyr: 0.734 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.472IleAla: 5.472 ± 0.085	0.779IleCys: 0.779 ± 0.032	4.82IleAsp: 4.82 ± 0.088	5.943IleGlu: 5.943 ± 0.103	3.972IlePhe: 3.972 ± 0.087	5.196IleGly: 5.196 ± 0.103	1.37IleHis: 1.37 ± 0.039	6.732IleIle: 6.732 ± 0.126	6.173IleLys: 6.173 ± 0.099	7.228IleLeu: 7.228 ± 0.113	1.425IleMet: 1.425 ± 0.045	5.553IleAsn: 5.553 ± 0.106	3.132IlePro: 3.132 ± 0.05	2.902IleGln: 2.902 ± 0.066	2.187IleArg: 2.187 ± 0.051	6.007IleSer: 6.007 ± 0.092	5.153IleThr: 5.153 ± 0.092	5.127IleVal: 5.127 ± 0.075	0.702IleTrp: 0.702 ± 0.026	3.079IleTyr: 3.079 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	4.828LysAla: 4.828 ± 0.097	0.425LysCys: 0.425 ± 0.023	4.268LysAsp: 4.268 ± 0.091	6.189LysGlu: 6.189 ± 0.111	3.487LysPhe: 3.487 ± 0.071	4.158LysGly: 4.158 ± 0.086	1.295LysHis: 1.295 ± 0.046	7.37LysIle: 7.37 ± 0.13	7.57LysLys: 7.57 ± 0.144	6.919LysLeu: 6.919 ± 0.101	2.313LysMet: 2.313 ± 0.068	6.325LysAsn: 6.325 ± 0.112	2.555LysPro: 2.555 ± 0.054	2.648LysGln: 2.648 ± 0.059	2.408LysArg: 2.408 ± 0.057	4.813LysSer: 4.813 ± 0.082	4.605LysThr: 4.605 ± 0.085	4.952LysVal: 4.952 ± 0.084	0.732LysTrp: 0.732 ± 0.028	3.372LysTyr: 3.372 ± 0.076	0.0LysXaa: 0.0 ± 0.0
Leu	5.236LeuAla: 5.236 ± 0.084	0.593LeuCys: 0.593 ± 0.029	4.558LeuAsp: 4.558 ± 0.077	5.754LeuGlu: 5.754 ± 0.108	5.04LeuPhe: 5.04 ± 0.102	5.335LeuGly: 5.335 ± 0.083	1.526LeuHis: 1.526 ± 0.043	7.025LeuIle: 7.025 ± 0.108	7.521LeuLys: 7.521 ± 0.13	8.051LeuLeu: 8.051 ± 0.148	1.898LeuMet: 1.898 ± 0.049	6.089LeuAsn: 6.089 ± 0.096	3.292LeuPro: 3.292 ± 0.064	3.199LeuGln: 3.199 ± 0.064	2.579LeuArg: 2.579 ± 0.054	6.269LeuSer: 6.269 ± 0.084	4.978LeuThr: 4.978 ± 0.079	5.281LeuVal: 5.281 ± 0.079	0.68LeuTrp: 0.68 ± 0.033	3.188LeuTyr: 3.188 ± 0.067	0.0LeuXaa: 0.0 ± 0.0
Met	1.459MetAla: 1.459 ± 0.044	0.154MetCys: 0.154 ± 0.014	0.962MetAsp: 0.962 ± 0.038	1.247MetGlu: 1.247 ± 0.041	0.91MetPhe: 0.91 ± 0.034	1.287MetGly: 1.287 ± 0.043	0.364MetHis: 0.364 ± 0.024	1.527MetIle: 1.527 ± 0.047	2.29MetLys: 2.29 ± 0.053	1.82MetLeu: 1.82 ± 0.053	0.559MetMet: 0.559 ± 0.03	1.451MetAsn: 1.451 ± 0.038	0.819MetPro: 0.819 ± 0.039	0.828MetGln: 0.828 ± 0.03	0.773MetArg: 0.773 ± 0.028	1.411MetSer: 1.411 ± 0.039	1.08MetThr: 1.08 ± 0.035	1.257MetVal: 1.257 ± 0.041	0.168MetTrp: 0.168 ± 0.016	0.808MetTyr: 0.808 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	4.402AsnAla: 4.402 ± 0.1	0.672AsnCys: 0.672 ± 0.037	3.618AsnAsp: 3.618 ± 0.062	4.349AsnGlu: 4.349 ± 0.082	3.831AsnPhe: 3.831 ± 0.079	4.691AsnGly: 4.691 ± 0.116	1.183AsnHis: 1.183 ± 0.039	5.361AsnIle: 5.361 ± 0.095	5.267AsnLys: 5.267 ± 0.113	6.175AsnLeu: 6.175 ± 0.095	1.35AsnMet: 1.35 ± 0.044	5.147AsnAsn: 5.147 ± 0.122	3.116AsnPro: 3.116 ± 0.065	2.755AsnGln: 2.755 ± 0.064	1.945AsnArg: 1.945 ± 0.057	4.641AsnSer: 4.641 ± 0.109	4.254AsnThr: 4.254 ± 0.105	4.11AsnVal: 4.11 ± 0.091	0.932AsnTrp: 0.932 ± 0.038	3.348AsnTyr: 3.348 ± 0.068	0.0AsnXaa: 0.0 ± 0.0
Pro	2.097ProAla: 2.097 ± 0.081	0.282ProCys: 0.282 ± 0.03	1.614ProAsp: 1.614 ± 0.04	2.448ProGlu: 2.448 ± 0.058	1.909ProPhe: 1.909 ± 0.046	1.828ProGly: 1.828 ± 0.053	0.518ProHis: 0.518 ± 0.022	2.847ProIle: 2.847 ± 0.067	2.466ProLys: 2.466 ± 0.06	2.531ProLeu: 2.531 ± 0.052	0.671ProMet: 0.671 ± 0.031	2.617ProAsn: 2.617 ± 0.063	0.718ProPro: 0.718 ± 0.034	1.022ProGln: 1.022 ± 0.038	0.768ProArg: 0.768 ± 0.05	2.063ProSer: 2.063 ± 0.054	2.371ProThr: 2.371 ± 0.085	2.297ProVal: 2.297 ± 0.064	0.233ProTrp: 0.233 ± 0.02	1.293ProTyr: 1.293 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.946GlnAla: 1.946 ± 0.051	0.22GlnCys: 0.22 ± 0.024	1.553GlnAsp: 1.553 ± 0.045	2.151GlnGlu: 2.151 ± 0.061	1.956GlnPhe: 1.956 ± 0.057	1.636GlnGly: 1.636 ± 0.049	0.529GlnHis: 0.529 ± 0.028	2.936GlnIle: 2.936 ± 0.064	2.996GlnLys: 2.996 ± 0.072	3.31GlnLeu: 3.31 ± 0.065	0.773GlnMet: 0.773 ± 0.032	2.673GlnAsn: 2.673 ± 0.063	1.148GlnPro: 1.148 ± 0.042	1.252GlnGln: 1.252 ± 0.046	0.91GlnArg: 0.91 ± 0.031	1.828GlnSer: 1.828 ± 0.046	2.08GlnThr: 2.08 ± 0.063	1.986GlnVal: 1.986 ± 0.051	0.29GlnTrp: 0.29 ± 0.021	1.316GlnTyr: 1.316 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	1.685ArgAla: 1.685 ± 0.052	0.185ArgCys: 0.185 ± 0.015	1.311ArgAsp: 1.311 ± 0.046	1.785ArgGlu: 1.785 ± 0.05	1.662ArgPhe: 1.662 ± 0.046	1.522ArgGly: 1.522 ± 0.047	0.484ArgHis: 0.484 ± 0.024	2.569ArgIle: 2.569 ± 0.059	2.502ArgLys: 2.502 ± 0.057	2.537ArgLeu: 2.537 ± 0.051	0.785ArgMet: 0.785 ± 0.033	2.024ArgAsn: 2.024 ± 0.049	0.808ArgPro: 0.808 ± 0.032	0.849ArgGln: 0.849 ± 0.032	1.003ArgArg: 1.003 ± 0.039	1.483ArgSer: 1.483 ± 0.044	1.588ArgThr: 1.588 ± 0.041	1.795ArgVal: 1.795 ± 0.048	0.289ArgTrp: 0.289 ± 0.018	1.22ArgTyr: 1.22 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.708SerAla: 3.708 ± 0.093	0.712SerCys: 0.712 ± 0.03	3.424SerAsp: 3.424 ± 0.058	4.034SerGlu: 4.034 ± 0.077	3.954SerPhe: 3.954 ± 0.066	4.605SerGly: 4.605 ± 0.114	1.038SerHis: 1.038 ± 0.034	5.506SerIle: 5.506 ± 0.09	5.289SerLys: 5.289 ± 0.105	5.402SerLeu: 5.402 ± 0.082	1.16SerMet: 1.16 ± 0.038	4.769SerAsn: 4.769 ± 0.113	2.029SerPro: 2.029 ± 0.057	2.23SerGln: 2.23 ± 0.057	1.651SerArg: 1.651 ± 0.046	4.339SerSer: 4.339 ± 0.105	4.019SerThr: 4.019 ± 0.113	4.124SerVal: 4.124 ± 0.091	0.688SerTrp: 0.688 ± 0.03	2.69SerTyr: 2.69 ± 0.064	0.0SerXaa: 0.0 ± 0.0
Thr	3.987ThrAla: 3.987 ± 0.139	0.565ThrCys: 0.565 ± 0.068	3.069ThrAsp: 3.069 ± 0.074	3.451ThrGlu: 3.451 ± 0.066	3.618ThrPhe: 3.618 ± 0.087	4.368ThrGly: 4.368 ± 0.131	0.946ThrHis: 0.946 ± 0.038	5.613ThrIle: 5.613 ± 0.11	4.235ThrLys: 4.235 ± 0.078	5.265ThrLeu: 5.265 ± 0.087	0.877ThrMet: 0.877 ± 0.037	4.348ThrAsn: 4.348 ± 0.111	2.675ThrPro: 2.675 ± 0.089	2.008ThrGln: 2.008 ± 0.062	1.455ThrArg: 1.455 ± 0.043	4.44ThrSer: 4.44 ± 0.138	4.456ThrThr: 4.456 ± 0.155	3.884ThrVal: 3.884 ± 0.115	0.724ThrTrp: 0.724 ± 0.047	2.611ThrTyr: 2.611 ± 0.077	0.0ThrXaa: 0.0 ± 0.0
Val	4.127ValAla: 4.127 ± 0.085	0.628ValCys: 0.628 ± 0.03	3.392ValAsp: 3.392 ± 0.062	3.912ValGlu: 3.912 ± 0.07	3.443ValPhe: 3.443 ± 0.069	3.773ValGly: 3.773 ± 0.088	0.917ValHis: 0.917 ± 0.034	4.825ValIle: 4.825 ± 0.079	4.666ValLys: 4.666 ± 0.083	5.799ValLeu: 5.799 ± 0.088	1.259ValMet: 1.259 ± 0.043	4.082ValAsn: 4.082 ± 0.081	2.124ValPro: 2.124 ± 0.054	1.758ValGln: 1.758 ± 0.045	1.773ValArg: 1.773 ± 0.048	4.449ValSer: 4.449 ± 0.089	3.951ValThr: 3.951 ± 0.099	4.257ValVal: 4.257 ± 0.077	0.54ValTrp: 0.54 ± 0.024	2.447ValTyr: 2.447 ± 0.056	0.0ValXaa: 0.0 ± 0.0
Trp	0.547TrpAla: 0.547 ± 0.028	0.11TrpCys: 0.11 ± 0.011	0.503TrpAsp: 0.503 ± 0.024	0.593TrpGlu: 0.593 ± 0.027	0.545TrpPhe: 0.545 ± 0.024	0.539TrpGly: 0.539 ± 0.026	0.201TrpHis: 0.201 ± 0.015	0.751TrpIle: 0.751 ± 0.037	0.83TrpLys: 0.83 ± 0.033	0.852TrpLeu: 0.852 ± 0.039	0.253TrpMet: 0.253 ± 0.016	0.779TrpAsn: 0.779 ± 0.034	0.174TrpPro: 0.174 ± 0.016	0.38TrpGln: 0.38 ± 0.021	0.306TrpArg: 0.306 ± 0.019	0.593TrpSer: 0.593 ± 0.036	0.643TrpThr: 0.643 ± 0.04	0.545TrpVal: 0.545 ± 0.028	0.111TrpTrp: 0.111 ± 0.013	0.442TrpTyr: 0.442 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.258TyrAla: 2.258 ± 0.045	0.373TyrCys: 0.373 ± 0.023	2.235TyrAsp: 2.235 ± 0.052	2.294TyrGlu: 2.294 ± 0.051	2.825TyrPhe: 2.825 ± 0.059	2.363TyrGly: 2.363 ± 0.054	0.758TyrHis: 0.758 ± 0.029	2.918TyrIle: 2.918 ± 0.057	3.181TyrLys: 3.181 ± 0.076	3.738TyrLeu: 3.738 ± 0.08	0.743TyrMet: 0.743 ± 0.03	3.082TyrAsn: 3.082 ± 0.072	1.38TyrPro: 1.38 ± 0.039	1.507TyrGln: 1.507 ± 0.045	1.305TyrArg: 1.305 ± 0.042	2.834TyrSer: 2.834 ± 0.057	2.68TyrThr: 2.68 ± 0.103	2.307TyrVal: 2.307 ± 0.054	0.463TyrTrp: 0.463 ± 0.023	2.001TyrTyr: 2.001 ± 0.06	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2554 proteins (874636 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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