Amino acid dipepetide frequency for Lichenicoccus roseus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.98AlaAla: 19.98 ± 0.2
1.497AlaCys: 1.497 ± 0.031
6.864AlaAsp: 6.864 ± 0.075
6.557AlaGlu: 6.557 ± 0.085
3.825AlaPhe: 3.825 ± 0.057
13.275AlaGly: 13.275 ± 0.149
2.632AlaHis: 2.632 ± 0.045
6.33AlaIle: 6.33 ± 0.071
2.263AlaLys: 2.263 ± 0.047
15.036AlaLeu: 15.036 ± 0.154
3.593AlaMet: 3.593 ± 0.049
2.433AlaAsn: 2.433 ± 0.046
6.644AlaPro: 6.644 ± 0.093
4.109AlaGln: 4.109 ± 0.07
10.231AlaArg: 10.231 ± 0.116
7.76AlaSer: 7.76 ± 0.099
7.194AlaThr: 7.194 ± 0.098
9.476AlaVal: 9.476 ± 0.093
1.803AlaTrp: 1.803 ± 0.041
2.31AlaTyr: 2.31 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
1.154CysAla: 1.154 ± 0.031
0.142CysCys: 0.142 ± 0.011
0.536CysAsp: 0.536 ± 0.02
0.373CysGlu: 0.373 ± 0.016
0.319CysPhe: 0.319 ± 0.016
1.023CysGly: 1.023 ± 0.03
0.231CysHis: 0.231 ± 0.014
0.441CysIle: 0.441 ± 0.019
0.114CysLys: 0.114 ± 0.01
1.02CysLeu: 1.02 ± 0.027
0.198CysMet: 0.198 ± 0.011
0.198CysAsn: 0.198 ± 0.012
0.482CysPro: 0.482 ± 0.019
0.218CysGln: 0.218 ± 0.014
0.738CysArg: 0.738 ± 0.022
0.537CysSer: 0.537 ± 0.019
0.479CysThr: 0.479 ± 0.019
0.704CysVal: 0.704 ± 0.026
0.16CysTrp: 0.16 ± 0.011
0.178CysTyr: 0.178 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.408AspAla: 7.408 ± 0.081
0.447AspCys: 0.447 ± 0.02
2.936AspAsp: 2.936 ± 0.055
2.925AspGlu: 2.925 ± 0.047
1.789AspPhe: 1.789 ± 0.043
5.68AspGly: 5.68 ± 0.089
1.325AspHis: 1.325 ± 0.033
2.532AspIle: 2.532 ± 0.048
0.917AspLys: 0.917 ± 0.031
5.904AspLeu: 5.904 ± 0.078
1.133AspMet: 1.133 ± 0.028
1.112AspAsn: 1.112 ± 0.032
3.815AspPro: 3.815 ± 0.056
1.705AspGln: 1.705 ± 0.042
4.849AspArg: 4.849 ± 0.072
2.134AspSer: 2.134 ± 0.049
2.676AspThr: 2.676 ± 0.081
3.921AspVal: 3.921 ± 0.054
0.998AspTrp: 0.998 ± 0.031
1.23AspTyr: 1.23 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
7.666GluAla: 7.666 ± 0.097
0.327GluCys: 0.327 ± 0.018
2.152GluAsp: 2.152 ± 0.048
2.215GluGlu: 2.215 ± 0.048
1.377GluPhe: 1.377 ± 0.034
3.431GluGly: 3.431 ± 0.059
1.2GluHis: 1.2 ± 0.026
2.7GluIle: 2.7 ± 0.048
1.007GluLys: 1.007 ± 0.034
4.704GluLeu: 4.704 ± 0.083
1.21GluMet: 1.21 ± 0.026
1.084GluAsn: 1.084 ± 0.03
2.62GluPro: 2.62 ± 0.041
2.126GluGln: 2.126 ± 0.04
4.493GluArg: 4.493 ± 0.072
1.833GluSer: 1.833 ± 0.036
3.053GluThr: 3.053 ± 0.054
3.414GluVal: 3.414 ± 0.058
0.552GluTrp: 0.552 ± 0.023
0.76GluTyr: 0.76 ± 0.026
0.0GluXaa: 0.0 ± 0.0
Phe
4.092PheAla: 4.092 ± 0.058
0.408PheCys: 0.408 ± 0.017
2.203PheAsp: 2.203 ± 0.048
1.676PheGlu: 1.676 ± 0.039
1.095PhePhe: 1.095 ± 0.03
3.428PheGly: 3.428 ± 0.055
0.677PheHis: 0.677 ± 0.027
1.386PheIle: 1.386 ± 0.032
0.604PheLys: 0.604 ± 0.019
3.165PheLeu: 3.165 ± 0.06
0.663PheMet: 0.663 ± 0.019
0.871PheAsn: 0.871 ± 0.026
1.412PhePro: 1.412 ± 0.032
0.807PheGln: 0.807 ± 0.024
2.132PheArg: 2.132 ± 0.044
1.952PheSer: 1.952 ± 0.036
1.87PheThr: 1.87 ± 0.037
2.43PheVal: 2.43 ± 0.039
0.508PheTrp: 0.508 ± 0.018
0.764PheTyr: 0.764 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
10.53GlyAla: 10.53 ± 0.1
1.019GlyCys: 1.019 ± 0.026
4.462GlyAsp: 4.462 ± 0.085
4.229GlyGlu: 4.229 ± 0.059
3.497GlyPhe: 3.497 ± 0.054
8.386GlyGly: 8.386 ± 0.115
2.299GlyHis: 2.299 ± 0.046
4.72GlyIle: 4.72 ± 0.066
2.083GlyLys: 2.083 ± 0.043
10.256GlyLeu: 10.256 ± 0.101
2.404GlyMet: 2.404 ± 0.043
2.229GlyAsn: 2.229 ± 0.067
4.111GlyPro: 4.111 ± 0.067
2.918GlyGln: 2.918 ± 0.051
7.507GlyArg: 7.507 ± 0.088
5.653GlySer: 5.653 ± 0.093
5.22GlyThr: 5.22 ± 0.138
6.464GlyVal: 6.464 ± 0.076
1.644GlyTrp: 1.644 ± 0.038
2.169GlyTyr: 2.169 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
3.024HisAla: 3.024 ± 0.045
0.246HisCys: 0.246 ± 0.013
1.573HisAsp: 1.573 ± 0.04
1.162HisGlu: 1.162 ± 0.028
0.755HisPhe: 0.755 ± 0.026
2.397HisGly: 2.397 ± 0.045
0.686HisHis: 0.686 ± 0.025
0.758HisIle: 0.758 ± 0.022
0.359HisLys: 0.359 ± 0.017
2.342HisLeu: 2.342 ± 0.042
0.439HisMet: 0.439 ± 0.018
0.422HisAsn: 0.422 ± 0.015
1.712HisPro: 1.712 ± 0.036
0.663HisGln: 0.663 ± 0.025
1.925HisArg: 1.925 ± 0.036
1.026HisSer: 1.026 ± 0.031
0.874HisThr: 0.874 ± 0.024
1.867HisVal: 1.867 ± 0.037
0.385HisTrp: 0.385 ± 0.015
0.536HisTyr: 0.536 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.86IleAla: 6.86 ± 0.074
0.451IleCys: 0.451 ± 0.018
3.207IleAsp: 3.207 ± 0.057
3.087IleGlu: 3.087 ± 0.046
1.184IlePhe: 1.184 ± 0.031
5.056IleGly: 5.056 ± 0.067
0.854IleHis: 0.854 ± 0.025
1.651IleIle: 1.651 ± 0.039
0.863IleLys: 0.863 ± 0.024
4.215IleLeu: 4.215 ± 0.061
0.835IleMet: 0.835 ± 0.028
1.04IleAsn: 1.04 ± 0.027
2.223IlePro: 2.223 ± 0.045
1.129IleGln: 1.129 ± 0.027
3.087IleArg: 3.087 ± 0.054
2.425IleSer: 2.425 ± 0.04
2.625IleThr: 2.625 ± 0.096
3.879IleVal: 3.879 ± 0.058
0.503IleTrp: 0.503 ± 0.021
0.888IleTyr: 0.888 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
2.447LysAla: 2.447 ± 0.049
0.097LysCys: 0.097 ± 0.009
0.855LysAsp: 0.855 ± 0.025
0.709LysGlu: 0.709 ± 0.026
0.51LysPhe: 0.51 ± 0.02
1.53LysGly: 1.53 ± 0.041
0.411LysHis: 0.411 ± 0.017
0.875LysIle: 0.875 ± 0.026
0.491LysLys: 0.491 ± 0.024
2.213LysLeu: 2.213 ± 0.045
0.412LysMet: 0.412 ± 0.02
0.371LysAsn: 0.371 ± 0.019
1.4LysPro: 1.4 ± 0.036
0.799LysGln: 0.799 ± 0.025
1.421LysArg: 1.421 ± 0.037
1.125LysSer: 1.125 ± 0.026
1.087LysThr: 1.087 ± 0.031
1.479LysVal: 1.479 ± 0.04
0.204LysTrp: 0.204 ± 0.012
0.336LysTyr: 0.336 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
15.928LeuAla: 15.928 ± 0.154
1.129LeuCys: 1.129 ± 0.029
6.739LeuAsp: 6.739 ± 0.073
4.781LeuGlu: 4.781 ± 0.068
3.602LeuPhe: 3.602 ± 0.062
9.314LeuGly: 9.314 ± 0.094
2.696LeuHis: 2.696 ± 0.045
4.298LeuIle: 4.298 ± 0.062
2.054LeuLys: 2.054 ± 0.047
12.56LeuLeu: 12.56 ± 0.155
2.127LeuMet: 2.127 ± 0.041
2.168LeuAsn: 2.168 ± 0.039
6.845LeuPro: 6.845 ± 0.082
3.664LeuGln: 3.664 ± 0.052
8.804LeuArg: 8.804 ± 0.099
6.509LeuSer: 6.509 ± 0.072
5.541LeuThr: 5.541 ± 0.094
8.37LeuVal: 8.37 ± 0.088
1.242LeuTrp: 1.242 ± 0.034
1.998LeuTyr: 1.998 ± 0.043
0.0LeuXaa: 0.0 ± 0.0
Met
2.865MetAla: 2.865 ± 0.05
0.129MetCys: 0.129 ± 0.009
1.026MetAsp: 1.026 ± 0.025
0.827MetGlu: 0.827 ± 0.027
0.673MetPhe: 0.673 ± 0.02
1.451MetGly: 1.451 ± 0.029
0.495MetHis: 0.495 ± 0.019
1.156MetIle: 1.156 ± 0.032
0.544MetLys: 0.544 ± 0.022
2.945MetLeu: 2.945 ± 0.047
0.564MetMet: 0.564 ± 0.023
0.595MetAsn: 0.595 ± 0.023
1.56MetPro: 1.56 ± 0.036
1.091MetGln: 1.091 ± 0.031
2.005MetArg: 2.005 ± 0.035
1.535MetSer: 1.535 ± 0.037
1.576MetThr: 1.576 ± 0.034
1.666MetVal: 1.666 ± 0.038
0.172MetTrp: 0.172 ± 0.011
0.225MetTyr: 0.225 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.717AsnAla: 2.717 ± 0.043
0.213AsnCys: 0.213 ± 0.013
1.144AsnAsp: 1.144 ± 0.035
0.941AsnGlu: 0.941 ± 0.028
0.771AsnPhe: 0.771 ± 0.023
2.163AsnGly: 2.163 ± 0.049
0.493AsnHis: 0.493 ± 0.022
1.049AsnIle: 1.049 ± 0.033
0.428AsnLys: 0.428 ± 0.019
2.304AsnLeu: 2.304 ± 0.044
0.462AsnMet: 0.462 ± 0.018
0.634AsnAsn: 0.634 ± 0.023
1.545AsnPro: 1.545 ± 0.041
0.662AsnGln: 0.662 ± 0.022
1.575AsnArg: 1.575 ± 0.032
1.103AsnSer: 1.103 ± 0.032
1.121AsnThr: 1.121 ± 0.039
1.609AsnVal: 1.609 ± 0.051
0.364AsnTrp: 0.364 ± 0.019
0.567AsnTyr: 0.567 ± 0.023
0.0AsnXaa: 0.0 ± 0.0
Pro
8.083ProAla: 8.083 ± 0.103
0.374ProCys: 0.374 ± 0.014
4.274ProAsp: 4.274 ± 0.063
3.31ProGlu: 3.31 ± 0.052
1.822ProPhe: 1.822 ± 0.026
6.068ProGly: 6.068 ± 0.07
1.292ProHis: 1.292 ± 0.034
2.121ProIle: 2.121 ± 0.042
1.005ProLys: 1.005 ± 0.027
5.204ProLeu: 5.204 ± 0.079
1.269ProMet: 1.269 ± 0.029
1.174ProAsn: 1.174 ± 0.03
3.461ProPro: 3.461 ± 0.07
1.675ProGln: 1.675 ± 0.037
3.466ProArg: 3.466 ± 0.056
3.03ProSer: 3.03 ± 0.051
2.691ProThr: 2.691 ± 0.046
4.9ProVal: 4.9 ± 0.066
0.745ProTrp: 0.745 ± 0.023
1.107ProTyr: 1.107 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
5.26GlnAla: 5.26 ± 0.078
0.202GlnCys: 0.202 ± 0.013
1.714GlnAsp: 1.714 ± 0.037
1.375GlnGlu: 1.375 ± 0.035
0.964GlnPhe: 0.964 ± 0.029
2.604GlnGly: 2.604 ± 0.048
0.814GlnHis: 0.814 ± 0.024
1.594GlnIle: 1.594 ± 0.036
0.683GlnLys: 0.683 ± 0.024
2.991GlnLeu: 2.991 ± 0.053
0.739GlnMet: 0.739 ± 0.024
0.67GlnAsn: 0.67 ± 0.023
2.136GlnPro: 2.136 ± 0.038
1.415GlnGln: 1.415 ± 0.036
2.665GlnArg: 2.665 ± 0.043
1.818GlnSer: 1.818 ± 0.033
1.719GlnThr: 1.719 ± 0.042
2.584GlnVal: 2.584 ± 0.044
0.373GlnTrp: 0.373 ± 0.016
0.595GlnTyr: 0.595 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
8.994ArgAla: 8.994 ± 0.113
0.66ArgCys: 0.66 ± 0.024
4.484ArgAsp: 4.484 ± 0.058
3.793ArgGlu: 3.793 ± 0.061
2.772ArgPhe: 2.772 ± 0.047
5.496ArgGly: 5.496 ± 0.072
2.324ArgHis: 2.324 ± 0.045
4.203ArgIle: 4.203 ± 0.056
1.415ArgLys: 1.415 ± 0.035
9.814ArgLeu: 9.814 ± 0.115
2.029ArgMet: 2.029 ± 0.038
1.75ArgAsn: 1.75 ± 0.037
4.48ArgPro: 4.48 ± 0.069
3.039ArgGln: 3.039 ± 0.052
7.562ArgArg: 7.562 ± 0.086
4.245ArgSer: 4.245 ± 0.05
3.878ArgThr: 3.878 ± 0.044
5.115ArgVal: 5.115 ± 0.069
1.141ArgTrp: 1.141 ± 0.03
1.79ArgTyr: 1.79 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.405SerAla: 6.405 ± 0.098
0.466SerCys: 0.466 ± 0.02
2.783SerAsp: 2.783 ± 0.062
2.408SerGlu: 2.408 ± 0.045
2.115SerPhe: 2.115 ± 0.039
5.983SerGly: 5.983 ± 0.101
1.241SerHis: 1.241 ± 0.028
2.684SerIle: 2.684 ± 0.059
1.032SerLys: 1.032 ± 0.027
6.338SerLeu: 6.338 ± 0.068
1.337SerMet: 1.337 ± 0.037
1.316SerAsn: 1.316 ± 0.039
3.132SerPro: 3.132 ± 0.049
1.571SerGln: 1.571 ± 0.04
4.206SerArg: 4.206 ± 0.058
3.196SerSer: 3.196 ± 0.058
2.932SerThr: 2.932 ± 0.095
4.1SerVal: 4.1 ± 0.065
0.838SerTrp: 0.838 ± 0.023
1.198SerTyr: 1.198 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
6.513ThrAla: 6.513 ± 0.116
0.416ThrCys: 0.416 ± 0.016
2.818ThrAsp: 2.818 ± 0.072
2.203ThrGlu: 2.203 ± 0.041
1.443ThrPhe: 1.443 ± 0.037
5.913ThrGly: 5.913 ± 0.113
1.111ThrHis: 1.111 ± 0.025
2.769ThrIle: 2.769 ± 0.065
0.86ThrLys: 0.86 ± 0.03
6.691ThrLeu: 6.691 ± 0.115
1.197ThrMet: 1.197 ± 0.033
1.158ThrAsn: 1.158 ± 0.048
3.436ThrPro: 3.436 ± 0.081
1.565ThrGln: 1.565 ± 0.044
3.684ThrArg: 3.684 ± 0.057
2.905ThrSer: 2.905 ± 0.095
2.963ThrThr: 2.963 ± 0.097
4.28ThrVal: 4.28 ± 0.086
0.675ThrTrp: 0.675 ± 0.025
1.133ThrTyr: 1.133 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
10.373ValAla: 10.373 ± 0.093
0.647ValCys: 0.647 ± 0.023
3.724ValAsp: 3.724 ± 0.058
3.876ValGlu: 3.876 ± 0.061
2.448ValPhe: 2.448 ± 0.046
5.742ValGly: 5.742 ± 0.064
1.528ValHis: 1.528 ± 0.033
3.422ValIle: 3.422 ± 0.061
1.367ValLys: 1.367 ± 0.035
8.71ValLeu: 8.71 ± 0.097
1.785ValMet: 1.785 ± 0.032
1.714ValAsn: 1.714 ± 0.035
4.268ValPro: 4.268 ± 0.061
2.422ValGln: 2.422 ± 0.042
5.429ValArg: 5.429 ± 0.068
4.415ValSer: 4.415 ± 0.07
4.507ValThr: 4.507 ± 0.107
6.275ValVal: 6.275 ± 0.076
0.896ValTrp: 0.896 ± 0.021
1.232ValTyr: 1.232 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.111TrpAla: 1.111 ± 0.029
0.151TrpCys: 0.151 ± 0.01
0.625TrpAsp: 0.625 ± 0.024
0.489TrpGlu: 0.489 ± 0.02
0.519TrpPhe: 0.519 ± 0.022
0.833TrpGly: 0.833 ± 0.027
0.406TrpHis: 0.406 ± 0.018
0.683TrpIle: 0.683 ± 0.023
0.3TrpLys: 0.3 ± 0.016
1.939TrpLeu: 1.939 ± 0.039
0.356TrpMet: 0.356 ± 0.015
0.437TrpAsn: 0.437 ± 0.019
0.734TrpPro: 0.734 ± 0.025
0.656TrpGln: 0.656 ± 0.025
1.408TrpArg: 1.408 ± 0.031
1.013TrpSer: 1.013 ± 0.041
0.814TrpThr: 0.814 ± 0.025
0.792TrpVal: 0.792 ± 0.027
0.253TrpTrp: 0.253 ± 0.016
0.256TrpTyr: 0.256 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.404TyrAla: 2.404 ± 0.043
0.225TyrCys: 0.225 ± 0.013
1.318TyrAsp: 1.318 ± 0.031
0.99TyrGlu: 0.99 ± 0.028
0.665TyrPhe: 0.665 ± 0.025
2.026TyrGly: 2.026 ± 0.045
0.436TyrHis: 0.436 ± 0.02
0.688TyrIle: 0.688 ± 0.022
0.381TyrLys: 0.381 ± 0.017
2.017TyrLeu: 2.017 ± 0.04
0.346TyrMet: 0.346 ± 0.014
0.49TyrAsn: 0.49 ± 0.021
1.056TyrPro: 1.056 ± 0.032
0.682TyrGln: 0.682 ± 0.022
1.799TyrArg: 1.799 ± 0.038
1.065TyrSer: 1.065 ± 0.031
0.912TyrThr: 0.912 ± 0.03
1.456TyrVal: 1.456 ± 0.037
0.319TyrTrp: 0.319 ± 0.015
0.504TyrTyr: 0.504 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4254 proteins (1424553 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski