Amino acid dipepetide frequency for Crucibulum laeve

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.595AlaAla: 7.595 ± 0.054	1.029AlaCys: 1.029 ± 0.014	3.655AlaAsp: 3.655 ± 0.026	4.488AlaGlu: 4.488 ± 0.037	3.267AlaPhe: 3.267 ± 0.027	5.169AlaGly: 5.169 ± 0.037	1.922AlaHis: 1.922 ± 0.019	4.445AlaIle: 4.445 ± 0.033	3.682AlaLys: 3.682 ± 0.036	8.0AlaLeu: 8.0 ± 0.045	1.839AlaMet: 1.839 ± 0.02	2.824AlaAsn: 2.824 ± 0.021	4.717AlaPro: 4.717 ± 0.039	3.055AlaGln: 3.055 ± 0.03	4.368AlaArg: 4.368 ± 0.03	7.468AlaSer: 7.468 ± 0.054	5.008AlaThr: 5.008 ± 0.033	5.101AlaVal: 5.101 ± 0.035	1.081AlaTrp: 1.081 ± 0.015	2.179AlaTyr: 2.179 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.922CysAla: 0.922 ± 0.013	0.279CysCys: 0.279 ± 0.008	0.629CysAsp: 0.629 ± 0.012	0.571CysGlu: 0.571 ± 0.01	0.537CysPhe: 0.537 ± 0.011	0.867CysGly: 0.867 ± 0.013	0.347CysHis: 0.347 ± 0.008	0.791CysIle: 0.791 ± 0.011	0.522CysLys: 0.522 ± 0.011	1.286CysLeu: 1.286 ± 0.018	0.282CysMet: 0.282 ± 0.007	0.484CysAsn: 0.484 ± 0.009	0.698CysPro: 0.698 ± 0.014	0.425CysGln: 0.425 ± 0.01	0.704CysArg: 0.704 ± 0.011	1.048CysSer: 1.048 ± 0.016	0.809CysThr: 0.809 ± 0.014	0.798CysVal: 0.798 ± 0.012	0.206CysTrp: 0.206 ± 0.006	0.358CysTyr: 0.358 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.351AspAla: 4.351 ± 0.027	0.555AspCys: 0.555 ± 0.012	3.855AspAsp: 3.855 ± 0.04	4.063AspGlu: 4.063 ± 0.039	2.018AspPhe: 2.018 ± 0.019	3.626AspGly: 3.626 ± 0.027	1.183AspHis: 1.183 ± 0.013	3.368AspIle: 3.368 ± 0.026	2.155AspLys: 2.155 ± 0.02	4.748AspLeu: 4.748 ± 0.033	1.193AspMet: 1.193 ± 0.014	1.821AspAsn: 1.821 ± 0.018	3.103AspPro: 3.103 ± 0.022	1.533AspGln: 1.533 ± 0.018	2.55AspArg: 2.55 ± 0.026	4.103AspSer: 4.103 ± 0.03	2.946AspThr: 2.946 ± 0.026	3.687AspVal: 3.687 ± 0.023	0.794AspTrp: 0.794 ± 0.012	1.447AspTyr: 1.447 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	4.611GluAla: 4.611 ± 0.037	0.657GluCys: 0.657 ± 0.014	3.947GluAsp: 3.947 ± 0.035	5.346GluGlu: 5.346 ± 0.055	1.868GluPhe: 1.868 ± 0.018	3.536GluGly: 3.536 ± 0.032	1.384GluHis: 1.384 ± 0.015	3.025GluIle: 3.025 ± 0.029	3.499GluLys: 3.499 ± 0.033	5.086GluLeu: 5.086 ± 0.038	1.34GluMet: 1.34 ± 0.014	2.053GluAsn: 2.053 ± 0.02	2.471GluPro: 2.471 ± 0.027	2.084GluGln: 2.084 ± 0.022	3.724GluArg: 3.724 ± 0.034	3.98GluSer: 3.98 ± 0.029	2.936GluThr: 2.936 ± 0.021	3.568GluVal: 3.568 ± 0.03	0.898GluTrp: 0.898 ± 0.012	1.579GluTyr: 1.579 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	2.977PheAla: 2.977 ± 0.025	0.555PheCys: 0.555 ± 0.009	2.235PheAsp: 2.235 ± 0.021	1.987PheGlu: 1.987 ± 0.02	1.75PhePhe: 1.75 ± 0.02	2.701PheGly: 2.701 ± 0.023	0.976PheHis: 0.976 ± 0.013	2.241PheIle: 2.241 ± 0.023	1.595PheLys: 1.595 ± 0.017	3.755PheLeu: 3.755 ± 0.034	0.798PheMet: 0.798 ± 0.012	1.575PheAsn: 1.575 ± 0.015	2.172PhePro: 2.172 ± 0.022	1.327PheGln: 1.327 ± 0.015	1.863PheArg: 1.863 ± 0.018	3.494PheSer: 3.494 ± 0.028	2.38PheThr: 2.38 ± 0.024	2.498PheVal: 2.498 ± 0.021	0.611PheTrp: 0.611 ± 0.012	1.177PheTyr: 1.177 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	4.674GlyAla: 4.674 ± 0.034	0.838GlyCys: 0.838 ± 0.013	3.213GlyAsp: 3.213 ± 0.03	3.287GlyGlu: 3.287 ± 0.03	2.58GlyPhe: 2.58 ± 0.025	5.503GlyGly: 5.503 ± 0.067	1.554GlyHis: 1.554 ± 0.02	3.58GlyIle: 3.58 ± 0.028	3.482GlyLys: 3.482 ± 0.026	5.526GlyLeu: 5.526 ± 0.035	1.488GlyMet: 1.488 ± 0.017	2.429GlyAsn: 2.429 ± 0.024	3.031GlyPro: 3.031 ± 0.028	2.114GlyGln: 2.114 ± 0.023	3.748GlyArg: 3.748 ± 0.032	5.6GlySer: 5.6 ± 0.04	3.883GlyThr: 3.883 ± 0.029	4.185GlyVal: 4.185 ± 0.03	1.13GlyTrp: 1.13 ± 0.014	1.931GlyTyr: 1.931 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.95HisAla: 1.95 ± 0.018	0.366HisCys: 0.366 ± 0.01	1.231HisAsp: 1.231 ± 0.015	1.219HisGlu: 1.219 ± 0.015	0.988HisPhe: 0.988 ± 0.013	1.54HisGly: 1.54 ± 0.017	0.905HisHis: 0.905 ± 0.018	1.506HisIle: 1.506 ± 0.014	0.924HisLys: 0.924 ± 0.013	2.574HisLeu: 2.574 ± 0.021	0.48HisMet: 0.48 ± 0.009	0.899HisAsn: 0.899 ± 0.012	2.029HisPro: 2.029 ± 0.024	0.949HisGln: 0.949 ± 0.015	1.514HisArg: 1.514 ± 0.018	2.269HisSer: 2.269 ± 0.024	1.548HisThr: 1.548 ± 0.016	1.526HisVal: 1.526 ± 0.014	0.324HisTrp: 0.324 ± 0.008	0.73HisTyr: 0.73 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.484IleAla: 4.484 ± 0.032	0.829IleCys: 0.829 ± 0.013	2.903IleAsp: 2.903 ± 0.023	2.828IleGlu: 2.828 ± 0.025	2.292IlePhe: 2.292 ± 0.024	3.208IleGly: 3.208 ± 0.026	1.439IleHis: 1.439 ± 0.016	3.095IleIle: 3.095 ± 0.031	2.315IleLys: 2.315 ± 0.019	5.294IleLeu: 5.294 ± 0.035	1.1IleMet: 1.1 ± 0.014	1.953IleAsn: 1.953 ± 0.021	3.705IlePro: 3.705 ± 0.029	2.087IleGln: 2.087 ± 0.023	2.863IleArg: 2.863 ± 0.022	4.73IleSer: 4.73 ± 0.035	3.282IleThr: 3.282 ± 0.025	3.439IleVal: 3.439 ± 0.03	0.792IleTrp: 0.792 ± 0.012	1.598IleTyr: 1.598 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	4.041LysAla: 4.041 ± 0.034	0.534LysCys: 0.534 ± 0.011	2.59LysAsp: 2.59 ± 0.025	3.389LysGlu: 3.389 ± 0.034	1.523LysPhe: 1.523 ± 0.018	2.904LysGly: 2.904 ± 0.026	1.133LysHis: 1.133 ± 0.014	2.319LysIle: 2.319 ± 0.021	3.271LysLys: 3.271 ± 0.037	4.151LysLeu: 4.151 ± 0.03	0.997LysMet: 0.997 ± 0.012	1.708LysAsn: 1.708 ± 0.019	2.565LysPro: 2.565 ± 0.024	1.68LysGln: 1.68 ± 0.018	3.276LysArg: 3.276 ± 0.03	3.508LysSer: 3.508 ± 0.027	2.663LysThr: 2.663 ± 0.023	2.801LysVal: 2.801 ± 0.024	0.748LysTrp: 0.748 ± 0.012	1.384LysTyr: 1.384 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	7.765LeuAla: 7.765 ± 0.049	1.292LeuCys: 1.292 ± 0.015	4.957LeuAsp: 4.957 ± 0.036	5.329LeuGlu: 5.329 ± 0.037	3.623LeuPhe: 3.623 ± 0.03	5.632LeuGly: 5.632 ± 0.04	2.547LeuHis: 2.547 ± 0.023	4.486LeuIle: 4.486 ± 0.037	4.406LeuLys: 4.406 ± 0.034	9.163LeuLeu: 9.163 ± 0.055	1.813LeuMet: 1.813 ± 0.017	3.481LeuAsn: 3.481 ± 0.025	6.257LeuPro: 6.257 ± 0.038	3.783LeuGln: 3.783 ± 0.031	5.568LeuArg: 5.568 ± 0.043	8.462LeuSer: 8.462 ± 0.046	5.388LeuThr: 5.388 ± 0.033	5.627LeuVal: 5.627 ± 0.038	1.227LeuTrp: 1.227 ± 0.017	2.539LeuTyr: 2.539 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	1.811MetAla: 1.811 ± 0.02	0.245MetCys: 0.245 ± 0.007	1.24MetAsp: 1.24 ± 0.016	1.249MetGlu: 1.249 ± 0.018	0.8MetPhe: 0.8 ± 0.012	1.365MetGly: 1.365 ± 0.018	0.557MetHis: 0.557 ± 0.009	1.056MetIle: 1.056 ± 0.014	1.046MetLys: 1.046 ± 0.014	1.98MetLeu: 1.98 ± 0.021	0.527MetMet: 0.527 ± 0.01	0.828MetAsn: 0.828 ± 0.013	1.286MetPro: 1.286 ± 0.017	0.85MetGln: 0.85 ± 0.013	1.218MetArg: 1.218 ± 0.013	2.019MetSer: 2.019 ± 0.02	1.256MetThr: 1.256 ± 0.015	1.237MetVal: 1.237 ± 0.017	0.271MetTrp: 0.271 ± 0.006	0.567MetTyr: 0.567 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.241AsnAla: 3.241 ± 0.028	0.42AsnCys: 0.42 ± 0.01	1.924AsnAsp: 1.924 ± 0.017	1.929AsnGlu: 1.929 ± 0.02	1.418AsnPhe: 1.418 ± 0.017	2.753AsnGly: 2.753 ± 0.028	0.902AsnHis: 0.902 ± 0.013	2.311AsnIle: 2.311 ± 0.022	1.516AsnLys: 1.516 ± 0.017	3.433AsnLeu: 3.433 ± 0.027	0.814AsnMet: 0.814 ± 0.011	1.553AsnAsn: 1.553 ± 0.02	2.473AsnPro: 2.473 ± 0.025	1.295AsnGln: 1.295 ± 0.016	1.754AsnArg: 1.754 ± 0.018	3.104AsnSer: 3.104 ± 0.025	2.378AsnThr: 2.378 ± 0.024	2.493AsnVal: 2.493 ± 0.022	0.53AsnTrp: 0.53 ± 0.01	1.012AsnTyr: 1.012 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	5.115ProAla: 5.115 ± 0.044	0.515ProCys: 0.515 ± 0.012	2.927ProAsp: 2.927 ± 0.029	3.377ProGlu: 3.377 ± 0.027	2.293ProPhe: 2.293 ± 0.026	3.556ProGly: 3.556 ± 0.032	1.587ProHis: 1.587 ± 0.02	3.1ProIle: 3.1 ± 0.027	2.503ProLys: 2.503 ± 0.023	5.381ProLeu: 5.381 ± 0.034	1.109ProMet: 1.109 ± 0.014	2.338ProAsn: 2.338 ± 0.024	6.143ProPro: 6.143 ± 0.073	2.35ProGln: 2.35 ± 0.027	3.233ProArg: 3.233 ± 0.032	7.226ProSer: 7.226 ± 0.064	4.581ProThr: 4.581 ± 0.038	3.681ProVal: 3.681 ± 0.031	0.708ProTrp: 0.708 ± 0.013	1.626ProTyr: 1.626 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.017GlnAla: 3.017 ± 0.027	0.5GlnCys: 0.5 ± 0.01	1.799GlnAsp: 1.799 ± 0.018	2.126GlnGlu: 2.126 ± 0.022	1.302GlnPhe: 1.302 ± 0.015	2.048GlnGly: 2.048 ± 0.022	1.101GlnHis: 1.101 ± 0.017	1.873GlnIle: 1.873 ± 0.019	1.721GlnLys: 1.721 ± 0.021	3.474GlnLeu: 3.474 ± 0.032	0.836GlnMet: 0.836 ± 0.012	1.404GlnAsn: 1.404 ± 0.018	2.311GlnPro: 2.311 ± 0.029	2.227GlnGln: 2.227 ± 0.058	2.302GlnArg: 2.302 ± 0.022	3.027GlnSer: 3.027 ± 0.029	2.243GlnThr: 2.243 ± 0.017	2.105GlnVal: 2.105 ± 0.019	0.549GlnTrp: 0.549 ± 0.009	1.096GlnTyr: 1.096 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.299ArgAla: 4.299 ± 0.029	0.722ArgCys: 0.722 ± 0.013	2.891ArgAsp: 2.891 ± 0.026	3.488ArgGlu: 3.488 ± 0.033	2.078ArgPhe: 2.078 ± 0.021	3.317ArgGly: 3.317 ± 0.031	1.461ArgHis: 1.461 ± 0.017	3.014ArgIle: 3.014 ± 0.023	3.26ArgLys: 3.26 ± 0.029	5.198ArgLeu: 5.198 ± 0.034	1.304ArgMet: 1.304 ± 0.015	2.139ArgAsn: 2.139 ± 0.021	3.294ArgPro: 3.294 ± 0.03	2.131ArgGln: 2.131 ± 0.023	4.607ArgArg: 4.607 ± 0.04	4.905ArgSer: 4.905 ± 0.045	3.345ArgThr: 3.345 ± 0.023	3.391ArgVal: 3.391 ± 0.025	0.892ArgTrp: 0.892 ± 0.012	1.593ArgTyr: 1.593 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.919SerAla: 6.919 ± 0.039	1.011SerCys: 1.011 ± 0.015	4.193SerAsp: 4.193 ± 0.034	4.106SerGlu: 4.106 ± 0.03	3.481SerPhe: 3.481 ± 0.025	5.521SerGly: 5.521 ± 0.035	2.253SerHis: 2.253 ± 0.023	4.761SerIle: 4.761 ± 0.028	3.784SerLys: 3.784 ± 0.029	8.323SerLeu: 8.323 ± 0.047	1.899SerMet: 1.899 ± 0.02	3.385SerAsn: 3.385 ± 0.026	6.391SerPro: 6.391 ± 0.068	3.196SerGln: 3.196 ± 0.033	5.086SerArg: 5.086 ± 0.047	10.954SerSer: 10.954 ± 0.087	6.588SerThr: 6.588 ± 0.045	5.113SerVal: 5.113 ± 0.028	1.134SerTrp: 1.134 ± 0.014	2.233SerTyr: 2.233 ± 0.023	0.0SerXaa: 0.0 ± 0.0
Thr	4.992ThrAla: 4.992 ± 0.034	0.787ThrCys: 0.787 ± 0.013	2.725ThrAsp: 2.725 ± 0.021	2.856ThrGlu: 2.856 ± 0.023	2.529ThrPhe: 2.529 ± 0.023	3.884ThrGly: 3.884 ± 0.031	1.563ThrHis: 1.563 ± 0.02	3.463ThrIle: 3.463 ± 0.025	2.504ThrLys: 2.504 ± 0.022	5.988ThrLeu: 5.988 ± 0.036	1.238ThrMet: 1.238 ± 0.015	2.244ThrAsn: 2.244 ± 0.019	4.808ThrPro: 4.808 ± 0.045	2.091ThrGln: 2.091 ± 0.021	3.259ThrArg: 3.259 ± 0.025	6.214ThrSer: 6.214 ± 0.045	4.553ThrThr: 4.553 ± 0.035	3.922ThrVal: 3.922 ± 0.029	0.813ThrTrp: 0.813 ± 0.012	1.69ThrTyr: 1.69 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	4.921ValAla: 4.921 ± 0.03	0.824ValCys: 0.824 ± 0.013	3.692ValAsp: 3.692 ± 0.026	3.731ValGlu: 3.731 ± 0.032	2.52ValPhe: 2.52 ± 0.024	3.861ValGly: 3.861 ± 0.028	1.547ValHis: 1.547 ± 0.016	3.351ValIle: 3.351 ± 0.03	3.026ValLys: 3.026 ± 0.023	6.013ValLeu: 6.013 ± 0.036	1.385ValMet: 1.385 ± 0.016	2.341ValAsn: 2.341 ± 0.023	3.675ValPro: 3.675 ± 0.028	2.353ValGln: 2.353 ± 0.019	3.248ValArg: 3.248 ± 0.025	4.795ValSer: 4.795 ± 0.033	3.654ValThr: 3.654 ± 0.028	4.422ValVal: 4.422 ± 0.033	0.921ValTrp: 0.921 ± 0.013	1.824ValTyr: 1.824 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.025TrpAla: 1.025 ± 0.013	0.214TrpCys: 0.214 ± 0.006	0.87TrpAsp: 0.87 ± 0.012	0.802TrpGlu: 0.802 ± 0.011	0.564TrpPhe: 0.564 ± 0.011	0.886TrpGly: 0.886 ± 0.015	0.33TrpHis: 0.33 ± 0.008	0.855TrpIle: 0.855 ± 0.012	0.862TrpLys: 0.862 ± 0.013	1.298TrpLeu: 1.298 ± 0.016	0.366TrpMet: 0.366 ± 0.009	0.669TrpAsn: 0.669 ± 0.012	0.567TrpPro: 0.567 ± 0.009	0.478TrpGln: 0.478 ± 0.011	0.898TrpArg: 0.898 ± 0.012	1.163TrpSer: 1.163 ± 0.017	0.923TrpThr: 0.923 ± 0.013	0.861TrpVal: 0.861 ± 0.013	0.292TrpTrp: 0.292 ± 0.007	0.401TrpTyr: 0.401 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.18TyrAla: 2.18 ± 0.021	0.393TyrCys: 0.393 ± 0.008	1.623TyrAsp: 1.623 ± 0.019	1.421TyrGlu: 1.421 ± 0.018	1.236TyrPhe: 1.236 ± 0.015	1.898TyrGly: 1.898 ± 0.022	0.781TyrHis: 0.781 ± 0.011	1.597TyrIle: 1.597 ± 0.019	1.112TyrLys: 1.112 ± 0.014	2.673TyrLeu: 2.673 ± 0.025	0.601TyrMet: 0.601 ± 0.01	1.123TyrAsn: 1.123 ± 0.014	1.654TyrPro: 1.654 ± 0.02	1.054TyrGln: 1.054 ± 0.015	1.544TyrArg: 1.544 ± 0.018	2.26TyrSer: 2.26 ± 0.021	1.761TyrThr: 1.761 ± 0.019	1.649TyrVal: 1.649 ± 0.017	0.404TyrTrp: 0.404 ± 0.008	0.9TyrTyr: 0.9 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.024XaaXaa: 0.024 ± 0.024

Statistics based on 14180 proteins (5698666 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---