Amino acid dipepetide frequency for Acidithiobacillus sulfuriphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.725AlaAla: 16.725 ± 0.199	1.177AlaCys: 1.177 ± 0.04	5.821AlaAsp: 5.821 ± 0.094	6.979AlaGlu: 6.979 ± 0.102	3.856AlaPhe: 3.856 ± 0.076	10.215AlaGly: 10.215 ± 0.13	2.731AlaHis: 2.731 ± 0.059	5.902AlaIle: 5.902 ± 0.089	3.158AlaLys: 3.158 ± 0.065	14.8AlaLeu: 14.8 ± 0.172	3.364AlaMet: 3.364 ± 0.063	2.741AlaAsn: 2.741 ± 0.059	5.433AlaPro: 5.433 ± 0.097	5.576AlaGln: 5.576 ± 0.112	8.185AlaArg: 8.185 ± 0.114	5.181AlaSer: 5.181 ± 0.092	5.014AlaThr: 5.014 ± 0.075	8.777AlaVal: 8.777 ± 0.118	1.902AlaTrp: 1.902 ± 0.058	2.853AlaTyr: 2.853 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.124CysAla: 1.124 ± 0.04	0.125CysCys: 0.125 ± 0.013	0.396CysAsp: 0.396 ± 0.022	0.403CysGlu: 0.403 ± 0.022	0.337CysPhe: 0.337 ± 0.019	0.921CysGly: 0.921 ± 0.039	0.336CysHis: 0.336 ± 0.022	0.428CysIle: 0.428 ± 0.024	0.234CysLys: 0.234 ± 0.019	0.961CysLeu: 0.961 ± 0.038	0.188CysMet: 0.188 ± 0.016	0.264CysAsn: 0.264 ± 0.017	0.655CysPro: 0.655 ± 0.031	0.375CysGln: 0.375 ± 0.019	0.716CysArg: 0.716 ± 0.031	0.513CysSer: 0.513 ± 0.028	0.401CysThr: 0.401 ± 0.019	0.568CysVal: 0.568 ± 0.029	0.123CysTrp: 0.123 ± 0.013	0.246CysTyr: 0.246 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	5.755AspAla: 5.755 ± 0.078	0.525AspCys: 0.525 ± 0.031	2.313AspAsp: 2.313 ± 0.06	2.642AspGlu: 2.642 ± 0.064	2.214AspPhe: 2.214 ± 0.062	4.131AspGly: 4.131 ± 0.081	1.268AspHis: 1.268 ± 0.044	2.525AspIle: 2.525 ± 0.064	1.302AspLys: 1.302 ± 0.045	6.466AspLeu: 6.466 ± 0.103	1.059AspMet: 1.059 ± 0.037	1.156AspAsn: 1.156 ± 0.044	3.161AspPro: 3.161 ± 0.056	1.78AspGln: 1.78 ± 0.045	3.314AspArg: 3.314 ± 0.066	2.037AspSer: 2.037 ± 0.053	2.192AspThr: 2.192 ± 0.047	3.083AspVal: 3.083 ± 0.066	1.037AspTrp: 1.037 ± 0.038	1.604AspTyr: 1.604 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	6.967GluAla: 6.967 ± 0.106	0.392GluCys: 0.392 ± 0.022	2.679GluAsp: 2.679 ± 0.057	3.48GluGlu: 3.48 ± 0.079	1.474GluPhe: 1.474 ± 0.046	4.432GluGly: 4.432 ± 0.074	1.371GluHis: 1.371 ± 0.041	3.367GluIle: 3.367 ± 0.073	2.133GluLys: 2.133 ± 0.052	5.221GluLeu: 5.221 ± 0.078	1.586GluMet: 1.586 ± 0.051	1.572GluAsn: 1.572 ± 0.044	2.026GluPro: 2.026 ± 0.05	2.635GluGln: 2.635 ± 0.062	4.856GluArg: 4.856 ± 0.093	2.624GluSer: 2.624 ± 0.059	2.662GluThr: 2.662 ± 0.059	3.705GluVal: 3.705 ± 0.076	0.725GluTrp: 0.725 ± 0.027	1.15GluTyr: 1.15 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.143PheAla: 4.143 ± 0.072	0.408PheCys: 0.408 ± 0.02	1.766PheAsp: 1.766 ± 0.05	1.306PheGlu: 1.306 ± 0.045	1.614PhePhe: 1.614 ± 0.055	3.18PheGly: 3.18 ± 0.066	1.021PheHis: 1.021 ± 0.032	1.651PheIle: 1.651 ± 0.046	0.72PheLys: 0.72 ± 0.03	4.274PheLeu: 4.274 ± 0.088	0.802PheMet: 0.802 ± 0.032	0.964PheAsn: 0.964 ± 0.041	1.861PhePro: 1.861 ± 0.054	1.302PheGln: 1.302 ± 0.042	2.132PheArg: 2.132 ± 0.052	2.282PheSer: 2.282 ± 0.054	1.853PheThr: 1.853 ± 0.049	2.354PheVal: 2.354 ± 0.059	0.608PheTrp: 0.608 ± 0.027	1.118PheTyr: 1.118 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.737GlyAla: 8.737 ± 0.127	0.878GlyCys: 0.878 ± 0.033	4.132GlyAsp: 4.132 ± 0.079	4.821GlyGlu: 4.821 ± 0.075	3.345GlyPhe: 3.345 ± 0.063	7.111GlyGly: 7.111 ± 0.128	2.203GlyHis: 2.203 ± 0.051	4.778GlyIle: 4.778 ± 0.089	3.243GlyLys: 3.243 ± 0.068	9.064GlyLeu: 9.064 ± 0.112	2.475GlyMet: 2.475 ± 0.061	2.406GlyAsn: 2.406 ± 0.063	3.604GlyPro: 3.604 ± 0.074	3.728GlyGln: 3.728 ± 0.073	5.93GlyArg: 5.93 ± 0.1	4.489GlySer: 4.489 ± 0.085	4.135GlyThr: 4.135 ± 0.078	6.504GlyVal: 6.504 ± 0.091	1.33GlyTrp: 1.33 ± 0.049	2.329GlyTyr: 2.329 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.661HisAla: 2.661 ± 0.053	0.387HisCys: 0.387 ± 0.021	1.19HisAsp: 1.19 ± 0.038	1.113HisGlu: 1.113 ± 0.036	1.162HisPhe: 1.162 ± 0.034	2.435HisGly: 2.435 ± 0.065	0.772HisHis: 0.772 ± 0.032	1.172HisIle: 1.172 ± 0.039	0.53HisLys: 0.53 ± 0.025	3.086HisLeu: 3.086 ± 0.067	0.508HisMet: 0.508 ± 0.027	0.641HisAsn: 0.641 ± 0.031	2.019HisPro: 2.019 ± 0.055	0.961HisGln: 0.961 ± 0.039	1.721HisArg: 1.721 ± 0.051	1.218HisSer: 1.218 ± 0.039	1.027HisThr: 1.027 ± 0.032	1.434HisVal: 1.434 ± 0.041	0.581HisTrp: 0.581 ± 0.03	0.895HisTyr: 0.895 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.158IleAla: 6.158 ± 0.086	0.482IleCys: 0.482 ± 0.024	2.525IleAsp: 2.525 ± 0.052	2.421IleGlu: 2.421 ± 0.068	1.894IlePhe: 1.894 ± 0.052	4.191IleGly: 4.191 ± 0.086	1.473IleHis: 1.473 ± 0.038	2.43IleIle: 2.43 ± 0.064	1.306IleLys: 1.306 ± 0.044	5.731IleLeu: 5.731 ± 0.106	0.943IleMet: 0.943 ± 0.039	1.529IleAsn: 1.529 ± 0.051	3.124IlePro: 3.124 ± 0.062	1.749IleGln: 1.749 ± 0.05	3.198IleArg: 3.198 ± 0.065	2.759IleSer: 2.759 ± 0.061	2.581IleThr: 2.581 ± 0.06	3.187IleVal: 3.187 ± 0.067	0.579IleTrp: 0.579 ± 0.029	1.289IleTyr: 1.289 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	3.48LysAla: 3.48 ± 0.077	0.144LysCys: 0.144 ± 0.013	1.5LysAsp: 1.5 ± 0.048	1.684LysGlu: 1.684 ± 0.05	0.644LysPhe: 0.644 ± 0.026	2.48LysGly: 2.48 ± 0.056	0.523LysHis: 0.523 ± 0.027	1.5LysIle: 1.5 ± 0.045	1.198LysLys: 1.198 ± 0.049	2.454LysLeu: 2.454 ± 0.055	0.699LysMet: 0.699 ± 0.03	0.883LysAsn: 0.883 ± 0.033	1.515LysPro: 1.515 ± 0.045	0.912LysGln: 0.912 ± 0.033	1.956LysArg: 1.956 ± 0.053	1.553LysSer: 1.553 ± 0.046	1.631LysThr: 1.631 ± 0.051	1.999LysVal: 1.999 ± 0.054	0.252LysTrp: 0.252 ± 0.019	0.62LysTyr: 0.62 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	14.871LeuAla: 14.871 ± 0.172	1.035LeuCys: 1.035 ± 0.035	5.991LeuAsp: 5.991 ± 0.087	6.173LeuGlu: 6.173 ± 0.103	3.859LeuPhe: 3.859 ± 0.08	9.763LeuGly: 9.763 ± 0.128	2.897LeuHis: 2.897 ± 0.061	4.542LeuIle: 4.542 ± 0.079	2.743LeuLys: 2.743 ± 0.064	13.392LeuLeu: 13.392 ± 0.214	2.25LeuMet: 2.25 ± 0.054	2.608LeuAsn: 2.608 ± 0.058	7.111LeuPro: 7.111 ± 0.11	5.287LeuGln: 5.287 ± 0.104	9.685LeuArg: 9.685 ± 0.146	6.25LeuSer: 6.25 ± 0.092	4.964LeuThr: 4.964 ± 0.079	7.306LeuVal: 7.306 ± 0.088	1.724LeuTrp: 1.724 ± 0.053	2.53LeuTyr: 2.53 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	3.254MetAla: 3.254 ± 0.067	0.093MetCys: 0.093 ± 0.011	1.545MetAsp: 1.545 ± 0.047	1.604MetGlu: 1.604 ± 0.041	0.486MetPhe: 0.486 ± 0.028	2.181MetGly: 2.181 ± 0.049	0.527MetHis: 0.527 ± 0.023	1.107MetIle: 1.107 ± 0.034	0.838MetLys: 0.838 ± 0.035	2.317MetLeu: 2.317 ± 0.057	0.545MetMet: 0.545 ± 0.029	0.83MetAsn: 0.83 ± 0.031	1.395MetPro: 1.395 ± 0.036	0.97MetGln: 0.97 ± 0.031	1.57MetArg: 1.57 ± 0.041	1.389MetSer: 1.389 ± 0.038	1.392MetThr: 1.392 ± 0.044	1.783MetVal: 1.783 ± 0.051	0.186MetTrp: 0.186 ± 0.014	0.306MetTyr: 0.306 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.996AsnAla: 2.996 ± 0.071	0.24AsnCys: 0.24 ± 0.018	1.296AsnAsp: 1.296 ± 0.043	1.06AsnGlu: 1.06 ± 0.037	0.916AsnPhe: 0.916 ± 0.041	2.377AsnGly: 2.377 ± 0.074	0.599AsnHis: 0.599 ± 0.029	1.47AsnIle: 1.47 ± 0.05	0.644AsnLys: 0.644 ± 0.027	2.983AsnLeu: 2.983 ± 0.071	0.602AsnMet: 0.602 ± 0.029	0.843AsnAsn: 0.843 ± 0.045	2.108AsnPro: 2.108 ± 0.053	1.039AsnGln: 1.039 ± 0.044	1.632AsnArg: 1.632 ± 0.043	1.179AsnSer: 1.179 ± 0.039	1.395AsnThr: 1.395 ± 0.051	1.684AsnVal: 1.684 ± 0.051	0.404AsnTrp: 0.404 ± 0.022	0.758AsnTyr: 0.758 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	6.546ProAla: 6.546 ± 0.097	0.457ProCys: 0.457 ± 0.024	3.145ProAsp: 3.145 ± 0.061	3.785ProGlu: 3.785 ± 0.075	2.049ProPhe: 2.049 ± 0.052	4.923ProGly: 4.923 ± 0.068	1.254ProHis: 1.254 ± 0.039	2.489ProIle: 2.489 ± 0.054	1.386ProLys: 1.386 ± 0.048	6.051ProLeu: 6.051 ± 0.094	1.385ProMet: 1.385 ± 0.043	1.262ProAsn: 1.262 ± 0.043	2.836ProPro: 2.836 ± 0.082	2.389ProGln: 2.389 ± 0.057	3.12ProArg: 3.12 ± 0.059	2.691ProSer: 2.691 ± 0.07	2.3ProThr: 2.3 ± 0.06	4.171ProVal: 4.171 ± 0.079	1.009ProTrp: 1.009 ± 0.038	1.464ProTyr: 1.464 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	5.443GlnAla: 5.443 ± 0.096	0.345GlnCys: 0.345 ± 0.022	1.902GlnAsp: 1.902 ± 0.051	2.613GlnGlu: 2.613 ± 0.07	1.217GlnPhe: 1.217 ± 0.037	3.904GlnGly: 3.904 ± 0.076	1.035GlnHis: 1.035 ± 0.037	2.14GlnIle: 2.14 ± 0.054	1.286GlnLys: 1.286 ± 0.041	3.7GlnLeu: 3.7 ± 0.073	1.159GlnMet: 1.159 ± 0.037	0.999GlnAsn: 0.999 ± 0.04	2.086GlnPro: 2.086 ± 0.058	2.109GlnGln: 2.109 ± 0.07	3.814GlnArg: 3.814 ± 0.074	2.281GlnSer: 2.281 ± 0.061	1.866GlnThr: 1.866 ± 0.052	3.337GlnVal: 3.337 ± 0.07	0.798GlnTrp: 0.798 ± 0.038	0.921GlnTyr: 0.921 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	7.248ArgAla: 7.248 ± 0.108	0.658ArgCys: 0.658 ± 0.029	3.549ArgAsp: 3.549 ± 0.073	4.683ArgGlu: 4.683 ± 0.087	2.804ArgPhe: 2.804 ± 0.061	4.651ArgGly: 4.651 ± 0.075	2.283ArgHis: 2.283 ± 0.051	3.968ArgIle: 3.968 ± 0.067	1.967ArgLys: 1.967 ± 0.05	9.088ArgLeu: 9.088 ± 0.139	1.893ArgMet: 1.893 ± 0.047	1.864ArgAsn: 1.864 ± 0.052	3.593ArgPro: 3.593 ± 0.066	3.468ArgGln: 3.468 ± 0.07	5.913ArgArg: 5.913 ± 0.1	3.591ArgSer: 3.591 ± 0.066	2.458ArgThr: 2.458 ± 0.054	4.699ArgVal: 4.699 ± 0.088	1.308ArgTrp: 1.308 ± 0.044	2.192ArgTyr: 2.192 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	6.131SerAla: 6.131 ± 0.097	0.51SerCys: 0.51 ± 0.028	2.129SerAsp: 2.129 ± 0.052	2.161SerGlu: 2.161 ± 0.055	1.837SerPhe: 1.837 ± 0.05	5.263SerGly: 5.263 ± 0.092	1.218SerHis: 1.218 ± 0.038	2.483SerIle: 2.483 ± 0.057	1.319SerLys: 1.319 ± 0.044	5.751SerLeu: 5.751 ± 0.093	1.366SerMet: 1.366 ± 0.039	1.403SerAsn: 1.403 ± 0.052	3.042SerPro: 3.042 ± 0.063	1.762SerGln: 1.762 ± 0.05	3.345SerArg: 3.345 ± 0.071	2.82SerSer: 2.82 ± 0.069	2.618SerThr: 2.618 ± 0.063	3.262SerVal: 3.262 ± 0.062	0.783SerTrp: 0.783 ± 0.03	1.361SerTyr: 1.361 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	5.599ThrAla: 5.599 ± 0.089	0.423ThrCys: 0.423 ± 0.022	2.089ThrAsp: 2.089 ± 0.055	2.041ThrGlu: 2.041 ± 0.062	1.591ThrPhe: 1.591 ± 0.047	4.269ThrGly: 4.269 ± 0.079	1.132ThrHis: 1.132 ± 0.035	2.19ThrIle: 2.19 ± 0.055	0.863ThrLys: 0.863 ± 0.035	6.208ThrLeu: 6.208 ± 0.092	1.012ThrMet: 1.012 ± 0.042	1.055ThrAsn: 1.055 ± 0.044	3.281ThrPro: 3.281 ± 0.063	1.81ThrGln: 1.81 ± 0.053	2.813ThrArg: 2.813 ± 0.06	2.109ThrSer: 2.109 ± 0.059	2.116ThrThr: 2.116 ± 0.058	3.725ThrVal: 3.725 ± 0.083	0.653ThrTrp: 0.653 ± 0.029	1.084ThrTyr: 1.084 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	8.301ValAla: 8.301 ± 0.111	0.575ValCys: 0.575 ± 0.027	3.78ValAsp: 3.78 ± 0.063	4.131ValGlu: 4.131 ± 0.07	2.507ValPhe: 2.507 ± 0.056	5.273ValGly: 5.273 ± 0.09	1.71ValHis: 1.71 ± 0.042	3.616ValIle: 3.616 ± 0.07	1.847ValLys: 1.847 ± 0.054	8.294ValLeu: 8.294 ± 0.116	1.654ValMet: 1.654 ± 0.049	2.042ValAsn: 2.042 ± 0.058	3.499ValPro: 3.499 ± 0.069	2.845ValGln: 2.845 ± 0.064	4.454ValArg: 4.454 ± 0.084	3.552ValSer: 3.552 ± 0.073	3.621ValThr: 3.621 ± 0.067	5.179ValVal: 5.179 ± 0.086	0.947ValTrp: 0.947 ± 0.032	1.593ValTyr: 1.593 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	1.486TrpAla: 1.486 ± 0.048	0.158TrpCys: 0.158 ± 0.015	0.619TrpAsp: 0.619 ± 0.03	0.842TrpGlu: 0.842 ± 0.034	0.507TrpPhe: 0.507 ± 0.029	1.14TrpGly: 1.14 ± 0.034	0.402TrpHis: 0.402 ± 0.021	0.759TrpIle: 0.759 ± 0.033	0.392TrpLys: 0.392 ± 0.023	2.095TrpLeu: 2.095 ± 0.064	0.379TrpMet: 0.379 ± 0.026	0.4TrpAsn: 0.4 ± 0.022	0.864TrpPro: 0.864 ± 0.034	1.001TrpGln: 1.001 ± 0.042	1.416TrpArg: 1.416 ± 0.049	0.778TrpSer: 0.778 ± 0.041	0.626TrpThr: 0.626 ± 0.031	1.1TrpVal: 1.1 ± 0.045	0.318TrpTrp: 0.318 ± 0.024	0.418TrpTyr: 0.418 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.764TyrAla: 2.764 ± 0.055	0.302TyrCys: 0.302 ± 0.02	1.198TyrAsp: 1.198 ± 0.035	1.115TyrGlu: 1.115 ± 0.038	1.043TyrPhe: 1.043 ± 0.036	2.404TyrGly: 2.404 ± 0.065	0.759TyrHis: 0.759 ± 0.029	1.032TyrIle: 1.032 ± 0.038	0.518TyrLys: 0.518 ± 0.028	3.046TyrLeu: 3.046 ± 0.064	0.45TyrMet: 0.45 ± 0.025	0.765TyrAsn: 0.765 ± 0.038	1.501TyrPro: 1.501 ± 0.046	1.256TyrGln: 1.256 ± 0.039	2.108TyrArg: 2.108 ± 0.052	1.269TyrSer: 1.269 ± 0.048	1.21TyrThr: 1.21 ± 0.044	1.562TyrVal: 1.562 ± 0.047	0.434TyrTrp: 0.434 ± 0.023	0.826TyrTyr: 0.826 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2736 proteins (820862 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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