Amino acid dipepetide frequency for Inquilinus limosus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.178AlaAla: 22.178 ± 0.157	1.027AlaCys: 1.027 ± 0.02	7.701AlaAsp: 7.701 ± 0.064	8.492AlaGlu: 8.492 ± 0.071	4.492AlaPhe: 4.492 ± 0.046	13.646AlaGly: 13.646 ± 0.117	2.145AlaHis: 2.145 ± 0.035	6.23AlaIle: 6.23 ± 0.053	3.218AlaLys: 3.218 ± 0.046	15.27AlaLeu: 15.27 ± 0.104	3.455AlaMet: 3.455 ± 0.045	2.315AlaAsn: 2.315 ± 0.032	6.711AlaPro: 6.711 ± 0.072	4.018AlaGln: 4.018 ± 0.047	9.744AlaArg: 9.744 ± 0.079	5.576AlaSer: 5.576 ± 0.059	6.235AlaThr: 6.235 ± 0.056	10.661AlaVal: 10.661 ± 0.074	1.911AlaTrp: 1.911 ± 0.034	2.568AlaTyr: 2.568 ± 0.034	0.008AlaXaa: 0.008 ± 0.002
Cys	0.917CysAla: 0.917 ± 0.02	0.096CysCys: 0.096 ± 0.006	0.491CysAsp: 0.491 ± 0.016	0.332CysGlu: 0.332 ± 0.012	0.268CysPhe: 0.268 ± 0.011	0.938CysGly: 0.938 ± 0.025	0.214CysHis: 0.214 ± 0.011	0.333CysIle: 0.333 ± 0.012	0.113CysLys: 0.113 ± 0.008	0.806CysLeu: 0.806 ± 0.02	0.123CysMet: 0.123 ± 0.007	0.151CysAsn: 0.151 ± 0.007	0.409CysPro: 0.409 ± 0.013	0.201CysGln: 0.201 ± 0.01	0.754CysArg: 0.754 ± 0.02	0.407CysSer: 0.407 ± 0.016	0.349CysThr: 0.349 ± 0.014	0.534CysVal: 0.534 ± 0.014	0.122CysTrp: 0.122 ± 0.009	0.174CysTyr: 0.174 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.325AspAla: 7.325 ± 0.069	0.444AspCys: 0.444 ± 0.014	3.192AspAsp: 3.192 ± 0.058	2.877AspGlu: 2.877 ± 0.04	2.077AspPhe: 2.077 ± 0.037	6.179AspGly: 6.179 ± 0.073	1.274AspHis: 1.274 ± 0.024	2.667AspIle: 2.667 ± 0.042	1.287AspLys: 1.287 ± 0.034	6.31AspLeu: 6.31 ± 0.058	1.004AspMet: 1.004 ± 0.019	1.042AspAsn: 1.042 ± 0.025	4.359AspPro: 4.359 ± 0.049	1.782AspGln: 1.782 ± 0.03	5.48AspArg: 5.48 ± 0.056	2.31AspSer: 2.31 ± 0.037	2.865AspThr: 2.865 ± 0.056	3.86AspVal: 3.86 ± 0.047	1.082AspTrp: 1.082 ± 0.025	1.395AspTyr: 1.395 ± 0.029	0.004AspXaa: 0.004 ± 0.001
Glu	8.258GluAla: 8.258 ± 0.072	0.263GluCys: 0.263 ± 0.012	2.464GluAsp: 2.464 ± 0.031	2.676GluGlu: 2.676 ± 0.042	1.511GluPhe: 1.511 ± 0.029	4.148GluGly: 4.148 ± 0.047	1.011GluHis: 1.011 ± 0.023	3.094GluIle: 3.094 ± 0.042	1.355GluLys: 1.355 ± 0.027	4.923GluLeu: 4.923 ± 0.051	1.224GluMet: 1.224 ± 0.025	1.072GluAsn: 1.072 ± 0.024	2.76GluPro: 2.76 ± 0.034	1.805GluGln: 1.805 ± 0.033	4.563GluArg: 4.563 ± 0.056	2.017GluSer: 2.017 ± 0.034	3.159GluThr: 3.159 ± 0.037	3.528GluVal: 3.528 ± 0.041	0.638GluTrp: 0.638 ± 0.018	0.792GluTyr: 0.792 ± 0.02	0.003GluXaa: 0.003 ± 0.001
Phe	4.562PheAla: 4.562 ± 0.049	0.339PheCys: 0.339 ± 0.012	2.498PheAsp: 2.498 ± 0.031	1.724PheGlu: 1.724 ± 0.032	1.201PhePhe: 1.201 ± 0.026	3.74PheGly: 3.74 ± 0.041	0.722PheHis: 0.722 ± 0.019	1.468PheIle: 1.468 ± 0.028	0.696PheLys: 0.696 ± 0.019	3.391PheLeu: 3.391 ± 0.045	0.603PheMet: 0.603 ± 0.016	0.86PheAsn: 0.86 ± 0.021	1.626PhePro: 1.626 ± 0.029	1.01PheGln: 1.01 ± 0.023	2.389PheArg: 2.389 ± 0.033	1.773PheSer: 1.773 ± 0.028	1.975PheThr: 1.975 ± 0.032	2.698PheVal: 2.698 ± 0.036	0.544PheTrp: 0.544 ± 0.016	0.81PheTyr: 0.81 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	10.784GlyAla: 10.784 ± 0.096	0.887GlyCys: 0.887 ± 0.022	5.308GlyAsp: 5.308 ± 0.096	4.47GlyGlu: 4.47 ± 0.051	3.755GlyPhe: 3.755 ± 0.044	8.976GlyGly: 8.976 ± 0.153	1.971GlyHis: 1.971 ± 0.034	4.675GlyIle: 4.675 ± 0.046	2.494GlyLys: 2.494 ± 0.038	10.485GlyLeu: 10.485 ± 0.074	2.275GlyMet: 2.275 ± 0.032	2.201GlyAsn: 2.201 ± 0.067	4.448GlyPro: 4.448 ± 0.051	2.966GlyGln: 2.966 ± 0.038	7.937GlyArg: 7.937 ± 0.083	4.672GlySer: 4.672 ± 0.063	5.233GlyThr: 5.233 ± 0.049	6.581GlyVal: 6.581 ± 0.058	1.717GlyTrp: 1.717 ± 0.028	2.27GlyTyr: 2.27 ± 0.036	0.004GlyXaa: 0.004 ± 0.001
His	2.302HisAla: 2.302 ± 0.035	0.212HisCys: 0.212 ± 0.009	1.213HisAsp: 1.213 ± 0.025	0.888HisGlu: 0.888 ± 0.02	0.731HisPhe: 0.731 ± 0.018	2.031HisGly: 2.031 ± 0.035	0.562HisHis: 0.562 ± 0.022	0.811HisIle: 0.811 ± 0.021	0.358HisLys: 0.358 ± 0.013	2.13HisLeu: 2.13 ± 0.033	0.397HisMet: 0.397 ± 0.012	0.375HisAsn: 0.375 ± 0.013	1.476HisPro: 1.476 ± 0.024	0.539HisGln: 0.539 ± 0.017	1.656HisArg: 1.656 ± 0.027	0.83HisSer: 0.83 ± 0.023	0.694HisThr: 0.694 ± 0.017	1.402HisVal: 1.402 ± 0.029	0.353HisTrp: 0.353 ± 0.011	0.471HisTyr: 0.471 ± 0.014	0.001HisXaa: 0.001 ± 0.001
Ile	7.061IleAla: 7.061 ± 0.071	0.42IleCys: 0.42 ± 0.013	3.544IleAsp: 3.544 ± 0.046	2.938IleGlu: 2.938 ± 0.039	1.417IlePhe: 1.417 ± 0.026	5.322IleGly: 5.322 ± 0.059	0.867IleHis: 0.867 ± 0.02	1.696IleIle: 1.696 ± 0.031	0.953IleLys: 0.953 ± 0.021	4.568IleLeu: 4.568 ± 0.053	0.72IleMet: 0.72 ± 0.018	1.025IleAsn: 1.025 ± 0.023	2.275IlePro: 2.275 ± 0.034	1.165IleGln: 1.165 ± 0.027	3.514IleArg: 3.514 ± 0.04	2.133IleSer: 2.133 ± 0.033	2.322IleThr: 2.322 ± 0.037	3.817IleVal: 3.817 ± 0.04	0.561IleTrp: 0.561 ± 0.017	0.974IleTyr: 0.974 ± 0.022	0.002IleXaa: 0.002 ± 0.001
Lys	3.531LysAla: 3.531 ± 0.049	0.082LysCys: 0.082 ± 0.006	1.291LysAsp: 1.291 ± 0.031	0.954LysGlu: 0.954 ± 0.022	0.586LysPhe: 0.586 ± 0.018	1.975LysGly: 1.975 ± 0.04	0.406LysHis: 0.406 ± 0.014	1.192LysIle: 1.192 ± 0.026	0.644LysLys: 0.644 ± 0.021	2.456LysLeu: 2.456 ± 0.038	0.495LysMet: 0.495 ± 0.016	0.459LysAsn: 0.459 ± 0.016	1.673LysPro: 1.673 ± 0.032	0.767LysGln: 0.767 ± 0.021	1.741LysArg: 1.741 ± 0.031	1.178LysSer: 1.178 ± 0.024	1.4LysThr: 1.4 ± 0.03	1.89LysVal: 1.89 ± 0.033	0.247LysTrp: 0.247 ± 0.012	0.427LysTyr: 0.427 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	16.02LeuAla: 16.02 ± 0.103	0.911LeuCys: 0.911 ± 0.021	6.599LeuAsp: 6.599 ± 0.062	4.676LeuGlu: 4.676 ± 0.052	3.526LeuPhe: 3.526 ± 0.045	9.517LeuGly: 9.517 ± 0.077	1.938LeuHis: 1.938 ± 0.034	4.493LeuIle: 4.493 ± 0.056	2.697LeuLys: 2.697 ± 0.04	10.807LeuLeu: 10.807 ± 0.1	2.118LeuMet: 2.118 ± 0.032	2.198LeuAsn: 2.198 ± 0.035	6.463LeuPro: 6.463 ± 0.052	3.116LeuGln: 3.116 ± 0.043	8.032LeuArg: 8.032 ± 0.069	6.091LeuSer: 6.091 ± 0.056	5.652LeuThr: 5.652 ± 0.053	8.295LeuVal: 8.295 ± 0.072	1.312LeuTrp: 1.312 ± 0.025	2.154LeuTyr: 2.154 ± 0.033	0.002LeuXaa: 0.002 ± 0.001
Met	3.11MetAla: 3.11 ± 0.04	0.122MetCys: 0.122 ± 0.008	0.956MetAsp: 0.956 ± 0.02	0.844MetGlu: 0.844 ± 0.018	0.556MetPhe: 0.556 ± 0.015	1.533MetGly: 1.533 ± 0.03	0.358MetHis: 0.358 ± 0.012	1.093MetIle: 1.093 ± 0.019	0.659MetLys: 0.659 ± 0.019	2.222MetLeu: 2.222 ± 0.033	0.524MetMet: 0.524 ± 0.016	0.494MetAsn: 0.494 ± 0.014	1.405MetPro: 1.405 ± 0.024	0.691MetGln: 0.691 ± 0.017	1.68MetArg: 1.68 ± 0.029	1.261MetSer: 1.261 ± 0.024	1.74MetThr: 1.74 ± 0.027	1.691MetVal: 1.691 ± 0.024	0.168MetTrp: 0.168 ± 0.009	0.303MetTyr: 0.303 ± 0.012	0.001MetXaa: 0.001 ± 0.001
Asn	2.486AsnAla: 2.486 ± 0.034	0.182AsnCys: 0.182 ± 0.009	1.32AsnAsp: 1.32 ± 0.049	0.808AsnGlu: 0.808 ± 0.019	0.735AsnPhe: 0.735 ± 0.02	2.089AsnGly: 2.089 ± 0.044	0.41AsnHis: 0.41 ± 0.012	1.016AsnIle: 1.016 ± 0.024	0.418AsnLys: 0.418 ± 0.017	2.21AsnLeu: 2.21 ± 0.035	0.39AsnMet: 0.39 ± 0.013	0.495AsnAsn: 0.495 ± 0.017	1.614AsnPro: 1.614 ± 0.03	0.646AsnGln: 0.646 ± 0.018	1.481AsnArg: 1.481 ± 0.026	0.948AsnSer: 0.948 ± 0.022	1.033AsnThr: 1.033 ± 0.022	1.497AsnVal: 1.497 ± 0.03	0.343AsnTrp: 0.343 ± 0.013	0.55AsnTyr: 0.55 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	8.264ProAla: 8.264 ± 0.077	0.329ProCys: 0.329 ± 0.013	4.237ProAsp: 4.237 ± 0.039	3.915ProGlu: 3.915 ± 0.044	1.946ProPhe: 1.946 ± 0.029	5.712ProGly: 5.712 ± 0.054	1.117ProHis: 1.117 ± 0.023	2.272ProIle: 2.272 ± 0.032	1.481ProLys: 1.481 ± 0.027	5.339ProLeu: 5.339 ± 0.049	1.24ProMet: 1.24 ± 0.025	1.173ProAsn: 1.173 ± 0.025	3.371ProPro: 3.371 ± 0.057	1.744ProGln: 1.744 ± 0.03	3.478ProArg: 3.478 ± 0.048	2.78ProSer: 2.78 ± 0.04	2.585ProThr: 2.585 ± 0.035	4.856ProVal: 4.856 ± 0.055	0.848ProTrp: 0.848 ± 0.021	1.222ProTyr: 1.222 ± 0.025	0.002ProXaa: 0.002 ± 0.001
Gln	4.782GlnAla: 4.782 ± 0.057	0.172GlnCys: 0.172 ± 0.009	1.588GlnAsp: 1.588 ± 0.028	1.376GlnGlu: 1.376 ± 0.027	0.919GlnPhe: 0.919 ± 0.019	2.705GlnGly: 2.705 ± 0.036	0.575GlnHis: 0.575 ± 0.016	1.629GlnIle: 1.629 ± 0.03	0.767GlnLys: 0.767 ± 0.02	2.78GlnLeu: 2.78 ± 0.043	0.698GlnMet: 0.698 ± 0.018	0.615GlnAsn: 0.615 ± 0.019	1.931GlnPro: 1.931 ± 0.035	1.271GlnGln: 1.271 ± 0.033	2.562GlnArg: 2.562 ± 0.038	1.462GlnSer: 1.462 ± 0.028	1.388GlnThr: 1.388 ± 0.025	2.242GlnVal: 2.242 ± 0.035	0.374GlnTrp: 0.374 ± 0.014	0.599GlnTyr: 0.599 ± 0.018	0.001GlnXaa: 0.001 ± 0.001
Arg	8.868ArgAla: 8.868 ± 0.073	0.609ArgCys: 0.609 ± 0.019	4.548ArgAsp: 4.548 ± 0.049	3.753ArgGlu: 3.753 ± 0.049	3.09ArgPhe: 3.09 ± 0.041	5.64ArgGly: 5.64 ± 0.055	1.984ArgHis: 1.984 ± 0.033	4.445ArgIle: 4.445 ± 0.043	1.663ArgLys: 1.663 ± 0.032	9.26ArgLeu: 9.26 ± 0.082	1.76ArgMet: 1.76 ± 0.028	1.517ArgAsn: 1.517 ± 0.027	4.752ArgPro: 4.752 ± 0.046	2.732ArgGln: 2.732 ± 0.038	7.529ArgArg: 7.529 ± 0.075	3.804ArgSer: 3.804 ± 0.044	3.443ArgThr: 3.443 ± 0.043	5.115ArgVal: 5.115 ± 0.056	1.299ArgTrp: 1.299 ± 0.023	1.742ArgTyr: 1.742 ± 0.033	0.002ArgXaa: 0.002 ± 0.001
Ser	5.733SerAla: 5.733 ± 0.058	0.364SerCys: 0.364 ± 0.014	2.497SerAsp: 2.497 ± 0.04	1.945SerGlu: 1.945 ± 0.032	2.041SerPhe: 2.041 ± 0.034	5.347SerGly: 5.347 ± 0.069	0.94SerHis: 0.94 ± 0.019	2.374SerIle: 2.374 ± 0.036	1.02SerLys: 1.02 ± 0.025	5.142SerLeu: 5.142 ± 0.056	1.049SerMet: 1.049 ± 0.02	1.032SerAsn: 1.032 ± 0.023	2.895SerPro: 2.895 ± 0.039	1.357SerGln: 1.357 ± 0.024	3.519SerArg: 3.519 ± 0.047	2.302SerSer: 2.302 ± 0.039	2.435SerThr: 2.435 ± 0.036	3.66SerVal: 3.66 ± 0.042	0.859SerTrp: 0.859 ± 0.022	1.172SerTyr: 1.172 ± 0.026	0.001SerXaa: 0.001 ± 0.001
Thr	6.877ThrAla: 6.877 ± 0.059	0.346ThrCys: 0.346 ± 0.013	2.776ThrAsp: 2.776 ± 0.039	2.411ThrGlu: 2.411 ± 0.033	1.708ThrPhe: 1.708 ± 0.03	5.415ThrGly: 5.415 ± 0.061	0.902ThrHis: 0.902 ± 0.022	2.701ThrIle: 2.701 ± 0.041	1.041ThrLys: 1.041 ± 0.024	6.183ThrLeu: 6.183 ± 0.059	0.969ThrMet: 0.969 ± 0.021	0.996ThrAsn: 0.996 ± 0.022	3.382ThrPro: 3.382 ± 0.039	1.277ThrGln: 1.277 ± 0.024	3.275ThrArg: 3.275 ± 0.038	2.336ThrSer: 2.336 ± 0.035	2.608ThrThr: 2.608 ± 0.042	4.866ThrVal: 4.866 ± 0.05	0.633ThrTrp: 0.633 ± 0.017	1.106ThrTyr: 1.106 ± 0.022	0.002ThrXaa: 0.002 ± 0.001
Val	10.423ValAla: 10.423 ± 0.08	0.604ValCys: 0.604 ± 0.017	4.399ValAsp: 4.399 ± 0.044	4.592ValGlu: 4.592 ± 0.047	2.753ValPhe: 2.753 ± 0.034	5.918ValGly: 5.918 ± 0.053	1.266ValHis: 1.266 ± 0.026	3.65ValIle: 3.65 ± 0.046	1.774ValLys: 1.774 ± 0.032	8.274ValLeu: 8.274 ± 0.068	1.679ValMet: 1.679 ± 0.027	1.754ValAsn: 1.754 ± 0.031	4.401ValPro: 4.401 ± 0.048	2.091ValGln: 2.091 ± 0.033	5.034ValArg: 5.034 ± 0.05	3.909ValSer: 3.909 ± 0.046	4.717ValThr: 4.717 ± 0.048	6.363ValVal: 6.363 ± 0.048	0.948ValTrp: 0.948 ± 0.022	1.455ValTyr: 1.455 ± 0.027	0.003ValXaa: 0.003 ± 0.001
Trp	1.518TrpAla: 1.518 ± 0.029	0.13TrpCys: 0.13 ± 0.008	0.762TrpAsp: 0.762 ± 0.019	0.55TrpGlu: 0.55 ± 0.015	0.53TrpPhe: 0.53 ± 0.015	1.115TrpGly: 1.115 ± 0.022	0.334TrpHis: 0.334 ± 0.013	0.683TrpIle: 0.683 ± 0.019	0.326TrpLys: 0.326 ± 0.013	1.809TrpLeu: 1.809 ± 0.029	0.343TrpMet: 0.343 ± 0.014	0.41TrpAsn: 0.41 ± 0.013	0.838TrpPro: 0.838 ± 0.021	0.599TrpGln: 0.599 ± 0.016	1.369TrpArg: 1.369 ± 0.03	0.869TrpSer: 0.869 ± 0.021	0.905TrpThr: 0.905 ± 0.022	0.926TrpVal: 0.926 ± 0.021	0.254TrpTrp: 0.254 ± 0.01	0.287TrpTyr: 0.287 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.596TyrAla: 2.596 ± 0.039	0.196TyrCys: 0.196 ± 0.009	1.424TyrAsp: 1.424 ± 0.031	1.04TyrGlu: 1.04 ± 0.024	0.783TyrPhe: 0.783 ± 0.019	2.159TyrGly: 2.159 ± 0.035	0.437TyrHis: 0.437 ± 0.014	0.772TyrIle: 0.772 ± 0.02	0.432TyrLys: 0.432 ± 0.016	2.25TyrLeu: 2.25 ± 0.032	0.341TyrMet: 0.341 ± 0.013	0.487TyrAsn: 0.487 ± 0.017	1.116TyrPro: 1.116 ± 0.021	0.66TyrGln: 0.66 ± 0.018	1.813TyrArg: 1.813 ± 0.03	1.025TyrSer: 1.025 ± 0.024	1.071TyrThr: 1.071 ± 0.022	1.522TyrVal: 1.522 ± 0.026	0.346TyrTrp: 0.346 ± 0.012	0.555TyrTyr: 0.555 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.006XaaAla: 0.006 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.003XaaAsp: 0.003 ± 0.001	0.003XaaGlu: 0.003 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.005XaaGly: 0.005 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.004XaaPro: 0.004 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.003XaaArg: 0.003 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.002XaaThr: 0.002 ± 0.001	0.003XaaVal: 0.003 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.001XaaTyr: 0.001 ± 0.001	0.003XaaXaa: 0.003 ± 0.001

Statistics based on 7046 proteins (2248913 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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