Amino acid dipepetide frequency for Melghiribacillus thermohalophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.153AlaAla: 5.153 ± 0.1	0.524AlaCys: 0.524 ± 0.028	3.273AlaAsp: 3.273 ± 0.073	4.567AlaGlu: 4.567 ± 0.089	3.103AlaPhe: 3.103 ± 0.066	5.275AlaGly: 5.275 ± 0.085	1.359AlaHis: 1.359 ± 0.047	5.383AlaIle: 5.383 ± 0.09	3.919AlaLys: 3.919 ± 0.073	6.788AlaLeu: 6.788 ± 0.099	1.907AlaMet: 1.907 ± 0.056	2.286AlaAsn: 2.286 ± 0.053	1.881AlaPro: 1.881 ± 0.055	2.272AlaGln: 2.272 ± 0.109	3.396AlaArg: 3.396 ± 0.06	3.656AlaSer: 3.656 ± 0.066	2.828AlaThr: 2.828 ± 0.064	5.222AlaVal: 5.222 ± 0.082	0.513AlaTrp: 0.513 ± 0.027	2.179AlaTyr: 2.179 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.348CysAla: 0.348 ± 0.023	0.092CysCys: 0.092 ± 0.013	0.372CysAsp: 0.372 ± 0.026	0.414CysGlu: 0.414 ± 0.026	0.286CysPhe: 0.286 ± 0.021	0.589CysGly: 0.589 ± 0.027	0.181CysHis: 0.181 ± 0.014	0.39CysIle: 0.39 ± 0.019	0.321CysLys: 0.321 ± 0.019	0.573CysLeu: 0.573 ± 0.028	0.178CysMet: 0.178 ± 0.016	0.242CysAsn: 0.242 ± 0.018	0.352CysPro: 0.352 ± 0.021	0.247CysGln: 0.247 ± 0.019	0.331CysArg: 0.331 ± 0.019	0.426CysSer: 0.426 ± 0.026	0.345CysThr: 0.345 ± 0.024	0.368CysVal: 0.368 ± 0.027	0.059CysTrp: 0.059 ± 0.009	0.265CysTyr: 0.265 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.127AspAla: 3.127 ± 0.072	0.354AspCys: 0.354 ± 0.02	2.945AspAsp: 2.945 ± 0.059	4.999AspGlu: 4.999 ± 0.093	2.39AspPhe: 2.39 ± 0.054	3.519AspGly: 3.519 ± 0.088	1.689AspHis: 1.689 ± 0.053	4.183AspIle: 4.183 ± 0.074	2.496AspLys: 2.496 ± 0.049	5.306AspLeu: 5.306 ± 0.073	1.486AspMet: 1.486 ± 0.04	1.47AspAsn: 1.47 ± 0.04	2.465AspPro: 2.465 ± 0.056	2.992AspGln: 2.992 ± 0.064	2.75AspArg: 2.75 ± 0.054	2.441AspSer: 2.441 ± 0.053	2.364AspThr: 2.364 ± 0.048	4.006AspVal: 4.006 ± 0.07	0.662AspTrp: 0.662 ± 0.03	2.218AspTyr: 2.218 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	5.116GluAla: 5.116 ± 0.089	0.389GluCys: 0.389 ± 0.029	4.152GluAsp: 4.152 ± 0.083	7.638GluGlu: 7.638 ± 0.122	2.433GluPhe: 2.433 ± 0.058	4.603GluGly: 4.603 ± 0.09	1.983GluHis: 1.983 ± 0.051	5.613GluIle: 5.613 ± 0.079	7.045GluLys: 7.045 ± 0.116	6.868GluLeu: 6.868 ± 0.098	2.518GluMet: 2.518 ± 0.057	3.81GluAsn: 3.81 ± 0.075	2.274GluPro: 2.274 ± 0.049	3.876GluGln: 3.876 ± 0.074	3.846GluArg: 3.846 ± 0.069	3.438GluSer: 3.438 ± 0.07	4.026GluThr: 4.026 ± 0.078	5.145GluVal: 5.145 ± 0.078	0.998GluTrp: 0.998 ± 0.036	2.428GluTyr: 2.428 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	2.799PheAla: 2.799 ± 0.061	0.308PheCys: 0.308 ± 0.023	2.387PheAsp: 2.387 ± 0.058	2.892PheGlu: 2.892 ± 0.054	2.594PhePhe: 2.594 ± 0.073	3.255PheGly: 3.255 ± 0.071	1.265PheHis: 1.265 ± 0.04	3.677PheIle: 3.677 ± 0.077	2.248PheLys: 2.248 ± 0.051	4.676PheLeu: 4.676 ± 0.112	1.326PheMet: 1.326 ± 0.047	1.564PheAsn: 1.564 ± 0.043	1.719PhePro: 1.719 ± 0.052	1.948PheGln: 1.948 ± 0.047	1.915PheArg: 1.915 ± 0.05	3.139PheSer: 3.139 ± 0.068	2.359PheThr: 2.359 ± 0.054	3.151PheVal: 3.151 ± 0.069	0.503PheTrp: 0.503 ± 0.027	1.826PheTyr: 1.826 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	4.65GlyAla: 4.65 ± 0.101	0.585GlyCys: 0.585 ± 0.029	3.441GlyAsp: 3.441 ± 0.062	4.767GlyGlu: 4.767 ± 0.082	3.367GlyPhe: 3.367 ± 0.072	4.629GlyGly: 4.629 ± 0.103	1.478GlyHis: 1.478 ± 0.054	5.77GlyIle: 5.77 ± 0.091	5.191GlyLys: 5.191 ± 0.082	6.464GlyLeu: 6.464 ± 0.082	2.228GlyMet: 2.228 ± 0.052	2.668GlyAsn: 2.668 ± 0.069	1.917GlyPro: 1.917 ± 0.063	2.224GlyGln: 2.224 ± 0.053	2.826GlyArg: 2.826 ± 0.059	3.768GlySer: 3.768 ± 0.075	3.932GlyThr: 3.932 ± 0.087	4.87GlyVal: 4.87 ± 0.097	0.769GlyTrp: 0.769 ± 0.03	3.01GlyTyr: 3.01 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	1.529HisAla: 1.529 ± 0.041	0.179HisCys: 0.179 ± 0.016	1.274HisAsp: 1.274 ± 0.04	1.67HisGlu: 1.67 ± 0.047	1.196HisPhe: 1.196 ± 0.041	1.483HisGly: 1.483 ± 0.041	0.926HisHis: 0.926 ± 0.033	1.849HisIle: 1.849 ± 0.051	1.138HisLys: 1.138 ± 0.038	2.578HisLeu: 2.578 ± 0.056	0.652HisMet: 0.652 ± 0.028	0.732HisAsn: 0.732 ± 0.031	1.495HisPro: 1.495 ± 0.044	1.162HisGln: 1.162 ± 0.038	1.082HisArg: 1.082 ± 0.039	1.353HisSer: 1.353 ± 0.045	1.188HisThr: 1.188 ± 0.036	1.702HisVal: 1.702 ± 0.054	0.208HisTrp: 0.208 ± 0.016	1.013HisTyr: 1.013 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.459IleAla: 5.459 ± 0.102	0.557IleCys: 0.557 ± 0.031	4.38IleAsp: 4.38 ± 0.074	5.633IleGlu: 5.633 ± 0.084	3.381IlePhe: 3.381 ± 0.084	5.608IleGly: 5.608 ± 0.096	2.114IleHis: 2.114 ± 0.059	5.365IleIle: 5.365 ± 0.102	4.143IleLys: 4.143 ± 0.072	7.232IleLeu: 7.232 ± 0.117	1.807IleMet: 1.807 ± 0.054	2.69IleAsn: 2.69 ± 0.061	3.637IlePro: 3.637 ± 0.072	3.667IleGln: 3.667 ± 0.071	3.562IleArg: 3.562 ± 0.07	4.835IleSer: 4.835 ± 0.078	4.078IleThr: 4.078 ± 0.072	5.21IleVal: 5.21 ± 0.08	0.713IleTrp: 0.713 ± 0.031	2.753IleTyr: 2.753 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	4.08LysAla: 4.08 ± 0.073	0.296LysCys: 0.296 ± 0.022	3.905LysAsp: 3.905 ± 0.081	6.705LysGlu: 6.705 ± 0.098	1.758LysPhe: 1.758 ± 0.048	4.508LysGly: 4.508 ± 0.081	1.64LysHis: 1.64 ± 0.046	4.486LysIle: 4.486 ± 0.082	6.032LysLys: 6.032 ± 0.099	5.166LysLeu: 5.166 ± 0.09	2.098LysMet: 2.098 ± 0.049	3.243LysAsn: 3.243 ± 0.067	2.416LysPro: 2.416 ± 0.049	3.376LysGln: 3.376 ± 0.075	3.59LysArg: 3.59 ± 0.069	3.079LysSer: 3.079 ± 0.062	3.555LysThr: 3.555 ± 0.068	4.063LysVal: 4.063 ± 0.082	0.842LysTrp: 0.842 ± 0.034	2.102LysTyr: 2.102 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	6.678LeuAla: 6.678 ± 0.1	0.524LeuCys: 0.524 ± 0.028	4.933LeuAsp: 4.933 ± 0.088	6.744LeuGlu: 6.744 ± 0.098	4.966LeuPhe: 4.966 ± 0.107	6.219LeuGly: 6.219 ± 0.112	2.082LeuHis: 2.082 ± 0.052	7.192LeuIle: 7.192 ± 0.118	7.122LeuLys: 7.122 ± 0.109	9.564LeuLeu: 9.564 ± 0.163	2.617LeuMet: 2.617 ± 0.053	4.402LeuAsn: 4.402 ± 0.082	3.826LeuPro: 3.826 ± 0.07	3.277LeuGln: 3.277 ± 0.067	3.699LeuArg: 3.699 ± 0.072	6.521LeuSer: 6.521 ± 0.103	5.653LeuThr: 5.653 ± 0.091	5.67LeuVal: 5.67 ± 0.085	0.863LeuTrp: 0.863 ± 0.033	3.309LeuTyr: 3.309 ± 0.071	0.0LeuXaa: 0.0 ± 0.0
Met	2.245MetAla: 2.245 ± 0.066	0.137MetCys: 0.137 ± 0.013	1.755MetAsp: 1.755 ± 0.055	2.357MetGlu: 2.357 ± 0.047	1.226MetPhe: 1.226 ± 0.04	1.854MetGly: 1.854 ± 0.053	0.413MetHis: 0.413 ± 0.019	2.493MetIle: 2.493 ± 0.059	2.777MetLys: 2.777 ± 0.063	2.546MetLeu: 2.546 ± 0.062	1.021MetMet: 1.021 ± 0.043	1.698MetAsn: 1.698 ± 0.048	1.038MetPro: 1.038 ± 0.04	0.833MetGln: 0.833 ± 0.032	1.079MetArg: 1.079 ± 0.037	1.496MetSer: 1.496 ± 0.039	1.705MetThr: 1.705 ± 0.043	1.833MetVal: 1.833 ± 0.05	0.187MetTrp: 0.187 ± 0.015	0.782MetTyr: 0.782 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.263AsnAla: 2.263 ± 0.053	0.26AsnCys: 0.26 ± 0.018	2.075AsnAsp: 2.075 ± 0.055	3.252AsnGlu: 3.252 ± 0.068	1.416AsnPhe: 1.416 ± 0.045	2.97AsnGly: 2.97 ± 0.067	1.2AsnHis: 1.2 ± 0.043	3.266AsnIle: 3.266 ± 0.064	2.302AsnLys: 2.302 ± 0.052	3.584AsnLeu: 3.584 ± 0.069	1.266AsnMet: 1.266 ± 0.039	1.502AsnAsn: 1.502 ± 0.048	2.089AsnPro: 2.089 ± 0.049	2.285AsnGln: 2.285 ± 0.046	2.355AsnArg: 2.355 ± 0.053	1.765AsnSer: 1.765 ± 0.047	1.791AsnThr: 1.791 ± 0.045	2.731AsnVal: 2.731 ± 0.059	0.551AsnTrp: 0.551 ± 0.029	1.354AsnTyr: 1.354 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.369ProAla: 2.369 ± 0.058	0.217ProCys: 0.217 ± 0.016	2.828ProAsp: 2.828 ± 0.058	3.793ProGlu: 3.793 ± 0.071	2.137ProPhe: 2.137 ± 0.047	2.92ProGly: 2.92 ± 0.065	0.882ProHis: 0.882 ± 0.033	2.603ProIle: 2.603 ± 0.054	2.05ProLys: 2.05 ± 0.06	3.564ProLeu: 3.564 ± 0.086	0.804ProMet: 0.804 ± 0.034	1.362ProAsn: 1.362 ± 0.039	1.115ProPro: 1.115 ± 0.039	1.037ProGln: 1.037 ± 0.04	1.299ProArg: 1.299 ± 0.042	2.194ProSer: 2.194 ± 0.057	1.569ProThr: 1.569 ± 0.044	3.351ProVal: 3.351 ± 0.068	0.393ProTrp: 0.393 ± 0.025	1.632ProTyr: 1.632 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	2.857GlnAla: 2.857 ± 0.061	0.158GlnCys: 0.158 ± 0.014	1.862GlnAsp: 1.862 ± 0.048	3.305GlnGlu: 3.305 ± 0.079	1.624GlnPhe: 1.624 ± 0.044	2.381GlnGly: 2.381 ± 0.064	0.92GlnHis: 0.92 ± 0.032	2.916GlnIle: 2.916 ± 0.062	3.316GlnLys: 3.316 ± 0.068	4.184GlnLeu: 4.184 ± 0.072	1.462GlnMet: 1.462 ± 0.042	1.84GlnAsn: 1.84 ± 0.049	1.346GlnPro: 1.346 ± 0.04	1.84GlnGln: 1.84 ± 0.068	1.617GlnArg: 1.617 ± 0.057	2.306GlnSer: 2.306 ± 0.06	2.324GlnThr: 2.324 ± 0.057	2.602GlnVal: 2.602 ± 0.063	0.463GlnTrp: 0.463 ± 0.023	1.508GlnTyr: 1.508 ± 0.052	0.0GlnXaa: 0.0 ± 0.0
Arg	2.596ArgAla: 2.596 ± 0.053	0.257ArgCys: 0.257 ± 0.02	2.33ArgAsp: 2.33 ± 0.057	3.898ArgGlu: 3.898 ± 0.068	2.108ArgPhe: 2.108 ± 0.041	2.683ArgGly: 2.683 ± 0.055	1.036ArgHis: 1.036 ± 0.034	3.323ArgIle: 3.323 ± 0.073	3.806ArgLys: 3.806 ± 0.077	4.444ArgLeu: 4.444 ± 0.093	1.543ArgMet: 1.543 ± 0.042	2.116ArgAsn: 2.116 ± 0.059	1.604ArgPro: 1.604 ± 0.047	1.841ArgGln: 1.841 ± 0.047	2.235ArgArg: 2.235 ± 0.055	2.389ArgSer: 2.389 ± 0.066	2.355ArgThr: 2.355 ± 0.057	2.893ArgVal: 2.893 ± 0.056	0.432ArgTrp: 0.432 ± 0.023	1.829ArgTyr: 1.829 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	3.371SerAla: 3.371 ± 0.067	0.372SerCys: 0.372 ± 0.02	2.867SerAsp: 2.867 ± 0.055	3.726SerGlu: 3.726 ± 0.077	3.153SerPhe: 3.153 ± 0.057	4.274SerGly: 4.274 ± 0.08	1.314SerHis: 1.314 ± 0.04	4.622SerIle: 4.622 ± 0.084	3.04SerLys: 3.04 ± 0.065	5.906SerLeu: 5.906 ± 0.088	1.748SerMet: 1.748 ± 0.047	1.925SerAsn: 1.925 ± 0.05	2.146SerPro: 2.146 ± 0.052	1.917SerGln: 1.917 ± 0.049	2.834SerArg: 2.834 ± 0.064	3.73SerSer: 3.73 ± 0.076	2.64SerThr: 2.64 ± 0.063	3.89SerVal: 3.89 ± 0.068	0.653SerTrp: 0.653 ± 0.03	2.134SerTyr: 2.134 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	3.867ThrAla: 3.867 ± 0.104	0.325ThrCys: 0.325 ± 0.019	2.803ThrAsp: 2.803 ± 0.065	3.423ThrGlu: 3.423 ± 0.072	2.661ThrPhe: 2.661 ± 0.058	4.376ThrGly: 4.376 ± 0.078	1.056ThrHis: 1.056 ± 0.038	4.38ThrIle: 4.38 ± 0.077	2.807ThrLys: 2.807 ± 0.056	4.875ThrLeu: 4.875 ± 0.083	1.337ThrMet: 1.337 ± 0.045	1.963ThrAsn: 1.963 ± 0.045	2.166ThrPro: 2.166 ± 0.05	1.247ThrGln: 1.247 ± 0.041	2.166ThrArg: 2.166 ± 0.046	3.023ThrSer: 3.023 ± 0.053	2.504ThrThr: 2.504 ± 0.067	3.954ThrVal: 3.954 ± 0.081	0.523ThrTrp: 0.523 ± 0.029	2.055ThrTyr: 2.055 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	4.328ValAla: 4.328 ± 0.076	0.535ValCys: 0.535 ± 0.029	3.526ValAsp: 3.526 ± 0.069	4.845ValGlu: 4.845 ± 0.086	3.245ValPhe: 3.245 ± 0.08	4.147ValGly: 4.147 ± 0.082	1.578ValHis: 1.578 ± 0.04	5.762ValIle: 5.762 ± 0.09	4.506ValLys: 4.506 ± 0.076	6.814ValLeu: 6.814 ± 0.097	2.098ValMet: 2.098 ± 0.057	2.896ValAsn: 2.896 ± 0.055	2.748ValPro: 2.748 ± 0.061	2.629ValGln: 2.629 ± 0.053	2.917ValArg: 2.917 ± 0.06	4.165ValSer: 4.165 ± 0.066	3.987ValThr: 3.987 ± 0.083	4.737ValVal: 4.737 ± 0.077	0.616ValTrp: 0.616 ± 0.027	2.439ValTyr: 2.439 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.515TrpAla: 0.515 ± 0.026	0.064TrpCys: 0.064 ± 0.008	0.54TrpAsp: 0.54 ± 0.027	0.665TrpGlu: 0.665 ± 0.028	0.568TrpPhe: 0.568 ± 0.034	0.683TrpGly: 0.683 ± 0.034	0.204TrpHis: 0.204 ± 0.014	0.972TrpIle: 0.972 ± 0.038	0.822TrpLys: 0.822 ± 0.031	1.194TrpLeu: 1.194 ± 0.034	0.414TrpMet: 0.414 ± 0.027	0.557TrpAsn: 0.557 ± 0.027	0.319TrpPro: 0.319 ± 0.024	0.315TrpGln: 0.315 ± 0.017	0.38TrpArg: 0.38 ± 0.02	0.559TrpSer: 0.559 ± 0.025	0.505TrpThr: 0.505 ± 0.028	0.704TrpVal: 0.704 ± 0.03	0.139TrpTrp: 0.139 ± 0.013	0.387TrpTyr: 0.387 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.135TyrAla: 2.135 ± 0.05	0.244TyrCys: 0.244 ± 0.017	2.213TyrAsp: 2.213 ± 0.086	2.904TyrGlu: 2.904 ± 0.061	1.94TyrPhe: 1.94 ± 0.055	2.579TyrGly: 2.579 ± 0.061	1.091TyrHis: 1.091 ± 0.041	2.579TyrIle: 2.579 ± 0.066	1.859TyrLys: 1.859 ± 0.053	3.534TyrLeu: 3.534 ± 0.075	0.962TyrMet: 0.962 ± 0.037	1.313TyrAsn: 1.313 ± 0.041	1.568TyrPro: 1.568 ± 0.037	1.846TyrGln: 1.846 ± 0.047	1.84TyrArg: 1.84 ± 0.044	1.978TyrSer: 1.978 ± 0.054	1.801TyrThr: 1.801 ± 0.043	2.416TyrVal: 2.416 ± 0.057	0.418TyrTrp: 0.418 ± 0.025	1.495TyrTyr: 1.495 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3015 proteins (846811 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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