Amino acid dipepetide frequency for Altererythrobacter salegens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.284AlaAla: 17.284 ± 0.202	1.107AlaCys: 1.107 ± 0.029	7.024AlaAsp: 7.024 ± 0.085	8.023AlaGlu: 8.023 ± 0.09	4.25AlaPhe: 4.25 ± 0.061	10.973AlaGly: 10.973 ± 0.102	2.129AlaHis: 2.129 ± 0.043	6.523AlaIle: 6.523 ± 0.083	4.254AlaLys: 4.254 ± 0.073	13.287AlaLeu: 13.287 ± 0.169	3.915AlaMet: 3.915 ± 0.06	3.238AlaAsn: 3.238 ± 0.065	5.691AlaPro: 5.691 ± 0.095	4.149AlaGln: 4.149 ± 0.068	8.494AlaArg: 8.494 ± 0.102	6.481AlaSer: 6.481 ± 0.076	6.059AlaThr: 6.059 ± 0.077	8.227AlaVal: 8.227 ± 0.093	1.689AlaTrp: 1.689 ± 0.043	2.679AlaTyr: 2.679 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.992CysAla: 0.992 ± 0.026	0.111CysCys: 0.111 ± 0.01	0.596CysAsp: 0.596 ± 0.021	0.517CysGlu: 0.517 ± 0.023	0.297CysPhe: 0.297 ± 0.015	0.901CysGly: 0.901 ± 0.028	0.237CysHis: 0.237 ± 0.015	0.344CysIle: 0.344 ± 0.018	0.213CysLys: 0.213 ± 0.015	0.71CysLeu: 0.71 ± 0.028	0.152CysMet: 0.152 ± 0.011	0.253CysAsn: 0.253 ± 0.019	0.435CysPro: 0.435 ± 0.021	0.197CysGln: 0.197 ± 0.011	0.592CysArg: 0.592 ± 0.025	0.531CysSer: 0.531 ± 0.023	0.429CysThr: 0.429 ± 0.022	0.585CysVal: 0.585 ± 0.026	0.127CysTrp: 0.127 ± 0.011	0.201CysTyr: 0.201 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.979AspAla: 6.979 ± 0.086	0.548AspCys: 0.548 ± 0.023	3.431AspAsp: 3.431 ± 0.06	4.145AspGlu: 4.145 ± 0.071	2.384AspPhe: 2.384 ± 0.044	5.807AspGly: 5.807 ± 0.091	1.293AspHis: 1.293 ± 0.034	2.75AspIle: 2.75 ± 0.056	1.983AspLys: 1.983 ± 0.049	5.776AspLeu: 5.776 ± 0.075	1.403AspMet: 1.403 ± 0.038	1.541AspAsn: 1.541 ± 0.042	4.039AspPro: 4.039 ± 0.062	1.668AspGln: 1.668 ± 0.036	4.329AspArg: 4.329 ± 0.068	2.59AspSer: 2.59 ± 0.056	2.76AspThr: 2.76 ± 0.053	3.97AspVal: 3.97 ± 0.071	1.243AspTrp: 1.243 ± 0.035	1.668AspTyr: 1.668 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	8.241GluAla: 8.241 ± 0.109	0.409GluCys: 0.409 ± 0.02	3.378GluAsp: 3.378 ± 0.062	3.73GluGlu: 3.73 ± 0.075	2.018GluPhe: 2.018 ± 0.046	5.175GluGly: 5.175 ± 0.071	1.358GluHis: 1.358 ± 0.041	3.182GluIle: 3.182 ± 0.058	2.276GluLys: 2.276 ± 0.053	5.865GluLeu: 5.865 ± 0.081	1.571GluMet: 1.571 ± 0.038	1.6GluAsn: 1.6 ± 0.043	2.939GluPro: 2.939 ± 0.053	2.233GluGln: 2.233 ± 0.048	5.051GluArg: 5.051 ± 0.08	2.566GluSer: 2.566 ± 0.054	3.251GluThr: 3.251 ± 0.049	4.219GluVal: 4.219 ± 0.068	0.967GluTrp: 0.967 ± 0.03	1.266GluTyr: 1.266 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	5.197PheAla: 5.197 ± 0.077	0.316PheCys: 0.316 ± 0.016	2.862PheAsp: 2.862 ± 0.05	2.316PheGlu: 2.316 ± 0.048	1.317PhePhe: 1.317 ± 0.042	3.941PheGly: 3.941 ± 0.073	0.731PheHis: 0.731 ± 0.025	1.462PheIle: 1.462 ± 0.041	0.97PheLys: 0.97 ± 0.034	3.051PheLeu: 3.051 ± 0.065	0.784PheMet: 0.784 ± 0.029	1.081PheAsn: 1.081 ± 0.036	1.667PhePro: 1.667 ± 0.041	0.928PheGln: 0.928 ± 0.03	2.154PheArg: 2.154 ± 0.039	2.076PheSer: 2.076 ± 0.047	2.151PheThr: 2.151 ± 0.04	2.772PheVal: 2.772 ± 0.055	0.564PheTrp: 0.564 ± 0.026	1.006PheTyr: 1.006 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.406GlyAla: 9.406 ± 0.1	0.873GlyCys: 0.873 ± 0.031	5.084GlyAsp: 5.084 ± 0.081	5.768GlyGlu: 5.768 ± 0.077	3.715GlyPhe: 3.715 ± 0.067	8.286GlyGly: 8.286 ± 0.165	1.913GlyHis: 1.913 ± 0.047	4.544GlyIle: 4.544 ± 0.07	3.992GlyLys: 3.992 ± 0.077	8.452GlyLeu: 8.452 ± 0.093	2.489GlyMet: 2.489 ± 0.05	2.663GlyAsn: 2.663 ± 0.06	4.005GlyPro: 4.005 ± 0.061	2.875GlyGln: 2.875 ± 0.057	5.785GlyArg: 5.785 ± 0.074	5.174GlySer: 5.174 ± 0.093	5.118GlyThr: 5.118 ± 0.093	6.118GlyVal: 6.118 ± 0.08	1.723GlyTrp: 1.723 ± 0.043	2.422GlyTyr: 2.422 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.177HisAla: 2.177 ± 0.05	0.236HisCys: 0.236 ± 0.017	1.279HisAsp: 1.279 ± 0.033	1.165HisGlu: 1.165 ± 0.031	0.906HisPhe: 0.906 ± 0.029	1.951HisGly: 1.951 ± 0.05	0.584HisHis: 0.584 ± 0.026	0.878HisIle: 0.878 ± 0.028	0.482HisLys: 0.482 ± 0.023	1.881HisLeu: 1.881 ± 0.047	0.459HisMet: 0.459 ± 0.02	0.494HisAsn: 0.494 ± 0.024	1.32HisPro: 1.32 ± 0.036	0.513HisGln: 0.513 ± 0.018	1.365HisArg: 1.365 ± 0.043	1.07HisSer: 1.07 ± 0.029	0.831HisThr: 0.831 ± 0.027	1.441HisVal: 1.441 ± 0.042	0.421HisTrp: 0.421 ± 0.022	0.593HisTyr: 0.593 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.175IleAla: 7.175 ± 0.099	0.417IleCys: 0.417 ± 0.016	3.819IleAsp: 3.819 ± 0.06	3.694IleGlu: 3.694 ± 0.071	1.462IlePhe: 1.462 ± 0.04	4.987IleGly: 4.987 ± 0.077	0.865IleHis: 0.865 ± 0.029	1.808IleIle: 1.808 ± 0.049	1.259IleLys: 1.259 ± 0.037	3.629IleLeu: 3.629 ± 0.059	0.904IleMet: 0.904 ± 0.031	1.217IleAsn: 1.217 ± 0.039	2.337IlePro: 2.337 ± 0.046	1.002IleGln: 1.002 ± 0.03	2.942IleArg: 2.942 ± 0.055	2.671IleSer: 2.671 ± 0.052	2.312IleThr: 2.312 ± 0.048	3.97IleVal: 3.97 ± 0.06	0.612IleTrp: 0.612 ± 0.028	1.061IleTyr: 1.061 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.215LysAla: 4.215 ± 0.067	0.19LysCys: 0.19 ± 0.015	1.88LysAsp: 1.88 ± 0.05	1.531LysGlu: 1.531 ± 0.048	1.073LysPhe: 1.073 ± 0.034	2.806LysGly: 2.806 ± 0.058	0.591LysHis: 0.591 ± 0.024	1.506LysIle: 1.506 ± 0.04	1.233LysLys: 1.233 ± 0.043	3.432LysLeu: 3.432 ± 0.052	0.796LysMet: 0.796 ± 0.03	0.773LysAsn: 0.773 ± 0.031	2.003LysPro: 2.003 ± 0.045	1.032LysGln: 1.032 ± 0.032	2.297LysArg: 2.297 ± 0.046	1.725LysSer: 1.725 ± 0.037	1.694LysThr: 1.694 ± 0.043	2.521LysVal: 2.521 ± 0.049	0.531LysTrp: 0.531 ± 0.023	0.725LysTyr: 0.725 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	14.339LeuAla: 14.339 ± 0.172	0.793LeuCys: 0.793 ± 0.028	6.136LeuAsp: 6.136 ± 0.074	5.472LeuGlu: 5.472 ± 0.081	3.492LeuPhe: 3.492 ± 0.074	8.354LeuGly: 8.354 ± 0.084	1.826LeuHis: 1.826 ± 0.046	4.065LeuIle: 4.065 ± 0.08	3.025LeuLys: 3.025 ± 0.064	9.279LeuLeu: 9.279 ± 0.115	2.066LeuMet: 2.066 ± 0.045	2.216LeuAsn: 2.216 ± 0.042	5.614LeuPro: 5.614 ± 0.079	2.549LeuGln: 2.549 ± 0.054	6.336LeuArg: 6.336 ± 0.083	5.753LeuSer: 5.753 ± 0.077	5.311LeuThr: 5.311 ± 0.073	7.55LeuVal: 7.55 ± 0.086	1.256LeuTrp: 1.256 ± 0.038	1.982LeuTyr: 1.982 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.221MetAla: 3.221 ± 0.065	0.165MetCys: 0.165 ± 0.012	1.17MetAsp: 1.17 ± 0.033	1.151MetGlu: 1.151 ± 0.038	0.794MetPhe: 0.794 ± 0.03	1.985MetGly: 1.985 ± 0.049	0.513MetHis: 0.513 ± 0.022	1.324MetIle: 1.324 ± 0.039	0.984MetLys: 0.984 ± 0.035	2.493MetLeu: 2.493 ± 0.051	0.631MetMet: 0.631 ± 0.024	0.73MetAsn: 0.73 ± 0.025	1.51MetPro: 1.51 ± 0.039	0.808MetGln: 0.808 ± 0.027	1.836MetArg: 1.836 ± 0.035	1.439MetSer: 1.439 ± 0.033	1.649MetThr: 1.649 ± 0.046	1.595MetVal: 1.595 ± 0.041	0.273MetTrp: 0.273 ± 0.018	0.344MetTyr: 0.344 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.108AsnAla: 3.108 ± 0.057	0.297AsnCys: 0.297 ± 0.016	1.443AsnAsp: 1.443 ± 0.037	1.328AsnGlu: 1.328 ± 0.035	1.055AsnPhe: 1.055 ± 0.034	2.604AsnGly: 2.604 ± 0.061	0.509AsnHis: 0.509 ± 0.025	1.236AsnIle: 1.236 ± 0.033	0.714AsnLys: 0.714 ± 0.027	2.579AsnLeu: 2.579 ± 0.053	0.624AsnMet: 0.624 ± 0.022	0.717AsnAsn: 0.717 ± 0.032	1.874AsnPro: 1.874 ± 0.05	0.743AsnGln: 0.743 ± 0.025	1.87AsnArg: 1.87 ± 0.05	1.429AsnSer: 1.429 ± 0.041	1.196AsnThr: 1.196 ± 0.037	1.942AsnVal: 1.942 ± 0.045	0.455AsnTrp: 0.455 ± 0.021	0.744AsnTyr: 0.744 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.474ProAla: 6.474 ± 0.091	0.353ProCys: 0.353 ± 0.018	3.955ProAsp: 3.955 ± 0.064	4.008ProGlu: 4.008 ± 0.062	2.094ProPhe: 2.094 ± 0.048	4.864ProGly: 4.864 ± 0.075	1.074ProHis: 1.074 ± 0.034	2.341ProIle: 2.341 ± 0.047	1.633ProLys: 1.633 ± 0.043	4.927ProLeu: 4.927 ± 0.075	1.183ProMet: 1.183 ± 0.036	1.396ProAsn: 1.396 ± 0.031	2.938ProPro: 2.938 ± 0.056	1.773ProGln: 1.773 ± 0.043	2.882ProArg: 2.882 ± 0.055	2.682ProSer: 2.682 ± 0.051	2.524ProThr: 2.524 ± 0.048	4.205ProVal: 4.205 ± 0.066	0.749ProTrp: 0.749 ± 0.024	1.219ProTyr: 1.219 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.88GlnAla: 3.88 ± 0.064	0.237GlnCys: 0.237 ± 0.013	1.544GlnAsp: 1.544 ± 0.044	1.416GlnGlu: 1.416 ± 0.038	1.2GlnPhe: 1.2 ± 0.036	2.457GlnGly: 2.457 ± 0.05	0.631GlnHis: 0.631 ± 0.026	1.535GlnIle: 1.535 ± 0.038	0.861GlnLys: 0.861 ± 0.029	3.04GlnLeu: 3.04 ± 0.058	0.819GlnMet: 0.819 ± 0.026	0.746GlnAsn: 0.746 ± 0.028	1.738GlnPro: 1.738 ± 0.04	1.148GlnGln: 1.148 ± 0.037	2.262GlnArg: 2.262 ± 0.05	1.639GlnSer: 1.639 ± 0.043	1.424GlnThr: 1.424 ± 0.041	2.521GlnVal: 2.521 ± 0.046	0.523GlnTrp: 0.523 ± 0.023	0.678GlnTyr: 0.678 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.394ArgAla: 7.394 ± 0.091	0.503ArgCys: 0.503 ± 0.024	3.868ArgAsp: 3.868 ± 0.07	4.527ArgGlu: 4.527 ± 0.066	2.945ArgPhe: 2.945 ± 0.05	4.904ArgGly: 4.904 ± 0.075	1.553ArgHis: 1.553 ± 0.04	3.789ArgIle: 3.789 ± 0.063	2.452ArgLys: 2.452 ± 0.056	7.309ArgLeu: 7.309 ± 0.097	1.818ArgMet: 1.818 ± 0.04	1.887ArgAsn: 1.887 ± 0.041	3.366ArgPro: 3.366 ± 0.059	2.348ArgGln: 2.348 ± 0.046	5.098ArgArg: 5.098 ± 0.09	3.524ArgSer: 3.524 ± 0.058	3.238ArgThr: 3.238 ± 0.056	4.319ArgVal: 4.319 ± 0.066	1.169ArgTrp: 1.169 ± 0.036	1.767ArgTyr: 1.767 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.126SerAla: 6.126 ± 0.088	0.455SerCys: 0.455 ± 0.021	3.267SerAsp: 3.267 ± 0.063	3.137SerGlu: 3.137 ± 0.056	2.165SerPhe: 2.165 ± 0.051	5.72SerGly: 5.72 ± 0.089	1.053SerHis: 1.053 ± 0.029	2.678SerIle: 2.678 ± 0.057	1.644SerLys: 1.644 ± 0.037	5.332SerLeu: 5.332 ± 0.073	1.239SerMet: 1.239 ± 0.038	1.524SerAsn: 1.524 ± 0.04	2.78SerPro: 2.78 ± 0.055	1.576SerGln: 1.576 ± 0.041	3.348SerArg: 3.348 ± 0.064	2.878SerSer: 2.878 ± 0.063	2.647SerThr: 2.647 ± 0.057	3.627SerVal: 3.627 ± 0.057	0.85SerTrp: 0.85 ± 0.031	1.401SerTyr: 1.401 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.072ThrAla: 6.072 ± 0.075	0.43ThrCys: 0.43 ± 0.023	2.826ThrAsp: 2.826 ± 0.059	2.622ThrGlu: 2.622 ± 0.055	2.005ThrPhe: 2.005 ± 0.048	5.484ThrGly: 5.484 ± 0.088	0.92ThrHis: 0.92 ± 0.03	2.84ThrIle: 2.84 ± 0.053	1.35ThrLys: 1.35 ± 0.04	5.275ThrLeu: 5.275 ± 0.061	1.234ThrMet: 1.234 ± 0.033	1.36ThrAsn: 1.36 ± 0.045	3.11ThrPro: 3.11 ± 0.063	1.331ThrGln: 1.331 ± 0.038	3.135ThrArg: 3.135 ± 0.049	2.819ThrSer: 2.819 ± 0.056	2.638ThrThr: 2.638 ± 0.066	4.151ThrVal: 4.151 ± 0.077	0.77ThrTrp: 0.77 ± 0.029	1.343ThrTyr: 1.343 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	9.052ValAla: 9.052 ± 0.11	0.586ValCys: 0.586 ± 0.024	4.207ValAsp: 4.207 ± 0.071	4.689ValGlu: 4.689 ± 0.077	2.537ValPhe: 2.537 ± 0.049	5.829ValGly: 5.829 ± 0.077	1.337ValHis: 1.337 ± 0.036	3.665ValIle: 3.665 ± 0.065	2.039ValLys: 2.039 ± 0.05	6.933ValLeu: 6.933 ± 0.098	1.677ValMet: 1.677 ± 0.041	1.862ValAsn: 1.862 ± 0.047	3.98ValPro: 3.98 ± 0.057	1.984ValGln: 1.984 ± 0.044	4.738ValArg: 4.738 ± 0.064	4.135ValSer: 4.135 ± 0.068	4.531ValThr: 4.531 ± 0.078	5.48ValVal: 5.48 ± 0.08	1.006ValTrp: 1.006 ± 0.03	1.438ValTyr: 1.438 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.49TrpAla: 1.49 ± 0.04	0.131TrpCys: 0.131 ± 0.012	0.879TrpAsp: 0.879 ± 0.031	0.711TrpGlu: 0.711 ± 0.025	0.649TrpPhe: 0.649 ± 0.023	1.084TrpGly: 1.084 ± 0.032	0.415TrpHis: 0.415 ± 0.019	0.747TrpIle: 0.747 ± 0.027	0.537TrpLys: 0.537 ± 0.023	1.876TrpLeu: 1.876 ± 0.045	0.404TrpMet: 0.404 ± 0.018	0.517TrpAsn: 0.517 ± 0.024	0.81TrpPro: 0.81 ± 0.03	0.736TrpGln: 0.736 ± 0.025	1.386TrpArg: 1.386 ± 0.039	0.937TrpSer: 0.937 ± 0.032	0.84TrpThr: 0.84 ± 0.029	0.865TrpVal: 0.865 ± 0.029	0.306TrpTrp: 0.306 ± 0.017	0.361TrpTyr: 0.361 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.654TyrAla: 2.654 ± 0.048	0.264TyrCys: 0.264 ± 0.017	1.662TyrAsp: 1.662 ± 0.039	1.341TyrGlu: 1.341 ± 0.04	0.99TyrPhe: 0.99 ± 0.032	2.292TyrGly: 2.292 ± 0.05	0.515TyrHis: 0.515 ± 0.021	0.927TyrIle: 0.927 ± 0.028	0.654TyrLys: 0.654 ± 0.027	2.284TyrLeu: 2.284 ± 0.05	0.446TyrMet: 0.446 ± 0.019	0.652TyrAsn: 0.652 ± 0.027	1.12TyrPro: 1.12 ± 0.032	0.702TyrGln: 0.702 ± 0.028	1.881TyrArg: 1.881 ± 0.05	1.33TyrSer: 1.33 ± 0.035	1.11TyrThr: 1.11 ± 0.034	1.627TyrVal: 1.627 ± 0.039	0.449TyrTrp: 0.449 ± 0.019	0.709TyrTyr: 0.709 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3438 proteins (1082438 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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