Amino acid dipepetide frequency for Anaerotruncus sp. 1XD22-93

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.471AlaAla: 9.471 ± 0.114
1.173AlaCys: 1.173 ± 0.026
4.918AlaAsp: 4.918 ± 0.056
6.324AlaGlu: 6.324 ± 0.068
3.311AlaPhe: 3.311 ± 0.042
7.127AlaGly: 7.127 ± 0.072
1.201AlaHis: 1.201 ± 0.027
4.473AlaIle: 4.473 ± 0.048
4.649AlaLys: 4.649 ± 0.057
7.8AlaLeu: 7.8 ± 0.083
2.256AlaMet: 2.256 ± 0.04
2.581AlaAsn: 2.581 ± 0.039
2.736AlaPro: 2.736 ± 0.046
3.116AlaGln: 3.116 ± 0.05
3.788AlaArg: 3.788 ± 0.057
4.561AlaSer: 4.561 ± 0.056
3.156AlaThr: 3.156 ± 0.047
7.164AlaVal: 7.164 ± 0.067
0.711AlaTrp: 0.711 ± 0.018
2.914AlaTyr: 2.914 ± 0.032
0.0AlaXaa: 0.0 ± 0.0
Cys
1.224CysAla: 1.224 ± 0.029
0.307CysCys: 0.307 ± 0.012
0.809CysAsp: 0.809 ± 0.02
0.96CysGlu: 0.96 ± 0.024
0.627CysPhe: 0.627 ± 0.019
1.635CysGly: 1.635 ± 0.033
0.28CysHis: 0.28 ± 0.013
0.975CysIle: 0.975 ± 0.023
0.79CysLys: 0.79 ± 0.02
1.182CysLeu: 1.182 ± 0.028
0.444CysMet: 0.444 ± 0.015
0.499CysAsn: 0.499 ± 0.015
0.69CysPro: 0.69 ± 0.022
0.427CysGln: 0.427 ± 0.012
0.971CysArg: 0.971 ± 0.025
0.964CysSer: 0.964 ± 0.022
0.808CysThr: 0.808 ± 0.021
0.989CysVal: 0.989 ± 0.024
0.14CysTrp: 0.14 ± 0.008
0.549CysTyr: 0.549 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.678AspAla: 4.678 ± 0.056
0.845AspCys: 0.845 ± 0.021
2.664AspAsp: 2.664 ± 0.043
4.165AspGlu: 4.165 ± 0.054
2.512AspPhe: 2.512 ± 0.036
4.985AspGly: 4.985 ± 0.074
0.72AspHis: 0.72 ± 0.019
3.786AspIle: 3.786 ± 0.044
3.053AspLys: 3.053 ± 0.045
4.509AspLeu: 4.509 ± 0.049
1.679AspMet: 1.679 ± 0.029
1.976AspAsn: 1.976 ± 0.034
1.9AspPro: 1.9 ± 0.037
1.253AspGln: 1.253 ± 0.025
2.864AspArg: 2.864 ± 0.047
3.195AspSer: 3.195 ± 0.044
3.149AspThr: 3.149 ± 0.043
3.616AspVal: 3.616 ± 0.05
0.614AspTrp: 0.614 ± 0.017
2.498AspTyr: 2.498 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
5.812GluAla: 5.812 ± 0.065
0.845GluCys: 0.845 ± 0.022
3.832GluAsp: 3.832 ± 0.051
6.678GluGlu: 6.678 ± 0.067
2.479GluPhe: 2.479 ± 0.038
4.706GluGly: 4.706 ± 0.053
1.329GluHis: 1.329 ± 0.03
5.295GluIle: 5.295 ± 0.057
5.804GluLys: 5.804 ± 0.068
6.854GluLeu: 6.854 ± 0.065
2.324GluMet: 2.324 ± 0.035
3.723GluAsn: 3.723 ± 0.051
2.371GluPro: 2.371 ± 0.041
3.431GluGln: 3.431 ± 0.052
4.255GluArg: 4.255 ± 0.057
3.698GluSer: 3.698 ± 0.044
3.921GluThr: 3.921 ± 0.053
4.396GluVal: 4.396 ± 0.051
0.725GluTrp: 0.725 ± 0.017
2.888GluTyr: 2.888 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.123PheAla: 3.123 ± 0.043
0.851PheCys: 0.851 ± 0.024
2.471PheAsp: 2.471 ± 0.034
2.585PheGlu: 2.585 ± 0.039
1.717PhePhe: 1.717 ± 0.033
2.993PheGly: 2.993 ± 0.043
0.737PheHis: 0.737 ± 0.018
2.255PheIle: 2.255 ± 0.036
1.78PheLys: 1.78 ± 0.035
3.911PheLeu: 3.911 ± 0.049
1.036PheMet: 1.036 ± 0.022
1.348PheAsn: 1.348 ± 0.026
1.443PhePro: 1.443 ± 0.025
1.363PheGln: 1.363 ± 0.025
2.018PheArg: 2.018 ± 0.033
3.071PheSer: 3.071 ± 0.037
2.294PheThr: 2.294 ± 0.035
2.583PheVal: 2.583 ± 0.037
0.434PheTrp: 0.434 ± 0.015
1.633PheTyr: 1.633 ± 0.036
0.0PheXaa: 0.0 ± 0.0
Gly
5.611GlyAla: 5.611 ± 0.057
1.337GlyCys: 1.337 ± 0.029
3.717GlyAsp: 3.717 ± 0.048
5.187GlyGlu: 5.187 ± 0.048
3.151GlyPhe: 3.151 ± 0.039
5.568GlyGly: 5.568 ± 0.072
1.261GlyHis: 1.261 ± 0.028
5.754GlyIle: 5.754 ± 0.058
5.571GlyLys: 5.571 ± 0.062
6.121GlyLeu: 6.121 ± 0.063
2.58GlyMet: 2.58 ± 0.037
3.176GlyAsn: 3.176 ± 0.051
1.31GlyPro: 1.31 ± 0.027
2.526GlyGln: 2.526 ± 0.039
3.941GlyArg: 3.941 ± 0.051
4.482GlySer: 4.482 ± 0.057
4.372GlyThr: 4.372 ± 0.069
5.166GlyVal: 5.166 ± 0.055
0.919GlyTrp: 0.919 ± 0.026
3.221GlyTyr: 3.221 ± 0.048
0.0GlyXaa: 0.0 ± 0.0
His
1.277HisAla: 1.277 ± 0.026
0.311HisCys: 0.311 ± 0.012
0.806HisAsp: 0.806 ± 0.021
1.058HisGlu: 1.058 ± 0.026
0.781HisPhe: 0.781 ± 0.018
1.263HisGly: 1.263 ± 0.023
0.379HisHis: 0.379 ± 0.017
1.191HisIle: 1.191 ± 0.026
0.85HisLys: 0.85 ± 0.021
1.578HisLeu: 1.578 ± 0.029
0.471HisMet: 0.471 ± 0.017
0.66HisAsn: 0.66 ± 0.02
0.945HisPro: 0.945 ± 0.023
0.572HisGln: 0.572 ± 0.015
0.882HisArg: 0.882 ± 0.021
0.991HisSer: 0.991 ± 0.024
0.959HisThr: 0.959 ± 0.024
0.996HisVal: 0.996 ± 0.021
0.177HisTrp: 0.177 ± 0.01
0.731HisTyr: 0.731 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.214IleAla: 5.214 ± 0.051
1.149IleCys: 1.149 ± 0.025
3.689IleAsp: 3.689 ± 0.042
4.288IleGlu: 4.288 ± 0.047
2.469IlePhe: 2.469 ± 0.039
4.622IleGly: 4.622 ± 0.05
1.158IleHis: 1.158 ± 0.026
3.642IleIle: 3.642 ± 0.051
3.388IleLys: 3.388 ± 0.044
6.05IleLeu: 6.05 ± 0.066
1.527IleMet: 1.527 ± 0.028
2.395IleAsn: 2.395 ± 0.041
3.007IlePro: 3.007 ± 0.041
2.177IleGln: 2.177 ± 0.035
3.773IleArg: 3.773 ± 0.051
4.456IleSer: 4.456 ± 0.045
3.584IleThr: 3.584 ± 0.039
4.145IleVal: 4.145 ± 0.056
0.56IleTrp: 0.56 ± 0.017
2.284IleTyr: 2.284 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
5.026LysAla: 5.026 ± 0.056
0.679LysCys: 0.679 ± 0.02
3.178LysAsp: 3.178 ± 0.044
5.318LysGlu: 5.318 ± 0.068
1.797LysPhe: 1.797 ± 0.033
3.97LysGly: 3.97 ± 0.051
0.902LysHis: 0.902 ± 0.019
4.081LysIle: 4.081 ± 0.051
5.288LysLys: 5.288 ± 0.071
5.065LysLeu: 5.065 ± 0.056
1.821LysMet: 1.821 ± 0.032
2.977LysAsn: 2.977 ± 0.047
2.162LysPro: 2.162 ± 0.038
2.379LysGln: 2.379 ± 0.038
3.299LysArg: 3.299 ± 0.041
3.327LysSer: 3.327 ± 0.044
3.398LysThr: 3.398 ± 0.046
3.887LysVal: 3.887 ± 0.053
0.547LysTrp: 0.547 ± 0.018
2.406LysTyr: 2.406 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
7.648LeuAla: 7.648 ± 0.074
1.609LeuCys: 1.609 ± 0.035
5.2LeuAsp: 5.2 ± 0.051
6.667LeuGlu: 6.667 ± 0.062
3.865LeuPhe: 3.865 ± 0.052
6.101LeuGly: 6.101 ± 0.061
1.615LeuHis: 1.615 ± 0.03
5.056LeuIle: 5.056 ± 0.053
5.441LeuLys: 5.441 ± 0.059
9.137LeuLeu: 9.137 ± 0.093
2.466LeuMet: 2.466 ± 0.039
3.535LeuAsn: 3.535 ± 0.042
3.94LeuPro: 3.94 ± 0.045
2.978LeuGln: 2.978 ± 0.041
4.688LeuArg: 4.688 ± 0.058
6.335LeuSer: 6.335 ± 0.058
5.099LeuThr: 5.099 ± 0.051
5.502LeuVal: 5.502 ± 0.052
0.828LeuTrp: 0.828 ± 0.022
3.279LeuTyr: 3.279 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
2.49MetAla: 2.49 ± 0.036
0.321MetCys: 0.321 ± 0.012
1.694MetAsp: 1.694 ± 0.03
2.366MetGlu: 2.366 ± 0.042
0.933MetPhe: 0.933 ± 0.022
2.098MetGly: 2.098 ± 0.033
0.42MetHis: 0.42 ± 0.014
1.668MetIle: 1.668 ± 0.027
2.078MetLys: 2.078 ± 0.034
2.703MetLeu: 2.703 ± 0.035
0.812MetMet: 0.812 ± 0.021
1.257MetAsn: 1.257 ± 0.022
1.194MetPro: 1.194 ± 0.022
1.147MetGln: 1.147 ± 0.022
1.458MetArg: 1.458 ± 0.028
1.677MetSer: 1.677 ± 0.028
1.545MetThr: 1.545 ± 0.03
1.837MetVal: 1.837 ± 0.031
0.204MetTrp: 0.204 ± 0.009
0.773MetTyr: 0.773 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.187AsnAla: 3.187 ± 0.048
0.59AsnCys: 0.59 ± 0.017
1.828AsnAsp: 1.828 ± 0.026
2.368AsnGlu: 2.368 ± 0.035
1.429AsnPhe: 1.429 ± 0.028
3.419AsnGly: 3.419 ± 0.058
0.739AsnHis: 0.739 ± 0.021
2.726AsnIle: 2.726 ± 0.046
2.037AsnLys: 2.037 ± 0.037
3.584AsnLeu: 3.584 ± 0.04
1.128AsnMet: 1.128 ± 0.021
1.55AsnAsn: 1.55 ± 0.033
2.204AsnPro: 2.204 ± 0.033
1.346AsnGln: 1.346 ± 0.025
2.304AsnArg: 2.304 ± 0.037
2.183AsnSer: 2.183 ± 0.036
2.183AsnThr: 2.183 ± 0.036
2.479AsnVal: 2.479 ± 0.037
0.373AsnTrp: 0.373 ± 0.013
1.576AsnTyr: 1.576 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
3.406ProAla: 3.406 ± 0.056
0.515ProCys: 0.515 ± 0.016
2.668ProAsp: 2.668 ± 0.046
3.765ProGlu: 3.765 ± 0.044
1.531ProPhe: 1.531 ± 0.029
2.742ProGly: 2.742 ± 0.043
0.649ProHis: 0.649 ± 0.016
1.957ProIle: 1.957 ± 0.032
1.941ProLys: 1.941 ± 0.034
3.011ProLeu: 3.011 ± 0.042
0.911ProMet: 0.911 ± 0.02
1.296ProAsn: 1.296 ± 0.027
1.335ProPro: 1.335 ± 0.035
1.376ProGln: 1.376 ± 0.028
1.408ProArg: 1.408 ± 0.031
2.112ProSer: 2.112 ± 0.038
1.646ProThr: 1.646 ± 0.029
3.236ProVal: 3.236 ± 0.04
0.316ProTrp: 0.316 ± 0.015
1.415ProTyr: 1.415 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.207GlnAla: 3.207 ± 0.047
0.357GlnCys: 0.357 ± 0.013
1.658GlnAsp: 1.658 ± 0.032
3.002GlnGlu: 3.002 ± 0.049
1.21GlnPhe: 1.21 ± 0.022
2.316GlnGly: 2.316 ± 0.038
0.498GlnHis: 0.498 ± 0.015
2.574GlnIle: 2.574 ± 0.038
2.679GlnLys: 2.679 ± 0.049
2.971GlnLeu: 2.971 ± 0.042
1.194GlnMet: 1.194 ± 0.025
1.639GlnAsn: 1.639 ± 0.031
1.322GlnPro: 1.322 ± 0.031
1.463GlnGln: 1.463 ± 0.031
1.851GlnArg: 1.851 ± 0.036
1.801GlnSer: 1.801 ± 0.032
1.951GlnThr: 1.951 ± 0.037
2.227GlnVal: 2.227 ± 0.038
0.348GlnTrp: 0.348 ± 0.012
1.329GlnTyr: 1.329 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
3.693ArgAla: 3.693 ± 0.048
0.743ArgCys: 0.743 ± 0.02
2.56ArgAsp: 2.56 ± 0.036
4.571ArgGlu: 4.571 ± 0.061
2.242ArgPhe: 2.242 ± 0.039
3.162ArgGly: 3.162 ± 0.042
0.98ArgHis: 0.98 ± 0.025
3.71ArgIle: 3.71 ± 0.044
3.607ArgLys: 3.607 ± 0.044
5.039ArgLeu: 5.039 ± 0.064
1.843ArgMet: 1.843 ± 0.032
2.097ArgAsn: 2.097 ± 0.033
1.788ArgPro: 1.788 ± 0.031
2.255ArgGln: 2.255 ± 0.041
3.266ArgArg: 3.266 ± 0.062
2.607ArgSer: 2.607 ± 0.035
2.668ArgThr: 2.668 ± 0.048
3.329ArgVal: 3.329 ± 0.045
0.549ArgTrp: 0.549 ± 0.017
2.188ArgTyr: 2.188 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
4.971SerAla: 4.971 ± 0.056
0.884SerCys: 0.884 ± 0.023
3.27SerAsp: 3.27 ± 0.045
4.107SerGlu: 4.107 ± 0.044
2.549SerPhe: 2.549 ± 0.036
5.531SerGly: 5.531 ± 0.054
1.044SerHis: 1.044 ± 0.022
3.759SerIle: 3.759 ± 0.044
3.073SerLys: 3.073 ± 0.038
5.41SerLeu: 5.41 ± 0.06
1.727SerMet: 1.727 ± 0.031
2.119SerAsn: 2.119 ± 0.037
2.161SerPro: 2.161 ± 0.034
1.992SerGln: 1.992 ± 0.038
3.302SerArg: 3.302 ± 0.042
3.789SerSer: 3.789 ± 0.064
2.829SerThr: 2.829 ± 0.047
4.395SerVal: 4.395 ± 0.046
0.617SerTrp: 0.617 ± 0.019
2.386SerTyr: 2.386 ± 0.038
0.0SerXaa: 0.0 ± 0.0
Thr
5.08ThrAla: 5.08 ± 0.066
0.652ThrCys: 0.652 ± 0.02
3.069ThrAsp: 3.069 ± 0.051
3.85ThrGlu: 3.85 ± 0.054
2.009ThrPhe: 2.009 ± 0.035
4.757ThrGly: 4.757 ± 0.056
0.836ThrHis: 0.836 ± 0.02
3.384ThrIle: 3.384 ± 0.054
2.598ThrLys: 2.598 ± 0.038
4.939ThrLeu: 4.939 ± 0.052
1.307ThrMet: 1.307 ± 0.023
1.769ThrAsn: 1.769 ± 0.035
2.367ThrPro: 2.367 ± 0.037
1.565ThrGln: 1.565 ± 0.03
2.319ThrArg: 2.319 ± 0.03
2.867ThrSer: 2.867 ± 0.046
2.629ThrThr: 2.629 ± 0.039
4.749ThrVal: 4.749 ± 0.061
0.505ThrTrp: 0.505 ± 0.017
1.887ThrTyr: 1.887 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
4.823ValAla: 4.823 ± 0.057
1.293ValCys: 1.293 ± 0.026
3.693ValAsp: 3.693 ± 0.046
4.68ValGlu: 4.68 ± 0.047
2.922ValPhe: 2.922 ± 0.041
4.339ValGly: 4.339 ± 0.051
1.121ValHis: 1.121 ± 0.023
4.354ValIle: 4.354 ± 0.051
4.159ValLys: 4.159 ± 0.056
6.517ValLeu: 6.517 ± 0.058
1.89ValMet: 1.89 ± 0.029
2.616ValAsn: 2.616 ± 0.034
2.747ValPro: 2.747 ± 0.04
2.284ValGln: 2.284 ± 0.034
3.679ValArg: 3.679 ± 0.041
5.015ValSer: 5.015 ± 0.051
4.141ValThr: 4.141 ± 0.06
4.806ValVal: 4.806 ± 0.055
0.699ValTrp: 0.699 ± 0.019
2.698ValTyr: 2.698 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.613TrpAla: 0.613 ± 0.019
0.166TrpCys: 0.166 ± 0.008
0.571TrpAsp: 0.571 ± 0.018
0.745TrpGlu: 0.745 ± 0.02
0.42TrpPhe: 0.42 ± 0.016
0.691TrpGly: 0.691 ± 0.019
0.198TrpHis: 0.198 ± 0.011
0.602TrpIle: 0.602 ± 0.019
0.696TrpLys: 0.696 ± 0.018
0.961TrpLeu: 0.961 ± 0.02
0.334TrpMet: 0.334 ± 0.013
0.497TrpAsn: 0.497 ± 0.017
0.211TrpPro: 0.211 ± 0.011
0.399TrpGln: 0.399 ± 0.013
0.487TrpArg: 0.487 ± 0.017
0.538TrpSer: 0.538 ± 0.017
0.47TrpThr: 0.47 ± 0.016
0.611TrpVal: 0.611 ± 0.018
0.126TrpTrp: 0.126 ± 0.008
0.413TrpTyr: 0.413 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.876TyrAla: 2.876 ± 0.043
0.641TyrCys: 0.641 ± 0.018
2.369TyrAsp: 2.369 ± 0.045
2.681TyrGlu: 2.681 ± 0.037
1.693TyrPhe: 1.693 ± 0.032
2.943TyrGly: 2.943 ± 0.038
0.812TyrHis: 0.812 ± 0.021
2.338TyrIle: 2.338 ± 0.037
2.025TyrLys: 2.025 ± 0.035
3.645TyrLeu: 3.645 ± 0.044
0.924TyrMet: 0.924 ± 0.024
1.526TyrAsn: 1.526 ± 0.03
1.401TyrPro: 1.401 ± 0.029
1.546TyrGln: 1.546 ± 0.028
2.343TyrArg: 2.343 ± 0.033
2.248TyrSer: 2.248 ± 0.039
2.336TyrThr: 2.336 ± 0.042
2.364TyrVal: 2.364 ± 0.034
0.357TyrTrp: 0.357 ± 0.013
1.727TyrTyr: 1.727 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6934 proteins (2116876 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski