Amino acid dipepetide frequency for Cucurbit chlorotic yellows virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.83AlaAla: 1.83 ± 0.557
0.203AlaCys: 0.203 ± 0.118
2.441AlaAsp: 2.441 ± 0.716
1.627AlaGlu: 1.627 ± 0.573
2.034AlaPhe: 2.034 ± 0.299
3.864AlaGly: 3.864 ± 1.139
0.407AlaHis: 0.407 ± 0.21
2.441AlaIle: 2.441 ± 0.954
3.661AlaLys: 3.661 ± 0.536
3.864AlaLeu: 3.864 ± 0.916
1.017AlaMet: 1.017 ± 0.477
3.254AlaAsn: 3.254 ± 0.532
1.017AlaPro: 1.017 ± 0.449
1.22AlaGln: 1.22 ± 0.629
2.441AlaArg: 2.441 ± 0.614
2.847AlaSer: 2.847 ± 0.648
1.22AlaThr: 1.22 ± 0.368
2.847AlaVal: 2.847 ± 0.863
0.0AlaTrp: 0.0 ± 0.0
1.22AlaTyr: 1.22 ± 0.23
0.0AlaXaa: 0.0 ± 0.0
Cys
0.61CysAla: 0.61 ± 0.319
0.0CysCys: 0.0 ± 0.0
1.22CysAsp: 1.22 ± 0.405
0.814CysGlu: 0.814 ± 0.349
1.424CysPhe: 1.424 ± 0.511
1.627CysGly: 1.627 ± 0.785
0.0CysHis: 0.0 ± 0.0
0.814CysIle: 0.814 ± 0.419
1.017CysLys: 1.017 ± 0.414
1.83CysLeu: 1.83 ± 0.639
0.61CysMet: 0.61 ± 0.281
1.627CysAsn: 1.627 ± 0.613
0.203CysPro: 0.203 ± 0.118
0.814CysGln: 0.814 ± 0.284
0.814CysArg: 0.814 ± 0.381
2.237CysSer: 2.237 ± 0.56
1.424CysThr: 1.424 ± 0.375
2.237CysVal: 2.237 ± 0.875
0.203CysTrp: 0.203 ± 0.118
1.017CysTyr: 1.017 ± 0.313
0.0CysXaa: 0.0 ± 0.0
Asp
1.627AspAla: 1.627 ± 0.759
1.83AspCys: 1.83 ± 0.495
5.084AspAsp: 5.084 ± 1.583
4.271AspGlu: 4.271 ± 0.943
5.695AspPhe: 5.695 ± 0.72
3.051AspGly: 3.051 ± 0.685
1.017AspHis: 1.017 ± 0.395
5.491AspIle: 5.491 ± 1.546
4.881AspLys: 4.881 ± 0.627
5.084AspLeu: 5.084 ± 1.218
2.644AspMet: 2.644 ± 0.989
3.457AspAsn: 3.457 ± 0.825
1.83AspPro: 1.83 ± 0.9
1.017AspGln: 1.017 ± 0.448
1.83AspArg: 1.83 ± 0.531
4.271AspSer: 4.271 ± 1.358
2.237AspThr: 2.237 ± 0.557
6.101AspVal: 6.101 ± 1.039
0.61AspTrp: 0.61 ± 0.334
2.441AspTyr: 2.441 ± 0.398
0.0AspXaa: 0.0 ± 0.0
Glu
1.627GluAla: 1.627 ± 0.74
1.22GluCys: 1.22 ± 0.489
3.864GluAsp: 3.864 ± 1.36
3.254GluGlu: 3.254 ± 0.858
3.661GluPhe: 3.661 ± 0.837
2.644GluGly: 2.644 ± 0.494
1.22GluHis: 1.22 ± 0.556
4.678GluIle: 4.678 ± 0.883
5.898GluLys: 5.898 ± 0.966
4.678GluLeu: 4.678 ± 1.062
1.424GluMet: 1.424 ± 0.511
2.441GluAsn: 2.441 ± 0.965
1.424GluPro: 1.424 ± 0.728
0.814GluGln: 0.814 ± 0.356
2.237GluArg: 2.237 ± 0.662
3.254GluSer: 3.254 ± 0.613
2.441GluThr: 2.441 ± 0.929
3.051GluVal: 3.051 ± 0.85
0.814GluTrp: 0.814 ± 0.494
3.254GluTyr: 3.254 ± 0.727
0.0GluXaa: 0.0 ± 0.0
Phe
1.627PheAla: 1.627 ± 0.223
1.017PheCys: 1.017 ± 0.388
4.881PheAsp: 4.881 ± 1.076
3.457PheGlu: 3.457 ± 0.935
2.034PhePhe: 2.034 ± 1.152
2.644PheGly: 2.644 ± 0.472
0.61PheHis: 0.61 ± 0.354
2.441PheIle: 2.441 ± 0.67
4.881PheLys: 4.881 ± 0.984
3.864PheLeu: 3.864 ± 1.105
2.034PheMet: 2.034 ± 0.516
3.457PheAsn: 3.457 ± 0.968
1.627PhePro: 1.627 ± 0.409
1.424PheGln: 1.424 ± 0.763
3.864PheArg: 3.864 ± 1.411
6.915PheSer: 6.915 ± 1.16
2.847PheThr: 2.847 ± 0.936
5.288PheVal: 5.288 ± 1.038
0.203PheTrp: 0.203 ± 0.269
2.644PheTyr: 2.644 ± 0.55
0.0PheXaa: 0.0 ± 0.0
Gly
1.83GlyAla: 1.83 ± 0.669
0.814GlyCys: 0.814 ± 0.343
3.864GlyAsp: 3.864 ± 0.366
3.661GlyGlu: 3.661 ± 0.58
3.051GlyPhe: 3.051 ± 1.097
3.864GlyGly: 3.864 ± 1.082
0.0GlyHis: 0.0 ± 0.0
2.847GlyIle: 2.847 ± 0.501
4.881GlyLys: 4.881 ± 1.449
3.457GlyLeu: 3.457 ± 1.042
1.22GlyMet: 1.22 ± 0.561
3.051GlyAsn: 3.051 ± 0.487
0.814GlyPro: 0.814 ± 0.322
0.814GlyGln: 0.814 ± 0.507
3.051GlyArg: 3.051 ± 0.794
4.474GlySer: 4.474 ± 0.322
1.424GlyThr: 1.424 ± 0.513
4.678GlyVal: 4.678 ± 1.065
0.203GlyTrp: 0.203 ± 0.118
1.22GlyTyr: 1.22 ± 0.707
0.0GlyXaa: 0.0 ± 0.0
His
1.627HisAla: 1.627 ± 0.374
0.407HisCys: 0.407 ± 0.247
1.83HisAsp: 1.83 ± 0.785
0.814HisGlu: 0.814 ± 0.356
1.83HisPhe: 1.83 ± 0.523
0.203HisGly: 0.203 ± 0.259
0.407HisHis: 0.407 ± 0.373
0.407HisIle: 0.407 ± 0.414
1.424HisLys: 1.424 ± 0.649
1.22HisLeu: 1.22 ± 0.454
0.61HisMet: 0.61 ± 0.281
0.61HisAsn: 0.61 ± 0.242
1.424HisPro: 1.424 ± 0.442
0.0HisGln: 0.0 ± 0.0
1.627HisArg: 1.627 ± 0.545
1.424HisSer: 1.424 ± 0.564
1.627HisThr: 1.627 ± 0.563
1.22HisVal: 1.22 ± 0.535
0.203HisTrp: 0.203 ± 0.118
1.22HisTyr: 1.22 ± 0.307
0.0HisXaa: 0.0 ± 0.0
Ile
1.83IleAla: 1.83 ± 0.492
0.814IleCys: 0.814 ± 0.391
2.644IleAsp: 2.644 ± 0.688
2.034IleGlu: 2.034 ± 1.09
4.068IlePhe: 4.068 ± 1.314
3.051IleGly: 3.051 ± 0.651
1.424IleHis: 1.424 ± 0.464
4.474IleIle: 4.474 ± 1.175
5.898IleLys: 5.898 ± 1.466
4.474IleLeu: 4.474 ± 0.768
1.627IleMet: 1.627 ± 0.564
6.101IleAsn: 6.101 ± 2.021
3.051IlePro: 3.051 ± 0.786
1.22IleGln: 1.22 ± 0.38
3.457IleArg: 3.457 ± 0.5
5.695IleSer: 5.695 ± 0.845
3.457IleThr: 3.457 ± 0.576
4.068IleVal: 4.068 ± 0.683
0.203IleTrp: 0.203 ± 0.268
4.474IleTyr: 4.474 ± 0.93
0.0IleXaa: 0.0 ± 0.0
Lys
3.457LysAla: 3.457 ± 1.116
1.627LysCys: 1.627 ± 0.372
3.457LysAsp: 3.457 ± 0.581
3.661LysGlu: 3.661 ± 0.884
5.898LysPhe: 5.898 ± 1.345
2.847LysGly: 2.847 ± 0.644
1.424LysHis: 1.424 ± 0.743
5.288LysIle: 5.288 ± 1.082
3.864LysLys: 3.864 ± 0.484
7.728LysLeu: 7.728 ± 1.14
2.441LysMet: 2.441 ± 0.603
4.678LysAsn: 4.678 ± 1.221
3.661LysPro: 3.661 ± 1.88
2.644LysGln: 2.644 ± 0.474
4.474LysArg: 4.474 ± 0.842
6.711LysSer: 6.711 ± 1.227
3.457LysThr: 3.457 ± 0.587
6.711LysVal: 6.711 ± 1.326
0.407LysTrp: 0.407 ± 0.247
4.474LysTyr: 4.474 ± 0.897
0.0LysXaa: 0.0 ± 0.0
Leu
4.068LeuAla: 4.068 ± 0.451
1.627LeuCys: 1.627 ± 0.595
6.508LeuAsp: 6.508 ± 1.624
4.474LeuGlu: 4.474 ± 1.081
6.305LeuPhe: 6.305 ± 1.593
5.288LeuGly: 5.288 ± 0.536
1.22LeuHis: 1.22 ± 0.529
8.135LeuIle: 8.135 ± 1.401
7.728LeuLys: 7.728 ± 0.928
8.542LeuLeu: 8.542 ± 1.104
3.051LeuMet: 3.051 ± 0.688
7.932LeuAsn: 7.932 ± 2.344
2.034LeuPro: 2.034 ± 0.504
1.627LeuGln: 1.627 ± 1.102
4.271LeuArg: 4.271 ± 0.684
6.915LeuSer: 6.915 ± 1.052
5.084LeuThr: 5.084 ± 1.023
4.474LeuVal: 4.474 ± 0.674
0.61LeuTrp: 0.61 ± 0.312
3.457LeuTyr: 3.457 ± 1.287
0.0LeuXaa: 0.0 ± 0.0
Met
1.424MetAla: 1.424 ± 0.46
0.814MetCys: 0.814 ± 0.471
1.22MetAsp: 1.22 ± 0.455
0.814MetGlu: 0.814 ± 0.284
1.424MetPhe: 1.424 ± 0.628
0.61MetGly: 0.61 ± 0.322
0.61MetHis: 0.61 ± 0.354
2.034MetIle: 2.034 ± 0.572
3.051MetLys: 3.051 ± 0.69
1.627MetLeu: 1.627 ± 0.602
0.203MetMet: 0.203 ± 0.118
3.254MetAsn: 3.254 ± 0.668
1.017MetPro: 1.017 ± 0.346
0.407MetGln: 0.407 ± 0.4
1.83MetArg: 1.83 ± 0.492
3.457MetSer: 3.457 ± 0.86
1.22MetThr: 1.22 ± 0.425
2.034MetVal: 2.034 ± 0.612
0.203MetTrp: 0.203 ± 0.268
1.22MetTyr: 1.22 ± 0.464
0.0MetXaa: 0.0 ± 0.0
Asn
1.627AsnAla: 1.627 ± 0.532
1.424AsnCys: 1.424 ± 0.394
4.474AsnAsp: 4.474 ± 0.616
2.644AsnGlu: 2.644 ± 0.681
3.661AsnPhe: 3.661 ± 1.409
3.457AsnGly: 3.457 ± 0.825
0.407AsnHis: 0.407 ± 0.294
6.508AsnIle: 6.508 ± 1.076
6.711AsnLys: 6.711 ± 0.896
7.322AsnLeu: 7.322 ± 1.155
1.22AsnMet: 1.22 ± 0.513
4.678AsnAsn: 4.678 ± 2.33
2.847AsnPro: 2.847 ± 0.783
2.034AsnGln: 2.034 ± 0.42
2.034AsnArg: 2.034 ± 0.641
4.474AsnSer: 4.474 ± 1.653
3.051AsnThr: 3.051 ± 0.52
4.474AsnVal: 4.474 ± 1.025
0.61AsnTrp: 0.61 ± 0.354
3.051AsnTyr: 3.051 ± 0.635
0.0AsnXaa: 0.0 ± 0.0
Pro
1.83ProAla: 1.83 ± 0.559
0.61ProCys: 0.61 ± 0.363
1.83ProAsp: 1.83 ± 0.559
2.847ProGlu: 2.847 ± 0.863
1.424ProPhe: 1.424 ± 0.438
2.441ProGly: 2.441 ± 0.924
0.407ProHis: 0.407 ± 0.243
1.424ProIle: 1.424 ± 0.457
2.441ProLys: 2.441 ± 0.588
3.864ProLeu: 3.864 ± 0.615
0.814ProMet: 0.814 ± 0.402
3.457ProAsn: 3.457 ± 0.404
2.441ProPro: 2.441 ± 0.653
0.61ProGln: 0.61 ± 0.278
1.627ProArg: 1.627 ± 0.563
2.034ProSer: 2.034 ± 0.757
2.441ProThr: 2.441 ± 0.34
2.644ProVal: 2.644 ± 1.003
0.407ProTrp: 0.407 ± 0.446
1.017ProTyr: 1.017 ± 0.414
0.0ProXaa: 0.0 ± 0.0
Gln
1.424GlnAla: 1.424 ± 0.695
1.017GlnCys: 1.017 ± 0.449
0.61GlnAsp: 0.61 ± 0.239
1.017GlnGlu: 1.017 ± 0.775
1.017GlnPhe: 1.017 ± 0.269
1.22GlnGly: 1.22 ± 0.542
0.61GlnHis: 0.61 ± 0.271
1.424GlnIle: 1.424 ± 0.338
1.627GlnLys: 1.627 ± 0.621
2.644GlnLeu: 2.644 ± 0.749
0.61GlnMet: 0.61 ± 0.372
1.22GlnAsn: 1.22 ± 0.556
1.22GlnPro: 1.22 ± 0.577
0.61GlnGln: 0.61 ± 0.312
1.627GlnArg: 1.627 ± 0.394
1.83GlnSer: 1.83 ± 1.138
1.424GlnThr: 1.424 ± 0.664
1.627GlnVal: 1.627 ± 0.668
0.407GlnTrp: 0.407 ± 0.396
1.22GlnTyr: 1.22 ± 0.478
0.0GlnXaa: 0.0 ± 0.0
Arg
1.83ArgAla: 1.83 ± 0.256
1.424ArgCys: 1.424 ± 0.6
3.254ArgAsp: 3.254 ± 1.274
2.441ArgGlu: 2.441 ± 0.459
2.441ArgPhe: 2.441 ± 0.945
1.627ArgGly: 1.627 ± 0.37
1.424ArgHis: 1.424 ± 0.416
1.83ArgIle: 1.83 ± 0.491
2.644ArgLys: 2.644 ± 0.545
6.101ArgLeu: 6.101 ± 1.068
1.424ArgMet: 1.424 ± 0.552
2.644ArgAsn: 2.644 ± 0.627
1.627ArgPro: 1.627 ± 0.759
2.034ArgGln: 2.034 ± 0.823
1.83ArgArg: 1.83 ± 0.467
3.051ArgSer: 3.051 ± 0.713
2.847ArgThr: 2.847 ± 0.93
4.271ArgVal: 4.271 ± 1.844
0.203ArgTrp: 0.203 ± 0.239
2.644ArgTyr: 2.644 ± 0.748
0.0ArgXaa: 0.0 ± 0.0
Ser
3.864SerAla: 3.864 ± 1.492
1.017SerCys: 1.017 ± 0.437
5.491SerAsp: 5.491 ± 2.282
4.068SerGlu: 4.068 ± 0.923
3.864SerPhe: 3.864 ± 1.588
3.661SerGly: 3.661 ± 0.992
4.068SerHis: 4.068 ± 1.38
4.271SerIle: 4.271 ± 0.862
5.898SerLys: 5.898 ± 1.03
8.745SerLeu: 8.745 ± 1.852
2.644SerMet: 2.644 ± 0.674
5.084SerAsn: 5.084 ± 1.244
2.847SerPro: 2.847 ± 0.602
2.237SerGln: 2.237 ± 1.072
3.254SerArg: 3.254 ± 1.019
4.678SerSer: 4.678 ± 1.324
3.457SerThr: 3.457 ± 1.158
6.101SerVal: 6.101 ± 0.892
0.407SerTrp: 0.407 ± 0.243
3.051SerTyr: 3.051 ± 1.526
0.0SerXaa: 0.0 ± 0.0
Thr
2.034ThrAla: 2.034 ± 0.583
1.22ThrCys: 1.22 ± 0.58
2.034ThrAsp: 2.034 ± 0.752
4.271ThrGlu: 4.271 ± 0.85
2.034ThrPhe: 2.034 ± 0.488
2.237ThrGly: 2.237 ± 0.752
2.441ThrHis: 2.441 ± 0.98
3.457ThrIle: 3.457 ± 0.978
1.017ThrLys: 1.017 ± 0.313
5.695ThrLeu: 5.695 ± 1.16
0.814ThrMet: 0.814 ± 0.303
2.237ThrAsn: 2.237 ± 0.549
2.847ThrPro: 2.847 ± 0.758
1.83ThrGln: 1.83 ± 0.455
2.441ThrArg: 2.441 ± 0.98
3.661ThrSer: 3.661 ± 0.795
2.237ThrThr: 2.237 ± 0.61
3.254ThrVal: 3.254 ± 0.85
0.814ThrTrp: 0.814 ± 0.284
2.237ThrTyr: 2.237 ± 0.753
0.0ThrXaa: 0.0 ± 0.0
Val
3.457ValAla: 3.457 ± 0.95
1.83ValCys: 1.83 ± 0.437
5.491ValAsp: 5.491 ± 0.788
4.068ValGlu: 4.068 ± 0.709
2.237ValPhe: 2.237 ± 0.607
2.644ValGly: 2.644 ± 0.841
1.424ValHis: 1.424 ± 0.63
3.051ValIle: 3.051 ± 0.871
8.135ValLys: 8.135 ± 1.723
6.101ValLeu: 6.101 ± 1.166
1.627ValMet: 1.627 ± 0.573
5.084ValAsn: 5.084 ± 1.079
3.457ValPro: 3.457 ± 0.752
2.034ValGln: 2.034 ± 0.759
2.847ValArg: 2.847 ± 0.457
6.711ValSer: 6.711 ± 0.765
4.068ValThr: 4.068 ± 0.475
4.271ValVal: 4.271 ± 0.955
0.203ValTrp: 0.203 ± 0.118
4.474ValTyr: 4.474 ± 0.65
0.0ValXaa: 0.0 ± 0.0
Trp
0.61TrpAla: 0.61 ± 0.358
0.203TrpCys: 0.203 ± 0.268
0.203TrpAsp: 0.203 ± 0.118
1.017TrpGlu: 1.017 ± 0.462
0.407TrpPhe: 0.407 ± 0.528
0.203TrpGly: 0.203 ± 0.118
0.203TrpHis: 0.203 ± 0.118
0.61TrpIle: 0.61 ± 0.286
0.203TrpLys: 0.203 ± 0.118
1.627TrpLeu: 1.627 ± 0.394
0.407TrpMet: 0.407 ± 0.362
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.203TrpGln: 0.203 ± 0.339
0.203TrpArg: 0.203 ± 0.259
0.203TrpSer: 0.203 ± 0.268
0.203TrpThr: 0.203 ± 0.118
0.407TrpVal: 0.407 ± 0.21
0.0TrpTrp: 0.0 ± 0.0
0.203TrpTyr: 0.203 ± 0.118
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.22TyrAla: 1.22 ± 0.368
1.424TyrCys: 1.424 ± 0.483
4.068TyrAsp: 4.068 ± 1.153
2.644TyrGlu: 2.644 ± 0.568
3.457TyrPhe: 3.457 ± 0.62
2.034TyrGly: 2.034 ± 0.746
0.814TyrHis: 0.814 ± 0.471
2.441TyrIle: 2.441 ± 0.813
3.051TyrLys: 3.051 ± 0.453
4.881TyrLeu: 4.881 ± 0.885
1.83TyrMet: 1.83 ± 0.599
2.441TyrAsn: 2.441 ± 0.48
1.22TyrPro: 1.22 ± 0.324
0.814TyrGln: 0.814 ± 0.25
1.83TyrArg: 1.83 ± 0.529
3.864TyrSer: 3.864 ± 0.647
2.644TyrThr: 2.644 ± 0.472
3.457TyrVal: 3.457 ± 1.364
0.407TyrTrp: 0.407 ± 0.448
2.034TyrTyr: 2.034 ± 0.703
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (4918 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski