Amino acid dipepetide frequency for Aeromonas virus 25

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.138AlaAla: 5.138 ± 0.343
0.605AlaCys: 0.605 ± 0.114
4.151AlaAsp: 4.151 ± 0.246
4.776AlaGlu: 4.776 ± 0.374
2.66AlaPhe: 2.66 ± 0.231
4.635AlaGly: 4.635 ± 0.466
1.39AlaHis: 1.39 ± 0.155
5.179AlaIle: 5.179 ± 0.306
5.421AlaLys: 5.421 ± 0.416
5.602AlaLeu: 5.602 ± 0.349
2.035AlaMet: 2.035 ± 0.217
3.929AlaAsn: 3.929 ± 0.301
2.055AlaPro: 2.055 ± 0.2
2.781AlaGln: 2.781 ± 0.289
3.405AlaArg: 3.405 ± 0.31
4.03AlaSer: 4.03 ± 0.329
3.768AlaThr: 3.768 ± 0.437
4.756AlaVal: 4.756 ± 0.281
1.169AlaTrp: 1.169 ± 0.159
2.72AlaTyr: 2.72 ± 0.238
0.0AlaXaa: 0.0 ± 0.0
Cys
0.846CysAla: 0.846 ± 0.133
0.222CysCys: 0.222 ± 0.067
0.786CysAsp: 0.786 ± 0.111
0.907CysGlu: 0.907 ± 0.138
0.484CysPhe: 0.484 ± 0.1
0.685CysGly: 0.685 ± 0.137
0.282CysHis: 0.282 ± 0.077
0.443CysIle: 0.443 ± 0.084
0.866CysLys: 0.866 ± 0.145
0.625CysLeu: 0.625 ± 0.105
0.181CysMet: 0.181 ± 0.056
0.504CysAsn: 0.504 ± 0.101
0.625CysPro: 0.625 ± 0.104
0.443CysGln: 0.443 ± 0.08
0.746CysArg: 0.746 ± 0.102
0.826CysSer: 0.826 ± 0.128
0.625CysThr: 0.625 ± 0.103
0.806CysVal: 0.806 ± 0.13
0.161CysTrp: 0.161 ± 0.055
0.524CysTyr: 0.524 ± 0.091
0.0CysXaa: 0.0 ± 0.0
Asp
3.97AspAla: 3.97 ± 0.262
0.766AspCys: 0.766 ± 0.125
4.212AspAsp: 4.212 ± 0.344
4.836AspGlu: 4.836 ± 0.398
3.506AspPhe: 3.506 ± 0.249
4.897AspGly: 4.897 ± 0.309
1.008AspHis: 1.008 ± 0.165
5.279AspIle: 5.279 ± 0.325
3.345AspLys: 3.345 ± 0.271
4.191AspLeu: 4.191 ± 0.294
2.217AspMet: 2.217 ± 0.239
2.68AspAsn: 2.68 ± 0.199
2.055AspPro: 2.055 ± 0.193
1.995AspGln: 1.995 ± 0.187
2.479AspArg: 2.479 ± 0.238
3.808AspSer: 3.808 ± 0.257
3.264AspThr: 3.264 ± 0.245
3.849AspVal: 3.849 ± 0.275
1.269AspTrp: 1.269 ± 0.187
2.599AspTyr: 2.599 ± 0.28
0.0AspXaa: 0.0 ± 0.0
Glu
4.756GluAla: 4.756 ± 0.368
0.766GluCys: 0.766 ± 0.123
3.244GluAsp: 3.244 ± 0.274
4.312GluGlu: 4.312 ± 0.376
3.365GluPhe: 3.365 ± 0.221
3.264GluGly: 3.264 ± 0.277
1.451GluHis: 1.451 ± 0.177
6.005GluIle: 6.005 ± 0.339
4.917GluLys: 4.917 ± 0.422
6.126GluLeu: 6.126 ± 0.399
2.458GluMet: 2.458 ± 0.243
4.03GluAsn: 4.03 ± 0.249
1.713GluPro: 1.713 ± 0.17
2.438GluGln: 2.438 ± 0.313
3.043GluArg: 3.043 ± 0.251
4.07GluSer: 4.07 ± 0.263
3.325GluThr: 3.325 ± 0.307
4.393GluVal: 4.393 ± 0.266
1.169GluTrp: 1.169 ± 0.212
2.922GluTyr: 2.922 ± 0.248
0.0GluXaa: 0.0 ± 0.0
Phe
3.244PheAla: 3.244 ± 0.296
0.625PheCys: 0.625 ± 0.107
3.688PheAsp: 3.688 ± 0.277
3.829PheGlu: 3.829 ± 0.312
1.592PhePhe: 1.592 ± 0.176
3.083PheGly: 3.083 ± 0.278
0.746PheHis: 0.746 ± 0.117
3.083PheIle: 3.083 ± 0.239
3.547PheLys: 3.547 ± 0.242
2.519PheLeu: 2.519 ± 0.231
1.189PheMet: 1.189 ± 0.208
2.821PheAsn: 2.821 ± 0.264
1.169PhePro: 1.169 ± 0.147
1.229PheGln: 1.229 ± 0.155
1.753PheArg: 1.753 ± 0.168
3.144PheSer: 3.144 ± 0.272
2.438PheThr: 2.438 ± 0.189
3.426PheVal: 3.426 ± 0.286
0.584PheTrp: 0.584 ± 0.113
1.33PheTyr: 1.33 ± 0.166
0.0PheXaa: 0.0 ± 0.0
Gly
4.433GlyAla: 4.433 ± 0.461
0.806GlyCys: 0.806 ± 0.143
3.869GlyAsp: 3.869 ± 0.302
3.829GlyGlu: 3.829 ± 0.309
2.599GlyPhe: 2.599 ± 0.236
3.97GlyGly: 3.97 ± 0.435
1.128GlyHis: 1.128 ± 0.135
4.514GlyIle: 4.514 ± 0.23
4.655GlyLys: 4.655 ± 0.327
4.232GlyLeu: 4.232 ± 0.297
1.834GlyMet: 1.834 ± 0.234
3.647GlyAsn: 3.647 ± 0.411
1.511GlyPro: 1.511 ± 0.167
2.579GlyGln: 2.579 ± 0.218
2.861GlyArg: 2.861 ± 0.208
4.393GlySer: 4.393 ± 0.395
4.07GlyThr: 4.07 ± 0.437
4.272GlyVal: 4.272 ± 0.305
0.927GlyTrp: 0.927 ± 0.128
3.063GlyTyr: 3.063 ± 0.244
0.0GlyXaa: 0.0 ± 0.0
His
1.149HisAla: 1.149 ± 0.16
0.363HisCys: 0.363 ± 0.088
1.632HisAsp: 1.632 ± 0.166
1.431HisGlu: 1.431 ± 0.175
0.967HisPhe: 0.967 ± 0.137
1.451HisGly: 1.451 ± 0.162
0.524HisHis: 0.524 ± 0.105
1.814HisIle: 1.814 ± 0.209
1.31HisLys: 1.31 ± 0.151
1.894HisLeu: 1.894 ± 0.224
0.302HisMet: 0.302 ± 0.075
0.846HisAsn: 0.846 ± 0.13
0.786HisPro: 0.786 ± 0.125
0.625HisGln: 0.625 ± 0.119
0.887HisArg: 0.887 ± 0.137
1.048HisSer: 1.048 ± 0.144
0.987HisThr: 0.987 ± 0.149
1.189HisVal: 1.189 ± 0.126
0.363HisTrp: 0.363 ± 0.08
0.625HisTyr: 0.625 ± 0.11
0.0HisXaa: 0.0 ± 0.0
Ile
5.562IleAla: 5.562 ± 0.367
0.866IleCys: 0.866 ± 0.126
5.239IleAsp: 5.239 ± 0.318
4.635IleGlu: 4.635 ± 0.375
2.599IlePhe: 2.599 ± 0.254
4.393IleGly: 4.393 ± 0.318
1.29IleHis: 1.29 ± 0.165
4.514IleIle: 4.514 ± 0.296
4.897IleLys: 4.897 ± 0.315
4.635IleLeu: 4.635 ± 0.362
1.753IleMet: 1.753 ± 0.228
4.232IleAsn: 4.232 ± 0.296
2.922IlePro: 2.922 ± 0.294
2.317IleGln: 2.317 ± 0.199
3.506IleArg: 3.506 ± 0.287
4.715IleSer: 4.715 ± 0.288
4.957IleThr: 4.957 ± 0.341
4.836IleVal: 4.836 ± 0.292
0.685IleTrp: 0.685 ± 0.109
2.599IleTyr: 2.599 ± 0.229
0.0IleXaa: 0.0 ± 0.0
Lys
5.34LysAla: 5.34 ± 0.365
0.705LysCys: 0.705 ± 0.117
3.526LysAsp: 3.526 ± 0.253
4.413LysGlu: 4.413 ± 0.347
3.446LysPhe: 3.446 ± 0.281
3.647LysGly: 3.647 ± 0.272
1.834LysHis: 1.834 ± 0.209
4.776LysIle: 4.776 ± 0.318
4.151LysLys: 4.151 ± 0.364
5.219LysLeu: 5.219 ± 0.291
2.358LysMet: 2.358 ± 0.225
3.97LysAsn: 3.97 ± 0.298
2.277LysPro: 2.277 ± 0.215
2.458LysGln: 2.458 ± 0.243
3.365LysArg: 3.365 ± 0.342
4.856LysSer: 4.856 ± 0.32
4.413LysThr: 4.413 ± 0.312
3.808LysVal: 3.808 ± 0.271
0.887LysTrp: 0.887 ± 0.128
2.942LysTyr: 2.942 ± 0.264
0.0LysXaa: 0.0 ± 0.0
Leu
5.38LeuAla: 5.38 ± 0.39
0.866LeuCys: 0.866 ± 0.123
4.615LeuAsp: 4.615 ± 0.335
4.635LeuGlu: 4.635 ± 0.328
3.103LeuPhe: 3.103 ± 0.317
4.413LeuGly: 4.413 ± 0.321
1.028LeuHis: 1.028 ± 0.131
4.252LeuIle: 4.252 ± 0.255
5.421LeuLys: 5.421 ± 0.337
5.018LeuLeu: 5.018 ± 0.293
2.438LeuMet: 2.438 ± 0.196
4.373LeuAsn: 4.373 ± 0.286
3.204LeuPro: 3.204 ± 0.291
2.559LeuGln: 2.559 ± 0.202
3.808LeuArg: 3.808 ± 0.258
5.259LeuSer: 5.259 ± 0.31
3.506LeuThr: 3.506 ± 0.298
4.735LeuVal: 4.735 ± 0.28
0.625LeuTrp: 0.625 ± 0.106
2.902LeuTyr: 2.902 ± 0.272
0.0LeuXaa: 0.0 ± 0.0
Met
2.136MetAla: 2.136 ± 0.179
0.202MetCys: 0.202 ± 0.064
1.33MetAsp: 1.33 ± 0.148
1.733MetGlu: 1.733 ± 0.171
1.753MetPhe: 1.753 ± 0.181
1.632MetGly: 1.632 ± 0.202
0.665MetHis: 0.665 ± 0.107
1.914MetIle: 1.914 ± 0.19
2.479MetLys: 2.479 ± 0.257
2.337MetLeu: 2.337 ± 0.203
0.826MetMet: 0.826 ± 0.133
1.491MetAsn: 1.491 ± 0.174
1.249MetPro: 1.249 ± 0.153
1.209MetGln: 1.209 ± 0.173
1.511MetArg: 1.511 ± 0.172
2.68MetSer: 2.68 ± 0.287
1.894MetThr: 1.894 ± 0.185
1.411MetVal: 1.411 ± 0.132
0.322MetTrp: 0.322 ± 0.09
0.967MetTyr: 0.967 ± 0.126
0.0MetXaa: 0.0 ± 0.0
Asn
3.647AsnAla: 3.647 ± 0.279
0.524AsnCys: 0.524 ± 0.108
3.063AsnAsp: 3.063 ± 0.257
3.526AsnGlu: 3.526 ± 0.254
2.64AsnPhe: 2.64 ± 0.221
4.191AsnGly: 4.191 ± 0.337
1.128AsnHis: 1.128 ± 0.153
3.869AsnIle: 3.869 ± 0.261
3.446AsnLys: 3.446 ± 0.3
3.688AsnLeu: 3.688 ± 0.266
1.612AsnMet: 1.612 ± 0.146
3.123AsnAsn: 3.123 ± 0.313
2.942AsnPro: 2.942 ± 0.232
1.814AsnGln: 1.814 ± 0.173
2.841AsnArg: 2.841 ± 0.255
3.95AsnSer: 3.95 ± 0.257
3.305AsnThr: 3.305 ± 0.358
3.385AsnVal: 3.385 ± 0.266
0.746AsnTrp: 0.746 ± 0.119
1.975AsnTyr: 1.975 ± 0.222
0.0AsnXaa: 0.0 ± 0.0
Pro
2.72ProAla: 2.72 ± 0.238
0.322ProCys: 0.322 ± 0.073
2.317ProAsp: 2.317 ± 0.234
2.882ProGlu: 2.882 ± 0.257
1.652ProPhe: 1.652 ± 0.19
2.358ProGly: 2.358 ± 0.243
0.746ProHis: 0.746 ± 0.111
2.337ProIle: 2.337 ± 0.208
2.217ProLys: 2.217 ± 0.217
2.055ProLeu: 2.055 ± 0.199
1.068ProMet: 1.068 ± 0.142
2.176ProAsn: 2.176 ± 0.207
0.866ProPro: 0.866 ± 0.152
0.826ProGln: 0.826 ± 0.121
1.612ProArg: 1.612 ± 0.187
2.519ProSer: 2.519 ± 0.225
2.196ProThr: 2.196 ± 0.197
2.499ProVal: 2.499 ± 0.271
0.584ProTrp: 0.584 ± 0.113
1.814ProTyr: 1.814 ± 0.184
0.0ProXaa: 0.0 ± 0.0
Gln
2.499GlnAla: 2.499 ± 0.221
0.363GlnCys: 0.363 ± 0.086
1.411GlnAsp: 1.411 ± 0.182
1.793GlnGlu: 1.793 ± 0.211
1.491GlnPhe: 1.491 ± 0.154
1.552GlnGly: 1.552 ± 0.185
0.806GlnHis: 0.806 ± 0.126
2.579GlnIle: 2.579 ± 0.254
2.418GlnLys: 2.418 ± 0.223
3.264GlnLeu: 3.264 ± 0.239
1.229GlnMet: 1.229 ± 0.163
1.834GlnAsn: 1.834 ± 0.191
1.108GlnPro: 1.108 ± 0.165
1.411GlnGln: 1.411 ± 0.181
1.269GlnArg: 1.269 ± 0.176
2.176GlnSer: 2.176 ± 0.15
2.337GlnThr: 2.337 ± 0.242
2.539GlnVal: 2.539 ± 0.233
0.383GlnTrp: 0.383 ± 0.076
1.673GlnTyr: 1.673 ± 0.2
0.0GlnXaa: 0.0 ± 0.0
Arg
3.224ArgAla: 3.224 ± 0.297
0.866ArgCys: 0.866 ± 0.145
2.962ArgAsp: 2.962 ± 0.219
3.264ArgGlu: 3.264 ± 0.27
2.176ArgPhe: 2.176 ± 0.211
2.882ArgGly: 2.882 ± 0.257
1.31ArgHis: 1.31 ± 0.15
3.426ArgIle: 3.426 ± 0.231
3.365ArgLys: 3.365 ± 0.292
3.667ArgLeu: 3.667 ± 0.268
1.471ArgMet: 1.471 ± 0.179
2.579ArgAsn: 2.579 ± 0.244
1.31ArgPro: 1.31 ± 0.182
2.055ArgGln: 2.055 ± 0.246
2.257ArgArg: 2.257 ± 0.245
2.64ArgSer: 2.64 ± 0.232
2.217ArgThr: 2.217 ± 0.222
3.204ArgVal: 3.204 ± 0.241
0.927ArgTrp: 0.927 ± 0.138
2.217ArgTyr: 2.217 ± 0.18
0.0ArgXaa: 0.0 ± 0.0
Ser
4.514SerAla: 4.514 ± 0.306
0.846SerCys: 0.846 ± 0.121
4.131SerAsp: 4.131 ± 0.333
4.353SerGlu: 4.353 ± 0.27
2.942SerPhe: 2.942 ± 0.199
4.735SerGly: 4.735 ± 0.417
1.491SerHis: 1.491 ± 0.184
5.118SerIle: 5.118 ± 0.333
4.312SerLys: 4.312 ± 0.278
4.332SerLeu: 4.332 ± 0.327
1.39SerMet: 1.39 ± 0.174
3.325SerAsn: 3.325 ± 0.26
2.458SerPro: 2.458 ± 0.237
1.874SerGln: 1.874 ± 0.187
3.768SerArg: 3.768 ± 0.199
4.937SerSer: 4.937 ± 0.362
3.849SerThr: 3.849 ± 0.351
4.514SerVal: 4.514 ± 0.303
0.927SerTrp: 0.927 ± 0.132
2.781SerTyr: 2.781 ± 0.237
0.0SerXaa: 0.0 ± 0.0
Thr
3.768ThrAla: 3.768 ± 0.472
0.564ThrCys: 0.564 ± 0.124
3.547ThrAsp: 3.547 ± 0.299
3.607ThrGlu: 3.607 ± 0.279
2.7ThrPhe: 2.7 ± 0.231
4.232ThrGly: 4.232 ± 0.458
1.008ThrHis: 1.008 ± 0.147
4.332ThrIle: 4.332 ± 0.301
3.063ThrLys: 3.063 ± 0.237
4.413ThrLeu: 4.413 ± 0.299
1.572ThrMet: 1.572 ± 0.19
3.144ThrAsn: 3.144 ± 0.256
3.043ThrPro: 3.043 ± 0.245
1.773ThrGln: 1.773 ± 0.217
2.821ThrArg: 2.821 ± 0.272
4.151ThrSer: 4.151 ± 0.376
3.144ThrThr: 3.144 ± 0.268
4.232ThrVal: 4.232 ± 0.286
0.806ThrTrp: 0.806 ± 0.142
1.753ThrTyr: 1.753 ± 0.2
0.0ThrXaa: 0.0 ± 0.0
Val
3.909ValAla: 3.909 ± 0.259
0.705ValCys: 0.705 ± 0.111
4.574ValAsp: 4.574 ± 0.304
5.098ValGlu: 5.098 ± 0.334
2.861ValPhe: 2.861 ± 0.24
4.151ValGly: 4.151 ± 0.351
1.108ValHis: 1.108 ± 0.139
4.433ValIle: 4.433 ± 0.341
5.179ValLys: 5.179 ± 0.391
4.494ValLeu: 4.494 ± 0.264
1.975ValMet: 1.975 ± 0.182
3.607ValAsn: 3.607 ± 0.277
2.358ValPro: 2.358 ± 0.221
1.733ValGln: 1.733 ± 0.196
3.184ValArg: 3.184 ± 0.231
4.292ValSer: 4.292 ± 0.292
4.07ValThr: 4.07 ± 0.395
4.473ValVal: 4.473 ± 0.302
0.887ValTrp: 0.887 ± 0.132
3.043ValTyr: 3.043 ± 0.249
0.0ValXaa: 0.0 ± 0.0
Trp
1.028TrpAla: 1.028 ± 0.14
0.262TrpCys: 0.262 ± 0.07
0.947TrpAsp: 0.947 ± 0.131
0.967TrpGlu: 0.967 ± 0.126
0.725TrpPhe: 0.725 ± 0.119
0.584TrpGly: 0.584 ± 0.112
0.343TrpHis: 0.343 ± 0.089
0.826TrpIle: 0.826 ± 0.125
1.149TrpLys: 1.149 ± 0.167
1.189TrpLeu: 1.189 ± 0.174
0.584TrpMet: 0.584 ± 0.105
0.746TrpAsn: 0.746 ± 0.125
0.343TrpPro: 0.343 ± 0.075
0.705TrpGln: 0.705 ± 0.129
0.746TrpArg: 0.746 ± 0.115
0.786TrpSer: 0.786 ± 0.137
0.685TrpThr: 0.685 ± 0.119
0.887TrpVal: 0.887 ± 0.137
0.161TrpTrp: 0.161 ± 0.054
0.605TrpTyr: 0.605 ± 0.117
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.942TyrAla: 2.942 ± 0.223
0.343TyrCys: 0.343 ± 0.082
2.982TyrAsp: 2.982 ± 0.241
2.942TyrGlu: 2.942 ± 0.252
1.773TyrPhe: 1.773 ± 0.189
2.438TyrGly: 2.438 ± 0.237
0.907TyrHis: 0.907 ± 0.136
2.458TyrIle: 2.458 ± 0.243
2.237TyrLys: 2.237 ± 0.206
2.66TyrLeu: 2.66 ± 0.245
1.229TyrMet: 1.229 ± 0.172
2.358TyrAsn: 2.358 ± 0.22
1.773TyrPro: 1.773 ± 0.185
1.31TyrGln: 1.31 ± 0.148
2.156TyrArg: 2.156 ± 0.246
2.317TyrSer: 2.317 ± 0.235
2.62TyrThr: 2.62 ± 0.205
2.922TyrVal: 2.922 ± 0.279
0.685TyrTrp: 0.685 ± 0.117
1.31TyrTyr: 1.31 ± 0.214
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 242 proteins (49627 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski