Amino acid dipepetide frequency for Leucobacter massiliensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.984AlaAla: 22.984 ± 0.333	0.795AlaCys: 0.795 ± 0.034	7.291AlaAsp: 7.291 ± 0.108	11.321AlaGlu: 11.321 ± 0.184	3.856AlaPhe: 3.856 ± 0.069	14.002AlaGly: 14.002 ± 0.174	2.505AlaHis: 2.505 ± 0.07	5.573AlaIle: 5.573 ± 0.089	2.603AlaLys: 2.603 ± 0.066	14.886AlaLeu: 14.886 ± 0.198	2.55AlaMet: 2.55 ± 0.053	2.159AlaAsn: 2.159 ± 0.048	7.197AlaPro: 7.197 ± 0.12	4.278AlaGln: 4.278 ± 0.083	10.11AlaArg: 10.11 ± 0.154	7.298AlaSer: 7.298 ± 0.118	6.24AlaThr: 6.24 ± 0.089	11.212AlaVal: 11.212 ± 0.136	1.73AlaTrp: 1.73 ± 0.054	2.311AlaTyr: 2.311 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.766CysAla: 0.766 ± 0.03	0.06CysCys: 0.06 ± 0.009	0.326CysAsp: 0.326 ± 0.02	0.364CysGlu: 0.364 ± 0.021	0.173CysPhe: 0.173 ± 0.014	0.638CysGly: 0.638 ± 0.028	0.108CysHis: 0.108 ± 0.011	0.183CysIle: 0.183 ± 0.016	0.06CysLys: 0.06 ± 0.009	0.445CysLeu: 0.445 ± 0.022	0.076CysMet: 0.076 ± 0.01	0.11CysAsn: 0.11 ± 0.011	0.271CysPro: 0.271 ± 0.019	0.109CysGln: 0.109 ± 0.01	0.376CysArg: 0.376 ± 0.02	0.348CysSer: 0.348 ± 0.022	0.371CysThr: 0.371 ± 0.021	0.428CysVal: 0.428 ± 0.021	0.078CysTrp: 0.078 ± 0.009	0.111CysTyr: 0.111 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.132AspAla: 8.132 ± 0.117	0.242AspCys: 0.242 ± 0.018	3.006AspAsp: 3.006 ± 0.07	4.099AspGlu: 4.099 ± 0.083	1.679AspPhe: 1.679 ± 0.042	5.64AspGly: 5.64 ± 0.103	1.056AspHis: 1.056 ± 0.035	1.81AspIle: 1.81 ± 0.054	0.754AspLys: 0.754 ± 0.038	4.701AspLeu: 4.701 ± 0.081	0.646AspMet: 0.646 ± 0.024	0.708AspAsn: 0.708 ± 0.031	4.677AspPro: 4.677 ± 0.084	1.238AspGln: 1.238 ± 0.039	4.508AspArg: 4.508 ± 0.082	2.694AspSer: 2.694 ± 0.299	2.727AspThr: 2.727 ± 0.066	4.052AspVal: 4.052 ± 0.076	0.821AspTrp: 0.821 ± 0.032	1.209AspTyr: 1.209 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	9.017GluAla: 9.017 ± 0.149	0.28GluCys: 0.28 ± 0.018	2.978GluAsp: 2.978 ± 0.068	4.095GluGlu: 4.095 ± 0.092	1.91GluPhe: 1.91 ± 0.042	4.835GluGly: 4.835 ± 0.074	1.71GluHis: 1.71 ± 0.048	2.784GluIle: 2.784 ± 0.071	1.234GluLys: 1.234 ± 0.041	8.639GluLeu: 8.639 ± 0.125	1.044GluMet: 1.044 ± 0.034	1.225GluAsn: 1.225 ± 0.04	3.622GluPro: 3.622 ± 0.079	2.892GluGln: 2.892 ± 0.065	6.982GluArg: 6.982 ± 0.147	2.95GluSer: 2.95 ± 0.071	3.251GluThr: 3.251 ± 0.068	5.108GluVal: 5.108 ± 0.077	0.913GluTrp: 0.913 ± 0.034	1.154GluTyr: 1.154 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	4.63PheAla: 4.63 ± 0.08	0.189PheCys: 0.189 ± 0.016	2.104PheAsp: 2.104 ± 0.054	1.955PheGlu: 1.955 ± 0.053	1.143PhePhe: 1.143 ± 0.055	3.394PheGly: 3.394 ± 0.07	0.508PheHis: 0.508 ± 0.027	1.13PheIle: 1.13 ± 0.042	0.44PheLys: 0.44 ± 0.024	2.662PheLeu: 2.662 ± 0.053	0.46PheMet: 0.46 ± 0.024	0.559PheAsn: 0.559 ± 0.025	1.399PhePro: 1.399 ± 0.034	0.753PheGln: 0.753 ± 0.028	1.749PheArg: 1.749 ± 0.041	1.811PheSer: 1.811 ± 0.052	2.166PheThr: 2.166 ± 0.063	2.643PheVal: 2.643 ± 0.056	0.441PheTrp: 0.441 ± 0.023	0.562PheTyr: 0.562 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	12.609GlyAla: 12.609 ± 0.166	0.587GlyCys: 0.587 ± 0.026	4.866GlyAsp: 4.866 ± 0.09	6.409GlyGlu: 6.409 ± 0.095	3.284GlyPhe: 3.284 ± 0.057	8.773GlyGly: 8.773 ± 0.141	1.677GlyHis: 1.677 ± 0.043	4.707GlyIle: 4.707 ± 0.087	2.145GlyLys: 2.145 ± 0.057	9.175GlyLeu: 9.175 ± 0.131	1.887GlyMet: 1.887 ± 0.046	1.627GlyAsn: 1.627 ± 0.051	4.277GlyPro: 4.277 ± 0.074	2.39GlyGln: 2.39 ± 0.05	6.948GlyArg: 6.948 ± 0.11	6.11GlySer: 6.11 ± 0.111	5.763GlyThr: 5.763 ± 0.266	8.124GlyVal: 8.124 ± 0.103	1.503GlyTrp: 1.503 ± 0.04	2.131GlyTyr: 2.131 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.466HisAla: 2.466 ± 0.057	0.132HisCys: 0.132 ± 0.013	1.106HisAsp: 1.106 ± 0.037	1.312HisGlu: 1.312 ± 0.041	0.573HisPhe: 0.573 ± 0.023	1.946HisGly: 1.946 ± 0.048	0.519HisHis: 0.519 ± 0.026	0.64HisIle: 0.64 ± 0.029	0.276HisLys: 0.276 ± 0.018	1.926HisLeu: 1.926 ± 0.047	0.275HisMet: 0.275 ± 0.016	0.29HisAsn: 0.29 ± 0.017	1.56HisPro: 1.56 ± 0.044	0.518HisGln: 0.518 ± 0.024	1.695HisArg: 1.695 ± 0.05	0.892HisSer: 0.892 ± 0.036	0.99HisThr: 0.99 ± 0.033	1.342HisVal: 1.342 ± 0.042	0.289HisTrp: 0.289 ± 0.017	0.42HisTyr: 0.42 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.96IleAla: 6.96 ± 0.105	0.287IleCys: 0.287 ± 0.017	2.954IleAsp: 2.954 ± 0.058	3.029IleGlu: 3.029 ± 0.065	1.123IlePhe: 1.123 ± 0.047	4.322IleGly: 4.322 ± 0.08	0.632IleHis: 0.632 ± 0.028	1.543IleIle: 1.543 ± 0.052	0.682IleLys: 0.682 ± 0.032	3.527IleLeu: 3.527 ± 0.073	0.622IleMet: 0.622 ± 0.026	0.815IleAsn: 0.815 ± 0.03	2.444IlePro: 2.444 ± 0.064	0.874IleGln: 0.874 ± 0.031	2.712IleArg: 2.712 ± 0.053	2.154IleSer: 2.154 ± 0.052	2.631IleThr: 2.631 ± 0.069	4.074IleVal: 4.074 ± 0.071	0.455IleTrp: 0.455 ± 0.023	0.679IleTyr: 0.679 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	1.906LysAla: 1.906 ± 0.057	0.068LysCys: 0.068 ± 0.009	0.953LysAsp: 0.953 ± 0.04	0.853LysGlu: 0.853 ± 0.036	0.493LysPhe: 0.493 ± 0.027	1.337LysGly: 1.337 ± 0.052	0.421LysHis: 0.421 ± 0.024	0.891LysIle: 0.891 ± 0.038	0.725LysLys: 0.725 ± 0.037	1.878LysLeu: 1.878 ± 0.049	0.361LysMet: 0.361 ± 0.022	0.514LysAsn: 0.514 ± 0.025	1.15LysPro: 1.15 ± 0.04	0.721LysGln: 0.721 ± 0.031	1.639LysArg: 1.639 ± 0.042	1.044LysSer: 1.044 ± 0.039	1.153LysThr: 1.153 ± 0.043	1.329LysVal: 1.329 ± 0.054	0.248LysTrp: 0.248 ± 0.018	0.408LysTyr: 0.408 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	15.84LeuAla: 15.84 ± 0.2	0.567LeuCys: 0.567 ± 0.024	6.388LeuAsp: 6.388 ± 0.099	5.255LeuGlu: 5.255 ± 0.097	2.853LeuPhe: 2.853 ± 0.066	10.247LeuGly: 10.247 ± 0.135	1.769LeuHis: 1.769 ± 0.043	4.403LeuIle: 4.403 ± 0.08	1.579LeuLys: 1.579 ± 0.047	11.209LeuLeu: 11.209 ± 0.209	1.588LeuMet: 1.588 ± 0.045	1.73LeuAsn: 1.73 ± 0.042	5.764LeuPro: 5.764 ± 0.084	2.481LeuGln: 2.481 ± 0.053	8.552LeuArg: 8.552 ± 0.129	6.067LeuSer: 6.067 ± 0.097	5.774LeuThr: 5.774 ± 0.075	8.657LeuVal: 8.657 ± 0.113	1.189LeuTrp: 1.189 ± 0.043	1.561LeuTyr: 1.561 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	1.884MetAla: 1.884 ± 0.045	0.096MetCys: 0.096 ± 0.011	0.743MetAsp: 0.743 ± 0.028	0.684MetGlu: 0.684 ± 0.029	0.448MetPhe: 0.448 ± 0.026	1.32MetGly: 1.32 ± 0.04	0.349MetHis: 0.349 ± 0.024	0.863MetIle: 0.863 ± 0.033	0.346MetLys: 0.346 ± 0.022	1.958MetLeu: 1.958 ± 0.052	0.285MetMet: 0.285 ± 0.017	0.483MetAsn: 0.483 ± 0.025	1.032MetPro: 1.032 ± 0.034	0.549MetGln: 0.549 ± 0.024	1.499MetArg: 1.499 ± 0.044	1.496MetSer: 1.496 ± 0.042	1.325MetThr: 1.325 ± 0.036	1.202MetVal: 1.202 ± 0.031	0.17MetTrp: 0.17 ± 0.016	0.278MetTyr: 0.278 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.358AsnAla: 2.358 ± 0.051	0.111AsnCys: 0.111 ± 0.012	0.937AsnAsp: 0.937 ± 0.037	1.011AsnGlu: 1.011 ± 0.037	0.565AsnPhe: 0.565 ± 0.027	1.782AsnGly: 1.782 ± 0.058	0.327AsnHis: 0.327 ± 0.02	0.758AsnIle: 0.758 ± 0.031	0.317AsnLys: 0.317 ± 0.021	1.659AsnLeu: 1.659 ± 0.039	0.322AsnMet: 0.322 ± 0.021	0.404AsnAsn: 0.404 ± 0.023	1.416AsnPro: 1.416 ± 0.043	0.509AsnGln: 0.509 ± 0.024	1.271AsnArg: 1.271 ± 0.039	0.895AsnSer: 0.895 ± 0.037	1.111AsnThr: 1.111 ± 0.046	1.546AsnVal: 1.546 ± 0.046	0.307AsnTrp: 0.307 ± 0.021	0.441AsnTyr: 0.441 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	8.195ProAla: 8.195 ± 0.141	0.219ProCys: 0.219 ± 0.016	3.126ProAsp: 3.126 ± 0.066	5.247ProGlu: 5.247 ± 0.088	1.64ProPhe: 1.64 ± 0.045	6.393ProGly: 6.393 ± 0.112	1.109ProHis: 1.109 ± 0.04	1.977ProIle: 1.977 ± 0.05	0.995ProLys: 0.995 ± 0.039	5.283ProLeu: 5.283 ± 0.082	0.852ProMet: 0.852 ± 0.031	1.002ProAsn: 1.002 ± 0.034	2.522ProPro: 2.522 ± 0.068	1.619ProGln: 1.619 ± 0.046	3.91ProArg: 3.91 ± 0.073	3.111ProSer: 3.111 ± 0.058	2.353ProThr: 2.353 ± 0.054	4.857ProVal: 4.857 ± 0.08	0.778ProTrp: 0.778 ± 0.03	0.981ProTyr: 0.981 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	3.646GlnAla: 3.646 ± 0.069	0.126GlnCys: 0.126 ± 0.011	1.194GlnAsp: 1.194 ± 0.039	1.467GlnGlu: 1.467 ± 0.048	0.786GlnPhe: 0.786 ± 0.033	2.159GlnGly: 2.159 ± 0.051	0.726GlnHis: 0.726 ± 0.027	1.489GlnIle: 1.489 ± 0.04	0.583GlnLys: 0.583 ± 0.027	3.627GlnLeu: 3.627 ± 0.075	0.485GlnMet: 0.485 ± 0.021	0.61GlnAsn: 0.61 ± 0.025	1.6GlnPro: 1.6 ± 0.044	1.414GlnGln: 1.414 ± 0.044	2.902GlnArg: 2.902 ± 0.067	1.429GlnSer: 1.429 ± 0.042	1.328GlnThr: 1.328 ± 0.037	1.943GlnVal: 1.943 ± 0.051	0.421GlnTrp: 0.421 ± 0.022	0.563GlnTyr: 0.563 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	10.272ArgAla: 10.272 ± 0.14	0.375ArgCys: 0.375 ± 0.022	4.263ArgAsp: 4.263 ± 0.075	5.94ArgGlu: 5.94 ± 0.112	2.639ArgPhe: 2.639 ± 0.061	6.561ArgGly: 6.561 ± 0.114	1.583ArgHis: 1.583 ± 0.048	3.977ArgIle: 3.977 ± 0.067	1.414ArgLys: 1.414 ± 0.043	8.177ArgLeu: 8.177 ± 0.126	1.675ArgMet: 1.675 ± 0.046	1.238ArgAsn: 1.238 ± 0.038	4.02ArgPro: 4.02 ± 0.072	2.057ArgGln: 2.057 ± 0.046	7.181ArgArg: 7.181 ± 0.118	4.386ArgSer: 4.386 ± 0.073	4.053ArgThr: 4.053 ± 0.061	6.344ArgVal: 6.344 ± 0.088	1.143ArgTrp: 1.143 ± 0.039	1.638ArgTyr: 1.638 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	7.303SerAla: 7.303 ± 0.114	0.331SerCys: 0.331 ± 0.021	2.909SerAsp: 2.909 ± 0.074	3.498SerGlu: 3.498 ± 0.078	1.91SerPhe: 1.91 ± 0.05	6.911SerGly: 6.911 ± 0.272	0.944SerHis: 0.944 ± 0.037	2.206SerIle: 2.206 ± 0.05	1.002SerLys: 1.002 ± 0.041	5.237SerLeu: 5.237 ± 0.075	1.077SerMet: 1.077 ± 0.033	1.026SerAsn: 1.026 ± 0.036	3.214SerPro: 3.214 ± 0.065	1.329SerGln: 1.329 ± 0.045	4.091SerArg: 4.091 ± 0.072	3.226SerSer: 3.226 ± 0.068	2.921SerThr: 2.921 ± 0.056	4.367SerVal: 4.367 ± 0.071	0.996SerTrp: 0.996 ± 0.041	1.229SerTyr: 1.229 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	7.34ThrAla: 7.34 ± 0.118	0.19ThrCys: 0.19 ± 0.015	2.779ThrAsp: 2.779 ± 0.292	3.16ThrGlu: 3.16 ± 0.066	1.577ThrPhe: 1.577 ± 0.05	5.743ThrGly: 5.743 ± 0.11	1.05ThrHis: 1.05 ± 0.033	2.414ThrIle: 2.414 ± 0.057	0.944ThrLys: 0.944 ± 0.035	5.534ThrLeu: 5.534 ± 0.093	0.896ThrMet: 0.896 ± 0.033	1.051ThrAsn: 1.051 ± 0.047	3.672ThrPro: 3.672 ± 0.07	1.398ThrGln: 1.398 ± 0.044	3.738ThrArg: 3.738 ± 0.057	2.882ThrSer: 2.882 ± 0.058	2.831ThrThr: 2.831 ± 0.066	5.615ThrVal: 5.615 ± 0.104	0.634ThrTrp: 0.634 ± 0.026	0.769ThrTyr: 0.769 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.608ValAla: 10.608 ± 0.113	0.516ValCys: 0.516 ± 0.027	4.612ValAsp: 4.612 ± 0.071	5.047ValGlu: 5.047 ± 0.087	2.861ValPhe: 2.861 ± 0.068	6.195ValGly: 6.195 ± 0.095	1.542ValHis: 1.542 ± 0.04	3.967ValIle: 3.967 ± 0.075	1.438ValLys: 1.438 ± 0.049	9.332ValLeu: 9.332 ± 0.131	1.373ValMet: 1.373 ± 0.039	1.736ValAsn: 1.736 ± 0.05	4.686ValPro: 4.686 ± 0.079	2.334ValGln: 2.334 ± 0.056	6.135ValArg: 6.135 ± 0.078	5.129ValSer: 5.129 ± 0.091	5.374ValThr: 5.374 ± 0.105	7.437ValVal: 7.437 ± 0.118	1.034ValTrp: 1.034 ± 0.039	1.474ValTyr: 1.474 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.565TrpAla: 1.565 ± 0.047	0.102TrpCys: 0.102 ± 0.012	0.724TrpAsp: 0.724 ± 0.028	0.715TrpGlu: 0.715 ± 0.026	0.524TrpPhe: 0.524 ± 0.026	1.057TrpGly: 1.057 ± 0.041	0.311TrpHis: 0.311 ± 0.019	0.645TrpIle: 0.645 ± 0.03	0.257TrpLys: 0.257 ± 0.017	1.569TrpLeu: 1.569 ± 0.051	0.292TrpMet: 0.292 ± 0.019	0.386TrpAsn: 0.386 ± 0.021	0.632TrpPro: 0.632 ± 0.025	0.498TrpGln: 0.498 ± 0.025	1.22TrpArg: 1.22 ± 0.047	0.832TrpSer: 0.832 ± 0.032	0.746TrpThr: 0.746 ± 0.03	1.061TrpVal: 1.061 ± 0.035	0.31TrpTrp: 0.31 ± 0.022	0.269TrpTyr: 0.269 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.421TyrAla: 2.421 ± 0.048	0.128TyrCys: 0.128 ± 0.012	1.139TyrAsp: 1.139 ± 0.04	1.164TyrGlu: 1.164 ± 0.04	0.662TyrPhe: 0.662 ± 0.025	1.736TyrGly: 1.736 ± 0.046	0.32TyrHis: 0.32 ± 0.019	0.556TyrIle: 0.556 ± 0.024	0.297TyrLys: 0.297 ± 0.019	2.049TyrLeu: 2.049 ± 0.053	0.241TyrMet: 0.241 ± 0.015	0.375TyrAsn: 0.375 ± 0.018	1.016TyrPro: 1.016 ± 0.036	0.538TyrGln: 0.538 ± 0.027	1.719TyrArg: 1.719 ± 0.05	0.974TyrSer: 0.974 ± 0.034	1.109TyrThr: 1.109 ± 0.046	1.491TyrVal: 1.491 ± 0.04	0.254TyrTrp: 0.254 ± 0.015	0.391TyrTyr: 0.391 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2663 proteins (899312 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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