Amino acid dipepetide frequency for Halomonas muralis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.473AlaAla: 12.473 ± 0.14	1.227AlaCys: 1.227 ± 0.033	5.929AlaAsp: 5.929 ± 0.087	7.301AlaGlu: 7.301 ± 0.095	4.073AlaPhe: 4.073 ± 0.058	9.258AlaGly: 9.258 ± 0.101	2.349AlaHis: 2.349 ± 0.044	5.89AlaIle: 5.89 ± 0.076	2.919AlaLys: 2.919 ± 0.054	14.302AlaLeu: 14.302 ± 0.138	3.412AlaMet: 3.412 ± 0.057	2.956AlaAsn: 2.956 ± 0.054	4.808AlaPro: 4.808 ± 0.075	4.191AlaGln: 4.191 ± 0.063	8.214AlaArg: 8.214 ± 0.094	6.439AlaSer: 6.439 ± 0.089	5.53AlaThr: 5.53 ± 0.072	7.502AlaVal: 7.502 ± 0.082	1.901AlaTrp: 1.901 ± 0.05	2.481AlaTyr: 2.481 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.987CysAla: 0.987 ± 0.026	0.129CysCys: 0.129 ± 0.012	0.584CysAsp: 0.584 ± 0.02	0.58CysGlu: 0.58 ± 0.025	0.342CysPhe: 0.342 ± 0.016	0.99CysGly: 0.99 ± 0.029	0.332CysHis: 0.332 ± 0.019	0.449CysIle: 0.449 ± 0.019	0.196CysLys: 0.196 ± 0.012	1.031CysLeu: 1.031 ± 0.029	0.194CysMet: 0.194 ± 0.013	0.241CysAsn: 0.241 ± 0.014	0.528CysPro: 0.528 ± 0.02	0.395CysGln: 0.395 ± 0.021	0.762CysArg: 0.762 ± 0.028	0.481CysSer: 0.481 ± 0.022	0.399CysThr: 0.399 ± 0.017	0.676CysVal: 0.676 ± 0.024	0.134CysTrp: 0.134 ± 0.011	0.266CysTyr: 0.266 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.859AspAla: 6.859 ± 0.082	0.525AspCys: 0.525 ± 0.022	4.093AspAsp: 4.093 ± 0.074	4.235AspGlu: 4.235 ± 0.066	2.175AspPhe: 2.175 ± 0.045	4.918AspGly: 4.918 ± 0.087	1.238AspHis: 1.238 ± 0.033	3.075AspIle: 3.075 ± 0.054	1.699AspLys: 1.699 ± 0.039	5.25AspLeu: 5.25 ± 0.06	1.343AspMet: 1.343 ± 0.035	1.706AspAsn: 1.706 ± 0.045	2.893AspPro: 2.893 ± 0.053	1.822AspGln: 1.822 ± 0.045	3.504AspArg: 3.504 ± 0.053	3.018AspSer: 3.018 ± 0.053	2.934AspThr: 2.934 ± 0.065	4.02AspVal: 4.02 ± 0.062	1.097AspTrp: 1.097 ± 0.03	1.812AspTyr: 1.812 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.699GluAla: 7.699 ± 0.087	0.511GluCys: 0.511 ± 0.023	2.883GluAsp: 2.883 ± 0.054	3.396GluGlu: 3.396 ± 0.067	1.762GluPhe: 1.762 ± 0.043	4.409GluGly: 4.409 ± 0.067	1.788GluHis: 1.788 ± 0.04	3.187GluIle: 3.187 ± 0.059	1.829GluLys: 1.829 ± 0.05	7.009GluLeu: 7.009 ± 0.089	1.394GluMet: 1.394 ± 0.035	1.602GluAsn: 1.602 ± 0.038	2.788GluPro: 2.788 ± 0.051	3.047GluGln: 3.047 ± 0.06	6.213GluArg: 6.213 ± 0.092	3.206GluSer: 3.206 ± 0.05	3.275GluThr: 3.275 ± 0.052	4.346GluVal: 4.346 ± 0.064	0.847GluTrp: 0.847 ± 0.025	1.276GluTyr: 1.276 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.832PheAla: 3.832 ± 0.05	0.397PheCys: 0.397 ± 0.019	2.566PheAsp: 2.566 ± 0.049	2.254PheGlu: 2.254 ± 0.046	1.37PhePhe: 1.37 ± 0.04	3.269PheGly: 3.269 ± 0.051	0.827PheHis: 0.827 ± 0.027	1.795PheIle: 1.795 ± 0.043	0.978PheLys: 0.978 ± 0.03	3.127PheLeu: 3.127 ± 0.061	0.915PheMet: 0.915 ± 0.029	1.066PheAsn: 1.066 ± 0.032	1.497PhePro: 1.497 ± 0.033	1.112PheGln: 1.112 ± 0.029	1.902PheArg: 1.902 ± 0.042	2.294PheSer: 2.294 ± 0.048	2.02PheThr: 2.02 ± 0.05	2.511PheVal: 2.511 ± 0.043	0.493PheTrp: 0.493 ± 0.018	0.978PheTyr: 0.978 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	7.829GlyAla: 7.829 ± 0.083	0.971GlyCys: 0.971 ± 0.027	4.712GlyAsp: 4.712 ± 0.084	5.818GlyGlu: 5.818 ± 0.076	3.253GlyPhe: 3.253 ± 0.058	6.806GlyGly: 6.806 ± 0.118	2.006GlyHis: 2.006 ± 0.045	4.576GlyIle: 4.576 ± 0.07	2.729GlyLys: 2.729 ± 0.054	9.312GlyLeu: 9.312 ± 0.097	2.488GlyMet: 2.488 ± 0.044	2.248GlyAsn: 2.248 ± 0.054	2.934GlyPro: 2.934 ± 0.045	3.203GlyGln: 3.203 ± 0.056	5.343GlyArg: 5.343 ± 0.071	4.479GlySer: 4.479 ± 0.072	3.755GlyThr: 3.755 ± 0.07	6.413GlyVal: 6.413 ± 0.072	1.418GlyTrp: 1.418 ± 0.036	2.434GlyTyr: 2.434 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.638HisAla: 2.638 ± 0.044	0.317HisCys: 0.317 ± 0.017	1.563HisAsp: 1.563 ± 0.037	1.386HisGlu: 1.386 ± 0.038	1.009HisPhe: 1.009 ± 0.033	2.3HisGly: 2.3 ± 0.047	0.717HisHis: 0.717 ± 0.027	0.998HisIle: 0.998 ± 0.028	0.549HisLys: 0.549 ± 0.019	2.525HisLeu: 2.525 ± 0.049	0.472HisMet: 0.472 ± 0.019	0.585HisAsn: 0.585 ± 0.02	1.559HisPro: 1.559 ± 0.044	0.891HisGln: 0.891 ± 0.026	1.8HisArg: 1.8 ± 0.039	1.154HisSer: 1.154 ± 0.031	0.949HisThr: 0.949 ± 0.028	1.533HisVal: 1.533 ± 0.034	0.447HisTrp: 0.447 ± 0.019	0.776HisTyr: 0.776 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.484IleAla: 6.484 ± 0.074	0.462IleCys: 0.462 ± 0.022	3.976IleAsp: 3.976 ± 0.061	3.745IleGlu: 3.745 ± 0.056	1.561IlePhe: 1.561 ± 0.039	4.8IleGly: 4.8 ± 0.075	1.076IleHis: 1.076 ± 0.034	2.068IleIle: 2.068 ± 0.047	1.375IleLys: 1.375 ± 0.034	4.031IleLeu: 4.031 ± 0.072	0.995IleMet: 0.995 ± 0.027	1.55IleAsn: 1.55 ± 0.043	2.329IlePro: 2.329 ± 0.046	1.488IleGln: 1.488 ± 0.037	2.973IleArg: 2.973 ± 0.053	2.686IleSer: 2.686 ± 0.053	2.666IleThr: 2.666 ± 0.052	3.831IleVal: 3.831 ± 0.06	0.489IleTrp: 0.489 ± 0.024	1.132IleTyr: 1.132 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.114LysAla: 3.114 ± 0.053	0.161LysCys: 0.161 ± 0.012	1.299LysAsp: 1.299 ± 0.037	1.389LysGlu: 1.389 ± 0.041	0.65LysPhe: 0.65 ± 0.027	2.135LysGly: 2.135 ± 0.045	0.639LysHis: 0.639 ± 0.023	1.227LysIle: 1.227 ± 0.038	0.967LysLys: 0.967 ± 0.034	2.972LysLeu: 2.972 ± 0.056	0.625LysMet: 0.625 ± 0.025	0.698LysAsn: 0.698 ± 0.025	1.593LysPro: 1.593 ± 0.035	1.179LysGln: 1.179 ± 0.036	2.435LysArg: 2.435 ± 0.049	1.521LysSer: 1.521 ± 0.033	1.467LysThr: 1.467 ± 0.039	2.027LysVal: 2.027 ± 0.048	0.283LysTrp: 0.283 ± 0.015	0.533LysTyr: 0.533 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	14.782LeuAla: 14.782 ± 0.129	1.173LeuCys: 1.173 ± 0.031	7.268LeuAsp: 7.268 ± 0.093	7.166LeuGlu: 7.166 ± 0.096	3.799LeuPhe: 3.799 ± 0.065	9.575LeuGly: 9.575 ± 0.105	2.412LeuHis: 2.412 ± 0.051	5.813LeuIle: 5.813 ± 0.071	3.341LeuLys: 3.341 ± 0.058	12.106LeuLeu: 12.106 ± 0.167	2.694LeuMet: 2.694 ± 0.054	2.908LeuAsn: 2.908 ± 0.052	5.968LeuPro: 5.968 ± 0.076	3.143LeuGln: 3.143 ± 0.055	7.102LeuArg: 7.102 ± 0.085	6.738LeuSer: 6.738 ± 0.085	5.905LeuThr: 5.905 ± 0.079	7.774LeuVal: 7.774 ± 0.088	1.517LeuTrp: 1.517 ± 0.043	2.411LeuTyr: 2.411 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.081MetAla: 3.081 ± 0.044	0.176MetCys: 0.176 ± 0.013	1.069MetAsp: 1.069 ± 0.03	1.064MetGlu: 1.064 ± 0.03	0.713MetPhe: 0.713 ± 0.027	1.856MetGly: 1.856 ± 0.042	0.579MetHis: 0.579 ± 0.025	1.324MetIle: 1.324 ± 0.035	0.811MetLys: 0.811 ± 0.026	2.899MetLeu: 2.899 ± 0.056	0.597MetMet: 0.597 ± 0.024	0.792MetAsn: 0.792 ± 0.023	1.528MetPro: 1.528 ± 0.039	1.019MetGln: 1.019 ± 0.031	1.692MetArg: 1.692 ± 0.037	1.749MetSer: 1.749 ± 0.037	1.657MetThr: 1.657 ± 0.037	1.64MetVal: 1.64 ± 0.034	0.201MetTrp: 0.201 ± 0.012	0.342MetTyr: 0.342 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.192AsnAla: 3.192 ± 0.055	0.243AsnCys: 0.243 ± 0.013	1.63AsnAsp: 1.63 ± 0.045	1.444AsnGlu: 1.444 ± 0.035	0.85AsnPhe: 0.85 ± 0.033	2.241AsnGly: 2.241 ± 0.055	0.602AsnHis: 0.602 ± 0.02	1.325AsnIle: 1.325 ± 0.037	0.664AsnLys: 0.664 ± 0.027	2.721AsnLeu: 2.721 ± 0.05	0.595AsnMet: 0.595 ± 0.021	0.7AsnAsn: 0.7 ± 0.027	1.755AsnPro: 1.755 ± 0.036	0.911AsnGln: 0.911 ± 0.026	1.877AsnArg: 1.877 ± 0.036	1.243AsnSer: 1.243 ± 0.032	1.327AsnThr: 1.327 ± 0.037	1.921AsnVal: 1.921 ± 0.044	0.384AsnTrp: 0.384 ± 0.018	0.688AsnTyr: 0.688 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.249ProAla: 5.249 ± 0.063	0.359ProCys: 0.359 ± 0.017	3.073ProAsp: 3.073 ± 0.052	3.661ProGlu: 3.661 ± 0.06	1.783ProPhe: 1.783 ± 0.036	4.259ProGly: 4.259 ± 0.059	1.129ProHis: 1.129 ± 0.031	2.142ProIle: 2.142 ± 0.048	1.196ProLys: 1.196 ± 0.029	5.653ProLeu: 5.653 ± 0.07	1.151ProMet: 1.151 ± 0.031	1.247ProAsn: 1.247 ± 0.031	2.203ProPro: 2.203 ± 0.054	1.864ProGln: 1.864 ± 0.041	3.147ProArg: 3.147 ± 0.047	2.807ProSer: 2.807 ± 0.05	2.355ProThr: 2.355 ± 0.043	3.616ProVal: 3.616 ± 0.055	0.827ProTrp: 0.827 ± 0.026	1.173ProTyr: 1.173 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.323GlnAla: 5.323 ± 0.076	0.318GlnCys: 0.318 ± 0.016	1.652GlnAsp: 1.652 ± 0.04	1.858GlnGlu: 1.858 ± 0.047	1.072GlnPhe: 1.072 ± 0.027	3.244GlnGly: 3.244 ± 0.056	0.96GlnHis: 0.96 ± 0.028	1.521GlnIle: 1.521 ± 0.041	0.843GlnLys: 0.843 ± 0.029	4.05GlnLeu: 4.05 ± 0.07	0.841GlnMet: 0.841 ± 0.027	0.774GlnAsn: 0.774 ± 0.027	1.991GlnPro: 1.991 ± 0.045	1.938GlnGln: 1.938 ± 0.048	3.628GlnArg: 3.628 ± 0.062	1.903GlnSer: 1.903 ± 0.042	1.649GlnThr: 1.649 ± 0.044	2.843GlnVal: 2.843 ± 0.054	0.595GlnTrp: 0.595 ± 0.019	0.721GlnTyr: 0.721 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	6.728ArgAla: 6.728 ± 0.078	0.648ArgCys: 0.648 ± 0.025	4.233ArgAsp: 4.233 ± 0.067	5.226ArgGlu: 5.226 ± 0.08	2.86ArgPhe: 2.86 ± 0.048	4.663ArgGly: 4.663 ± 0.056	2.305ArgHis: 2.305 ± 0.047	3.684ArgIle: 3.684 ± 0.06	1.792ArgLys: 1.792 ± 0.042	9.743ArgLeu: 9.743 ± 0.131	1.726ArgMet: 1.726 ± 0.039	1.741ArgAsn: 1.741 ± 0.041	2.906ArgPro: 2.906 ± 0.049	3.33ArgGln: 3.33 ± 0.059	5.81ArgArg: 5.81 ± 0.092	3.228ArgSer: 3.228 ± 0.049	2.841ArgThr: 2.841 ± 0.042	5.005ArgVal: 5.005 ± 0.058	1.117ArgTrp: 1.117 ± 0.031	2.206ArgTyr: 2.206 ± 0.042	0.001ArgXaa: 0.001 ± 0.001
Ser	5.735SerAla: 5.735 ± 0.075	0.453SerCys: 0.453 ± 0.021	3.106SerAsp: 3.106 ± 0.057	3.227SerGlu: 3.227 ± 0.048	1.928SerPhe: 1.928 ± 0.042	5.268SerGly: 5.268 ± 0.075	1.346SerHis: 1.346 ± 0.032	2.524SerIle: 2.524 ± 0.055	1.265SerLys: 1.265 ± 0.029	6.53SerLeu: 6.53 ± 0.075	1.431SerMet: 1.431 ± 0.035	1.395SerAsn: 1.395 ± 0.035	2.787SerPro: 2.787 ± 0.051	2.198SerGln: 2.198 ± 0.047	4.0SerArg: 4.0 ± 0.065	2.963SerSer: 2.963 ± 0.053	2.589SerThr: 2.589 ± 0.046	4.003SerVal: 4.003 ± 0.068	0.728SerTrp: 0.728 ± 0.026	1.266SerTyr: 1.266 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	5.075ThrAla: 5.075 ± 0.07	0.446ThrCys: 0.446 ± 0.02	2.364ThrAsp: 2.364 ± 0.049	2.342ThrGlu: 2.342 ± 0.046	1.898ThrPhe: 1.898 ± 0.042	4.29ThrGly: 4.29 ± 0.067	1.252ThrHis: 1.252 ± 0.035	2.252ThrIle: 2.252 ± 0.058	0.929ThrLys: 0.929 ± 0.027	7.396ThrLeu: 7.396 ± 0.085	1.051ThrMet: 1.051 ± 0.026	1.171ThrAsn: 1.171 ± 0.034	3.457ThrPro: 3.457 ± 0.057	1.941ThrGln: 1.941 ± 0.039	3.534ThrArg: 3.534 ± 0.053	2.614ThrSer: 2.614 ± 0.046	2.721ThrThr: 2.721 ± 0.068	3.394ThrVal: 3.394 ± 0.066	0.681ThrTrp: 0.681 ± 0.023	1.074ThrTyr: 1.074 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.397ValAla: 8.397 ± 0.1	0.731ValCys: 0.731 ± 0.025	4.305ValAsp: 4.305 ± 0.068	4.604ValGlu: 4.604 ± 0.07	2.602ValPhe: 2.602 ± 0.053	5.477ValGly: 5.477 ± 0.07	1.485ValHis: 1.485 ± 0.032	4.191ValIle: 4.191 ± 0.064	1.901ValLys: 1.901 ± 0.042	7.601ValLeu: 7.601 ± 0.087	2.009ValMet: 2.009 ± 0.046	1.94ValAsn: 1.94 ± 0.044	3.31ValPro: 3.31 ± 0.062	2.041ValGln: 2.041 ± 0.036	4.422ValArg: 4.422 ± 0.049	4.171ValSer: 4.171 ± 0.062	3.983ValThr: 3.983 ± 0.074	5.577ValVal: 5.577 ± 0.075	0.848ValTrp: 0.848 ± 0.026	1.559ValTyr: 1.559 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.159TrpAla: 1.159 ± 0.03	0.177TrpCys: 0.177 ± 0.011	0.577TrpAsp: 0.577 ± 0.024	0.631TrpGlu: 0.631 ± 0.022	0.57TrpPhe: 0.57 ± 0.021	0.912TrpGly: 0.912 ± 0.03	0.431TrpHis: 0.431 ± 0.019	0.672TrpIle: 0.672 ± 0.029	0.382TrpLys: 0.382 ± 0.02	2.454TrpLeu: 2.454 ± 0.053	0.376TrpMet: 0.376 ± 0.016	0.402TrpAsn: 0.402 ± 0.019	0.753TrpPro: 0.753 ± 0.026	0.96TrpGln: 0.96 ± 0.032	1.252TrpArg: 1.252 ± 0.034	0.788TrpSer: 0.788 ± 0.025	0.644TrpThr: 0.644 ± 0.025	0.927TrpVal: 0.927 ± 0.028	0.292TrpTrp: 0.292 ± 0.014	0.318TrpTyr: 0.318 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.515TyrAla: 2.515 ± 0.05	0.274TyrCys: 0.274 ± 0.014	1.337TyrAsp: 1.337 ± 0.031	1.141TyrGlu: 1.141 ± 0.035	0.933TyrPhe: 0.933 ± 0.03	2.056TyrGly: 2.056 ± 0.043	0.692TyrHis: 0.692 ± 0.027	1.003TyrIle: 1.003 ± 0.029	0.548TyrLys: 0.548 ± 0.019	2.885TyrLeu: 2.885 ± 0.046	0.479TyrMet: 0.479 ± 0.018	0.59TyrAsn: 0.59 ± 0.026	1.309TyrPro: 1.309 ± 0.033	1.054TyrGln: 1.054 ± 0.032	2.183TyrArg: 2.183 ± 0.046	1.26TyrSer: 1.26 ± 0.036	1.215TyrThr: 1.215 ± 0.033	1.594TyrVal: 1.594 ± 0.041	0.378TyrTrp: 0.378 ± 0.016	0.725TyrTyr: 0.725 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.002XaaXaa: 0.002 ± 0.003

Statistics based on 3825 proteins (1244899 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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