Amino acid dipepetide frequency for Frankia alni (strain ACN14a)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.893AlaAla: 25.893 ± 0.195	1.087AlaCys: 1.087 ± 0.025	9.763AlaAsp: 9.763 ± 0.086	8.061AlaGlu: 8.061 ± 0.09	3.43AlaPhe: 3.43 ± 0.036	16.92AlaGly: 16.92 ± 0.125	2.717AlaHis: 2.717 ± 0.033	3.93AlaIle: 3.93 ± 0.047	1.731AlaLys: 1.731 ± 0.036	13.904AlaLeu: 13.904 ± 0.117	2.34AlaMet: 2.34 ± 0.032	1.836AlaAsn: 1.836 ± 0.032	8.222AlaPro: 8.222 ± 0.095	3.707AlaGln: 3.707 ± 0.048	12.223AlaArg: 12.223 ± 0.089	6.558AlaSer: 6.558 ± 0.066	8.125AlaThr: 8.125 ± 0.091	12.993AlaVal: 12.993 ± 0.111	1.868AlaTrp: 1.868 ± 0.029	2.226AlaTyr: 2.226 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.055CysAla: 1.055 ± 0.028	0.087CysCys: 0.087 ± 0.007	0.472CysAsp: 0.472 ± 0.014	0.353CysGlu: 0.353 ± 0.014	0.202CysPhe: 0.202 ± 0.01	0.897CysGly: 0.897 ± 0.022	0.206CysHis: 0.206 ± 0.01	0.17CysIle: 0.17 ± 0.008	0.071CysLys: 0.071 ± 0.006	0.796CysLeu: 0.796 ± 0.019	0.099CysMet: 0.099 ± 0.008	0.124CysAsn: 0.124 ± 0.007	0.53CysPro: 0.53 ± 0.02	0.184CysGln: 0.184 ± 0.008	0.693CysArg: 0.693 ± 0.023	0.425CysSer: 0.425 ± 0.014	0.402CysThr: 0.402 ± 0.018	0.597CysVal: 0.597 ± 0.019	0.135CysTrp: 0.135 ± 0.009	0.159CysTyr: 0.159 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.554AspAla: 8.554 ± 0.085	0.39AspCys: 0.39 ± 0.016	4.024AspAsp: 4.024 ± 0.059	3.489AspGlu: 3.489 ± 0.047	1.33AspPhe: 1.33 ± 0.027	6.725AspGly: 6.725 ± 0.069	1.474AspHis: 1.474 ± 0.026	1.705AspIle: 1.705 ± 0.032	0.647AspLys: 0.647 ± 0.022	6.956AspLeu: 6.956 ± 0.071	0.659AspMet: 0.659 ± 0.019	0.836AspAsn: 0.836 ± 0.022	5.294AspPro: 5.294 ± 0.058	1.642AspGln: 1.642 ± 0.034	5.613AspArg: 5.613 ± 0.058	2.416AspSer: 2.416 ± 0.036	2.904AspThr: 2.904 ± 0.037	5.117AspVal: 5.117 ± 0.053	0.855AspTrp: 0.855 ± 0.026	1.072AspTyr: 1.072 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.001GluAla: 6.001 ± 0.066	0.281GluCys: 0.281 ± 0.011	2.096GluAsp: 2.096 ± 0.037	2.166GluGlu: 2.166 ± 0.037	1.313GluPhe: 1.313 ± 0.027	3.182GluGly: 3.182 ± 0.049	1.334GluHis: 1.334 ± 0.025	2.284GluIle: 2.284 ± 0.037	0.798GluLys: 0.798 ± 0.025	6.082GluLeu: 6.082 ± 0.07	0.704GluMet: 0.704 ± 0.018	0.77GluAsn: 0.77 ± 0.019	3.354GluPro: 3.354 ± 0.053	1.982GluGln: 1.982 ± 0.036	4.993GluArg: 4.993 ± 0.065	2.198GluSer: 2.198 ± 0.038	2.41GluThr: 2.41 ± 0.037	4.234GluVal: 4.234 ± 0.044	0.588GluTrp: 0.588 ± 0.016	0.838GluTyr: 0.838 ± 0.021	0.0GluXaa: 0.0 ± 0.0
Phe	3.789PheAla: 3.789 ± 0.042	0.264PheCys: 0.264 ± 0.012	2.061PheAsp: 2.061 ± 0.036	1.173PheGlu: 1.173 ± 0.027	0.764PhePhe: 0.764 ± 0.024	2.967PheGly: 2.967 ± 0.041	0.564PheHis: 0.564 ± 0.016	0.629PheIle: 0.629 ± 0.015	0.263PheLys: 0.263 ± 0.011	2.359PheLeu: 2.359 ± 0.04	0.301PheMet: 0.301 ± 0.013	0.418PheAsn: 0.418 ± 0.015	1.419PhePro: 1.419 ± 0.029	0.567PheGln: 0.567 ± 0.015	1.79PheArg: 1.79 ± 0.031	1.288PheSer: 1.288 ± 0.03	1.762PheThr: 1.762 ± 0.032	2.306PheVal: 2.306 ± 0.033	0.338PheTrp: 0.338 ± 0.014	0.513PheTyr: 0.513 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	12.561GlyAla: 12.561 ± 0.102	0.814GlyCys: 0.814 ± 0.021	5.374GlyAsp: 5.374 ± 0.055	4.723GlyGlu: 4.723 ± 0.056	2.702GlyPhe: 2.702 ± 0.039	10.635GlyGly: 10.635 ± 0.132	2.289GlyHis: 2.289 ± 0.032	3.405GlyIle: 3.405 ± 0.039	1.415GlyLys: 1.415 ± 0.028	9.792GlyLeu: 9.792 ± 0.085	1.802GlyMet: 1.802 ± 0.027	1.437GlyAsn: 1.437 ± 0.028	6.859GlyPro: 6.859 ± 0.083	2.887GlyGln: 2.887 ± 0.041	9.74GlyArg: 9.74 ± 0.079	5.988GlySer: 5.988 ± 0.069	5.994GlyThr: 5.994 ± 0.068	7.951GlyVal: 7.951 ± 0.069	1.81GlyTrp: 1.81 ± 0.034	2.116GlyTyr: 2.116 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.66HisAla: 2.66 ± 0.039	0.195HisCys: 0.195 ± 0.01	1.306HisAsp: 1.306 ± 0.026	0.94HisGlu: 0.94 ± 0.019	0.539HisPhe: 0.539 ± 0.016	2.305HisGly: 2.305 ± 0.031	0.717HisHis: 0.717 ± 0.021	0.564HisIle: 0.564 ± 0.016	0.179HisLys: 0.179 ± 0.01	2.471HisLeu: 2.471 ± 0.04	0.243HisMet: 0.243 ± 0.01	0.3HisAsn: 0.3 ± 0.011	2.063HisPro: 2.063 ± 0.037	0.61HisGln: 0.61 ± 0.016	2.291HisArg: 2.291 ± 0.032	0.999HisSer: 0.999 ± 0.023	1.15HisThr: 1.15 ± 0.029	1.603HisVal: 1.603 ± 0.027	0.318HisTrp: 0.318 ± 0.012	0.401HisTyr: 0.401 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.755IleAla: 4.755 ± 0.05	0.284IleCys: 0.284 ± 0.012	2.31IleAsp: 2.31 ± 0.033	1.813IleGlu: 1.813 ± 0.035	0.737IlePhe: 0.737 ± 0.018	3.479IleGly: 3.479 ± 0.049	0.643IleHis: 0.643 ± 0.017	1.063IleIle: 1.063 ± 0.027	0.443IleLys: 0.443 ± 0.015	2.661IleLeu: 2.661 ± 0.041	0.428IleMet: 0.428 ± 0.015	0.628IleAsn: 0.628 ± 0.02	1.882IlePro: 1.882 ± 0.029	0.632IleGln: 0.632 ± 0.016	2.528IleArg: 2.528 ± 0.036	1.747IleSer: 1.747 ± 0.034	2.134IleThr: 2.134 ± 0.038	3.085IleVal: 3.085 ± 0.041	0.345IleTrp: 0.345 ± 0.014	0.569IleTyr: 0.569 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	1.592LysAla: 1.592 ± 0.036	0.062LysCys: 0.062 ± 0.005	0.656LysAsp: 0.656 ± 0.024	0.585LysGlu: 0.585 ± 0.02	0.261LysPhe: 0.261 ± 0.012	0.996LysGly: 0.996 ± 0.027	0.248LysHis: 0.248 ± 0.01	0.714LysIle: 0.714 ± 0.02	0.34LysLys: 0.34 ± 0.017	1.219LysLeu: 1.219 ± 0.028	0.208LysMet: 0.208 ± 0.01	0.291LysAsn: 0.291 ± 0.015	0.786LysPro: 0.786 ± 0.017	0.351LysGln: 0.351 ± 0.013	0.877LysArg: 0.877 ± 0.021	0.666LysSer: 0.666 ± 0.021	0.743LysThr: 0.743 ± 0.022	1.247LysVal: 1.247 ± 0.029	0.13LysTrp: 0.13 ± 0.008	0.246LysTyr: 0.246 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	17.045LeuAla: 17.045 ± 0.102	0.793LeuCys: 0.793 ± 0.02	7.073LeuAsp: 7.073 ± 0.073	3.804LeuGlu: 3.804 ± 0.053	2.452LeuPhe: 2.452 ± 0.037	9.43LeuGly: 9.43 ± 0.08	2.213LeuHis: 2.213 ± 0.034	3.0LeuIle: 3.0 ± 0.048	0.971LeuLys: 0.971 ± 0.024	10.784LeuLeu: 10.784 ± 0.096	1.182LeuMet: 1.182 ± 0.025	1.339LeuAsn: 1.339 ± 0.033	6.636LeuPro: 6.636 ± 0.056	1.725LeuGln: 1.725 ± 0.029	9.245LeuArg: 9.245 ± 0.069	4.877LeuSer: 4.877 ± 0.045	6.528LeuThr: 6.528 ± 0.073	9.155LeuVal: 9.155 ± 0.08	1.232LeuTrp: 1.232 ± 0.031	1.504LeuTyr: 1.504 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	1.98MetAla: 1.98 ± 0.036	0.123MetCys: 0.123 ± 0.008	0.704MetAsp: 0.704 ± 0.019	0.558MetGlu: 0.558 ± 0.016	0.456MetPhe: 0.456 ± 0.016	1.097MetGly: 1.097 ± 0.024	0.279MetHis: 0.279 ± 0.012	0.699MetIle: 0.699 ± 0.017	0.235MetLys: 0.235 ± 0.009	1.552MetLeu: 1.552 ± 0.026	0.253MetMet: 0.253 ± 0.011	0.306MetAsn: 0.306 ± 0.012	1.07MetPro: 1.07 ± 0.022	0.36MetGln: 0.36 ± 0.013	1.342MetArg: 1.342 ± 0.026	1.157MetSer: 1.157 ± 0.022	1.36MetThr: 1.36 ± 0.026	1.186MetVal: 1.186 ± 0.023	0.174MetTrp: 0.174 ± 0.01	0.251MetTyr: 0.251 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	1.91AsnAla: 1.91 ± 0.034	0.125AsnCys: 0.125 ± 0.008	0.814AsnAsp: 0.814 ± 0.022	0.599AsnGlu: 0.599 ± 0.019	0.372AsnPhe: 0.372 ± 0.013	1.522AsnGly: 1.522 ± 0.037	0.331AsnHis: 0.331 ± 0.013	0.588AsnIle: 0.588 ± 0.017	0.222AsnLys: 0.222 ± 0.013	1.605AsnLeu: 1.605 ± 0.032	0.216AsnMet: 0.216 ± 0.01	0.347AsnAsn: 0.347 ± 0.017	1.33AsnPro: 1.33 ± 0.023	0.416AsnGln: 0.416 ± 0.015	1.231AsnArg: 1.231 ± 0.028	0.739AsnSer: 0.739 ± 0.023	0.889AsnThr: 0.889 ± 0.021	1.247AsnVal: 1.247 ± 0.024	0.203AsnTrp: 0.203 ± 0.01	0.334AsnTyr: 0.334 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	12.02ProAla: 12.02 ± 0.123	0.367ProCys: 0.367 ± 0.014	5.116ProAsp: 5.116 ± 0.063	3.354ProGlu: 3.354 ± 0.046	1.575ProPhe: 1.575 ± 0.027	7.948ProGly: 7.948 ± 0.084	1.37ProHis: 1.37 ± 0.028	1.694ProIle: 1.694 ± 0.027	0.757ProLys: 0.757 ± 0.02	5.259ProLeu: 5.259 ± 0.053	0.986ProMet: 0.986 ± 0.022	0.928ProAsn: 0.928 ± 0.025	5.428ProPro: 5.428 ± 0.091	1.566ProGln: 1.566 ± 0.031	5.017ProArg: 5.017 ± 0.064	3.774ProSer: 3.774 ± 0.05	4.327ProThr: 4.327 ± 0.053	5.77ProVal: 5.77 ± 0.062	0.902ProTrp: 0.902 ± 0.02	1.083ProTyr: 1.083 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.861GlnAla: 3.861 ± 0.044	0.16GlnCys: 0.16 ± 0.009	1.122GlnAsp: 1.122 ± 0.04	1.013GlnGlu: 1.013 ± 0.024	0.623GlnPhe: 0.623 ± 0.017	1.954GlnGly: 1.954 ± 0.037	0.591GlnHis: 0.591 ± 0.017	1.101GlnIle: 1.101 ± 0.023	0.344GlnLys: 0.344 ± 0.015	2.578GlnLeu: 2.578 ± 0.039	0.405GlnMet: 0.405 ± 0.014	0.415GlnAsn: 0.415 ± 0.018	1.977GlnPro: 1.977 ± 0.042	0.93GlnGln: 0.93 ± 0.027	2.415GlnArg: 2.415 ± 0.038	1.14GlnSer: 1.14 ± 0.028	1.29GlnThr: 1.29 ± 0.027	2.465GlnVal: 2.465 ± 0.034	0.389GlnTrp: 0.389 ± 0.014	0.458GlnTyr: 0.458 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	11.646ArgAla: 11.646 ± 0.084	0.723ArgCys: 0.723 ± 0.019	4.789ArgAsp: 4.789 ± 0.052	4.301ArgGlu: 4.301 ± 0.05	2.497ArgPhe: 2.497 ± 0.038	7.037ArgGly: 7.037 ± 0.06	2.254ArgHis: 2.254 ± 0.035	3.353ArgIle: 3.353 ± 0.043	0.998ArgLys: 0.998 ± 0.025	9.772ArgLeu: 9.772 ± 0.087	1.796ArgMet: 1.796 ± 0.03	1.25ArgAsn: 1.25 ± 0.028	6.599ArgPro: 6.599 ± 0.07	2.474ArgGln: 2.474 ± 0.042	10.049ArgArg: 10.049 ± 0.096	4.733ArgSer: 4.733 ± 0.047	5.084ArgThr: 5.084 ± 0.047	6.521ArgVal: 6.521 ± 0.061	1.536ArgTrp: 1.536 ± 0.03	1.727ArgTyr: 1.727 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	7.304SerAla: 7.304 ± 0.062	0.395SerCys: 0.395 ± 0.015	2.716SerAsp: 2.716 ± 0.038	1.996SerGlu: 1.996 ± 0.036	1.477SerPhe: 1.477 ± 0.029	6.035SerGly: 6.035 ± 0.07	0.952SerHis: 0.952 ± 0.022	1.528SerIle: 1.528 ± 0.026	0.643SerLys: 0.643 ± 0.019	4.615SerLeu: 4.615 ± 0.049	0.992SerMet: 0.992 ± 0.023	0.757SerAsn: 0.757 ± 0.021	4.036SerPro: 4.036 ± 0.046	1.148SerGln: 1.148 ± 0.025	4.152SerArg: 4.152 ± 0.047	2.989SerSer: 2.989 ± 0.049	3.275SerThr: 3.275 ± 0.047	4.176SerVal: 4.176 ± 0.049	0.861SerTrp: 0.861 ± 0.02	1.046SerTyr: 1.046 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.86ThrAla: 8.86 ± 0.088	0.448ThrCys: 0.448 ± 0.016	3.514ThrAsp: 3.514 ± 0.045	2.641ThrGlu: 2.641 ± 0.036	1.625ThrPhe: 1.625 ± 0.03	6.673ThrGly: 6.673 ± 0.069	1.084ThrHis: 1.084 ± 0.022	1.974ThrIle: 1.974 ± 0.036	0.744ThrLys: 0.744 ± 0.023	5.559ThrLeu: 5.559 ± 0.059	0.944ThrMet: 0.944 ± 0.022	0.916ThrAsn: 0.916 ± 0.024	4.344ThrPro: 4.344 ± 0.058	1.182ThrGln: 1.182 ± 0.023	4.329ThrArg: 4.329 ± 0.044	3.308ThrSer: 3.308 ± 0.047	3.925ThrThr: 3.925 ± 0.062	5.726ThrVal: 5.726 ± 0.072	0.804ThrTrp: 0.804 ± 0.022	1.053ThrTyr: 1.053 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	12.233ValAla: 12.233 ± 0.096	0.74ValCys: 0.74 ± 0.021	5.851ValAsp: 5.851 ± 0.047	4.534ValGlu: 4.534 ± 0.051	2.217ValPhe: 2.217 ± 0.035	7.753ValGly: 7.753 ± 0.065	1.86ValHis: 1.86 ± 0.031	2.83ValIle: 2.83 ± 0.038	0.986ValLys: 0.986 ± 0.023	9.208ValLeu: 9.208 ± 0.078	1.145ValMet: 1.145 ± 0.021	1.527ValAsn: 1.527 ± 0.028	5.431ValPro: 5.431 ± 0.054	1.813ValGln: 1.813 ± 0.031	7.369ValArg: 7.369 ± 0.075	4.294ValSer: 4.294 ± 0.051	5.487ValThr: 5.487 ± 0.062	8.576ValVal: 8.576 ± 0.084	1.064ValTrp: 1.064 ± 0.021	1.296ValTyr: 1.296 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.618TrpAla: 1.618 ± 0.031	0.167TrpCys: 0.167 ± 0.009	0.782TrpAsp: 0.782 ± 0.024	0.633TrpGlu: 0.633 ± 0.019	0.419TrpPhe: 0.419 ± 0.014	0.968TrpGly: 0.968 ± 0.024	0.354TrpHis: 0.354 ± 0.012	0.511TrpIle: 0.511 ± 0.016	0.209TrpLys: 0.209 ± 0.01	1.699TrpLeu: 1.699 ± 0.028	0.261TrpMet: 0.261 ± 0.009	0.321TrpAsn: 0.321 ± 0.013	0.875TrpPro: 0.875 ± 0.023	0.501TrpGln: 0.501 ± 0.017	1.468TrpArg: 1.468 ± 0.028	0.957TrpSer: 0.957 ± 0.02	0.905TrpThr: 0.905 ± 0.02	0.939TrpVal: 0.939 ± 0.02	0.315TrpTrp: 0.315 ± 0.014	0.26TrpTyr: 0.26 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.196TyrAla: 2.196 ± 0.032	0.155TyrCys: 0.155 ± 0.008	1.155TyrAsp: 1.155 ± 0.026	0.871TyrGlu: 0.871 ± 0.023	0.546TyrPhe: 0.546 ± 0.017	1.769TyrGly: 1.769 ± 0.033	0.374TyrHis: 0.374 ± 0.014	0.427TyrIle: 0.427 ± 0.017	0.222TyrLys: 0.222 ± 0.011	2.119TyrLeu: 2.119 ± 0.034	0.179TyrMet: 0.179 ± 0.011	0.292TyrAsn: 0.292 ± 0.014	1.109TyrPro: 1.109 ± 0.029	0.556TyrGln: 0.556 ± 0.015	1.772TyrArg: 1.772 ± 0.035	0.838TyrSer: 0.838 ± 0.02	0.958TyrThr: 0.958 ± 0.027	1.319TyrVal: 1.319 ± 0.028	0.295TyrTrp: 0.295 ± 0.01	0.37TyrTyr: 0.37 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6710 proteins (2157716 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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