Amino acid dipepetide frequency for Ramie mosaic virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.056AlaAla: 3.056 ± 1.618
1.222AlaCys: 1.222 ± 0.743
2.445AlaAsp: 2.445 ± 0.609
3.056AlaGlu: 3.056 ± 1.472
0.611AlaPhe: 0.611 ± 0.619
0.611AlaGly: 0.611 ± 0.72
1.222AlaHis: 1.222 ± 0.885
3.056AlaIle: 3.056 ± 1.062
3.667AlaLys: 3.667 ± 1.222
8.557AlaLeu: 8.557 ± 1.453
0.0AlaMet: 0.0 ± 0.0
3.056AlaAsn: 3.056 ± 1.321
3.056AlaPro: 3.056 ± 1.518
2.445AlaGln: 2.445 ± 1.145
4.89AlaArg: 4.89 ± 1.486
4.89AlaSer: 4.89 ± 1.492
3.667AlaThr: 3.667 ± 1.475
1.834AlaVal: 1.834 ± 1.209
1.222AlaTrp: 1.222 ± 0.659
1.834AlaTyr: 1.834 ± 1.022
0.0AlaXaa: 0.0 ± 0.0
Cys
0.611CysAla: 0.611 ± 0.619
0.0CysCys: 0.0 ± 0.0
0.611CysAsp: 0.611 ± 0.591
0.611CysGlu: 0.611 ± 0.555
0.611CysPhe: 0.611 ± 0.653
1.222CysGly: 1.222 ± 0.741
0.0CysHis: 0.0 ± 0.0
2.445CysIle: 2.445 ± 1.303
0.611CysLys: 0.611 ± 0.555
0.611CysLeu: 0.611 ± 0.543
1.222CysMet: 1.222 ± 0.84
3.667CysAsn: 3.667 ± 1.462
2.445CysPro: 2.445 ± 1.622
1.834CysGln: 1.834 ± 0.741
2.445CysArg: 2.445 ± 0.997
1.222CysSer: 1.222 ± 0.764
1.222CysThr: 1.222 ± 0.707
1.222CysVal: 1.222 ± 0.743
0.611CysTrp: 0.611 ± 0.459
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.056AspAla: 3.056 ± 1.301
0.0AspCys: 0.0 ± 0.0
1.834AspAsp: 1.834 ± 1.022
1.222AspGlu: 1.222 ± 0.659
2.445AspPhe: 2.445 ± 1.495
4.279AspGly: 4.279 ± 1.212
0.611AspHis: 0.611 ± 0.543
1.222AspIle: 1.222 ± 0.778
1.834AspLys: 1.834 ± 0.838
7.335AspLeu: 7.335 ± 2.694
0.0AspMet: 0.0 ± 0.0
1.834AspAsn: 1.834 ± 0.645
4.279AspPro: 4.279 ± 1.374
1.834AspGln: 1.834 ± 0.741
4.89AspArg: 4.89 ± 1.833
5.501AspSer: 5.501 ± 1.493
3.667AspThr: 3.667 ± 1.386
6.724AspVal: 6.724 ± 1.758
0.611AspTrp: 0.611 ± 0.459
0.611AspTyr: 0.611 ± 0.459
0.0AspXaa: 0.0 ± 0.0
Glu
3.056GluAla: 3.056 ± 1.488
1.834GluCys: 1.834 ± 1.286
1.834GluAsp: 1.834 ± 0.628
3.667GluGlu: 3.667 ± 1.222
3.056GluPhe: 3.056 ± 1.05
5.501GluGly: 5.501 ± 1.092
0.611GluHis: 0.611 ± 0.591
2.445GluIle: 2.445 ± 0.995
1.222GluLys: 1.222 ± 0.577
3.667GluLeu: 3.667 ± 1.456
0.611GluMet: 0.611 ± 0.543
3.056GluAsn: 3.056 ± 1.737
1.834GluPro: 1.834 ± 0.838
1.834GluGln: 1.834 ± 1.099
1.222GluArg: 1.222 ± 0.659
1.834GluSer: 1.834 ± 1.119
1.222GluThr: 1.222 ± 1.182
2.445GluVal: 2.445 ± 0.995
1.222GluTrp: 1.222 ± 0.741
1.222GluTyr: 1.222 ± 0.577
0.0GluXaa: 0.0 ± 0.0
Phe
1.834PheAla: 1.834 ± 0.838
1.222PheCys: 1.222 ± 0.681
1.834PheAsp: 1.834 ± 0.99
1.222PheGlu: 1.222 ± 0.659
2.445PhePhe: 2.445 ± 1.396
1.834PheGly: 1.834 ± 1.222
1.222PheHis: 1.222 ± 0.918
0.611PheIle: 0.611 ± 0.459
3.056PheLys: 3.056 ± 0.673
6.112PheLeu: 6.112 ± 2.37
0.611PheMet: 0.611 ± 0.459
4.89PheAsn: 4.89 ± 1.45
1.222PhePro: 1.222 ± 0.84
2.445PheGln: 2.445 ± 0.667
3.056PheArg: 3.056 ± 1.826
4.279PheSer: 4.279 ± 2.933
4.279PheThr: 4.279 ± 1.325
0.0PheVal: 0.0 ± 0.0
0.611PheTrp: 0.611 ± 0.543
0.611PheTyr: 0.611 ± 0.555
0.0PheXaa: 0.0 ± 0.0
Gly
3.056GlyAla: 3.056 ± 1.718
1.834GlyCys: 1.834 ± 0.733
1.834GlyAsp: 1.834 ± 0.743
2.445GlyGlu: 2.445 ± 1.246
1.222GlyPhe: 1.222 ± 0.842
5.501GlyGly: 5.501 ± 2.106
2.445GlyHis: 2.445 ± 1.24
3.667GlyIle: 3.667 ± 1.389
5.501GlyLys: 5.501 ± 2.198
3.056GlyLeu: 3.056 ± 1.102
1.222GlyMet: 1.222 ± 1.114
1.834GlyAsn: 1.834 ± 1.14
3.056GlyPro: 3.056 ± 1.258
4.279GlyGln: 4.279 ± 0.929
1.834GlyArg: 1.834 ± 0.838
3.056GlySer: 3.056 ± 1.126
2.445GlyThr: 2.445 ± 0.918
1.834GlyVal: 1.834 ± 0.92
0.0GlyTrp: 0.0 ± 0.0
1.222GlyTyr: 1.222 ± 0.811
0.0GlyXaa: 0.0 ± 0.0
His
0.611HisAla: 0.611 ± 0.72
1.222HisCys: 1.222 ± 0.919
1.834HisAsp: 1.834 ± 0.892
0.611HisGlu: 0.611 ± 0.459
1.834HisPhe: 1.834 ± 0.889
1.222HisGly: 1.222 ± 0.842
1.834HisHis: 1.834 ± 1.857
1.834HisIle: 1.834 ± 1.022
1.222HisLys: 1.222 ± 0.919
1.834HisLeu: 1.834 ± 0.92
0.0HisMet: 0.0 ± 0.0
1.834HisAsn: 1.834 ± 1.029
1.222HisPro: 1.222 ± 0.623
1.222HisGln: 1.222 ± 0.778
2.445HisArg: 2.445 ± 0.801
1.222HisSer: 1.222 ± 0.681
2.445HisThr: 2.445 ± 1.608
3.056HisVal: 3.056 ± 0.968
0.0HisTrp: 0.0 ± 0.0
2.445HisTyr: 2.445 ± 0.769
0.0HisXaa: 0.0 ± 0.0
Ile
1.222IleAla: 1.222 ± 0.842
1.834IleCys: 1.834 ± 0.645
2.445IleAsp: 2.445 ± 1.199
3.667IleGlu: 3.667 ± 1.455
3.056IlePhe: 3.056 ± 1.341
1.834IleGly: 1.834 ± 1.209
2.445IleHis: 2.445 ± 1.278
3.056IleIle: 3.056 ± 2.288
7.335IleLys: 7.335 ± 1.374
1.834IleLeu: 1.834 ± 1.218
0.611IleMet: 0.611 ± 0.586
3.056IleAsn: 3.056 ± 0.887
3.056IlePro: 3.056 ± 1.152
3.667IleGln: 3.667 ± 1.455
4.279IleArg: 4.279 ± 1.576
3.667IleSer: 3.667 ± 1.674
1.834IleThr: 1.834 ± 1.503
3.056IleVal: 3.056 ± 1.084
1.222IleTrp: 1.222 ± 0.778
0.611IleTyr: 0.611 ± 0.555
0.0IleXaa: 0.0 ± 0.0
Lys
2.445LysAla: 2.445 ± 1.145
2.445LysCys: 2.445 ± 0.769
3.056LysAsp: 3.056 ± 1.301
4.279LysGlu: 4.279 ± 1.935
1.834LysPhe: 1.834 ± 1.029
1.222LysGly: 1.222 ± 0.741
0.611LysHis: 0.611 ± 0.459
4.279LysIle: 4.279 ± 1.078
4.89LysLys: 4.89 ± 0.971
3.056LysLeu: 3.056 ± 1.475
1.834LysMet: 1.834 ± 1.313
4.279LysAsn: 4.279 ± 0.926
3.056LysPro: 3.056 ± 0.617
1.834LysGln: 1.834 ± 1.218
2.445LysArg: 2.445 ± 1.109
3.667LysSer: 3.667 ± 0.882
3.056LysThr: 3.056 ± 1.073
4.279LysVal: 4.279 ± 1.988
0.0LysTrp: 0.0 ± 0.0
4.89LysTyr: 4.89 ± 1.356
0.0LysXaa: 0.0 ± 0.0
Leu
3.056LeuAla: 3.056 ± 1.085
3.056LeuCys: 3.056 ± 1.126
5.501LeuAsp: 5.501 ± 1.44
1.834LeuGlu: 1.834 ± 0.878
1.834LeuPhe: 1.834 ± 0.94
2.445LeuGly: 2.445 ± 1.293
2.445LeuHis: 2.445 ± 0.825
3.056LeuIle: 3.056 ± 1.434
3.667LeuLys: 3.667 ± 1.026
4.279LeuLeu: 4.279 ± 1.207
1.222LeuMet: 1.222 ± 0.802
3.667LeuAsn: 3.667 ± 1.663
3.056LeuPro: 3.056 ± 1.52
3.667LeuGln: 3.667 ± 1.595
4.89LeuArg: 4.89 ± 1.834
8.557LeuSer: 8.557 ± 2.135
3.667LeuThr: 3.667 ± 1.261
4.89LeuVal: 4.89 ± 2.407
0.0LeuTrp: 0.0 ± 0.0
4.89LeuTyr: 4.89 ± 1.76
0.0LeuXaa: 0.0 ± 0.0
Met
1.834MetAla: 1.834 ± 0.645
0.0MetCys: 0.0 ± 0.0
1.222MetAsp: 1.222 ± 0.778
1.834MetGlu: 1.834 ± 0.911
1.834MetPhe: 1.834 ± 1.283
1.222MetGly: 1.222 ± 0.577
0.611MetHis: 0.611 ± 0.543
0.0MetIle: 0.0 ± 0.0
1.222MetLys: 1.222 ± 0.928
0.611MetLeu: 0.611 ± 0.72
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
0.611MetPro: 0.611 ± 0.591
1.834MetGln: 1.834 ± 1.261
0.611MetArg: 0.611 ± 0.591
1.834MetSer: 1.834 ± 0.941
0.611MetThr: 0.611 ± 0.543
0.0MetVal: 0.0 ± 0.0
1.222MetTrp: 1.222 ± 0.811
2.445MetTyr: 2.445 ± 1.628
0.0MetXaa: 0.0 ± 0.0
Asn
6.112AsnAla: 6.112 ± 1.487
1.222AsnCys: 1.222 ± 0.577
3.056AsnAsp: 3.056 ± 1.006
1.222AsnGlu: 1.222 ± 0.681
0.611AsnPhe: 0.611 ± 0.555
1.834AsnGly: 1.834 ± 1.022
2.445AsnHis: 2.445 ± 1.678
3.667AsnIle: 3.667 ± 1.475
0.611AsnLys: 0.611 ± 0.459
5.501AsnLeu: 5.501 ± 2.076
1.834AsnMet: 1.834 ± 1.061
3.056AsnAsn: 3.056 ± 1.357
2.445AsnPro: 2.445 ± 0.802
1.222AsnGln: 1.222 ± 0.577
1.834AsnArg: 1.834 ± 0.71
4.279AsnSer: 4.279 ± 1.555
6.112AsnThr: 6.112 ± 1.615
7.335AsnVal: 7.335 ± 2.659
0.0AsnTrp: 0.0 ± 0.0
3.056AsnTyr: 3.056 ± 1.164
0.0AsnXaa: 0.0 ± 0.0
Pro
3.667ProAla: 3.667 ± 1.365
2.445ProCys: 2.445 ± 0.923
3.667ProAsp: 3.667 ± 2.197
2.445ProGlu: 2.445 ± 1.247
1.222ProPhe: 1.222 ± 0.623
3.667ProGly: 3.667 ± 0.92
3.056ProHis: 3.056 ± 1.366
4.89ProIle: 4.89 ± 1.422
1.834ProLys: 1.834 ± 0.743
2.445ProLeu: 2.445 ± 0.83
1.222ProMet: 1.222 ± 0.928
3.056ProAsn: 3.056 ± 1.112
3.056ProPro: 3.056 ± 1.604
3.056ProGln: 3.056 ± 1.113
6.112ProArg: 6.112 ± 1.864
1.834ProSer: 1.834 ± 1.099
4.279ProThr: 4.279 ± 2.128
4.279ProVal: 4.279 ± 1.169
1.222ProTrp: 1.222 ± 0.577
2.445ProTyr: 2.445 ± 1.191
0.0ProXaa: 0.0 ± 0.0
Gln
3.667GlnAla: 3.667 ± 1.483
1.834GlnCys: 1.834 ± 1.306
3.667GlnAsp: 3.667 ± 1.315
1.834GlnGlu: 1.834 ± 0.645
3.056GlnPhe: 3.056 ± 0.887
2.445GlnGly: 2.445 ± 1.153
1.834GlnHis: 1.834 ± 1.127
1.222GlnIle: 1.222 ± 0.729
3.056GlnLys: 3.056 ± 1.395
2.445GlnLeu: 2.445 ± 0.914
0.0GlnMet: 0.0 ± 0.0
2.445GlnAsn: 2.445 ± 1.464
3.056GlnPro: 3.056 ± 2.278
0.611GlnGln: 0.611 ± 0.459
2.445GlnArg: 2.445 ± 1.068
4.279GlnSer: 4.279 ± 1.314
1.834GlnThr: 1.834 ± 1.044
4.89GlnVal: 4.89 ± 1.496
0.0GlnTrp: 0.0 ± 0.0
0.611GlnTyr: 0.611 ± 0.555
0.0GlnXaa: 0.0 ± 0.0
Arg
2.445ArgAla: 2.445 ± 1.34
1.834ArgCys: 1.834 ± 2.161
5.501ArgAsp: 5.501 ± 1.609
3.056ArgGlu: 3.056 ± 2.145
6.112ArgPhe: 6.112 ± 2.3
3.056ArgGly: 3.056 ± 1.082
2.445ArgHis: 2.445 ± 0.925
3.667ArgIle: 3.667 ± 1.182
2.445ArgLys: 2.445 ± 1.306
3.667ArgLeu: 3.667 ± 1.292
2.445ArgMet: 2.445 ± 1.203
3.056ArgAsn: 3.056 ± 0.961
6.112ArgPro: 6.112 ± 1.255
1.222ArgGln: 1.222 ± 0.764
11.002ArgArg: 11.002 ± 3.609
4.89ArgSer: 4.89 ± 1.726
3.667ArgThr: 3.667 ± 1.185
3.667ArgVal: 3.667 ± 1.663
0.611ArgTrp: 0.611 ± 0.459
3.056ArgTyr: 3.056 ± 1.438
0.0ArgXaa: 0.0 ± 0.0
Ser
5.501SerAla: 5.501 ± 2.435
0.0SerCys: 0.0 ± 0.0
3.667SerAsp: 3.667 ± 1.192
4.89SerGlu: 4.89 ± 2.422
2.445SerPhe: 2.445 ± 1.07
1.834SerGly: 1.834 ± 1.317
1.222SerHis: 1.222 ± 0.884
2.445SerIle: 2.445 ± 0.956
7.335SerLys: 7.335 ± 1.252
1.834SerLeu: 1.834 ± 1.124
0.611SerMet: 0.611 ± 0.832
3.667SerAsn: 3.667 ± 1.132
7.335SerPro: 7.335 ± 1.637
4.279SerGln: 4.279 ± 1.2
6.112SerArg: 6.112 ± 1.498
12.225SerSer: 12.225 ± 3.495
6.112SerThr: 6.112 ± 1.392
4.279SerVal: 4.279 ± 1.795
0.611SerTrp: 0.611 ± 0.543
3.667SerTyr: 3.667 ± 2.185
0.0SerXaa: 0.0 ± 0.0
Thr
3.056ThrAla: 3.056 ± 0.872
0.611ThrCys: 0.611 ± 0.653
0.611ThrAsp: 0.611 ± 0.832
2.445ThrGlu: 2.445 ± 1.105
1.222ThrPhe: 1.222 ± 0.913
6.112ThrGly: 6.112 ± 1.694
3.056ThrHis: 3.056 ± 1.397
3.056ThrIle: 3.056 ± 1.272
0.611ThrLys: 0.611 ± 0.459
3.056ThrLeu: 3.056 ± 1.202
1.222ThrMet: 1.222 ± 0.897
4.89ThrAsn: 4.89 ± 1.391
4.279ThrPro: 4.279 ± 1.386
1.834ThrGln: 1.834 ± 0.917
4.279ThrArg: 4.279 ± 1.324
4.89ThrSer: 4.89 ± 1.057
1.222ThrThr: 1.222 ± 0.727
6.112ThrVal: 6.112 ± 2.274
3.056ThrTrp: 3.056 ± 2.368
3.056ThrTyr: 3.056 ± 0.83
0.0ThrXaa: 0.0 ± 0.0
Val
1.834ValAla: 1.834 ± 0.915
0.0ValCys: 0.0 ± 0.0
4.89ValAsp: 4.89 ± 1.654
1.834ValGlu: 1.834 ± 0.82
4.279ValPhe: 4.279 ± 1.404
1.834ValGly: 1.834 ± 0.956
1.834ValHis: 1.834 ± 0.81
7.946ValIle: 7.946 ± 1.527
4.89ValLys: 4.89 ± 1.923
4.279ValLeu: 4.279 ± 1.498
1.222ValMet: 1.222 ± 0.681
3.056ValAsn: 3.056 ± 1.342
3.667ValPro: 3.667 ± 0.845
4.279ValGln: 4.279 ± 1.559
3.667ValArg: 3.667 ± 1.926
4.279ValSer: 4.279 ± 1.349
4.279ValThr: 4.279 ± 1.847
2.445ValVal: 2.445 ± 1.256
0.611ValTrp: 0.611 ± 0.591
5.501ValTyr: 5.501 ± 2.389
0.0ValXaa: 0.0 ± 0.0
Trp
1.834TrpAla: 1.834 ± 0.889
0.0TrpCys: 0.0 ± 0.0
0.611TrpAsp: 0.611 ± 0.72
0.0TrpGlu: 0.0 ± 0.0
0.0TrpPhe: 0.0 ± 0.0
0.611TrpGly: 0.611 ± 0.459
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
1.222TrpLys: 1.222 ± 0.926
1.222TrpLeu: 1.222 ± 0.764
0.611TrpMet: 0.611 ± 0.555
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.611TrpGln: 0.611 ± 0.459
1.834TrpArg: 1.834 ± 0.917
0.611TrpSer: 0.611 ± 0.543
1.834TrpThr: 1.834 ± 1.325
0.611TrpVal: 0.611 ± 0.459
0.0TrpTrp: 0.0 ± 0.0
1.222TrpTyr: 1.222 ± 0.916
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.445TyrAla: 2.445 ± 1.056
0.611TyrCys: 0.611 ± 0.72
3.667TyrAsp: 3.667 ± 1.628
1.222TyrGlu: 1.222 ± 0.681
3.667TyrPhe: 3.667 ± 0.656
3.056TyrGly: 3.056 ± 1.012
0.0TyrHis: 0.0 ± 0.0
1.222TyrIle: 1.222 ± 1.182
1.834TyrLys: 1.834 ± 1.066
4.279TyrLeu: 4.279 ± 1.501
2.445TyrMet: 2.445 ± 1.147
3.056TyrAsn: 3.056 ± 0.756
3.056TyrPro: 3.056 ± 1.686
1.222TyrGln: 1.222 ± 0.794
3.667TyrArg: 3.667 ± 1.707
3.056TyrSer: 3.056 ± 0.814
1.222TyrThr: 1.222 ± 0.87
3.667TyrVal: 3.667 ± 0.986
0.0TyrTrp: 0.0 ± 0.0
1.834TyrTyr: 1.834 ± 0.878
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (1637 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski