Amino acid dipepetide frequency for Corynebacterium sp. HMSC04H06

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.658AlaAla: 17.658 ± 0.275	0.962AlaCys: 0.962 ± 0.045	7.672AlaAsp: 7.672 ± 0.127	8.604AlaGlu: 8.604 ± 0.168	3.742AlaPhe: 3.742 ± 0.078	11.658AlaGly: 11.658 ± 0.161	2.51AlaHis: 2.51 ± 0.067	5.203AlaIle: 5.203 ± 0.1	3.415AlaLys: 3.415 ± 0.076	11.8AlaLeu: 11.8 ± 0.156	2.56AlaMet: 2.56 ± 0.065	2.976AlaAsn: 2.976 ± 0.069	5.248AlaPro: 5.248 ± 0.143	4.844AlaGln: 4.844 ± 0.098	7.582AlaArg: 7.582 ± 0.124	5.72AlaSer: 5.72 ± 0.095	6.641AlaThr: 6.641 ± 0.113	9.888AlaVal: 9.888 ± 0.16	1.637AlaTrp: 1.637 ± 0.052	2.429AlaTyr: 2.429 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.841CysAla: 0.841 ± 0.036	0.072CysCys: 0.072 ± 0.012	0.386CysAsp: 0.386 ± 0.021	0.41CysGlu: 0.41 ± 0.027	0.231CysPhe: 0.231 ± 0.02	0.798CysGly: 0.798 ± 0.035	0.169CysHis: 0.169 ± 0.017	0.288CysIle: 0.288 ± 0.022	0.125CysLys: 0.125 ± 0.017	0.657CysLeu: 0.657 ± 0.034	0.122CysMet: 0.122 ± 0.015	0.191CysAsn: 0.191 ± 0.019	0.448CysPro: 0.448 ± 0.03	0.289CysGln: 0.289 ± 0.021	0.392CysArg: 0.392 ± 0.026	0.449CysSer: 0.449 ± 0.026	0.413CysThr: 0.413 ± 0.027	0.529CysVal: 0.529 ± 0.029	0.1CysTrp: 0.1 ± 0.011	0.16CysTyr: 0.16 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.289AspAla: 7.289 ± 0.123	0.434AspCys: 0.434 ± 0.023	3.7AspAsp: 3.7 ± 0.089	4.307AspGlu: 4.307 ± 0.093	2.359AspPhe: 2.359 ± 0.066	5.188AspGly: 5.188 ± 0.099	1.259AspHis: 1.259 ± 0.046	3.08AspIle: 3.08 ± 0.067	2.438AspLys: 2.438 ± 0.067	5.661AspLeu: 5.661 ± 0.104	1.244AspMet: 1.244 ± 0.039	1.945AspAsn: 1.945 ± 0.057	3.689AspPro: 3.689 ± 0.096	1.919AspGln: 1.919 ± 0.062	3.33AspArg: 3.33 ± 0.068	3.502AspSer: 3.502 ± 0.086	3.16AspThr: 3.16 ± 0.074	4.586AspVal: 4.586 ± 0.095	0.888AspTrp: 0.888 ± 0.042	1.891AspTyr: 1.891 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	6.958GluAla: 6.958 ± 0.124	0.351GluCys: 0.351 ± 0.023	3.876GluAsp: 3.876 ± 0.076	4.589GluGlu: 4.589 ± 0.12	2.194GluPhe: 2.194 ± 0.059	4.411GluGly: 4.411 ± 0.096	1.598GluHis: 1.598 ± 0.054	3.172GluIle: 3.172 ± 0.077	2.387GluLys: 2.387 ± 0.063	6.93GluLeu: 6.93 ± 0.128	1.265GluMet: 1.265 ± 0.041	1.818GluAsn: 1.818 ± 0.055	2.962GluPro: 2.962 ± 0.086	2.729GluGln: 2.729 ± 0.072	4.137GluArg: 4.137 ± 0.084	3.229GluSer: 3.229 ± 0.082	3.302GluThr: 3.302 ± 0.068	5.191GluVal: 5.191 ± 0.101	0.861GluTrp: 0.861 ± 0.039	1.309GluTyr: 1.309 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	4.095PheAla: 4.095 ± 0.074	0.259PheCys: 0.259 ± 0.022	2.457PheAsp: 2.457 ± 0.058	1.726PheGlu: 1.726 ± 0.056	1.318PhePhe: 1.318 ± 0.052	3.407PheGly: 3.407 ± 0.083	0.718PheHis: 0.718 ± 0.037	1.695PheIle: 1.695 ± 0.053	0.831PheLys: 0.831 ± 0.035	3.054PheLeu: 3.054 ± 0.076	0.712PheMet: 0.712 ± 0.032	1.039PheAsn: 1.039 ± 0.037	1.432PhePro: 1.432 ± 0.045	0.936PheGln: 0.936 ± 0.042	1.711PheArg: 1.711 ± 0.052	2.283PheSer: 2.283 ± 0.066	2.019PheThr: 2.019 ± 0.057	2.619PheVal: 2.619 ± 0.069	0.519PheTrp: 0.519 ± 0.033	0.825PheTyr: 0.825 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	9.147GlyAla: 9.147 ± 0.132	0.693GlyCys: 0.693 ± 0.038	4.532GlyAsp: 4.532 ± 0.08	5.26GlyGlu: 5.26 ± 0.1	3.199GlyPhe: 3.199 ± 0.072	6.982GlyGly: 6.982 ± 0.153	1.963GlyHis: 1.963 ± 0.059	4.686GlyIle: 4.686 ± 0.084	3.201GlyLys: 3.201 ± 0.074	8.753GlyLeu: 8.753 ± 0.122	2.12GlyMet: 2.12 ± 0.055	2.436GlyAsn: 2.436 ± 0.066	3.489GlyPro: 3.489 ± 0.072	3.415GlyGln: 3.415 ± 0.069	5.097GlyArg: 5.097 ± 0.086	4.898GlySer: 4.898 ± 0.092	5.206GlyThr: 5.206 ± 0.098	7.039GlyVal: 7.039 ± 0.118	1.461GlyTrp: 1.461 ± 0.048	2.334GlyTyr: 2.334 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	2.359HisAla: 2.359 ± 0.068	0.184HisCys: 0.184 ± 0.018	1.307HisAsp: 1.307 ± 0.044	1.098HisGlu: 1.098 ± 0.044	0.647HisPhe: 0.647 ± 0.035	1.856HisGly: 1.856 ± 0.058	0.558HisHis: 0.558 ± 0.033	0.844HisIle: 0.844 ± 0.035	0.475HisLys: 0.475 ± 0.027	2.139HisLeu: 2.139 ± 0.063	0.407HisMet: 0.407 ± 0.027	0.669HisAsn: 0.669 ± 0.032	1.499HisPro: 1.499 ± 0.046	0.752HisGln: 0.752 ± 0.034	1.493HisArg: 1.493 ± 0.056	1.18HisSer: 1.18 ± 0.045	1.274HisThr: 1.274 ± 0.045	1.643HisVal: 1.643 ± 0.052	0.271HisTrp: 0.271 ± 0.019	0.579HisTyr: 0.579 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.005IleAla: 6.005 ± 0.101	0.418IleCys: 0.418 ± 0.025	3.351IleAsp: 3.351 ± 0.078	2.751IleGlu: 2.751 ± 0.067	1.556IlePhe: 1.556 ± 0.05	4.28IleGly: 4.28 ± 0.102	0.906IleHis: 0.906 ± 0.04	2.482IleIle: 2.482 ± 0.08	1.321IleLys: 1.321 ± 0.048	3.798IleLeu: 3.798 ± 0.075	0.965IleMet: 0.965 ± 0.035	1.471IleAsn: 1.471 ± 0.047	2.371IlePro: 2.371 ± 0.058	1.333IleGln: 1.333 ± 0.045	2.501IleArg: 2.501 ± 0.076	2.78IleSer: 2.78 ± 0.065	2.852IleThr: 2.852 ± 0.06	4.025IleVal: 4.025 ± 0.084	0.531IleTrp: 0.531 ± 0.027	1.078IleTyr: 1.078 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	3.575LysAla: 3.575 ± 0.085	0.14LysCys: 0.14 ± 0.016	1.978LysAsp: 1.978 ± 0.069	2.02LysGlu: 2.02 ± 0.059	0.896LysPhe: 0.896 ± 0.036	1.976LysGly: 1.976 ± 0.067	0.611LysHis: 0.611 ± 0.031	1.517LysIle: 1.517 ± 0.056	1.713LysLys: 1.713 ± 0.075	2.952LysLeu: 2.952 ± 0.063	0.748LysMet: 0.748 ± 0.033	0.96LysAsn: 0.96 ± 0.038	1.566LysPro: 1.566 ± 0.057	1.227LysGln: 1.227 ± 0.044	2.032LysArg: 2.032 ± 0.059	1.71LysSer: 1.71 ± 0.055	1.707LysThr: 1.707 ± 0.047	2.438LysVal: 2.438 ± 0.064	0.378LysTrp: 0.378 ± 0.027	0.754LysTyr: 0.754 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	12.7LeuAla: 12.7 ± 0.168	0.678LeuCys: 0.678 ± 0.032	6.471LeuAsp: 6.471 ± 0.12	5.284LeuGlu: 5.284 ± 0.097	2.944LeuPhe: 2.944 ± 0.08	8.881LeuGly: 8.881 ± 0.132	1.883LeuHis: 1.883 ± 0.057	4.536LeuIle: 4.536 ± 0.089	2.61LeuLys: 2.61 ± 0.077	8.978LeuLeu: 8.978 ± 0.159	1.895LeuMet: 1.895 ± 0.058	2.631LeuAsn: 2.631 ± 0.064	5.418LeuPro: 5.418 ± 0.096	2.703LeuGln: 2.703 ± 0.075	6.415LeuArg: 6.415 ± 0.112	5.975LeuSer: 5.975 ± 0.096	5.516LeuThr: 5.516 ± 0.092	8.17LeuVal: 8.17 ± 0.124	1.162LeuTrp: 1.162 ± 0.043	1.776LeuTyr: 1.776 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.649MetAla: 2.649 ± 0.075	0.137MetCys: 0.137 ± 0.014	1.188MetAsp: 1.188 ± 0.048	1.095MetGlu: 1.095 ± 0.04	0.697MetPhe: 0.697 ± 0.035	1.72MetGly: 1.72 ± 0.047	0.424MetHis: 0.424 ± 0.025	0.914MetIle: 0.914 ± 0.039	0.647MetLys: 0.647 ± 0.028	2.077MetLeu: 2.077 ± 0.059	0.488MetMet: 0.488 ± 0.029	0.645MetAsn: 0.645 ± 0.037	1.177MetPro: 1.177 ± 0.043	0.639MetGln: 0.639 ± 0.032	1.333MetArg: 1.333 ± 0.049	1.666MetSer: 1.666 ± 0.049	1.615MetThr: 1.615 ± 0.052	1.698MetVal: 1.698 ± 0.049	0.252MetTrp: 0.252 ± 0.018	0.39MetTyr: 0.39 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.104AsnAla: 3.104 ± 0.06	0.188AsnCys: 0.188 ± 0.017	1.597AsnAsp: 1.597 ± 0.054	1.569AsnGlu: 1.569 ± 0.053	1.018AsnPhe: 1.018 ± 0.041	2.284AsnGly: 2.284 ± 0.065	0.647AsnHis: 0.647 ± 0.035	1.291AsnIle: 1.291 ± 0.046	0.903AsnLys: 0.903 ± 0.039	2.688AsnLeu: 2.688 ± 0.065	0.672AsnMet: 0.672 ± 0.033	0.885AsnAsn: 0.885 ± 0.039	2.091AsnPro: 2.091 ± 0.059	1.107AsnGln: 1.107 ± 0.038	1.685AsnArg: 1.685 ± 0.054	1.655AsnSer: 1.655 ± 0.046	1.509AsnThr: 1.509 ± 0.045	1.989AsnVal: 1.989 ± 0.051	0.395AsnTrp: 0.395 ± 0.025	0.826AsnTyr: 0.826 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	6.67ProAla: 6.67 ± 0.14	0.226ProCys: 0.226 ± 0.019	3.501ProAsp: 3.501 ± 0.075	4.279ProGlu: 4.279 ± 0.1	1.589ProPhe: 1.589 ± 0.045	4.707ProGly: 4.707 ± 0.097	1.152ProHis: 1.152 ± 0.042	1.883ProIle: 1.883 ± 0.058	1.455ProLys: 1.455 ± 0.055	4.351ProLeu: 4.351 ± 0.087	0.959ProMet: 0.959 ± 0.039	1.431ProAsn: 1.431 ± 0.051	1.64ProPro: 1.64 ± 0.059	2.028ProGln: 2.028 ± 0.056	2.846ProArg: 2.846 ± 0.07	2.519ProSer: 2.519 ± 0.075	2.947ProThr: 2.947 ± 0.075	4.422ProVal: 4.422 ± 0.096	0.704ProTrp: 0.704 ± 0.032	1.134ProTyr: 1.134 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	4.686GlnAla: 4.686 ± 0.103	0.148GlnCys: 0.148 ± 0.014	1.992GlnAsp: 1.992 ± 0.058	2.237GlnGlu: 2.237 ± 0.059	1.067GlnPhe: 1.067 ± 0.039	2.338GlnGly: 2.338 ± 0.057	0.712GlnHis: 0.712 ± 0.031	1.575GlnIle: 1.575 ± 0.045	0.965GlnLys: 0.965 ± 0.045	4.141GlnLeu: 4.141 ± 0.083	0.844GlnMet: 0.844 ± 0.032	0.798GlnAsn: 0.798 ± 0.038	2.016GlnPro: 2.016 ± 0.068	1.598GlnGln: 1.598 ± 0.064	2.763GlnArg: 2.763 ± 0.071	1.612GlnSer: 1.612 ± 0.055	1.661GlnThr: 1.661 ± 0.052	3.02GlnVal: 3.02 ± 0.068	0.528GlnTrp: 0.528 ± 0.031	0.687GlnTyr: 0.687 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	7.051ArgAla: 7.051 ± 0.128	0.338ArgCys: 0.338 ± 0.02	3.704ArgAsp: 3.704 ± 0.084	4.244ArgGlu: 4.244 ± 0.099	2.068ArgPhe: 2.068 ± 0.059	4.808ArgGly: 4.808 ± 0.085	1.358ArgHis: 1.358 ± 0.046	2.788ArgIle: 2.788 ± 0.069	1.96ArgLys: 1.96 ± 0.06	6.0ArgLeu: 6.0 ± 0.099	1.493ArgMet: 1.493 ± 0.041	1.741ArgAsn: 1.741 ± 0.05	3.074ArgPro: 3.074 ± 0.077	2.438ArgGln: 2.438 ± 0.064	4.882ArgArg: 4.882 ± 0.113	3.16ArgSer: 3.16 ± 0.072	3.477ArgThr: 3.477 ± 0.07	4.764ArgVal: 4.764 ± 0.092	0.95ArgTrp: 0.95 ± 0.041	1.61ArgTyr: 1.61 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	6.944SerAla: 6.944 ± 0.132	0.381SerCys: 0.381 ± 0.026	2.872SerAsp: 2.872 ± 0.066	3.202SerGlu: 3.202 ± 0.075	2.067SerPhe: 2.067 ± 0.064	5.338SerGly: 5.338 ± 0.102	1.214SerHis: 1.214 ± 0.042	2.346SerIle: 2.346 ± 0.069	1.595SerLys: 1.595 ± 0.054	5.412SerLeu: 5.412 ± 0.096	1.322SerMet: 1.322 ± 0.041	1.447SerAsn: 1.447 ± 0.054	2.919SerPro: 2.919 ± 0.065	2.105SerGln: 2.105 ± 0.06	3.422SerArg: 3.422 ± 0.064	3.437SerSer: 3.437 ± 0.095	3.498SerThr: 3.498 ± 0.076	4.3SerVal: 4.3 ± 0.088	0.816SerTrp: 0.816 ± 0.037	1.266SerTyr: 1.266 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	6.682ThrAla: 6.682 ± 0.101	0.479ThrCys: 0.479 ± 0.03	3.43ThrAsp: 3.43 ± 0.078	3.357ThrGlu: 3.357 ± 0.07	1.871ThrPhe: 1.871 ± 0.054	5.454ThrGly: 5.454 ± 0.092	1.117ThrHis: 1.117 ± 0.04	2.73ThrIle: 2.73 ± 0.068	1.72ThrLys: 1.72 ± 0.059	5.262ThrLeu: 5.262 ± 0.089	1.174ThrMet: 1.174 ± 0.043	1.598ThrAsn: 1.598 ± 0.052	3.496ThrPro: 3.496 ± 0.091	1.903ThrGln: 1.903 ± 0.054	3.119ThrArg: 3.119 ± 0.072	3.08ThrSer: 3.08 ± 0.071	3.718ThrThr: 3.718 ± 0.094	5.298ThrVal: 5.298 ± 0.104	0.858ThrTrp: 0.858 ± 0.036	1.301ThrTyr: 1.301 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	10.362ValAla: 10.362 ± 0.137	0.671ValCys: 0.671 ± 0.031	5.675ValAsp: 5.675 ± 0.098	5.197ValGlu: 5.197 ± 0.109	2.623ValPhe: 2.623 ± 0.07	6.728ValGly: 6.728 ± 0.111	1.601ValHis: 1.601 ± 0.047	4.297ValIle: 4.297 ± 0.083	2.192ValLys: 2.192 ± 0.06	7.894ValLeu: 7.894 ± 0.13	1.714ValMet: 1.714 ± 0.055	2.346ValAsn: 2.346 ± 0.057	3.962ValPro: 3.962 ± 0.081	1.982ValGln: 1.982 ± 0.056	4.598ValArg: 4.598 ± 0.085	4.696ValSer: 4.696 ± 0.095	5.162ValThr: 5.162 ± 0.096	7.796ValVal: 7.796 ± 0.141	1.003ValTrp: 1.003 ± 0.041	1.664ValTyr: 1.664 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	1.58TrpAla: 1.58 ± 0.057	0.104TrpCys: 0.104 ± 0.014	0.776TrpAsp: 0.776 ± 0.033	0.763TrpGlu: 0.763 ± 0.031	0.588TrpPhe: 0.588 ± 0.037	1.003TrpGly: 1.003 ± 0.045	0.329TrpHis: 0.329 ± 0.024	0.609TrpIle: 0.609 ± 0.029	0.422TrpLys: 0.422 ± 0.029	1.606TrpLeu: 1.606 ± 0.057	0.384TrpMet: 0.384 ± 0.023	0.439TrpAsn: 0.439 ± 0.028	0.686TrpPro: 0.686 ± 0.037	0.541TrpGln: 0.541 ± 0.031	0.936TrpArg: 0.936 ± 0.035	0.788TrpSer: 0.788 ± 0.034	0.69TrpThr: 0.69 ± 0.032	1.125TrpVal: 1.125 ± 0.043	0.33TrpTrp: 0.33 ± 0.022	0.285TrpTyr: 0.285 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.396TyrAla: 2.396 ± 0.066	0.205TyrCys: 0.205 ± 0.017	1.405TyrAsp: 1.405 ± 0.049	1.275TyrGlu: 1.275 ± 0.043	0.98TyrPhe: 0.98 ± 0.041	2.091TyrGly: 2.091 ± 0.05	0.508TyrHis: 0.508 ± 0.03	0.841TyrIle: 0.841 ± 0.036	0.525TyrLys: 0.525 ± 0.03	2.472TyrLeu: 2.472 ± 0.071	0.36TyrMet: 0.36 ± 0.024	0.636TyrAsn: 0.636 ± 0.032	1.257TyrPro: 1.257 ± 0.043	0.9TyrGln: 0.9 ± 0.039	1.631TyrArg: 1.631 ± 0.063	1.563TyrSer: 1.563 ± 0.044	1.281TyrThr: 1.281 ± 0.044	1.625TyrVal: 1.625 ± 0.056	0.344TyrTrp: 0.344 ± 0.023	0.666TyrTyr: 0.666 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2014 proteins (663308 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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