Amino acid dipepetide frequency for Coriobacteriaceae bacterium BV3Ac1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.405AlaAla: 12.405 ± 0.258	1.696AlaCys: 1.696 ± 0.069	6.358AlaAsp: 6.358 ± 0.11	6.506AlaGlu: 6.506 ± 0.137	3.583AlaPhe: 3.583 ± 0.077	7.999AlaGly: 7.999 ± 0.141	2.532AlaHis: 2.532 ± 0.077	5.734AlaIle: 5.734 ± 0.118	4.75AlaLys: 4.75 ± 0.1	10.709AlaLeu: 10.709 ± 0.191	2.668AlaMet: 2.668 ± 0.07	3.197AlaAsn: 3.197 ± 0.069	3.358AlaPro: 3.358 ± 0.095	4.136AlaGln: 4.136 ± 0.091	5.968AlaArg: 5.968 ± 0.128	6.084AlaSer: 6.084 ± 0.113	5.635AlaThr: 5.635 ± 0.121	7.094AlaVal: 7.094 ± 0.121	1.012AlaTrp: 1.012 ± 0.046	2.856AlaTyr: 2.856 ± 0.075	0.0AlaXaa: 0.0 ± 0.0
Cys	1.495CysAla: 1.495 ± 0.063	0.289CysCys: 0.289 ± 0.024	0.944CysAsp: 0.944 ± 0.037	0.948CysGlu: 0.948 ± 0.045	0.521CysPhe: 0.521 ± 0.029	1.538CysGly: 1.538 ± 0.065	0.326CysHis: 0.326 ± 0.025	0.965CysIle: 0.965 ± 0.046	0.525CysLys: 0.525 ± 0.028	1.207CysLeu: 1.207 ± 0.048	0.3CysMet: 0.3 ± 0.026	0.399CysAsn: 0.399 ± 0.03	0.718CysPro: 0.718 ± 0.047	0.453CysGln: 0.453 ± 0.033	0.714CysArg: 0.714 ± 0.035	0.939CysSer: 0.939 ± 0.051	0.716CysThr: 0.716 ± 0.042	1.111CysVal: 1.111 ± 0.047	0.184CysTrp: 0.184 ± 0.019	0.461CysTyr: 0.461 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	6.56AspAla: 6.56 ± 0.133	0.74AspCys: 0.74 ± 0.047	3.42AspAsp: 3.42 ± 0.101	5.183AspGlu: 5.183 ± 0.114	2.58AspPhe: 2.58 ± 0.071	4.82AspGly: 4.82 ± 0.107	1.068AspHis: 1.068 ± 0.045	3.59AspIle: 3.59 ± 0.078	2.874AspLys: 2.874 ± 0.088	5.389AspLeu: 5.389 ± 0.104	1.576AspMet: 1.576 ± 0.057	1.878AspAsn: 1.878 ± 0.065	2.573AspPro: 2.573 ± 0.077	1.585AspGln: 1.585 ± 0.062	2.794AspArg: 2.794 ± 0.071	3.352AspSer: 3.352 ± 0.086	3.122AspThr: 3.122 ± 0.074	4.647AspVal: 4.647 ± 0.091	0.783AspTrp: 0.783 ± 0.041	2.05AspTyr: 2.05 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	6.508GluAla: 6.508 ± 0.119	0.626GluCys: 0.626 ± 0.043	3.504GluAsp: 3.504 ± 0.086	4.325GluGlu: 4.325 ± 0.118	2.069GluPhe: 2.069 ± 0.061	4.398GluGly: 4.398 ± 0.104	1.668GluHis: 1.668 ± 0.056	3.394GluIle: 3.394 ± 0.076	3.075GluLys: 3.075 ± 0.085	7.276GluLeu: 7.276 ± 0.139	1.716GluMet: 1.716 ± 0.061	2.142GluAsn: 2.142 ± 0.064	2.147GluPro: 2.147 ± 0.07	2.805GluGln: 2.805 ± 0.075	4.285GluArg: 4.285 ± 0.098	3.221GluSer: 3.221 ± 0.082	3.039GluThr: 3.039 ± 0.071	4.48GluVal: 4.48 ± 0.098	0.648GluTrp: 0.648 ± 0.034	1.696GluTyr: 1.696 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.946PheAla: 3.946 ± 0.084	0.682PheCys: 0.682 ± 0.04	2.805PheAsp: 2.805 ± 0.079	2.339PheGlu: 2.339 ± 0.062	1.696PhePhe: 1.696 ± 0.07	3.189PheGly: 3.189 ± 0.092	0.693PheHis: 0.693 ± 0.037	2.031PheIle: 2.031 ± 0.068	1.349PheLys: 1.349 ± 0.048	3.165PheLeu: 3.165 ± 0.098	0.869PheMet: 0.869 ± 0.035	1.246PheAsn: 1.246 ± 0.042	1.304PhePro: 1.304 ± 0.056	0.976PheGln: 0.976 ± 0.04	1.552PheArg: 1.552 ± 0.056	2.661PheSer: 2.661 ± 0.074	2.003PheThr: 2.003 ± 0.063	3.107PheVal: 3.107 ± 0.076	0.457PheTrp: 0.457 ± 0.032	1.139PheTyr: 1.139 ± 0.048	0.0PheXaa: 0.0 ± 0.0
Gly	6.684GlyAla: 6.684 ± 0.13	1.147GlyCys: 1.147 ± 0.048	4.207GlyAsp: 4.207 ± 0.09	4.417GlyGlu: 4.417 ± 0.098	3.082GlyPhe: 3.082 ± 0.084	5.468GlyGly: 5.468 ± 0.13	1.6GlyHis: 1.6 ± 0.064	5.056GlyIle: 5.056 ± 0.096	4.433GlyLys: 4.433 ± 0.11	6.841GlyLeu: 6.841 ± 0.126	2.258GlyMet: 2.258 ± 0.068	2.492GlyAsn: 2.492 ± 0.07	2.086GlyPro: 2.086 ± 0.066	2.314GlyGln: 2.314 ± 0.068	4.074GlyArg: 4.074 ± 0.091	5.05GlySer: 5.05 ± 0.111	4.598GlyThr: 4.598 ± 0.098	5.651GlyVal: 5.651 ± 0.112	0.886GlyTrp: 0.886 ± 0.043	2.481GlyTyr: 2.481 ± 0.068	0.0GlyXaa: 0.0 ± 0.0
His	2.132HisAla: 2.132 ± 0.064	0.341HisCys: 0.341 ± 0.027	1.362HisAsp: 1.362 ± 0.055	1.488HisGlu: 1.488 ± 0.054	0.836HisPhe: 0.836 ± 0.041	1.778HisGly: 1.778 ± 0.055	0.603HisHis: 0.603 ± 0.039	1.426HisIle: 1.426 ± 0.053	0.978HisLys: 0.978 ± 0.044	1.848HisLeu: 1.848 ± 0.058	0.616HisMet: 0.616 ± 0.034	0.751HisAsn: 0.751 ± 0.039	1.201HisPro: 1.201 ± 0.053	0.656HisGln: 0.656 ± 0.031	1.231HisArg: 1.231 ± 0.048	1.24HisSer: 1.24 ± 0.05	1.209HisThr: 1.209 ± 0.053	1.636HisVal: 1.636 ± 0.066	0.197HisTrp: 0.197 ± 0.02	0.673HisTyr: 0.673 ± 0.039	0.0HisXaa: 0.0 ± 0.0
Ile	6.729IleAla: 6.729 ± 0.121	1.186IleCys: 1.186 ± 0.047	4.032IleAsp: 4.032 ± 0.088	3.888IleGlu: 3.888 ± 0.084	2.039IlePhe: 2.039 ± 0.074	4.171IleGly: 4.171 ± 0.099	1.023IleHis: 1.023 ± 0.044	2.966IleIle: 2.966 ± 0.081	2.481IleLys: 2.481 ± 0.072	4.696IleLeu: 4.696 ± 0.112	1.272IleMet: 1.272 ± 0.054	1.956IleAsn: 1.956 ± 0.057	2.601IlePro: 2.601 ± 0.07	1.583IleGln: 1.583 ± 0.059	2.826IleArg: 2.826 ± 0.073	4.096IleSer: 4.096 ± 0.099	3.03IleThr: 3.03 ± 0.096	4.653IleVal: 4.653 ± 0.101	0.59IleTrp: 0.59 ± 0.032	1.591IleTyr: 1.591 ± 0.06	0.0IleXaa: 0.0 ± 0.0
Lys	4.538LysAla: 4.538 ± 0.095	0.395LysCys: 0.395 ± 0.029	2.798LysAsp: 2.798 ± 0.099	2.67LysGlu: 2.67 ± 0.079	1.265LysPhe: 1.265 ± 0.052	3.032LysGly: 3.032 ± 0.077	0.993LysHis: 0.993 ± 0.04	2.47LysIle: 2.47 ± 0.062	2.916LysLys: 2.916 ± 0.086	4.552LysLeu: 4.552 ± 0.109	1.25LysMet: 1.25 ± 0.046	1.765LysAsn: 1.765 ± 0.07	1.994LysPro: 1.994 ± 0.068	2.026LysGln: 2.026 ± 0.066	2.8LysArg: 2.8 ± 0.08	2.689LysSer: 2.689 ± 0.083	3.092LysThr: 3.092 ± 0.079	3.066LysVal: 3.066 ± 0.082	0.373LysTrp: 0.373 ± 0.029	1.13LysTyr: 1.13 ± 0.051	0.0LysXaa: 0.0 ± 0.0
Leu	11.069LeuAla: 11.069 ± 0.187	1.458LeuCys: 1.458 ± 0.055	6.071LeuAsp: 6.071 ± 0.089	5.518LeuGlu: 5.518 ± 0.104	3.502LeuPhe: 3.502 ± 0.09	7.287LeuGly: 7.287 ± 0.121	1.938LeuHis: 1.938 ± 0.065	5.295LeuIle: 5.295 ± 0.127	3.973LeuLys: 3.973 ± 0.091	9.714LeuLeu: 9.714 ± 0.186	2.629LeuMet: 2.629 ± 0.069	2.636LeuAsn: 2.636 ± 0.071	4.43LeuPro: 4.43 ± 0.09	2.921LeuGln: 2.921 ± 0.084	5.473LeuArg: 5.473 ± 0.127	7.13LeuSer: 7.13 ± 0.106	5.168LeuThr: 5.168 ± 0.082	7.559LeuVal: 7.559 ± 0.124	0.926LeuTrp: 0.926 ± 0.045	2.537LeuTyr: 2.537 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	2.831MetAla: 2.831 ± 0.078	0.339MetCys: 0.339 ± 0.028	1.505MetAsp: 1.505 ± 0.056	1.291MetGlu: 1.291 ± 0.046	0.755MetPhe: 0.755 ± 0.042	2.161MetGly: 2.161 ± 0.07	0.639MetHis: 0.639 ± 0.043	1.257MetIle: 1.257 ± 0.048	1.092MetLys: 1.092 ± 0.045	2.477MetLeu: 2.477 ± 0.067	0.703MetMet: 0.703 ± 0.04	0.961MetAsn: 0.961 ± 0.044	1.37MetPro: 1.37 ± 0.046	0.935MetGln: 0.935 ± 0.043	1.653MetArg: 1.653 ± 0.067	1.988MetSer: 1.988 ± 0.056	1.439MetThr: 1.439 ± 0.045	1.855MetVal: 1.855 ± 0.058	0.227MetTrp: 0.227 ± 0.022	0.579MetTyr: 0.579 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	3.159AsnAla: 3.159 ± 0.079	0.461AsnCys: 0.461 ± 0.028	1.861AsnAsp: 1.861 ± 0.067	2.001AsnGlu: 2.001 ± 0.056	1.265AsnPhe: 1.265 ± 0.045	2.252AsnGly: 2.252 ± 0.071	0.697AsnHis: 0.697 ± 0.033	1.971AsnIle: 1.971 ± 0.063	1.666AsnLys: 1.666 ± 0.059	3.152AsnLeu: 3.152 ± 0.072	0.838AsnMet: 0.838 ± 0.035	1.28AsnAsn: 1.28 ± 0.065	1.979AsnPro: 1.979 ± 0.061	1.042AsnGln: 1.042 ± 0.047	1.512AsnArg: 1.512 ± 0.054	1.863AsnSer: 1.863 ± 0.062	1.868AsnThr: 1.868 ± 0.075	2.348AsnVal: 2.348 ± 0.057	0.395AsnTrp: 0.395 ± 0.031	1.134AsnTyr: 1.134 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	3.956ProAla: 3.956 ± 0.114	0.502ProCys: 0.502 ± 0.034	2.62ProAsp: 2.62 ± 0.071	3.156ProGlu: 3.156 ± 0.09	1.544ProPhe: 1.544 ± 0.053	2.753ProGly: 2.753 ± 0.1	1.014ProHis: 1.014 ± 0.048	2.125ProIle: 2.125 ± 0.059	1.908ProLys: 1.908 ± 0.054	3.74ProLeu: 3.74 ± 0.085	0.8ProMet: 0.8 ± 0.035	1.291ProAsn: 1.291 ± 0.049	0.907ProPro: 0.907 ± 0.045	1.649ProGln: 1.649 ± 0.054	1.949ProArg: 1.949 ± 0.064	2.599ProSer: 2.599 ± 0.067	2.449ProThr: 2.449 ± 0.079	3.028ProVal: 3.028 ± 0.083	0.468ProTrp: 0.468 ± 0.027	1.355ProTyr: 1.355 ± 0.055	0.0ProXaa: 0.0 ± 0.0
Gln	3.72GlnAla: 3.72 ± 0.092	0.275GlnCys: 0.275 ± 0.021	1.814GlnAsp: 1.814 ± 0.051	1.891GlnGlu: 1.891 ± 0.059	1.046GlnPhe: 1.046 ± 0.043	2.447GlnGly: 2.447 ± 0.069	0.783GlnHis: 0.783 ± 0.039	2.209GlnIle: 2.209 ± 0.078	1.557GlnLys: 1.557 ± 0.067	3.982GlnLeu: 3.982 ± 0.097	1.036GlnMet: 1.036 ± 0.047	1.227GlnAsn: 1.227 ± 0.051	1.261GlnPro: 1.261 ± 0.05	1.486GlnGln: 1.486 ± 0.072	2.286GlnArg: 2.286 ± 0.07	2.078GlnSer: 2.078 ± 0.072	1.96GlnThr: 1.96 ± 0.058	2.479GlnVal: 2.479 ± 0.068	0.311GlnTrp: 0.311 ± 0.024	0.826GlnTyr: 0.826 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	5.254ArgAla: 5.254 ± 0.102	0.751ArgCys: 0.751 ± 0.039	3.092ArgAsp: 3.092 ± 0.08	3.826ArgGlu: 3.826 ± 0.093	2.016ArgPhe: 2.016 ± 0.066	3.573ArgGly: 3.573 ± 0.091	1.338ArgHis: 1.338 ± 0.052	3.467ArgIle: 3.467 ± 0.083	2.532ArgLys: 2.532 ± 0.071	5.376ArgLeu: 5.376 ± 0.126	1.675ArgMet: 1.675 ± 0.059	1.769ArgAsn: 1.769 ± 0.063	2.027ArgPro: 2.027 ± 0.062	2.097ArgGln: 2.097 ± 0.057	3.841ArgArg: 3.841 ± 0.108	3.217ArgSer: 3.217 ± 0.08	2.816ArgThr: 2.816 ± 0.067	4.019ArgVal: 4.019 ± 0.088	0.688ArgTrp: 0.688 ± 0.049	1.833ArgTyr: 1.833 ± 0.068	0.0ArgXaa: 0.0 ± 0.0
Ser	6.405SerAla: 6.405 ± 0.117	1.061SerCys: 1.061 ± 0.046	3.772SerAsp: 3.772 ± 0.087	3.826SerGlu: 3.826 ± 0.081	2.953SerPhe: 2.953 ± 0.075	4.988SerGly: 4.988 ± 0.095	1.411SerHis: 1.411 ± 0.053	3.53SerIle: 3.53 ± 0.09	2.775SerLys: 2.775 ± 0.085	5.886SerLeu: 5.886 ± 0.122	1.647SerMet: 1.647 ± 0.056	2.166SerAsn: 2.166 ± 0.07	2.162SerPro: 2.162 ± 0.066	2.176SerGln: 2.176 ± 0.069	3.216SerArg: 3.216 ± 0.082	4.527SerSer: 4.527 ± 0.107	3.444SerThr: 3.444 ± 0.075	4.501SerVal: 4.501 ± 0.11	0.89SerTrp: 0.89 ± 0.044	2.4SerTyr: 2.4 ± 0.083	0.0SerXaa: 0.0 ± 0.0
Thr	5.159ThrAla: 5.159 ± 0.101	0.785ThrCys: 0.785 ± 0.04	3.077ThrAsp: 3.077 ± 0.082	2.762ThrGlu: 2.762 ± 0.068	1.992ThrPhe: 1.992 ± 0.068	4.437ThrGly: 4.437 ± 0.108	1.441ThrHis: 1.441 ± 0.055	3.309ThrIle: 3.309 ± 0.078	2.355ThrLys: 2.355 ± 0.078	5.76ThrLeu: 5.76 ± 0.121	1.267ThrMet: 1.267 ± 0.048	1.893ThrAsn: 1.893 ± 0.064	2.848ThrPro: 2.848 ± 0.077	2.057ThrGln: 2.057 ± 0.07	2.672ThrArg: 2.672 ± 0.072	3.491ThrSer: 3.491 ± 0.084	3.448ThrThr: 3.448 ± 0.103	4.124ThrVal: 4.124 ± 0.097	0.545ThrTrp: 0.545 ± 0.032	1.78ThrTyr: 1.78 ± 0.074	0.0ThrXaa: 0.0 ± 0.0
Val	7.902ValAla: 7.902 ± 0.124	1.355ValCys: 1.355 ± 0.06	4.705ValAsp: 4.705 ± 0.1	4.508ValGlu: 4.508 ± 0.115	2.76ValPhe: 2.76 ± 0.078	5.292ValGly: 5.292 ± 0.107	1.404ValHis: 1.404 ± 0.052	4.505ValIle: 4.505 ± 0.11	2.773ValLys: 2.773 ± 0.087	7.285ValLeu: 7.285 ± 0.143	1.977ValMet: 1.977 ± 0.066	2.342ValAsn: 2.342 ± 0.069	3.3ValPro: 3.3 ± 0.077	2.161ValGln: 2.161 ± 0.065	4.066ValArg: 4.066 ± 0.088	5.196ValSer: 5.196 ± 0.097	4.109ValThr: 4.109 ± 0.115	6.244ValVal: 6.244 ± 0.12	0.802ValTrp: 0.802 ± 0.041	1.902ValTyr: 1.902 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.914TrpAla: 0.914 ± 0.04	0.206TrpCys: 0.206 ± 0.02	0.678TrpAsp: 0.678 ± 0.037	0.637TrpGlu: 0.637 ± 0.036	0.395TrpPhe: 0.395 ± 0.027	0.845TrpGly: 0.845 ± 0.043	0.32TrpHis: 0.32 ± 0.025	0.592TrpIle: 0.592 ± 0.035	0.506TrpLys: 0.506 ± 0.032	1.122TrpLeu: 1.122 ± 0.053	0.358TrpMet: 0.358 ± 0.025	0.414TrpAsn: 0.414 ± 0.028	0.386TrpPro: 0.386 ± 0.026	0.523TrpGln: 0.523 ± 0.032	0.691TrpArg: 0.691 ± 0.039	0.624TrpSer: 0.624 ± 0.034	0.525TrpThr: 0.525 ± 0.039	0.658TrpVal: 0.658 ± 0.031	0.157TrpTrp: 0.157 ± 0.016	0.324TrpTyr: 0.324 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.912TyrAla: 2.912 ± 0.077	0.457TyrCys: 0.457 ± 0.03	1.96TyrAsp: 1.96 ± 0.061	1.842TyrGlu: 1.842 ± 0.061	1.312TyrPhe: 1.312 ± 0.06	2.397TyrGly: 2.397 ± 0.062	0.712TyrHis: 0.712 ± 0.043	1.518TyrIle: 1.518 ± 0.051	1.293TyrLys: 1.293 ± 0.05	3.058TyrLeu: 3.058 ± 0.081	0.6TyrMet: 0.6 ± 0.033	0.937TyrAsn: 0.937 ± 0.046	1.16TyrPro: 1.16 ± 0.046	1.094TyrGln: 1.094 ± 0.048	1.608TyrArg: 1.608 ± 0.056	1.69TyrSer: 1.69 ± 0.067	1.533TyrThr: 1.533 ± 0.063	2.327TyrVal: 2.327 ± 0.066	0.337TyrTrp: 0.337 ± 0.025	1.016TyrTyr: 1.016 ± 0.061	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1610 proteins (533666 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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