Amino acid dipepetide frequency for Gordonia phage AnClar

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.679AlaAla: 16.679 ± 0.989
0.782AlaCys: 0.782 ± 0.265
9.017AlaAsp: 9.017 ± 0.872
8.392AlaGlu: 8.392 ± 0.816
2.971AlaPhe: 2.971 ± 0.409
9.017AlaGly: 9.017 ± 1.042
2.398AlaHis: 2.398 ± 0.339
5.16AlaIle: 5.16 ± 0.628
3.44AlaLys: 3.44 ± 0.493
11.258AlaLeu: 11.258 ± 0.739
3.596AlaMet: 3.596 ± 0.513
3.388AlaAsn: 3.388 ± 0.455
6.619AlaPro: 6.619 ± 0.728
4.952AlaGln: 4.952 ± 0.511
7.922AlaArg: 7.922 ± 0.716
6.724AlaSer: 6.724 ± 0.656
7.818AlaThr: 7.818 ± 0.643
10.581AlaVal: 10.581 ± 0.68
1.981AlaTrp: 1.981 ± 0.37
2.502AlaTyr: 2.502 ± 0.327
0.0AlaXaa: 0.0 ± 0.0
Cys
1.095CysAla: 1.095 ± 0.268
0.156CysCys: 0.156 ± 0.092
0.834CysAsp: 0.834 ± 0.29
0.625CysGlu: 0.625 ± 0.191
0.104CysPhe: 0.104 ± 0.086
1.355CysGly: 1.355 ± 0.404
0.313CysHis: 0.313 ± 0.139
0.104CysIle: 0.104 ± 0.083
0.156CysLys: 0.156 ± 0.093
0.365CysLeu: 0.365 ± 0.163
0.156CysMet: 0.156 ± 0.094
0.313CysAsn: 0.313 ± 0.116
0.678CysPro: 0.678 ± 0.223
0.313CysGln: 0.313 ± 0.127
0.678CysArg: 0.678 ± 0.19
0.886CysSer: 0.886 ± 0.236
0.417CysThr: 0.417 ± 0.183
0.886CysVal: 0.886 ± 0.221
0.052CysTrp: 0.052 ± 0.049
0.313CysTyr: 0.313 ± 0.122
0.0CysXaa: 0.0 ± 0.0
Asp
8.392AspAla: 8.392 ± 0.525
0.625AspCys: 0.625 ± 0.234
5.056AspAsp: 5.056 ± 0.598
5.473AspGlu: 5.473 ± 0.623
1.095AspPhe: 1.095 ± 0.179
5.89AspGly: 5.89 ± 0.486
1.147AspHis: 1.147 ± 0.353
2.762AspIle: 2.762 ± 0.396
1.407AspLys: 1.407 ± 0.318
6.359AspLeu: 6.359 ± 0.562
1.772AspMet: 1.772 ± 0.365
2.033AspAsn: 2.033 ± 0.325
4.378AspPro: 4.378 ± 0.497
1.668AspGln: 1.668 ± 0.287
4.847AspArg: 4.847 ± 0.458
4.274AspSer: 4.274 ± 0.552
3.909AspThr: 3.909 ± 0.42
4.952AspVal: 4.952 ± 0.497
1.459AspTrp: 1.459 ± 0.319
1.355AspTyr: 1.355 ± 0.286
0.0AspXaa: 0.0 ± 0.0
Glu
7.089GluAla: 7.089 ± 0.561
0.886GluCys: 0.886 ± 0.229
3.701GluAsp: 3.701 ± 0.464
1.981GluGlu: 1.981 ± 0.442
1.459GluPhe: 1.459 ± 0.29
4.847GluGly: 4.847 ± 0.612
1.72GluHis: 1.72 ± 0.328
2.762GluIle: 2.762 ± 0.439
0.99GluLys: 0.99 ± 0.271
6.255GluLeu: 6.255 ± 0.765
1.407GluMet: 1.407 ± 0.261
1.251GluAsn: 1.251 ± 0.243
3.648GluPro: 3.648 ± 0.599
2.554GluGln: 2.554 ± 0.301
4.118GluArg: 4.118 ± 0.446
2.45GluSer: 2.45 ± 0.302
3.492GluThr: 3.492 ± 0.482
5.212GluVal: 5.212 ± 0.551
1.407GluTrp: 1.407 ± 0.3
0.938GluTyr: 0.938 ± 0.207
0.0GluXaa: 0.0 ± 0.0
Phe
2.762PheAla: 2.762 ± 0.378
0.052PheCys: 0.052 ± 0.05
2.241PheAsp: 2.241 ± 0.396
1.199PheGlu: 1.199 ± 0.274
0.678PhePhe: 0.678 ± 0.257
2.606PheGly: 2.606 ± 0.388
0.208PheHis: 0.208 ± 0.155
1.147PheIle: 1.147 ± 0.261
0.469PheLys: 0.469 ± 0.138
1.459PheLeu: 1.459 ± 0.257
0.625PheMet: 0.625 ± 0.198
0.678PheAsn: 0.678 ± 0.183
0.99PhePro: 0.99 ± 0.204
1.042PheGln: 1.042 ± 0.214
1.564PheArg: 1.564 ± 0.308
1.407PheSer: 1.407 ± 0.244
1.928PheThr: 1.928 ± 0.281
2.085PheVal: 2.085 ± 0.313
0.208PheTrp: 0.208 ± 0.099
0.365PheTyr: 0.365 ± 0.127
0.0PheXaa: 0.0 ± 0.0
Gly
9.121GlyAla: 9.121 ± 1.018
0.938GlyCys: 0.938 ± 0.262
5.733GlyAsp: 5.733 ± 0.531
5.525GlyGlu: 5.525 ± 0.464
2.189GlyPhe: 2.189 ± 0.478
8.444GlyGly: 8.444 ± 0.948
1.981GlyHis: 1.981 ± 0.291
4.326GlyIle: 4.326 ± 0.698
3.232GlyLys: 3.232 ± 0.404
7.558GlyLeu: 7.558 ± 0.884
1.564GlyMet: 1.564 ± 0.251
2.241GlyAsn: 2.241 ± 0.451
3.961GlyPro: 3.961 ± 0.399
3.336GlyGln: 3.336 ± 0.386
6.098GlyArg: 6.098 ± 0.476
5.16GlySer: 5.16 ± 0.565
5.368GlyThr: 5.368 ± 0.586
6.88GlyVal: 6.88 ± 0.533
2.345GlyTrp: 2.345 ± 0.405
2.189GlyTyr: 2.189 ± 0.416
0.0GlyXaa: 0.0 ± 0.0
His
2.606HisAla: 2.606 ± 0.419
0.052HisCys: 0.052 ± 0.059
1.303HisAsp: 1.303 ± 0.346
0.834HisGlu: 0.834 ± 0.238
0.521HisPhe: 0.521 ± 0.188
1.095HisGly: 1.095 ± 0.281
0.834HisHis: 0.834 ± 0.202
0.886HisIle: 0.886 ± 0.259
0.417HisLys: 0.417 ± 0.141
1.928HisLeu: 1.928 ± 0.325
0.313HisMet: 0.313 ± 0.136
0.521HisAsn: 0.521 ± 0.158
1.199HisPro: 1.199 ± 0.299
0.782HisGln: 0.782 ± 0.224
1.616HisArg: 1.616 ± 0.273
0.834HisSer: 0.834 ± 0.239
1.147HisThr: 1.147 ± 0.211
0.782HisVal: 0.782 ± 0.208
0.573HisTrp: 0.573 ± 0.182
0.521HisTyr: 0.521 ± 0.169
0.0HisXaa: 0.0 ± 0.0
Ile
6.255IleAla: 6.255 ± 0.743
0.261IleCys: 0.261 ± 0.129
4.013IleAsp: 4.013 ± 0.494
4.118IleGlu: 4.118 ± 0.655
0.834IlePhe: 0.834 ± 0.191
4.587IleGly: 4.587 ± 0.993
0.886IleHis: 0.886 ± 0.189
1.616IleIle: 1.616 ± 0.335
1.199IleLys: 1.199 ± 0.343
1.981IleLeu: 1.981 ± 0.377
0.938IleMet: 0.938 ± 0.299
1.407IleAsn: 1.407 ± 0.295
1.72IlePro: 1.72 ± 0.328
0.834IleGln: 0.834 ± 0.226
2.502IleArg: 2.502 ± 0.395
1.772IleSer: 1.772 ± 0.328
3.492IleThr: 3.492 ± 0.462
3.544IleVal: 3.544 ± 0.325
0.73IleTrp: 0.73 ± 0.186
0.834IleTyr: 0.834 ± 0.241
0.0IleXaa: 0.0 ± 0.0
Lys
3.023LysAla: 3.023 ± 0.383
0.156LysCys: 0.156 ± 0.095
1.042LysAsp: 1.042 ± 0.17
0.678LysGlu: 0.678 ± 0.149
0.625LysPhe: 0.625 ± 0.168
2.085LysGly: 2.085 ± 0.331
0.417LysHis: 0.417 ± 0.155
1.095LysIle: 1.095 ± 0.289
0.365LysLys: 0.365 ± 0.132
1.824LysLeu: 1.824 ± 0.367
0.417LysMet: 0.417 ± 0.138
0.573LysAsn: 0.573 ± 0.144
1.928LysPro: 1.928 ± 0.42
0.469LysGln: 0.469 ± 0.159
1.928LysArg: 1.928 ± 0.354
1.616LysSer: 1.616 ± 0.29
1.876LysThr: 1.876 ± 0.297
2.345LysVal: 2.345 ± 0.266
0.417LysTrp: 0.417 ± 0.127
0.365LysTyr: 0.365 ± 0.122
0.0LysXaa: 0.0 ± 0.0
Leu
11.05LeuAla: 11.05 ± 0.874
0.782LeuCys: 0.782 ± 0.254
6.098LeuAsp: 6.098 ± 0.688
2.919LeuGlu: 2.919 ± 0.357
2.137LeuPhe: 2.137 ± 0.353
8.131LeuGly: 8.131 ± 0.769
1.512LeuHis: 1.512 ± 0.414
3.857LeuIle: 3.857 ± 0.48
1.824LeuLys: 1.824 ± 0.359
5.89LeuLeu: 5.89 ± 0.532
1.981LeuMet: 1.981 ± 0.341
1.928LeuAsn: 1.928 ± 0.367
4.795LeuPro: 4.795 ± 0.525
3.232LeuGln: 3.232 ± 0.394
5.994LeuArg: 5.994 ± 0.688
4.639LeuSer: 4.639 ± 0.485
5.89LeuThr: 5.89 ± 0.545
5.733LeuVal: 5.733 ± 0.499
1.512LeuTrp: 1.512 ± 0.268
1.616LeuTyr: 1.616 ± 0.298
0.0LeuXaa: 0.0 ± 0.0
Met
3.023MetAla: 3.023 ± 0.403
0.365MetCys: 0.365 ± 0.186
1.459MetAsp: 1.459 ± 0.354
0.99MetGlu: 0.99 ± 0.22
0.73MetPhe: 0.73 ± 0.212
2.085MetGly: 2.085 ± 0.311
0.521MetHis: 0.521 ± 0.207
1.147MetIle: 1.147 ± 0.244
0.365MetLys: 0.365 ± 0.157
1.459MetLeu: 1.459 ± 0.324
0.208MetMet: 0.208 ± 0.098
0.573MetAsn: 0.573 ± 0.164
1.407MetPro: 1.407 ± 0.219
0.73MetGln: 0.73 ± 0.211
1.876MetArg: 1.876 ± 0.266
2.345MetSer: 2.345 ± 0.364
2.45MetThr: 2.45 ± 0.348
1.824MetVal: 1.824 ± 0.266
0.261MetTrp: 0.261 ± 0.131
0.521MetTyr: 0.521 ± 0.161
0.0MetXaa: 0.0 ± 0.0
Asn
3.753AsnAla: 3.753 ± 0.5
0.417AsnCys: 0.417 ± 0.149
2.137AsnAsp: 2.137 ± 0.342
0.678AsnGlu: 0.678 ± 0.167
0.782AsnPhe: 0.782 ± 0.289
2.971AsnGly: 2.971 ± 0.518
0.625AsnHis: 0.625 ± 0.185
0.73AsnIle: 0.73 ± 0.241
0.625AsnLys: 0.625 ± 0.201
2.085AsnLeu: 2.085 ± 0.339
0.365AsnMet: 0.365 ± 0.156
0.886AsnAsn: 0.886 ± 0.264
1.876AsnPro: 1.876 ± 0.275
0.678AsnGln: 0.678 ± 0.217
1.303AsnArg: 1.303 ± 0.237
2.033AsnSer: 2.033 ± 0.308
2.241AsnThr: 2.241 ± 0.289
2.241AsnVal: 2.241 ± 0.594
0.573AsnTrp: 0.573 ± 0.146
0.521AsnTyr: 0.521 ± 0.165
0.0AsnXaa: 0.0 ± 0.0
Pro
6.098ProAla: 6.098 ± 0.743
0.469ProCys: 0.469 ± 0.158
4.378ProAsp: 4.378 ± 0.565
5.056ProGlu: 5.056 ± 0.478
1.616ProPhe: 1.616 ± 0.253
5.16ProGly: 5.16 ± 0.587
1.042ProHis: 1.042 ± 0.278
2.189ProIle: 2.189 ± 0.319
0.834ProLys: 0.834 ± 0.218
3.753ProLeu: 3.753 ± 0.437
1.824ProMet: 1.824 ± 0.277
1.095ProAsn: 1.095 ± 0.26
4.013ProPro: 4.013 ± 0.572
2.033ProGln: 2.033 ± 0.328
3.179ProArg: 3.179 ± 0.487
3.179ProSer: 3.179 ± 0.312
4.013ProThr: 4.013 ± 0.547
4.795ProVal: 4.795 ± 0.612
0.938ProTrp: 0.938 ± 0.198
1.147ProTyr: 1.147 ± 0.293
0.0ProXaa: 0.0 ± 0.0
Gln
4.952GlnAla: 4.952 ± 0.509
0.261GlnCys: 0.261 ± 0.13
1.459GlnAsp: 1.459 ± 0.306
1.303GlnGlu: 1.303 ± 0.25
1.095GlnPhe: 1.095 ± 0.228
2.606GlnGly: 2.606 ± 0.405
0.469GlnHis: 0.469 ± 0.141
1.512GlnIle: 1.512 ± 0.284
0.521GlnLys: 0.521 ± 0.171
4.17GlnLeu: 4.17 ± 0.42
1.407GlnMet: 1.407 ± 0.344
0.99GlnAsn: 0.99 ± 0.291
1.147GlnPro: 1.147 ± 0.259
1.981GlnGln: 1.981 ± 0.496
2.815GlnArg: 2.815 ± 0.343
1.512GlnSer: 1.512 ± 0.294
2.398GlnThr: 2.398 ± 0.301
3.544GlnVal: 3.544 ± 0.484
0.521GlnTrp: 0.521 ± 0.168
0.365GlnTyr: 0.365 ± 0.128
0.0GlnXaa: 0.0 ± 0.0
Arg
8.6ArgAla: 8.6 ± 0.687
0.782ArgCys: 0.782 ± 0.208
4.482ArgAsp: 4.482 ± 0.554
4.065ArgGlu: 4.065 ± 0.435
1.512ArgPhe: 1.512 ± 0.276
4.587ArgGly: 4.587 ± 0.458
1.459ArgHis: 1.459 ± 0.294
2.867ArgIle: 2.867 ± 0.367
1.876ArgLys: 1.876 ± 0.307
6.098ArgLeu: 6.098 ± 0.702
1.72ArgMet: 1.72 ± 0.314
1.928ArgAsn: 1.928 ± 0.365
3.544ArgPro: 3.544 ± 0.53
2.971ArgGln: 2.971 ± 0.379
6.046ArgArg: 6.046 ± 0.881
3.961ArgSer: 3.961 ± 0.554
4.274ArgThr: 4.274 ± 0.521
4.691ArgVal: 4.691 ± 0.467
1.459ArgTrp: 1.459 ± 0.305
2.554ArgTyr: 2.554 ± 0.487
0.0ArgXaa: 0.0 ± 0.0
Ser
6.411SerAla: 6.411 ± 0.596
0.834SerCys: 0.834 ± 0.347
3.023SerAsp: 3.023 ± 0.404
2.45SerGlu: 2.45 ± 0.344
1.147SerPhe: 1.147 ± 0.325
6.046SerGly: 6.046 ± 0.567
0.625SerHis: 0.625 ± 0.203
3.179SerIle: 3.179 ± 0.423
1.407SerLys: 1.407 ± 0.297
4.43SerLeu: 4.43 ± 0.593
1.72SerMet: 1.72 ± 0.253
1.512SerAsn: 1.512 ± 0.299
3.179SerPro: 3.179 ± 0.385
2.45SerGln: 2.45 ± 0.392
3.44SerArg: 3.44 ± 0.451
3.805SerSer: 3.805 ± 0.426
3.805SerThr: 3.805 ± 0.422
4.535SerVal: 4.535 ± 0.45
1.616SerTrp: 1.616 ± 0.332
1.459SerTyr: 1.459 ± 0.29
0.0SerXaa: 0.0 ± 0.0
Thr
9.642ThrAla: 9.642 ± 0.772
0.834ThrCys: 0.834 ± 0.239
4.535ThrAsp: 4.535 ± 0.567
4.013ThrGlu: 4.013 ± 0.489
1.407ThrPhe: 1.407 ± 0.26
6.619ThrGly: 6.619 ± 0.539
0.782ThrHis: 0.782 ± 0.168
3.492ThrIle: 3.492 ± 0.493
1.928ThrLys: 1.928 ± 0.311
4.639ThrLeu: 4.639 ± 0.436
1.303ThrMet: 1.303 ± 0.252
1.981ThrAsn: 1.981 ± 0.475
4.743ThrPro: 4.743 ± 0.518
1.512ThrGln: 1.512 ± 0.279
4.639ThrArg: 4.639 ± 0.57
3.857ThrSer: 3.857 ± 0.474
5.212ThrThr: 5.212 ± 0.645
4.743ThrVal: 4.743 ± 0.513
1.303ThrTrp: 1.303 ± 0.3
1.459ThrTyr: 1.459 ± 0.274
0.0ThrXaa: 0.0 ± 0.0
Val
10.216ValAla: 10.216 ± 0.782
0.678ValCys: 0.678 ± 0.241
5.264ValAsp: 5.264 ± 0.53
5.264ValGlu: 5.264 ± 0.495
1.512ValPhe: 1.512 ± 0.295
7.245ValGly: 7.245 ± 0.579
1.042ValHis: 1.042 ± 0.283
3.753ValIle: 3.753 ± 0.639
1.616ValLys: 1.616 ± 0.256
6.619ValLeu: 6.619 ± 0.645
1.824ValMet: 1.824 ± 0.315
2.658ValAsn: 2.658 ± 0.337
4.482ValPro: 4.482 ± 0.462
1.876ValGln: 1.876 ± 0.361
5.838ValArg: 5.838 ± 0.721
3.909ValSer: 3.909 ± 0.478
5.994ValThr: 5.994 ± 0.657
5.785ValVal: 5.785 ± 0.552
1.824ValTrp: 1.824 ± 0.42
1.459ValTyr: 1.459 ± 0.283
0.0ValXaa: 0.0 ± 0.0
Trp
2.085TrpAla: 2.085 ± 0.394
0.261TrpCys: 0.261 ± 0.125
1.564TrpAsp: 1.564 ± 0.245
1.407TrpGlu: 1.407 ± 0.225
0.678TrpPhe: 0.678 ± 0.253
0.834TrpGly: 0.834 ± 0.217
0.365TrpHis: 0.365 ± 0.144
0.469TrpIle: 0.469 ± 0.131
0.313TrpLys: 0.313 ± 0.129
1.199TrpLeu: 1.199 ± 0.23
0.678TrpMet: 0.678 ± 0.229
1.095TrpAsn: 1.095 ± 0.399
1.303TrpPro: 1.303 ± 0.354
1.095TrpGln: 1.095 ± 0.244
1.147TrpArg: 1.147 ± 0.226
1.303TrpSer: 1.303 ± 0.259
1.564TrpThr: 1.564 ± 0.284
1.981TrpVal: 1.981 ± 0.29
0.469TrpTrp: 0.469 ± 0.178
0.365TrpTyr: 0.365 ± 0.126
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.345TyrAla: 2.345 ± 0.405
0.208TyrCys: 0.208 ± 0.101
1.564TyrAsp: 1.564 ± 0.316
1.199TyrGlu: 1.199 ± 0.271
0.625TyrPhe: 0.625 ± 0.165
1.981TyrGly: 1.981 ± 0.36
0.417TyrHis: 0.417 ± 0.161
0.469TyrIle: 0.469 ± 0.194
0.261TyrLys: 0.261 ± 0.117
2.189TyrLeu: 2.189 ± 0.377
0.469TyrMet: 0.469 ± 0.122
0.469TyrAsn: 0.469 ± 0.149
1.199TyrPro: 1.199 ± 0.246
0.521TyrGln: 0.521 ± 0.16
1.928TyrArg: 1.928 ± 0.353
1.407TyrSer: 1.407 ± 0.321
1.355TyrThr: 1.355 ± 0.227
1.72TyrVal: 1.72 ± 0.295
0.521TyrTrp: 0.521 ± 0.188
0.261TyrTyr: 0.261 ± 0.096
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 81 proteins (19187 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski