Amino acid dipepetide frequency for candidate division MSBL1 archaeon SCGC-AAA259E22

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.098AlaAla: 4.098 ± 0.184
0.683AlaCys: 0.683 ± 0.07
3.191AlaAsp: 3.191 ± 0.132
5.704AlaGlu: 5.704 ± 0.193
2.539AlaPhe: 2.539 ± 0.106
4.995AlaGly: 4.995 ± 0.231
0.939AlaHis: 0.939 ± 0.08
4.156AlaIle: 4.156 ± 0.152
3.984AlaLys: 3.984 ± 0.141
5.59AlaLeu: 5.59 ± 0.196
1.564AlaMet: 1.564 ± 0.096
1.846AlaAsn: 1.846 ± 0.097
1.95AlaPro: 1.95 ± 0.113
1.481AlaGln: 1.481 ± 0.083
3.41AlaArg: 3.41 ± 0.138
3.65AlaSer: 3.65 ± 0.164
2.711AlaThr: 2.711 ± 0.142
4.562AlaVal: 4.562 ± 0.184
0.766AlaTrp: 0.766 ± 0.067
1.908AlaTyr: 1.908 ± 0.113
0.0AlaXaa: 0.0 ± 0.0
Cys
0.537CysAla: 0.537 ± 0.049
0.172CysCys: 0.172 ± 0.038
0.6CysAsp: 0.6 ± 0.058
1.085CysGlu: 1.085 ± 0.089
0.495CysPhe: 0.495 ± 0.053
1.116CysGly: 1.116 ± 0.094
0.209CysHis: 0.209 ± 0.032
0.626CysIle: 0.626 ± 0.063
0.516CysLys: 0.516 ± 0.05
0.798CysLeu: 0.798 ± 0.071
0.177CysMet: 0.177 ± 0.032
0.355CysAsn: 0.355 ± 0.042
0.902CysPro: 0.902 ± 0.09
0.323CysGln: 0.323 ± 0.044
0.574CysArg: 0.574 ± 0.053
0.756CysSer: 0.756 ± 0.066
0.428CysThr: 0.428 ± 0.05
0.678CysVal: 0.678 ± 0.062
0.115CysTrp: 0.115 ± 0.021
0.297CysTyr: 0.297 ± 0.045
0.0CysXaa: 0.0 ± 0.0
Asp
3.123AspAla: 3.123 ± 0.132
0.626AspCys: 0.626 ± 0.051
2.894AspAsp: 2.894 ± 0.174
5.48AspGlu: 5.48 ± 0.187
2.748AspPhe: 2.748 ± 0.127
3.801AspGly: 3.801 ± 0.149
0.918AspHis: 0.918 ± 0.064
4.39AspIle: 4.39 ± 0.166
3.713AspLys: 3.713 ± 0.15
6.507AspLeu: 6.507 ± 0.192
1.272AspMet: 1.272 ± 0.084
1.695AspAsn: 1.695 ± 0.107
2.878AspPro: 2.878 ± 0.125
1.178AspGln: 1.178 ± 0.074
3.66AspArg: 3.66 ± 0.161
3.285AspSer: 3.285 ± 0.136
2.414AspThr: 2.414 ± 0.137
4.26AspVal: 4.26 ± 0.154
0.839AspTrp: 0.839 ± 0.072
2.242AspTyr: 2.242 ± 0.11
0.0AspXaa: 0.0 ± 0.0
Glu
5.652GluAla: 5.652 ± 0.176
0.892GluCys: 0.892 ± 0.08
5.97GluAsp: 5.97 ± 0.189
12.18GluGlu: 12.18 ± 0.372
3.259GluPhe: 3.259 ± 0.143
6.262GluGly: 6.262 ± 0.198
1.309GluHis: 1.309 ± 0.085
8.202GluIle: 8.202 ± 0.194
10.528GluLys: 10.528 ± 0.288
8.317GluLeu: 8.317 ± 0.251
2.305GluMet: 2.305 ± 0.108
5.371GluAsn: 5.371 ± 0.197
2.79GluPro: 2.79 ± 0.118
1.601GluGln: 1.601 ± 0.103
6.054GluArg: 6.054 ± 0.216
4.818GluSer: 4.818 ± 0.16
4.688GluThr: 4.688 ± 0.167
6.716GluVal: 6.716 ± 0.19
0.939GluTrp: 0.939 ± 0.085
2.498GluTyr: 2.498 ± 0.114
0.0GluXaa: 0.0 ± 0.0
Phe
2.2PheAla: 2.2 ± 0.116
0.474PheCys: 0.474 ± 0.053
2.664PheAsp: 2.664 ± 0.113
3.77PheGlu: 3.77 ± 0.146
1.95PhePhe: 1.95 ± 0.145
3.394PheGly: 3.394 ± 0.14
0.855PheHis: 0.855 ± 0.073
2.206PheIle: 2.206 ± 0.106
2.159PheLys: 2.159 ± 0.119
4.562PheLeu: 4.562 ± 0.201
0.871PheMet: 0.871 ± 0.078
1.163PheAsn: 1.163 ± 0.076
1.731PhePro: 1.731 ± 0.104
1.074PheGln: 1.074 ± 0.082
2.023PheArg: 2.023 ± 0.11
3.321PheSer: 3.321 ± 0.164
1.762PheThr: 1.762 ± 0.105
2.685PheVal: 2.685 ± 0.114
0.532PheTrp: 0.532 ± 0.06
1.335PheTyr: 1.335 ± 0.088
0.0PheXaa: 0.0 ± 0.0
Gly
4.656GlyAla: 4.656 ± 0.207
0.845GlyCys: 0.845 ± 0.088
3.963GlyAsp: 3.963 ± 0.144
7.128GlyGlu: 7.128 ± 0.196
3.191GlyPhe: 3.191 ± 0.131
6.304GlyGly: 6.304 ± 0.233
1.231GlyHis: 1.231 ± 0.085
5.595GlyIle: 5.595 ± 0.185
6.101GlyLys: 6.101 ± 0.164
6.122GlyLeu: 6.122 ± 0.229
2.039GlyMet: 2.039 ± 0.104
2.258GlyAsn: 2.258 ± 0.125
2.425GlyPro: 2.425 ± 0.127
1.356GlyGln: 1.356 ± 0.087
4.302GlyArg: 4.302 ± 0.179
4.964GlySer: 4.964 ± 0.187
3.54GlyThr: 3.54 ± 0.155
5.699GlyVal: 5.699 ± 0.195
0.996GlyTrp: 0.996 ± 0.08
2.529GlyTyr: 2.529 ± 0.13
0.0GlyXaa: 0.0 ± 0.0
His
0.933HisAla: 0.933 ± 0.075
0.25HisCys: 0.25 ± 0.037
0.98HisAsp: 0.98 ± 0.071
1.319HisGlu: 1.319 ± 0.089
0.667HisPhe: 0.667 ± 0.059
1.267HisGly: 1.267 ± 0.08
0.412HisHis: 0.412 ± 0.054
1.027HisIle: 1.027 ± 0.077
0.813HisLys: 0.813 ± 0.066
1.705HisLeu: 1.705 ± 0.089
0.386HisMet: 0.386 ± 0.054
0.6HisAsn: 0.6 ± 0.052
1.204HisPro: 1.204 ± 0.09
0.37HisGln: 0.37 ± 0.044
0.933HisArg: 0.933 ± 0.069
0.991HisSer: 0.991 ± 0.076
0.693HisThr: 0.693 ± 0.059
1.121HisVal: 1.121 ± 0.083
0.24HisTrp: 0.24 ± 0.031
0.542HisTyr: 0.542 ± 0.052
0.0HisXaa: 0.0 ± 0.0
Ile
4.589IleAla: 4.589 ± 0.176
0.683IleCys: 0.683 ± 0.056
4.338IleAsp: 4.338 ± 0.16
7.321IleGlu: 7.321 ± 0.2
3.139IlePhe: 3.139 ± 0.158
5.496IleGly: 5.496 ± 0.196
1.184IleHis: 1.184 ± 0.079
4.338IleIle: 4.338 ± 0.174
4.114IleLys: 4.114 ± 0.166
6.591IleLeu: 6.591 ± 0.222
1.246IleMet: 1.246 ± 0.093
2.55IleAsn: 2.55 ± 0.122
3.165IlePro: 3.165 ± 0.119
1.669IleGln: 1.669 ± 0.107
3.817IleArg: 3.817 ± 0.138
4.974IleSer: 4.974 ± 0.18
3.499IleThr: 3.499 ± 0.151
4.86IleVal: 4.86 ± 0.176
0.678IleTrp: 0.678 ± 0.069
1.961IleTyr: 1.961 ± 0.092
0.0IleXaa: 0.0 ± 0.0
Lys
4.594LysAla: 4.594 ± 0.171
0.834LysCys: 0.834 ± 0.075
4.01LysAsp: 4.01 ± 0.155
7.8LysGlu: 7.8 ± 0.251
2.456LysPhe: 2.456 ± 0.11
5.063LysGly: 5.063 ± 0.17
0.996LysHis: 0.996 ± 0.081
6.695LysIle: 6.695 ± 0.198
6.898LysLys: 6.898 ± 0.294
6.335LysLeu: 6.335 ± 0.183
1.736LysMet: 1.736 ± 0.1
3.561LysAsn: 3.561 ± 0.16
2.498LysPro: 2.498 ± 0.116
1.742LysGln: 1.742 ± 0.114
4.203LysArg: 4.203 ± 0.149
4.182LysSer: 4.182 ± 0.153
3.905LysThr: 3.905 ± 0.134
5.016LysVal: 5.016 ± 0.165
0.876LysTrp: 0.876 ± 0.06
2.326LysTyr: 2.326 ± 0.108
0.0LysXaa: 0.0 ± 0.0
Leu
6.215LeuAla: 6.215 ± 0.21
0.819LeuCys: 0.819 ± 0.069
5.866LeuAsp: 5.866 ± 0.183
9.485LeuGlu: 9.485 ± 0.245
3.332LeuPhe: 3.332 ± 0.159
6.878LeuGly: 6.878 ± 0.206
1.465LeuHis: 1.465 ± 0.079
5.861LeuIle: 5.861 ± 0.193
7.003LeuLys: 7.003 ± 0.231
7.498LeuLeu: 7.498 ± 0.271
1.825LeuMet: 1.825 ± 0.096
3.645LeuAsn: 3.645 ± 0.128
3.572LeuPro: 3.572 ± 0.135
2.19LeuGln: 2.19 ± 0.108
5.047LeuArg: 5.047 ± 0.179
6.507LeuSer: 6.507 ± 0.203
4.656LeuThr: 4.656 ± 0.17
5.673LeuVal: 5.673 ± 0.171
0.855LeuTrp: 0.855 ± 0.08
2.273LeuTyr: 2.273 ± 0.114
0.0LeuXaa: 0.0 ± 0.0
Met
1.403MetAla: 1.403 ± 0.087
0.229MetCys: 0.229 ± 0.035
1.559MetAsp: 1.559 ± 0.102
2.226MetGlu: 2.226 ± 0.108
0.6MetPhe: 0.6 ± 0.049
1.898MetGly: 1.898 ± 0.108
0.334MetHis: 0.334 ± 0.05
1.397MetIle: 1.397 ± 0.085
2.028MetLys: 2.028 ± 0.106
1.601MetLeu: 1.601 ± 0.089
0.532MetMet: 0.532 ± 0.055
1.058MetAsn: 1.058 ± 0.074
0.933MetPro: 0.933 ± 0.071
0.386MetGln: 0.386 ± 0.039
1.262MetArg: 1.262 ± 0.074
1.554MetSer: 1.554 ± 0.089
1.121MetThr: 1.121 ± 0.065
1.736MetVal: 1.736 ± 0.101
0.151MetTrp: 0.151 ± 0.024
0.428MetTyr: 0.428 ± 0.056
0.0MetXaa: 0.0 ± 0.0
Asn
2.294AsnAla: 2.294 ± 0.112
0.516AsnCys: 0.516 ± 0.055
1.564AsnAsp: 1.564 ± 0.104
2.805AsnGlu: 2.805 ± 0.123
1.893AsnPhe: 1.893 ± 0.099
2.539AsnGly: 2.539 ± 0.127
0.693AsnHis: 0.693 ± 0.058
2.951AsnIle: 2.951 ± 0.128
2.299AsnLys: 2.299 ± 0.118
4.39AsnLeu: 4.39 ± 0.159
0.86AsnMet: 0.86 ± 0.064
1.502AsnAsn: 1.502 ± 0.087
2.477AsnPro: 2.477 ± 0.123
0.907AsnGln: 0.907 ± 0.073
2.237AsnArg: 2.237 ± 0.12
2.445AsnSer: 2.445 ± 0.121
1.653AsnThr: 1.653 ± 0.105
2.659AsnVal: 2.659 ± 0.124
0.542AsnTrp: 0.542 ± 0.054
1.304AsnTyr: 1.304 ± 0.083
0.0AsnXaa: 0.0 ± 0.0
Pro
2.211ProAla: 2.211 ± 0.113
0.438ProCys: 0.438 ± 0.046
2.664ProAsp: 2.664 ± 0.103
4.651ProGlu: 4.651 ± 0.161
1.637ProPhe: 1.637 ± 0.109
2.821ProGly: 2.821 ± 0.148
0.803ProHis: 0.803 ± 0.055
2.555ProIle: 2.555 ± 0.121
2.55ProLys: 2.55 ± 0.105
3.431ProLeu: 3.431 ± 0.135
0.756ProMet: 0.756 ± 0.053
1.47ProAsn: 1.47 ± 0.078
1.955ProPro: 1.955 ± 0.109
0.965ProGln: 0.965 ± 0.064
1.788ProArg: 1.788 ± 0.097
2.904ProSer: 2.904 ± 0.124
2.023ProThr: 2.023 ± 0.119
2.951ProVal: 2.951 ± 0.14
0.401ProTrp: 0.401 ± 0.05
1.319ProTyr: 1.319 ± 0.086
0.0ProXaa: 0.0 ± 0.0
Gln
1.33GlnAla: 1.33 ± 0.087
0.219GlnCys: 0.219 ± 0.033
1.121GlnAsp: 1.121 ± 0.084
2.091GlnGlu: 2.091 ± 0.107
0.897GlnPhe: 0.897 ± 0.071
1.543GlnGly: 1.543 ± 0.093
0.365GlnHis: 0.365 ± 0.04
1.762GlnIle: 1.762 ± 0.099
2.091GlnLys: 2.091 ± 0.099
1.783GlnLeu: 1.783 ± 0.087
0.485GlnMet: 0.485 ± 0.052
1.158GlnAsn: 1.158 ± 0.083
0.678GlnPro: 0.678 ± 0.059
0.532GlnGln: 0.532 ± 0.057
1.413GlnArg: 1.413 ± 0.082
1.173GlnSer: 1.173 ± 0.078
1.09GlnThr: 1.09 ± 0.077
1.59GlnVal: 1.59 ± 0.095
0.25GlnTrp: 0.25 ± 0.037
0.584GlnTyr: 0.584 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
3.348ArgAla: 3.348 ± 0.135
0.589ArgCys: 0.589 ± 0.057
3.275ArgAsp: 3.275 ± 0.15
6.758ArgGlu: 6.758 ± 0.196
2.289ArgPhe: 2.289 ± 0.126
4.276ArgGly: 4.276 ± 0.161
0.803ArgHis: 0.803 ± 0.061
3.937ArgIle: 3.937 ± 0.151
5.678ArgLys: 5.678 ± 0.179
4.625ArgLeu: 4.625 ± 0.159
1.371ArgMet: 1.371 ± 0.077
2.56ArgAsn: 2.56 ± 0.128
1.658ArgPro: 1.658 ± 0.1
1.121ArgGln: 1.121 ± 0.081
3.713ArgArg: 3.713 ± 0.193
2.784ArgSer: 2.784 ± 0.139
2.508ArgThr: 2.508 ± 0.129
3.723ArgVal: 3.723 ± 0.137
0.657ArgTrp: 0.657 ± 0.061
1.762ArgTyr: 1.762 ± 0.107
0.0ArgXaa: 0.0 ± 0.0
Ser
3.16SerAla: 3.16 ± 0.135
0.605SerCys: 0.605 ± 0.059
3.676SerAsp: 3.676 ± 0.131
6.132SerGlu: 6.132 ± 0.183
2.972SerPhe: 2.972 ± 0.152
5.141SerGly: 5.141 ± 0.175
1.017SerHis: 1.017 ± 0.07
4.307SerIle: 4.307 ± 0.151
4.781SerLys: 4.781 ± 0.174
6.002SerLeu: 6.002 ± 0.179
1.601SerMet: 1.601 ± 0.102
2.247SerAsn: 2.247 ± 0.116
2.696SerPro: 2.696 ± 0.124
1.648SerGln: 1.648 ± 0.1
3.791SerArg: 3.791 ± 0.172
4.093SerSer: 4.093 ± 0.174
2.936SerThr: 2.936 ± 0.121
4.265SerVal: 4.265 ± 0.185
0.641SerTrp: 0.641 ± 0.065
1.903SerTyr: 1.903 ± 0.094
0.0SerXaa: 0.0 ± 0.0
Thr
2.988ThrAla: 2.988 ± 0.143
0.501ThrCys: 0.501 ± 0.048
2.534ThrAsp: 2.534 ± 0.111
4.015ThrGlu: 4.015 ± 0.158
2.002ThrPhe: 2.002 ± 0.102
4.218ThrGly: 4.218 ± 0.162
0.866ThrHis: 0.866 ± 0.067
3.473ThrIle: 3.473 ± 0.161
2.706ThrLys: 2.706 ± 0.132
4.547ThrLeu: 4.547 ± 0.17
1.012ThrMet: 1.012 ± 0.065
1.59ThrAsn: 1.59 ± 0.092
2.352ThrPro: 2.352 ± 0.115
1.131ThrGln: 1.131 ± 0.079
2.357ThrArg: 2.357 ± 0.116
3.097ThrSer: 3.097 ± 0.142
2.508ThrThr: 2.508 ± 0.127
3.666ThrVal: 3.666 ± 0.176
0.474ThrTrp: 0.474 ± 0.048
1.47ThrTyr: 1.47 ± 0.08
0.0ThrXaa: 0.0 ± 0.0
Val
4.161ValAla: 4.161 ± 0.162
0.756ValCys: 0.756 ± 0.066
4.531ValAsp: 4.531 ± 0.159
6.851ValGlu: 6.851 ± 0.201
2.878ValPhe: 2.878 ± 0.155
4.985ValGly: 4.985 ± 0.179
1.251ValHis: 1.251 ± 0.079
4.307ValIle: 4.307 ± 0.166
4.927ValLys: 4.927 ± 0.189
6.184ValLeu: 6.184 ± 0.169
1.46ValMet: 1.46 ± 0.096
2.529ValAsn: 2.529 ± 0.115
2.784ValPro: 2.784 ± 0.126
1.45ValGln: 1.45 ± 0.088
3.916ValArg: 3.916 ± 0.16
5.058ValSer: 5.058 ± 0.206
3.426ValThr: 3.426 ± 0.142
4.776ValVal: 4.776 ± 0.179
0.766ValTrp: 0.766 ± 0.081
1.976ValTyr: 1.976 ± 0.106
0.0ValXaa: 0.0 ± 0.0
Trp
0.641TrpAla: 0.641 ± 0.067
0.172TrpCys: 0.172 ± 0.031
0.662TrpAsp: 0.662 ± 0.067
0.907TrpGlu: 0.907 ± 0.078
0.391TrpPhe: 0.391 ± 0.052
0.709TrpGly: 0.709 ± 0.07
0.219TrpHis: 0.219 ± 0.036
0.834TrpIle: 0.834 ± 0.068
0.965TrpLys: 0.965 ± 0.078
0.97TrpLeu: 0.97 ± 0.082
0.328TrpMet: 0.328 ± 0.037
0.381TrpAsn: 0.381 ± 0.043
0.355TrpPro: 0.355 ± 0.039
0.245TrpGln: 0.245 ± 0.034
0.923TrpArg: 0.923 ± 0.075
0.793TrpSer: 0.793 ± 0.066
0.636TrpThr: 0.636 ± 0.06
0.714TrpVal: 0.714 ± 0.066
0.141TrpTrp: 0.141 ± 0.031
0.229TrpTyr: 0.229 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.596TyrAla: 1.596 ± 0.095
0.454TyrCys: 0.454 ± 0.046
1.861TyrAsp: 1.861 ± 0.093
2.638TyrGlu: 2.638 ± 0.104
1.397TyrPhe: 1.397 ± 0.096
2.534TyrGly: 2.534 ± 0.104
0.589TyrHis: 0.589 ± 0.053
1.59TyrIle: 1.59 ± 0.096
1.872TyrLys: 1.872 ± 0.098
3.108TyrLeu: 3.108 ± 0.15
0.605TyrMet: 0.605 ± 0.051
0.996TyrAsn: 0.996 ± 0.074
1.293TyrPro: 1.293 ± 0.08
0.787TyrGln: 0.787 ± 0.058
2.013TyrArg: 2.013 ± 0.098
2.268TyrSer: 2.268 ± 0.116
1.309TyrThr: 1.309 ± 0.083
1.622TyrVal: 1.622 ± 0.085
0.355TyrTrp: 0.355 ± 0.049
1.158TyrTyr: 1.158 ± 0.077
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 843 proteins (191784 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski