Amino acid dipepetide frequency for Treponema lecithinolyticum ATCC 700332

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.72AlaAla: 10.72 ± 0.178	1.364AlaCys: 1.364 ± 0.052	5.406AlaAsp: 5.406 ± 0.089	6.008AlaGlu: 6.008 ± 0.114	4.24AlaPhe: 4.24 ± 0.09	6.85AlaGly: 6.85 ± 0.106	1.701AlaHis: 1.701 ± 0.052	3.91AlaIle: 3.91 ± 0.08	5.065AlaLys: 5.065 ± 0.092	9.98AlaLeu: 9.98 ± 0.154	1.803AlaMet: 1.803 ± 0.048	2.926AlaAsn: 2.926 ± 0.07	2.602AlaPro: 2.602 ± 0.061	4.168AlaGln: 4.168 ± 0.076	3.432AlaArg: 3.432 ± 0.077	5.793AlaSer: 5.793 ± 0.099	2.577AlaThr: 2.577 ± 0.063	8.482AlaVal: 8.482 ± 0.126	0.773AlaTrp: 0.773 ± 0.037	2.952AlaTyr: 2.952 ± 0.065	0.0AlaXaa: 0.0 ± 0.0
Cys	1.956CysAla: 1.956 ± 0.059	0.264CysCys: 0.264 ± 0.02	0.689CysAsp: 0.689 ± 0.03	0.787CysGlu: 0.787 ± 0.033	0.755CysPhe: 0.755 ± 0.038	1.205CysGly: 1.205 ± 0.042	0.182CysHis: 0.182 ± 0.017	1.16CysIle: 1.16 ± 0.038	0.803CysLys: 0.803 ± 0.036	1.068CysLeu: 1.068 ± 0.043	0.349CysMet: 0.349 ± 0.021	0.484CysAsn: 0.484 ± 0.025	0.581CysPro: 0.581 ± 0.031	0.209CysGln: 0.209 ± 0.017	0.716CysArg: 0.716 ± 0.035	1.102CysSer: 1.102 ± 0.041	1.067CysThr: 1.067 ± 0.046	1.024CysVal: 1.024 ± 0.042	0.148CysTrp: 0.148 ± 0.013	0.477CysTyr: 0.477 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.156AspAla: 4.156 ± 0.09	0.743AspCys: 0.743 ± 0.033	2.446AspAsp: 2.446 ± 0.068	3.655AspGlu: 3.655 ± 0.078	3.157AspPhe: 3.157 ± 0.074	3.901AspGly: 3.901 ± 0.099	0.493AspHis: 0.493 ± 0.024	4.445AspIle: 4.445 ± 0.086	3.585AspLys: 3.585 ± 0.069	4.013AspLeu: 4.013 ± 0.081	1.478AspMet: 1.478 ± 0.048	1.917AspAsn: 1.917 ± 0.057	1.845AspPro: 1.845 ± 0.048	0.863AspGln: 0.863 ± 0.038	1.808AspArg: 1.808 ± 0.049	3.121AspSer: 3.121 ± 0.065	3.513AspThr: 3.513 ± 0.075	3.287AspVal: 3.287 ± 0.077	0.704AspTrp: 0.704 ± 0.031	2.094AspTyr: 2.094 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	4.914GluAla: 4.914 ± 0.08	0.655GluCys: 0.655 ± 0.032	2.61GluAsp: 2.61 ± 0.075	3.557GluGlu: 3.557 ± 0.096	2.318GluPhe: 2.318 ± 0.055	2.916GluGly: 2.916 ± 0.06	1.349GluHis: 1.349 ± 0.048	4.094GluIle: 4.094 ± 0.088	6.429GluLys: 6.429 ± 0.103	5.603GluLeu: 5.603 ± 0.101	1.318GluMet: 1.318 ± 0.051	4.088GluAsn: 4.088 ± 0.079	1.618GluPro: 1.618 ± 0.046	3.197GluGln: 3.197 ± 0.081	3.625GluArg: 3.625 ± 0.076	3.133GluSer: 3.133 ± 0.069	3.327GluThr: 3.327 ± 0.077	2.875GluVal: 2.875 ± 0.066	0.622GluTrp: 0.622 ± 0.029	2.349GluTyr: 2.349 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	4.528PheAla: 4.528 ± 0.092	0.909PheCys: 0.909 ± 0.039	2.758PheAsp: 2.758 ± 0.069	2.702PheGlu: 2.702 ± 0.061	3.297PhePhe: 3.297 ± 0.086	3.113PheGly: 3.113 ± 0.075	0.622PheHis: 0.622 ± 0.028	3.717PheIle: 3.717 ± 0.082	2.698PheLys: 2.698 ± 0.059	4.55PheLeu: 4.55 ± 0.089	1.179PheMet: 1.179 ± 0.043	2.028PheAsn: 2.028 ± 0.054	1.899PhePro: 1.899 ± 0.055	1.077PheGln: 1.077 ± 0.036	1.731PheArg: 1.731 ± 0.051	4.106PheSer: 4.106 ± 0.104	3.201PheThr: 3.201 ± 0.071	3.134PheVal: 3.134 ± 0.071	0.48PheTrp: 0.48 ± 0.029	1.982PheTyr: 1.982 ± 0.056	0.0PheXaa: 0.0 ± 0.0
Gly	5.589GlyAla: 5.589 ± 0.098	1.094GlyCys: 1.094 ± 0.046	2.804GlyAsp: 2.804 ± 0.073	3.8GlyGlu: 3.8 ± 0.076	3.617GlyPhe: 3.617 ± 0.087	4.823GlyGly: 4.823 ± 0.113	0.94GlyHis: 0.94 ± 0.031	5.576GlyIle: 5.576 ± 0.111	5.736GlyLys: 5.736 ± 0.106	5.356GlyLeu: 5.356 ± 0.094	1.773GlyMet: 1.773 ± 0.057	2.845GlyAsn: 2.845 ± 0.075	1.268GlyPro: 1.268 ± 0.043	1.821GlyGln: 1.821 ± 0.047	2.463GlyArg: 2.463 ± 0.065	4.884GlySer: 4.884 ± 0.089	4.701GlyThr: 4.701 ± 0.088	4.205GlyVal: 4.205 ± 0.085	0.717GlyTrp: 0.717 ± 0.035	2.376GlyTyr: 2.376 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.378HisAla: 1.378 ± 0.043	0.308HisCys: 0.308 ± 0.021	0.778HisAsp: 0.778 ± 0.035	0.788HisGlu: 0.788 ± 0.036	0.86HisPhe: 0.86 ± 0.035	1.172HisGly: 1.172 ± 0.041	0.262HisHis: 0.262 ± 0.021	1.61HisIle: 1.61 ± 0.052	1.107HisLys: 1.107 ± 0.036	1.456HisLeu: 1.456 ± 0.04	0.337HisMet: 0.337 ± 0.021	0.778HisAsn: 0.778 ± 0.034	0.806HisPro: 0.806 ± 0.035	0.399HisGln: 0.399 ± 0.02	0.746HisArg: 0.746 ± 0.032	1.091HisSer: 1.091 ± 0.04	1.296HisThr: 1.296 ± 0.042	0.918HisVal: 0.918 ± 0.034	0.179HisTrp: 0.179 ± 0.016	0.599HisTyr: 0.599 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.217IleAla: 6.217 ± 0.102	0.905IleCys: 0.905 ± 0.034	3.898IleAsp: 3.898 ± 0.079	4.129IleGlu: 4.129 ± 0.091	2.903IlePhe: 2.903 ± 0.067	4.569IleGly: 4.569 ± 0.099	1.163IleHis: 1.163 ± 0.041	4.608IleIle: 4.608 ± 0.105	4.632IleLys: 4.632 ± 0.088	5.915IleLeu: 5.915 ± 0.103	1.418IleMet: 1.418 ± 0.049	2.72IleAsn: 2.72 ± 0.062	3.445IlePro: 3.445 ± 0.075	2.296IleGln: 2.296 ± 0.055	3.41IleArg: 3.41 ± 0.063	4.433IleSer: 4.433 ± 0.088	4.012IleThr: 4.012 ± 0.081	4.513IleVal: 4.513 ± 0.085	0.424IleTrp: 0.424 ± 0.024	2.049IleTyr: 2.049 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	5.903LysAla: 5.903 ± 0.096	0.493LysCys: 0.493 ± 0.031	3.758LysAsp: 3.758 ± 0.072	4.871LysGlu: 4.871 ± 0.093	1.596LysPhe: 1.596 ± 0.058	3.811LysGly: 3.811 ± 0.076	1.182LysHis: 1.182 ± 0.04	5.061LysIle: 5.061 ± 0.095	6.96LysLys: 6.96 ± 0.097	5.886LysLeu: 5.886 ± 0.09	1.693LysMet: 1.693 ± 0.052	4.988LysAsn: 4.988 ± 0.094	2.386LysPro: 2.386 ± 0.064	2.508LysGln: 2.508 ± 0.062	3.473LysArg: 3.473 ± 0.082	3.789LysSer: 3.789 ± 0.067	5.67LysThr: 5.67 ± 0.092	3.289LysVal: 3.289 ± 0.069	0.584LysTrp: 0.584 ± 0.029	2.162LysTyr: 2.162 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	7.483LeuAla: 7.483 ± 0.12	2.076LeuCys: 2.076 ± 0.05	4.471LeuAsp: 4.471 ± 0.081	5.148LeuGlu: 5.148 ± 0.106	5.255LeuPhe: 5.255 ± 0.113	5.121LeuGly: 5.121 ± 0.096	1.909LeuHis: 1.909 ± 0.052	6.19LeuIle: 6.19 ± 0.109	6.453LeuLys: 6.453 ± 0.089	9.07LeuLeu: 9.07 ± 0.147	1.937LeuMet: 1.937 ± 0.053	4.386LeuAsn: 4.386 ± 0.086	4.113LeuPro: 4.113 ± 0.081	3.364LeuGln: 3.364 ± 0.074	3.952LeuArg: 3.952 ± 0.085	7.289LeuSer: 7.289 ± 0.106	5.415LeuThr: 5.415 ± 0.084	5.096LeuVal: 5.096 ± 0.091	1.057LeuTrp: 1.057 ± 0.044	4.099LeuTyr: 4.099 ± 0.077	0.0LeuXaa: 0.0 ± 0.0
Met	1.621MetAla: 1.621 ± 0.052	0.325MetCys: 0.325 ± 0.02	1.099MetAsp: 1.099 ± 0.037	1.413MetGlu: 1.413 ± 0.044	0.932MetPhe: 0.932 ± 0.031	1.458MetGly: 1.458 ± 0.045	0.527MetHis: 0.527 ± 0.026	1.414MetIle: 1.414 ± 0.051	1.74MetLys: 1.74 ± 0.046	2.372MetLeu: 2.372 ± 0.065	0.561MetMet: 0.561 ± 0.027	1.274MetAsn: 1.274 ± 0.037	1.12MetPro: 1.12 ± 0.037	1.049MetGln: 1.049 ± 0.04	1.129MetArg: 1.129 ± 0.04	1.561MetSer: 1.561 ± 0.044	1.13MetThr: 1.13 ± 0.039	1.224MetVal: 1.224 ± 0.044	0.19MetTrp: 0.19 ± 0.02	0.821MetTyr: 0.821 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	4.344AsnAla: 4.344 ± 0.092	0.632AsnCys: 0.632 ± 0.029	2.155AsnAsp: 2.155 ± 0.059	2.871AsnGlu: 2.871 ± 0.072	1.849AsnPhe: 1.849 ± 0.051	3.974AsnGly: 3.974 ± 0.088	0.526AsnHis: 0.526 ± 0.026	3.378AsnIle: 3.378 ± 0.074	2.873AsnLys: 2.873 ± 0.064	3.679AsnLeu: 3.679 ± 0.074	1.175AsnMet: 1.175 ± 0.042	1.694AsnAsn: 1.694 ± 0.059	2.171AsnPro: 2.171 ± 0.054	1.072AsnGln: 1.072 ± 0.037	2.035AsnArg: 2.035 ± 0.054	2.59AsnSer: 2.59 ± 0.073	2.974AsnThr: 2.974 ± 0.074	2.696AsnVal: 2.696 ± 0.069	0.465AsnTrp: 0.465 ± 0.025	1.507AsnTyr: 1.507 ± 0.051	0.0AsnXaa: 0.0 ± 0.0
Pro	3.682ProAla: 3.682 ± 0.079	0.461ProCys: 0.461 ± 0.025	2.312ProAsp: 2.312 ± 0.064	2.878ProGlu: 2.878 ± 0.063	2.171ProPhe: 2.171 ± 0.061	2.077ProGly: 2.077 ± 0.052	0.761ProHis: 0.761 ± 0.032	1.97ProIle: 1.97 ± 0.055	1.808ProLys: 1.808 ± 0.05	4.019ProLeu: 4.019 ± 0.076	0.653ProMet: 0.653 ± 0.032	1.272ProAsn: 1.272 ± 0.04	1.308ProPro: 1.308 ± 0.052	1.308ProGln: 1.308 ± 0.043	1.121ProArg: 1.121 ± 0.043	2.291ProSer: 2.291 ± 0.06	1.369ProThr: 1.369 ± 0.045	3.399ProVal: 3.399 ± 0.07	0.34ProTrp: 0.34 ± 0.023	1.471ProTyr: 1.471 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	3.215GlnAla: 3.215 ± 0.064	0.374GlnCys: 0.374 ± 0.019	1.522GlnAsp: 1.522 ± 0.048	1.802GlnGlu: 1.802 ± 0.049	1.217GlnPhe: 1.217 ± 0.042	1.908GlnGly: 1.908 ± 0.055	0.509GlnHis: 0.509 ± 0.029	2.012GlnIle: 2.012 ± 0.056	3.498GlnLys: 3.498 ± 0.069	2.731GlnLeu: 2.731 ± 0.059	0.849GlnMet: 0.849 ± 0.036	2.557GlnAsn: 2.557 ± 0.071	1.03GlnPro: 1.03 ± 0.041	1.144GlnGln: 1.144 ± 0.047	1.56GlnArg: 1.56 ± 0.046	2.38GlnSer: 2.38 ± 0.063	2.572GlnThr: 2.572 ± 0.064	1.683GlnVal: 1.683 ± 0.043	0.349GlnTrp: 0.349 ± 0.023	1.162GlnTyr: 1.162 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	3.183ArgAla: 3.183 ± 0.072	0.663ArgCys: 0.663 ± 0.034	1.935ArgAsp: 1.935 ± 0.058	2.436ArgGlu: 2.436 ± 0.063	2.884ArgPhe: 2.884 ± 0.08	2.311ArgGly: 2.311 ± 0.052	0.701ArgHis: 0.701 ± 0.031	3.748ArgIle: 3.748 ± 0.077	2.844ArgLys: 2.844 ± 0.065	4.508ArgLeu: 4.508 ± 0.093	1.255ArgMet: 1.255 ± 0.037	1.694ArgAsn: 1.694 ± 0.046	1.235ArgPro: 1.235 ± 0.04	1.455ArgGln: 1.455 ± 0.045	2.287ArgArg: 2.287 ± 0.069	3.205ArgSer: 3.205 ± 0.071	2.624ArgThr: 2.624 ± 0.062	2.413ArgVal: 2.413 ± 0.06	0.447ArgTrp: 0.447 ± 0.022	1.886ArgTyr: 1.886 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	7.183SerAla: 7.183 ± 0.119	1.028SerCys: 1.028 ± 0.036	3.572SerAsp: 3.572 ± 0.082	3.883SerGlu: 3.883 ± 0.081	3.916SerPhe: 3.916 ± 0.085	5.987SerGly: 5.987 ± 0.109	0.913SerHis: 0.913 ± 0.039	4.065SerIle: 4.065 ± 0.081	3.269SerLys: 3.269 ± 0.062	6.335SerLeu: 6.335 ± 0.102	1.341SerMet: 1.341 ± 0.044	2.08SerAsn: 2.08 ± 0.057	2.17SerPro: 2.17 ± 0.056	1.83SerGln: 1.83 ± 0.061	2.598SerArg: 2.598 ± 0.062	4.384SerSer: 4.384 ± 0.103	2.856SerThr: 2.856 ± 0.067	5.569SerVal: 5.569 ± 0.09	0.648SerTrp: 0.648 ± 0.032	2.263SerTyr: 2.263 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	6.445ThrAla: 6.445 ± 0.103	0.62ThrCys: 0.62 ± 0.024	3.611ThrAsp: 3.611 ± 0.073	3.78ThrGlu: 3.78 ± 0.085	2.292ThrPhe: 2.292 ± 0.055	4.822ThrGly: 4.822 ± 0.079	1.012ThrHis: 1.012 ± 0.041	3.119ThrIle: 3.119 ± 0.069	3.114ThrLys: 3.114 ± 0.061	5.755ThrLeu: 5.755 ± 0.103	1.14ThrMet: 1.14 ± 0.039	1.985ThrAsn: 1.985 ± 0.055	2.291ThrPro: 2.291 ± 0.067	1.982ThrGln: 1.982 ± 0.053	1.797ThrArg: 1.797 ± 0.057	3.088ThrSer: 3.088 ± 0.076	2.206ThrThr: 2.206 ± 0.063	5.82ThrVal: 5.82 ± 0.109	0.477ThrTrp: 0.477 ± 0.026	1.831ThrTyr: 1.831 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	4.036ValAla: 4.036 ± 0.082	1.441ValCys: 1.441 ± 0.053	2.792ValAsp: 2.792 ± 0.066	3.182ValGlu: 3.182 ± 0.067	4.147ValPhe: 4.147 ± 0.08	3.273ValGly: 3.273 ± 0.073	1.38ValHis: 1.38 ± 0.047	4.409ValIle: 4.409 ± 0.101	4.301ValLys: 4.301 ± 0.092	7.79ValLeu: 7.79 ± 0.106	1.658ValMet: 1.658 ± 0.047	2.743ValAsn: 2.743 ± 0.063	3.085ValPro: 3.085 ± 0.066	2.94ValGln: 2.94 ± 0.074	3.364ValArg: 3.364 ± 0.07	4.988ValSer: 4.988 ± 0.09	3.454ValThr: 3.454 ± 0.082	3.848ValVal: 3.848 ± 0.087	0.712ValTrp: 0.712 ± 0.034	2.694ValTyr: 2.694 ± 0.07	0.0ValXaa: 0.0 ± 0.0
Trp	0.755TrpAla: 0.755 ± 0.03	0.17TrpCys: 0.17 ± 0.017	0.557TrpAsp: 0.557 ± 0.031	0.628TrpGlu: 0.628 ± 0.031	0.486TrpPhe: 0.486 ± 0.027	0.605TrpGly: 0.605 ± 0.031	0.22TrpHis: 0.22 ± 0.02	0.599TrpIle: 0.599 ± 0.034	0.762TrpLys: 0.762 ± 0.035	0.943TrpLeu: 0.943 ± 0.039	0.219TrpMet: 0.219 ± 0.019	0.596TrpAsn: 0.596 ± 0.031	0.213TrpPro: 0.213 ± 0.018	0.509TrpGln: 0.509 ± 0.031	0.428TrpArg: 0.428 ± 0.025	0.492TrpSer: 0.492 ± 0.029	0.558TrpThr: 0.558 ± 0.03	0.505TrpVal: 0.505 ± 0.026	0.113TrpTrp: 0.113 ± 0.013	0.452TrpTyr: 0.452 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.444TyrAla: 3.444 ± 0.07	0.503TyrCys: 0.503 ± 0.025	2.052TyrAsp: 2.052 ± 0.064	2.281TyrGlu: 2.281 ± 0.062	1.819TyrPhe: 1.819 ± 0.052	2.494TyrGly: 2.494 ± 0.062	0.518TyrHis: 0.518 ± 0.026	2.575TyrIle: 2.575 ± 0.067	2.382TyrLys: 2.382 ± 0.06	2.854TyrLeu: 2.854 ± 0.066	0.822TyrMet: 0.822 ± 0.039	1.602TyrAsn: 1.602 ± 0.052	1.486TyrPro: 1.486 ± 0.046	0.88TyrGln: 0.88 ± 0.037	2.039TyrArg: 2.039 ± 0.067	2.171TyrSer: 2.171 ± 0.055	2.666TyrThr: 2.666 ± 0.06	2.255TyrVal: 2.255 ± 0.065	0.383TyrTrp: 0.383 ± 0.027	1.389TyrTyr: 1.389 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2175 proteins (736040 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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