Amino acid dipepetide frequency for Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.94AlaAla: 10.94 ± 0.221
0.578AlaCys: 0.578 ± 0.037
4.021AlaAsp: 4.021 ± 0.076
6.929AlaGlu: 6.929 ± 0.136
3.363AlaPhe: 3.363 ± 0.091
6.925AlaGly: 6.925 ± 0.114
1.373AlaHis: 1.373 ± 0.052
5.413AlaIle: 5.413 ± 0.107
4.826AlaLys: 4.826 ± 0.111
13.453AlaLeu: 13.453 ± 0.23
2.223AlaMet: 2.223 ± 0.066
1.94AlaAsn: 1.94 ± 0.069
4.131AlaPro: 4.131 ± 0.106
2.455AlaGln: 2.455 ± 0.076
7.048AlaArg: 7.048 ± 0.133
5.616AlaSer: 5.616 ± 0.111
4.167AlaThr: 4.167 ± 0.108
10.312AlaVal: 10.312 ± 0.147
1.143AlaTrp: 1.143 ± 0.045
3.853AlaTyr: 3.853 ± 0.097
0.0AlaXaa: 0.0 ± 0.0
Cys
0.634CysAla: 0.634 ± 0.034
0.128CysCys: 0.128 ± 0.014
0.372CysAsp: 0.372 ± 0.025
0.443CysGlu: 0.443 ± 0.028
0.21CysPhe: 0.21 ± 0.019
1.058CysGly: 1.058 ± 0.053
0.114CysHis: 0.114 ± 0.013
0.433CysIle: 0.433 ± 0.027
0.378CysLys: 0.378 ± 0.027
0.605CysLeu: 0.605 ± 0.035
0.191CysMet: 0.191 ± 0.019
0.231CysAsn: 0.231 ± 0.02
0.863CysPro: 0.863 ± 0.049
0.152CysGln: 0.152 ± 0.016
0.627CysArg: 0.627 ± 0.037
0.446CysSer: 0.446 ± 0.028
0.396CysThr: 0.396 ± 0.031
0.553CysVal: 0.553 ± 0.034
0.076CysTrp: 0.076 ± 0.011
0.228CysTyr: 0.228 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.974AspAla: 3.974 ± 0.093
0.338AspCys: 0.338 ± 0.024
1.895AspAsp: 1.895 ± 0.059
3.448AspGlu: 3.448 ± 0.102
1.701AspPhe: 1.701 ± 0.059
3.195AspGly: 3.195 ± 0.086
0.545AspHis: 0.545 ± 0.036
3.309AspIle: 3.309 ± 0.076
2.164AspLys: 2.164 ± 0.075
5.314AspLeu: 5.314 ± 0.109
0.981AspMet: 0.981 ± 0.045
0.965AspAsn: 0.965 ± 0.044
2.848AspPro: 2.848 ± 0.076
0.789AspGln: 0.789 ± 0.034
2.744AspArg: 2.744 ± 0.067
1.792AspSer: 1.792 ± 0.06
1.398AspThr: 1.398 ± 0.051
5.444AspVal: 5.444 ± 0.106
0.656AspTrp: 0.656 ± 0.038
1.873AspTyr: 1.873 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
7.059GluAla: 7.059 ± 0.112
0.461GluCys: 0.461 ± 0.031
2.939GluAsp: 2.939 ± 0.076
6.094GluGlu: 6.094 ± 0.128
2.102GluPhe: 2.102 ± 0.058
4.96GluGly: 4.96 ± 0.101
0.975GluHis: 0.975 ± 0.044
4.364GluIle: 4.364 ± 0.098
3.112GluLys: 3.112 ± 0.084
8.07GluLeu: 8.07 ± 0.137
1.225GluMet: 1.225 ± 0.047
1.431GluAsn: 1.431 ± 0.05
2.684GluPro: 2.684 ± 0.086
1.226GluGln: 1.226 ± 0.054
5.708GluArg: 5.708 ± 0.126
2.549GluSer: 2.549 ± 0.061
2.485GluThr: 2.485 ± 0.071
6.351GluVal: 6.351 ± 0.116
0.782GluTrp: 0.782 ± 0.038
2.384GluTyr: 2.384 ± 0.067
0.0GluXaa: 0.0 ± 0.0
Phe
3.105PheAla: 3.105 ± 0.08
0.26PheCys: 0.26 ± 0.024
1.711PheAsp: 1.711 ± 0.055
1.929PheGlu: 1.929 ± 0.062
1.362PhePhe: 1.362 ± 0.057
2.76PheGly: 2.76 ± 0.072
0.504PheHis: 0.504 ± 0.032
2.267PheIle: 2.267 ± 0.074
1.85PheLys: 1.85 ± 0.058
3.566PheLeu: 3.566 ± 0.086
0.713PheMet: 0.713 ± 0.033
1.203PheAsn: 1.203 ± 0.055
1.414PhePro: 1.414 ± 0.052
0.703PheGln: 0.703 ± 0.038
2.102PheArg: 2.102 ± 0.059
2.242PheSer: 2.242 ± 0.066
1.73PheThr: 1.73 ± 0.059
2.904PheVal: 2.904 ± 0.062
0.48PheTrp: 0.48 ± 0.029
1.521PheTyr: 1.521 ± 0.051
0.0PheXaa: 0.0 ± 0.0
Gly
7.373GlyAla: 7.373 ± 0.132
0.657GlyCys: 0.657 ± 0.036
3.86GlyAsp: 3.86 ± 0.095
4.971GlyGlu: 4.971 ± 0.097
2.841GlyPhe: 2.841 ± 0.08
6.806GlyGly: 6.806 ± 0.155
1.297GlyHis: 1.297 ± 0.051
4.805GlyIle: 4.805 ± 0.09
3.504GlyLys: 3.504 ± 0.088
8.639GlyLeu: 8.639 ± 0.145
1.47GlyMet: 1.47 ± 0.054
1.839GlyAsn: 1.839 ± 0.072
3.564GlyPro: 3.564 ± 0.076
1.707GlyGln: 1.707 ± 0.057
6.029GlyArg: 6.029 ± 0.108
4.239GlySer: 4.239 ± 0.093
3.356GlyThr: 3.356 ± 0.111
7.559GlyVal: 7.559 ± 0.132
1.194GlyTrp: 1.194 ± 0.054
3.199GlyTyr: 3.199 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.102HisAla: 1.102 ± 0.043
0.135HisCys: 0.135 ± 0.014
0.591HisAsp: 0.591 ± 0.032
0.802HisGlu: 0.802 ± 0.036
0.549HisPhe: 0.549 ± 0.032
1.232HisGly: 1.232 ± 0.052
0.314HisHis: 0.314 ± 0.028
1.098HisIle: 1.098 ± 0.046
0.721HisLys: 0.721 ± 0.034
1.483HisLeu: 1.483 ± 0.045
0.408HisMet: 0.408 ± 0.026
0.37HisAsn: 0.37 ± 0.029
0.914HisPro: 0.914 ± 0.044
0.275HisGln: 0.275 ± 0.023
0.9HisArg: 0.9 ± 0.039
0.667HisSer: 0.667 ± 0.036
0.636HisThr: 0.636 ± 0.03
1.367HisVal: 1.367 ± 0.051
0.195HisTrp: 0.195 ± 0.016
0.585HisTyr: 0.585 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
6.602IleAla: 6.602 ± 0.119
0.468IleCys: 0.468 ± 0.029
3.535IleAsp: 3.535 ± 0.103
3.948IleGlu: 3.948 ± 0.091
2.202IlePhe: 2.202 ± 0.062
4.53IleGly: 4.53 ± 0.091
0.834IleHis: 0.834 ± 0.042
3.784IleIle: 3.784 ± 0.108
3.553IleLys: 3.553 ± 0.09
5.565IleLeu: 5.565 ± 0.123
1.335IleMet: 1.335 ± 0.053
1.962IleAsn: 1.962 ± 0.07
2.915IlePro: 2.915 ± 0.073
1.183IleGln: 1.183 ± 0.052
3.499IleArg: 3.499 ± 0.079
4.093IleSer: 4.093 ± 0.102
2.93IleThr: 2.93 ± 0.07
5.655IleVal: 5.655 ± 0.101
0.67IleTrp: 0.67 ± 0.032
3.08IleTyr: 3.08 ± 0.085
0.0IleXaa: 0.0 ± 0.0
Lys
4.725LysAla: 4.725 ± 0.095
0.464LysCys: 0.464 ± 0.034
1.673LysAsp: 1.673 ± 0.055
3.063LysGlu: 3.063 ± 0.092
1.691LysPhe: 1.691 ± 0.053
2.968LysGly: 2.968 ± 0.09
0.571LysHis: 0.571 ± 0.033
3.791LysIle: 3.791 ± 0.1
1.951LysLys: 1.951 ± 0.079
5.157LysLeu: 5.157 ± 0.12
1.216LysMet: 1.216 ± 0.046
1.282LysAsn: 1.282 ± 0.063
2.211LysPro: 2.211 ± 0.072
0.791LysGln: 0.791 ± 0.04
4.019LysArg: 4.019 ± 0.095
2.617LysSer: 2.617 ± 0.072
2.205LysThr: 2.205 ± 0.058
3.788LysVal: 3.788 ± 0.089
0.656LysTrp: 0.656 ± 0.032
2.42LysTyr: 2.42 ± 0.068
0.0LysXaa: 0.0 ± 0.0
Leu
12.584LeuAla: 12.584 ± 0.208
0.726LeuCys: 0.726 ± 0.043
5.039LeuAsp: 5.039 ± 0.113
7.138LeuGlu: 7.138 ± 0.128
3.544LeuPhe: 3.544 ± 0.093
9.336LeuGly: 9.336 ± 0.139
1.407LeuHis: 1.407 ± 0.052
6.046LeuIle: 6.046 ± 0.123
5.863LeuLys: 5.863 ± 0.109
10.877LeuLeu: 10.877 ± 0.215
2.372LeuMet: 2.372 ± 0.072
3.101LeuAsn: 3.101 ± 0.074
4.958LeuPro: 4.958 ± 0.099
2.095LeuGln: 2.095 ± 0.064
8.038LeuArg: 8.038 ± 0.138
7.407LeuSer: 7.407 ± 0.134
4.414LeuThr: 4.414 ± 0.102
8.227LeuVal: 8.227 ± 0.136
1.346LeuTrp: 1.346 ± 0.054
4.283LeuTyr: 4.283 ± 0.096
0.0LeuXaa: 0.0 ± 0.0
Met
2.509MetAla: 2.509 ± 0.069
0.166MetCys: 0.166 ± 0.017
0.966MetAsp: 0.966 ± 0.044
1.353MetGlu: 1.353 ± 0.054
0.674MetPhe: 0.674 ± 0.035
1.931MetGly: 1.931 ± 0.064
0.305MetHis: 0.305 ± 0.024
1.087MetIle: 1.087 ± 0.044
0.997MetLys: 0.997 ± 0.051
1.976MetLeu: 1.976 ± 0.052
0.361MetMet: 0.361 ± 0.028
0.52MetAsn: 0.52 ± 0.031
1.317MetPro: 1.317 ± 0.05
0.414MetGln: 0.414 ± 0.027
1.799MetArg: 1.799 ± 0.057
1.51MetSer: 1.51 ± 0.054
0.948MetThr: 0.948 ± 0.04
1.263MetVal: 1.263 ± 0.046
0.267MetTrp: 0.267 ± 0.02
0.784MetTyr: 0.784 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
2.556AsnAla: 2.556 ± 0.086
0.276AsnCys: 0.276 ± 0.024
0.999AsnAsp: 0.999 ± 0.04
1.31AsnGlu: 1.31 ± 0.049
0.993AsnPhe: 0.993 ± 0.045
2.032AsnGly: 2.032 ± 0.1
0.231AsnHis: 0.231 ± 0.02
2.222AsnIle: 2.222 ± 0.076
1.436AsnLys: 1.436 ± 0.055
2.433AsnLeu: 2.433 ± 0.074
0.555AsnMet: 0.555 ± 0.031
0.936AsnAsn: 0.936 ± 0.051
1.682AsnPro: 1.682 ± 0.047
0.426AsnGln: 0.426 ± 0.029
1.405AsnArg: 1.405 ± 0.054
1.317AsnSer: 1.317 ± 0.062
1.145AsnThr: 1.145 ± 0.048
2.328AsnVal: 2.328 ± 0.066
0.331AsnTrp: 0.331 ± 0.027
1.176AsnTyr: 1.176 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
3.965ProAla: 3.965 ± 0.096
0.417ProCys: 0.417 ± 0.03
2.527ProAsp: 2.527 ± 0.072
3.537ProGlu: 3.537 ± 0.088
1.653ProPhe: 1.653 ± 0.055
3.748ProGly: 3.748 ± 0.09
1.001ProHis: 1.001 ± 0.049
2.829ProIle: 2.829 ± 0.082
2.177ProLys: 2.177 ± 0.066
5.442ProLeu: 5.442 ± 0.103
0.993ProMet: 0.993 ± 0.048
1.447ProAsn: 1.447 ± 0.063
3.73ProPro: 3.73 ± 0.109
1.523ProGln: 1.523 ± 0.056
3.278ProArg: 3.278 ± 0.086
3.146ProSer: 3.146 ± 0.084
2.502ProThr: 2.502 ± 0.078
3.853ProVal: 3.853 ± 0.097
0.777ProTrp: 0.777 ± 0.044
2.281ProTyr: 2.281 ± 0.069
0.0ProXaa: 0.0 ± 0.0
Gln
1.942GlnAla: 1.942 ± 0.063
0.231GlnCys: 0.231 ± 0.023
0.744GlnAsp: 0.744 ± 0.036
1.347GlnGlu: 1.347 ± 0.05
0.713GlnPhe: 0.713 ± 0.038
1.492GlnGly: 1.492 ± 0.054
0.318GlnHis: 0.318 ± 0.022
1.667GlnIle: 1.667 ± 0.059
0.724GlnLys: 0.724 ± 0.041
2.447GlnLeu: 2.447 ± 0.074
0.555GlnMet: 0.555 ± 0.031
0.574GlnAsn: 0.574 ± 0.03
0.983GlnPro: 0.983 ± 0.045
0.686GlnGln: 0.686 ± 0.05
1.754GlnArg: 1.754 ± 0.056
1.136GlnSer: 1.136 ± 0.051
1.082GlnThr: 1.082 ± 0.055
1.403GlnVal: 1.403 ± 0.053
0.309GlnTrp: 0.309 ± 0.024
1.042GlnTyr: 1.042 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
7.212ArgAla: 7.212 ± 0.156
0.733ArgCys: 0.733 ± 0.043
3.37ArgAsp: 3.37 ± 0.084
5.755ArgGlu: 5.755 ± 0.128
2.063ArgPhe: 2.063 ± 0.066
6.56ArgGly: 6.56 ± 0.117
1.113ArgHis: 1.113 ± 0.05
4.026ArgIle: 4.026 ± 0.093
2.601ArgLys: 2.601 ± 0.075
7.613ArgLeu: 7.613 ± 0.129
1.47ArgMet: 1.47 ± 0.06
1.422ArgAsn: 1.422 ± 0.058
3.811ArgPro: 3.811 ± 0.094
1.427ArgGln: 1.427 ± 0.048
6.847ArgArg: 6.847 ± 0.153
3.477ArgSer: 3.477 ± 0.089
2.298ArgThr: 2.298 ± 0.066
5.296ArgVal: 5.296 ± 0.104
1.017ArgTrp: 1.017 ± 0.052
2.803ArgTyr: 2.803 ± 0.08
0.0ArgXaa: 0.0 ± 0.0
Ser
5.513SerAla: 5.513 ± 0.129
0.558SerCys: 0.558 ± 0.032
2.211SerAsp: 2.211 ± 0.064
3.002SerGlu: 3.002 ± 0.072
2.043SerPhe: 2.043 ± 0.065
4.541SerGly: 4.541 ± 0.102
0.818SerHis: 0.818 ± 0.042
3.632SerIle: 3.632 ± 0.076
2.393SerLys: 2.393 ± 0.065
6.867SerLeu: 6.867 ± 0.132
1.391SerMet: 1.391 ± 0.057
1.38SerAsn: 1.38 ± 0.057
3.192SerPro: 3.192 ± 0.079
1.436SerGln: 1.436 ± 0.048
3.564SerArg: 3.564 ± 0.071
3.799SerSer: 3.799 ± 0.113
2.61SerThr: 2.61 ± 0.072
4.563SerVal: 4.563 ± 0.111
0.896SerTrp: 0.896 ± 0.044
2.222SerTyr: 2.222 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
4.564ThrAla: 4.564 ± 0.108
0.39ThrCys: 0.39 ± 0.029
1.627ThrAsp: 1.627 ± 0.058
2.01ThrGlu: 2.01 ± 0.063
1.546ThrPhe: 1.546 ± 0.057
3.598ThrGly: 3.598 ± 0.103
0.641ThrHis: 0.641 ± 0.035
2.747ThrIle: 2.747 ± 0.071
1.68ThrLys: 1.68 ± 0.06
4.579ThrLeu: 4.579 ± 0.1
0.914ThrMet: 0.914 ± 0.039
1.133ThrAsn: 1.133 ± 0.051
2.8ThrPro: 2.8 ± 0.072
0.878ThrGln: 0.878 ± 0.043
2.077ThrArg: 2.077 ± 0.067
2.731ThrSer: 2.731 ± 0.069
2.485ThrThr: 2.485 ± 0.095
3.564ThrVal: 3.564 ± 0.106
0.674ThrTrp: 0.674 ± 0.041
1.88ThrTyr: 1.88 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
9.266ValAla: 9.266 ± 0.122
0.694ValCys: 0.694 ± 0.039
4.803ValAsp: 4.803 ± 0.088
6.918ValGlu: 6.918 ± 0.12
3.08ValPhe: 3.08 ± 0.08
6.68ValGly: 6.68 ± 0.127
1.254ValHis: 1.254 ± 0.051
4.745ValIle: 4.745 ± 0.088
4.953ValLys: 4.953 ± 0.108
8.695ValLeu: 8.695 ± 0.136
1.555ValMet: 1.555 ± 0.058
2.307ValAsn: 2.307 ± 0.072
4.34ValPro: 4.34 ± 0.09
1.821ValGln: 1.821 ± 0.073
5.572ValArg: 5.572 ± 0.123
4.615ValSer: 4.615 ± 0.111
3.213ValThr: 3.213 ± 0.096
9.62ValVal: 9.62 ± 0.145
1.024ValTrp: 1.024 ± 0.044
3.764ValTyr: 3.764 ± 0.092
0.0ValXaa: 0.0 ± 0.0
Trp
1.282TrpAla: 1.282 ± 0.047
0.094TrpCys: 0.094 ± 0.013
0.591TrpAsp: 0.591 ± 0.033
0.746TrpGlu: 0.746 ± 0.039
0.461TrpPhe: 0.461 ± 0.028
1.19TrpGly: 1.19 ± 0.05
0.228TrpHis: 0.228 ± 0.02
0.831TrpIle: 0.831 ± 0.04
0.408TrpLys: 0.408 ± 0.03
1.427TrpLeu: 1.427 ± 0.061
0.273TrpMet: 0.273 ± 0.024
0.396TrpAsn: 0.396 ± 0.028
0.668TrpPro: 0.668 ± 0.037
0.35TrpGln: 0.35 ± 0.025
1.297TrpArg: 1.297 ± 0.047
0.825TrpSer: 0.825 ± 0.042
0.611TrpThr: 0.611 ± 0.038
0.825TrpVal: 0.825 ± 0.038
0.228TrpTrp: 0.228 ± 0.023
0.522TrpTyr: 0.522 ± 0.036
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.802TyrAla: 3.802 ± 0.075
0.361TyrCys: 0.361 ± 0.026
1.9TyrAsp: 1.9 ± 0.059
2.218TyrGlu: 2.218 ± 0.069
1.535TyrPhe: 1.535 ± 0.053
3.367TyrGly: 3.367 ± 0.074
0.5TyrHis: 0.5 ± 0.03
3.246TyrIle: 3.246 ± 0.082
1.969TyrLys: 1.969 ± 0.062
4.593TyrLeu: 4.593 ± 0.102
0.945TyrMet: 0.945 ± 0.04
1.351TyrAsn: 1.351 ± 0.066
1.801TyrPro: 1.801 ± 0.065
0.815TyrGln: 0.815 ± 0.039
2.608TyrArg: 2.608 ± 0.08
2.406TyrSer: 2.406 ± 0.074
1.907TyrThr: 1.907 ± 0.067
4.042TyrVal: 4.042 ± 0.095
0.533TyrTrp: 0.533 ± 0.034
1.792TyrTyr: 1.792 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2047 proteins (553635 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski