Amino acid dipepetide frequency for Lachnospiraceae bacterium G11

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.591AlaAla: 6.591 ± 0.119	1.112AlaCys: 1.112 ± 0.035	4.662AlaAsp: 4.662 ± 0.077	5.248AlaGlu: 5.248 ± 0.097	3.469AlaPhe: 3.469 ± 0.066	5.903AlaGly: 5.903 ± 0.094	1.026AlaHis: 1.026 ± 0.034	5.642AlaIle: 5.642 ± 0.089	5.292AlaLys: 5.292 ± 0.095	7.046AlaLeu: 7.046 ± 0.095	2.342AlaMet: 2.342 ± 0.048	2.941AlaAsn: 2.941 ± 0.057	2.166AlaPro: 2.166 ± 0.063	1.662AlaGln: 1.662 ± 0.049	2.786AlaArg: 2.786 ± 0.055	4.166AlaSer: 4.166 ± 0.072	3.787AlaThr: 3.787 ± 0.067	5.729AlaVal: 5.729 ± 0.075	0.587AlaTrp: 0.587 ± 0.029	2.844AlaTyr: 2.844 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	0.92CysAla: 0.92 ± 0.037	0.215CysCys: 0.215 ± 0.015	0.883CysAsp: 0.883 ± 0.032	0.87CysGlu: 0.87 ± 0.032	0.702CysPhe: 0.702 ± 0.031	1.369CysGly: 1.369 ± 0.04	0.256CysHis: 0.256 ± 0.017	1.036CysIle: 1.036 ± 0.038	0.874CysLys: 0.874 ± 0.029	1.12CysLeu: 1.12 ± 0.038	0.416CysMet: 0.416 ± 0.019	0.553CysAsn: 0.553 ± 0.024	0.548CysPro: 0.548 ± 0.026	0.266CysGln: 0.266 ± 0.017	0.481CysArg: 0.481 ± 0.023	0.778CysSer: 0.778 ± 0.03	0.65CysThr: 0.65 ± 0.029	1.012CysVal: 1.012 ± 0.037	0.105CysTrp: 0.105 ± 0.01	0.559CysTyr: 0.559 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	4.494AspAla: 4.494 ± 0.08	0.773AspCys: 0.773 ± 0.031	3.81AspAsp: 3.81 ± 0.078	5.813AspGlu: 5.813 ± 0.091	3.061AspPhe: 3.061 ± 0.059	4.541AspGly: 4.541 ± 0.088	0.756AspHis: 0.756 ± 0.028	4.872AspIle: 4.872 ± 0.07	4.403AspLys: 4.403 ± 0.075	4.874AspLeu: 4.874 ± 0.073	1.982AspMet: 1.982 ± 0.05	2.858AspAsn: 2.858 ± 0.063	1.86AspPro: 1.86 ± 0.053	0.928AspGln: 0.928 ± 0.036	2.441AspArg: 2.441 ± 0.049	3.573AspSer: 3.573 ± 0.066	3.275AspThr: 3.275 ± 0.059	4.317AspVal: 4.317 ± 0.08	0.628AspTrp: 0.628 ± 0.025	3.301AspTyr: 3.301 ± 0.061	0.0AspXaa: 0.0 ± 0.0
Glu	6.095GluAla: 6.095 ± 0.105	0.782GluCys: 0.782 ± 0.027	4.512GluAsp: 4.512 ± 0.076	7.294GluGlu: 7.294 ± 0.136	2.821GluPhe: 2.821 ± 0.054	4.984GluGly: 4.984 ± 0.086	1.124GluHis: 1.124 ± 0.034	5.731GluIle: 5.731 ± 0.084	6.356GluLys: 6.356 ± 0.1	6.496GluLeu: 6.496 ± 0.094	2.287GluMet: 2.287 ± 0.048	3.948GluAsn: 3.948 ± 0.071	1.957GluPro: 1.957 ± 0.045	1.874GluGln: 1.874 ± 0.044	3.242GluArg: 3.242 ± 0.069	3.645GluSer: 3.645 ± 0.067	4.037GluThr: 4.037 ± 0.076	4.771GluVal: 4.771 ± 0.078	0.702GluTrp: 0.702 ± 0.029	3.408GluTyr: 3.408 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	3.293PheAla: 3.293 ± 0.069	0.643PheCys: 0.643 ± 0.024	3.172PheAsp: 3.172 ± 0.056	3.069PheGlu: 3.069 ± 0.057	2.204PhePhe: 2.204 ± 0.066	3.296PheGly: 3.296 ± 0.067	0.672PheHis: 0.672 ± 0.027	3.348PheIle: 3.348 ± 0.07	2.757PheLys: 2.757 ± 0.063	3.744PheLeu: 3.744 ± 0.065	1.326PheMet: 1.326 ± 0.043	1.908PheAsn: 1.908 ± 0.041	1.326PhePro: 1.326 ± 0.038	0.848PheGln: 0.848 ± 0.033	1.544PheArg: 1.544 ± 0.04	2.882PheSer: 2.882 ± 0.059	2.479PheThr: 2.479 ± 0.052	3.177PheVal: 3.177 ± 0.063	0.413PheTrp: 0.413 ± 0.021	1.968PheTyr: 1.968 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.992GlyAla: 4.992 ± 0.088	1.194GlyCys: 1.194 ± 0.041	4.079GlyAsp: 4.079 ± 0.071	4.964GlyGlu: 4.964 ± 0.09	3.491GlyPhe: 3.491 ± 0.069	4.881GlyGly: 4.881 ± 0.105	1.139GlyHis: 1.139 ± 0.037	6.258GlyIle: 6.258 ± 0.094	5.403GlyLys: 5.403 ± 0.08	6.192GlyLeu: 6.192 ± 0.093	2.362GlyMet: 2.362 ± 0.05	3.271GlyAsn: 3.271 ± 0.068	1.435GlyPro: 1.435 ± 0.043	1.677GlyGln: 1.677 ± 0.04	2.873GlyArg: 2.873 ± 0.07	4.109GlySer: 4.109 ± 0.079	4.092GlyThr: 4.092 ± 0.078	5.17GlyVal: 5.17 ± 0.086	0.652GlyTrp: 0.652 ± 0.028	3.467GlyTyr: 3.467 ± 0.075	0.0GlyXaa: 0.0 ± 0.0
His	0.933HisAla: 0.933 ± 0.032	0.228HisCys: 0.228 ± 0.017	0.911HisAsp: 0.911 ± 0.032	1.015HisGlu: 1.015 ± 0.034	0.817HisPhe: 0.817 ± 0.031	1.096HisGly: 1.096 ± 0.036	0.308HisHis: 0.308 ± 0.03	1.16HisIle: 1.16 ± 0.037	0.873HisLys: 0.873 ± 0.033	1.237HisLeu: 1.237 ± 0.04	0.428HisMet: 0.428 ± 0.02	0.685HisAsn: 0.685 ± 0.028	0.735HisPro: 0.735 ± 0.03	0.372HisGln: 0.372 ± 0.02	0.647HisArg: 0.647 ± 0.023	0.819HisSer: 0.819 ± 0.032	0.796HisThr: 0.796 ± 0.031	1.031HisVal: 1.031 ± 0.034	0.125HisTrp: 0.125 ± 0.01	0.68HisTyr: 0.68 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.957IleAla: 5.957 ± 0.084	1.238IleCys: 1.238 ± 0.043	4.691IleAsp: 4.691 ± 0.066	5.147IleGlu: 5.147 ± 0.07	3.062IlePhe: 3.062 ± 0.065	5.349IleGly: 5.349 ± 0.091	1.122IleHis: 1.122 ± 0.035	5.994IleIle: 5.994 ± 0.113	5.386IleLys: 5.386 ± 0.078	6.968IleLeu: 6.968 ± 0.119	2.034IleMet: 2.034 ± 0.049	3.627IleAsn: 3.627 ± 0.057	3.151IlePro: 3.151 ± 0.064	1.551IleGln: 1.551 ± 0.044	3.303IleArg: 3.303 ± 0.063	5.161IleSer: 5.161 ± 0.084	4.315IleThr: 4.315 ± 0.07	5.182IleVal: 5.182 ± 0.088	0.628IleTrp: 0.628 ± 0.028	2.919IleTyr: 2.919 ± 0.062	0.0IleXaa: 0.0 ± 0.0
Lys	5.806LysAla: 5.806 ± 0.106	0.737LysCys: 0.737 ± 0.032	4.818LysAsp: 4.818 ± 0.084	6.898LysGlu: 6.898 ± 0.105	2.2LysPhe: 2.2 ± 0.045	4.709LysGly: 4.709 ± 0.079	1.008LysHis: 1.008 ± 0.03	4.929LysIle: 4.929 ± 0.066	6.131LysLys: 6.131 ± 0.093	5.665LysLeu: 5.665 ± 0.088	2.163LysMet: 2.163 ± 0.052	3.705LysAsn: 3.705 ± 0.067	2.101LysPro: 2.101 ± 0.053	1.892LysGln: 1.892 ± 0.046	2.925LysArg: 2.925 ± 0.06	3.59LysSer: 3.59 ± 0.063	3.819LysThr: 3.819 ± 0.073	4.835LysVal: 4.835 ± 0.061	0.611LysTrp: 0.611 ± 0.025	3.098LysTyr: 3.098 ± 0.064	0.0LysXaa: 0.0 ± 0.0
Leu	6.495LeuAla: 6.495 ± 0.085	1.277LeuCys: 1.277 ± 0.043	5.127LeuAsp: 5.127 ± 0.078	5.635LeuGlu: 5.635 ± 0.09	3.904LeuPhe: 3.904 ± 0.076	6.013LeuGly: 6.013 ± 0.093	1.198LeuHis: 1.198 ± 0.037	6.699LeuIle: 6.699 ± 0.096	6.457LeuLys: 6.457 ± 0.092	7.891LeuLeu: 7.891 ± 0.127	2.541LeuMet: 2.541 ± 0.049	4.079LeuAsn: 4.079 ± 0.064	3.216LeuPro: 3.216 ± 0.068	1.906LeuGln: 1.906 ± 0.046	3.439LeuArg: 3.439 ± 0.06	6.205LeuSer: 6.205 ± 0.095	4.958LeuThr: 4.958 ± 0.07	5.703LeuVal: 5.703 ± 0.079	0.793LeuTrp: 0.793 ± 0.032	3.396LeuTyr: 3.396 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	2.441MetAla: 2.441 ± 0.055	0.366MetCys: 0.366 ± 0.021	1.938MetAsp: 1.938 ± 0.043	2.166MetGlu: 2.166 ± 0.051	1.097MetPhe: 1.097 ± 0.036	2.223MetGly: 2.223 ± 0.045	0.435MetHis: 0.435 ± 0.022	2.16MetIle: 2.16 ± 0.056	2.339MetLys: 2.339 ± 0.049	2.522MetLeu: 2.522 ± 0.058	0.919MetMet: 0.919 ± 0.034	1.573MetAsn: 1.573 ± 0.047	1.106MetPro: 1.106 ± 0.038	0.751MetGln: 0.751 ± 0.032	1.136MetArg: 1.136 ± 0.029	1.949MetSer: 1.949 ± 0.045	1.642MetThr: 1.642 ± 0.04	1.925MetVal: 1.925 ± 0.044	0.23MetTrp: 0.23 ± 0.017	0.997MetTyr: 0.997 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.327AsnAla: 3.327 ± 0.068	0.635AsnCys: 0.635 ± 0.03	2.648AsnAsp: 2.648 ± 0.058	3.298AsnGlu: 3.298 ± 0.06	1.739AsnPhe: 1.739 ± 0.046	3.498AsnGly: 3.498 ± 0.07	0.789AsnHis: 0.789 ± 0.025	3.476AsnIle: 3.476 ± 0.055	3.217AsnLys: 3.217 ± 0.055	4.121AsnLeu: 4.121 ± 0.062	1.506AsnMet: 1.506 ± 0.042	2.281AsnAsn: 2.281 ± 0.059	2.225AsnPro: 2.225 ± 0.051	1.113AsnGln: 1.113 ± 0.034	1.941AsnArg: 1.941 ± 0.048	2.652AsnSer: 2.652 ± 0.062	2.446AsnThr: 2.446 ± 0.063	3.364AsnVal: 3.364 ± 0.058	0.446AsnTrp: 0.446 ± 0.024	2.041AsnTyr: 2.041 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.38ProAla: 2.38 ± 0.057	0.411ProCys: 0.411 ± 0.023	2.415ProAsp: 2.415 ± 0.058	3.365ProGlu: 3.365 ± 0.077	1.597ProPhe: 1.597 ± 0.045	2.29ProGly: 2.29 ± 0.053	0.484ProHis: 0.484 ± 0.025	2.296ProIle: 2.296 ± 0.053	1.962ProLys: 1.962 ± 0.048	2.558ProLeu: 2.558 ± 0.051	0.869ProMet: 0.869 ± 0.032	1.33ProAsn: 1.33 ± 0.037	0.602ProPro: 0.602 ± 0.028	0.825ProGln: 0.825 ± 0.031	0.894ProArg: 0.894 ± 0.033	1.785ProSer: 1.785 ± 0.049	1.79ProThr: 1.79 ± 0.055	2.67ProVal: 2.67 ± 0.064	0.315ProTrp: 0.315 ± 0.018	1.418ProTyr: 1.418 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.799GlnAla: 1.799 ± 0.048	0.253GlnCys: 0.253 ± 0.018	1.184GlnAsp: 1.184 ± 0.039	1.495GlnGlu: 1.495 ± 0.034	0.974GlnPhe: 0.974 ± 0.031	1.517GlnGly: 1.517 ± 0.041	0.346GlnHis: 0.346 ± 0.018	1.985GlnIle: 1.985 ± 0.043	1.675GlnLys: 1.675 ± 0.045	1.888GlnLeu: 1.888 ± 0.046	0.84GlnMet: 0.84 ± 0.029	1.203GlnAsn: 1.203 ± 0.038	0.603GlnPro: 0.603 ± 0.024	0.659GlnGln: 0.659 ± 0.03	1.005GlnArg: 1.005 ± 0.034	1.173GlnSer: 1.173 ± 0.04	1.29GlnThr: 1.29 ± 0.036	1.578GlnVal: 1.578 ± 0.045	0.218GlnTrp: 0.218 ± 0.015	1.05GlnTyr: 1.05 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.546ArgAla: 2.546 ± 0.05	0.496ArgCys: 0.496 ± 0.027	2.413ArgAsp: 2.413 ± 0.051	3.228ArgGlu: 3.228 ± 0.064	1.858ArgPhe: 1.858 ± 0.052	2.335ArgGly: 2.335 ± 0.053	0.662ArgHis: 0.662 ± 0.03	3.468ArgIle: 3.468 ± 0.07	2.959ArgLys: 2.959 ± 0.057	3.364ArgLeu: 3.364 ± 0.073	1.355ArgMet: 1.355 ± 0.044	2.072ArgAsn: 2.072 ± 0.048	1.113ArgPro: 1.113 ± 0.051	1.164ArgGln: 1.164 ± 0.039	1.87ArgArg: 1.87 ± 0.052	1.996ArgSer: 1.996 ± 0.044	1.97ArgThr: 1.97 ± 0.042	2.684ArgVal: 2.684 ± 0.061	0.322ArgTrp: 0.322 ± 0.017	1.655ArgTyr: 1.655 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.141SerAla: 4.141 ± 0.078	0.704SerCys: 0.704 ± 0.026	3.827SerAsp: 3.827 ± 0.071	4.347SerGlu: 4.347 ± 0.082	2.963SerPhe: 2.963 ± 0.055	4.853SerGly: 4.853 ± 0.084	0.905SerHis: 0.905 ± 0.03	4.37SerIle: 4.37 ± 0.083	3.909SerLys: 3.909 ± 0.072	5.324SerLeu: 5.324 ± 0.087	1.692SerMet: 1.692 ± 0.045	2.531SerAsn: 2.531 ± 0.056	1.655SerPro: 1.655 ± 0.051	1.372SerGln: 1.372 ± 0.038	2.271SerArg: 2.271 ± 0.055	3.427SerSer: 3.427 ± 0.08	3.013SerThr: 3.013 ± 0.064	4.45SerVal: 4.45 ± 0.072	0.48SerTrp: 0.48 ± 0.022	2.508SerTyr: 2.508 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	4.153ThrAla: 4.153 ± 0.078	0.678ThrCys: 0.678 ± 0.023	3.443ThrAsp: 3.443 ± 0.064	3.861ThrGlu: 3.861 ± 0.082	2.396ThrPhe: 2.396 ± 0.048	4.477ThrGly: 4.477 ± 0.066	0.805ThrHis: 0.805 ± 0.03	4.097ThrIle: 4.097 ± 0.068	3.324ThrLys: 3.324 ± 0.058	4.852ThrLeu: 4.852 ± 0.067	1.392ThrMet: 1.392 ± 0.041	2.208ThrAsn: 2.208 ± 0.053	2.349ThrPro: 2.349 ± 0.06	1.235ThrGln: 1.235 ± 0.042	1.902ThrArg: 1.902 ± 0.047	2.985ThrSer: 2.985 ± 0.06	2.913ThrThr: 2.913 ± 0.064	4.33ThrVal: 4.33 ± 0.078	0.543ThrTrp: 0.543 ± 0.026	2.328ThrTyr: 2.328 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	5.274ValAla: 5.274 ± 0.085	1.111ValCys: 1.111 ± 0.034	4.356ValAsp: 4.356 ± 0.071	4.601ValGlu: 4.601 ± 0.072	3.272ValPhe: 3.272 ± 0.063	4.7ValGly: 4.7 ± 0.082	0.989ValHis: 0.989 ± 0.031	5.592ValIle: 5.592 ± 0.096	4.968ValLys: 4.968 ± 0.088	6.484ValLeu: 6.484 ± 0.084	2.003ValMet: 2.003 ± 0.046	3.244ValAsn: 3.244 ± 0.062	2.382ValPro: 2.382 ± 0.048	1.331ValGln: 1.331 ± 0.044	2.701ValArg: 2.701 ± 0.067	4.746ValSer: 4.746 ± 0.077	4.222ValThr: 4.222 ± 0.074	5.272ValVal: 5.272 ± 0.084	0.58ValTrp: 0.58 ± 0.029	2.86ValTyr: 2.86 ± 0.068	0.0ValXaa: 0.0 ± 0.0
Trp	0.593TrpAla: 0.593 ± 0.027	0.135TrpCys: 0.135 ± 0.012	0.615TrpAsp: 0.615 ± 0.026	0.557TrpGlu: 0.557 ± 0.026	0.448TrpPhe: 0.448 ± 0.029	0.678TrpGly: 0.678 ± 0.029	0.157TrpHis: 0.157 ± 0.015	0.673TrpIle: 0.673 ± 0.03	0.55TrpLys: 0.55 ± 0.024	0.823TrpLeu: 0.823 ± 0.033	0.267TrpMet: 0.267 ± 0.017	0.53TrpAsn: 0.53 ± 0.024	0.239TrpPro: 0.239 ± 0.015	0.313TrpGln: 0.313 ± 0.018	0.318TrpArg: 0.318 ± 0.02	0.433TrpSer: 0.433 ± 0.023	0.465TrpThr: 0.465 ± 0.023	0.574TrpVal: 0.574 ± 0.027	0.121TrpTrp: 0.121 ± 0.013	0.404TrpTyr: 0.404 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.772TyrAla: 2.772 ± 0.058	0.626TyrCys: 0.626 ± 0.027	3.057TyrAsp: 3.057 ± 0.059	3.196TyrGlu: 3.196 ± 0.059	1.992TyrPhe: 1.992 ± 0.051	2.985TyrGly: 2.985 ± 0.058	0.711TyrHis: 0.711 ± 0.026	3.002TyrIle: 3.002 ± 0.067	2.807TyrLys: 2.807 ± 0.054	3.763TyrLeu: 3.763 ± 0.076	1.193TyrMet: 1.193 ± 0.033	2.215TyrAsn: 2.215 ± 0.053	1.49TyrPro: 1.49 ± 0.042	0.998TyrGln: 0.998 ± 0.03	1.808TyrArg: 1.808 ± 0.047	2.666TyrSer: 2.666 ± 0.055	2.312TyrThr: 2.312 ± 0.058	2.913TyrVal: 2.913 ± 0.055	0.395TyrTrp: 0.395 ± 0.024	2.052TyrTyr: 2.052 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2732 proteins (939179 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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