Amino acid dipepetide frequency for Arcobacter sp. CECT 8987

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.973AlaAla: 3.973 ± 0.101	0.742AlaCys: 0.742 ± 0.038	2.564AlaAsp: 2.564 ± 0.066	2.549AlaGlu: 2.549 ± 0.065	3.395AlaPhe: 3.395 ± 0.065	3.688AlaGly: 3.688 ± 0.088	1.461AlaHis: 1.461 ± 0.042	5.937AlaIle: 5.937 ± 0.098	5.55AlaLys: 5.55 ± 0.097	7.673AlaLeu: 7.673 ± 0.119	1.94AlaMet: 1.94 ± 0.06	3.479AlaAsn: 3.479 ± 0.081	1.68AlaPro: 1.68 ± 0.055	3.115AlaGln: 3.115 ± 0.072	1.905AlaArg: 1.905 ± 0.056	4.217AlaSer: 4.217 ± 0.083	3.599AlaThr: 3.599 ± 0.078	4.209AlaVal: 4.209 ± 0.088	0.475AlaTrp: 0.475 ± 0.028	2.655AlaTyr: 2.655 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	0.704CysAla: 0.704 ± 0.035	0.138CysCys: 0.138 ± 0.016	0.673CysAsp: 0.673 ± 0.035	0.803CysGlu: 0.803 ± 0.034	0.415CysPhe: 0.415 ± 0.026	0.761CysGly: 0.761 ± 0.043	0.276CysHis: 0.276 ± 0.021	0.682CysIle: 0.682 ± 0.034	0.606CysLys: 0.606 ± 0.031	0.675CysLeu: 0.675 ± 0.027	0.231CysMet: 0.231 ± 0.017	0.508CysAsn: 0.508 ± 0.029	0.382CysPro: 0.382 ± 0.025	0.29CysGln: 0.29 ± 0.021	0.257CysArg: 0.257 ± 0.018	0.743CysSer: 0.743 ± 0.035	0.506CysThr: 0.506 ± 0.023	0.61CysVal: 0.61 ± 0.029	0.064CysTrp: 0.064 ± 0.01	0.295CysTyr: 0.295 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.773AspAla: 3.773 ± 0.074	0.459AspCys: 0.459 ± 0.027	2.88AspAsp: 2.88 ± 0.083	4.878AspGlu: 4.878 ± 0.084	3.044AspPhe: 3.044 ± 0.067	3.012AspGly: 3.012 ± 0.078	0.691AspHis: 0.691 ± 0.035	5.452AspIle: 5.452 ± 0.098	4.332AspLys: 4.332 ± 0.078	4.709AspLeu: 4.709 ± 0.085	1.414AspMet: 1.414 ± 0.038	2.673AspAsn: 2.673 ± 0.066	1.283AspPro: 1.283 ± 0.046	1.1AspGln: 1.1 ± 0.038	1.497AspArg: 1.497 ± 0.045	2.775AspSer: 2.775 ± 0.065	2.718AspThr: 2.718 ± 0.066	3.584AspVal: 3.584 ± 0.071	0.379AspTrp: 0.379 ± 0.023	2.268AspTyr: 2.268 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	4.921GluAla: 4.921 ± 0.1	0.645GluCys: 0.645 ± 0.028	3.81GluAsp: 3.81 ± 0.071	5.74GluGlu: 5.74 ± 0.106	3.655GluPhe: 3.655 ± 0.066	3.372GluGly: 3.372 ± 0.072	1.798GluHis: 1.798 ± 0.059	6.008GluIle: 6.008 ± 0.094	6.481GluLys: 6.481 ± 0.094	7.603GluLeu: 7.603 ± 0.113	1.788GluMet: 1.788 ± 0.046	4.42GluAsn: 4.42 ± 0.079	1.686GluPro: 1.686 ± 0.051	3.16GluGln: 3.16 ± 0.083	2.16GluArg: 2.16 ± 0.056	3.758GluSer: 3.758 ± 0.075	3.249GluThr: 3.249 ± 0.073	4.874GluVal: 4.874 ± 0.08	0.435GluTrp: 0.435 ± 0.024	3.094GluTyr: 3.094 ± 0.073	0.0GluXaa: 0.0 ± 0.0
Phe	3.179PheAla: 3.179 ± 0.069	0.57PheCys: 0.57 ± 0.028	3.354PheAsp: 3.354 ± 0.072	3.92PheGlu: 3.92 ± 0.08	2.944PhePhe: 2.944 ± 0.08	3.099PheGly: 3.099 ± 0.071	0.828PheHis: 0.828 ± 0.036	4.599PheIle: 4.599 ± 0.096	4.111PheLys: 4.111 ± 0.065	5.03PheLeu: 5.03 ± 0.105	1.323PheMet: 1.323 ± 0.043	2.841PheAsn: 2.841 ± 0.068	1.274PhePro: 1.274 ± 0.044	1.297PheGln: 1.297 ± 0.044	1.268PheArg: 1.268 ± 0.041	3.551PheSer: 3.551 ± 0.071	2.754PheThr: 2.754 ± 0.056	3.192PheVal: 3.192 ± 0.07	0.447PheTrp: 0.447 ± 0.025	2.033PheTyr: 2.033 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	3.776GlyAla: 3.776 ± 0.088	0.746GlyCys: 0.746 ± 0.037	2.616GlyAsp: 2.616 ± 0.072	3.707GlyGlu: 3.707 ± 0.075	3.399GlyPhe: 3.399 ± 0.075	3.612GlyGly: 3.612 ± 0.088	1.184GlyHis: 1.184 ± 0.043	4.871GlyIle: 4.871 ± 0.09	4.104GlyLys: 4.104 ± 0.082	5.322GlyLeu: 5.322 ± 0.093	1.621GlyMet: 1.621 ± 0.056	2.413GlyAsn: 2.413 ± 0.061	0.968GlyPro: 0.968 ± 0.037	1.589GlyGln: 1.589 ± 0.044	1.756GlyArg: 1.756 ± 0.054	3.314GlySer: 3.314 ± 0.062	2.785GlyThr: 2.785 ± 0.066	4.202GlyVal: 4.202 ± 0.084	0.501GlyTrp: 0.501 ± 0.028	2.648GlyTyr: 2.648 ± 0.061	0.0GlyXaa: 0.0 ± 0.0
His	1.155HisAla: 1.155 ± 0.04	0.245HisCys: 0.245 ± 0.019	1.074HisAsp: 1.074 ± 0.04	1.376HisGlu: 1.376 ± 0.043	1.155HisPhe: 1.155 ± 0.033	1.119HisGly: 1.119 ± 0.04	0.59HisHis: 0.59 ± 0.031	1.831HisIle: 1.831 ± 0.05	1.471HisLys: 1.471 ± 0.039	1.999HisLeu: 1.999 ± 0.055	0.507HisMet: 0.507 ± 0.026	1.155HisAsn: 1.155 ± 0.043	0.884HisPro: 0.884 ± 0.032	0.855HisGln: 0.855 ± 0.035	0.64HisArg: 0.64 ± 0.028	1.202HisSer: 1.202 ± 0.038	1.202HisThr: 1.202 ± 0.038	0.953HisVal: 0.953 ± 0.033	0.147HisTrp: 0.147 ± 0.014	0.934HisTyr: 0.934 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	6.293IleAla: 6.293 ± 0.104	0.762IleCys: 0.762 ± 0.033	5.412IleAsp: 5.412 ± 0.077	6.746IleGlu: 6.746 ± 0.113	4.021IlePhe: 4.021 ± 0.092	4.96IleGly: 4.96 ± 0.102	1.596IleHis: 1.596 ± 0.053	6.796IleIle: 6.796 ± 0.118	7.499IleLys: 7.499 ± 0.111	7.805IleLeu: 7.805 ± 0.133	1.785IleMet: 1.785 ± 0.054	4.717IleAsn: 4.717 ± 0.081	2.758IlePro: 2.758 ± 0.064	2.931IleGln: 2.931 ± 0.061	2.293IleArg: 2.293 ± 0.051	5.595IleSer: 5.595 ± 0.092	4.858IleThr: 4.858 ± 0.078	5.428IleVal: 5.428 ± 0.087	0.471IleTrp: 0.471 ± 0.025	3.028IleTyr: 3.028 ± 0.065	0.0IleXaa: 0.0 ± 0.0
Lys	5.407LysAla: 5.407 ± 0.089	0.543LysCys: 0.543 ± 0.028	4.526LysAsp: 4.526 ± 0.084	9.225LysGlu: 9.225 ± 0.127	2.855LysPhe: 2.855 ± 0.054	3.979LysGly: 3.979 ± 0.079	1.624LysHis: 1.624 ± 0.045	6.659LysIle: 6.659 ± 0.11	7.896LysLys: 7.896 ± 0.125	7.213LysLeu: 7.213 ± 0.101	2.223LysMet: 2.223 ± 0.059	5.384LysAsn: 5.384 ± 0.099	2.438LysPro: 2.438 ± 0.062	3.247LysGln: 3.247 ± 0.078	3.211LysArg: 3.211 ± 0.065	4.964LysSer: 4.964 ± 0.085	4.411LysThr: 4.411 ± 0.083	5.059LysVal: 5.059 ± 0.094	0.483LysTrp: 0.483 ± 0.025	3.137LysTyr: 3.137 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	5.913LeuAla: 5.913 ± 0.106	0.92LeuCys: 0.92 ± 0.033	5.306LeuAsp: 5.306 ± 0.087	7.242LeuGlu: 7.242 ± 0.108	5.555LeuPhe: 5.555 ± 0.13	5.487LeuGly: 5.487 ± 0.096	1.952LeuHis: 1.952 ± 0.051	7.549LeuIle: 7.549 ± 0.124	8.909LeuLys: 8.909 ± 0.137	9.697LeuLeu: 9.697 ± 0.143	2.309LeuMet: 2.309 ± 0.055	6.13LeuAsn: 6.13 ± 0.094	3.211LeuPro: 3.211 ± 0.071	3.766LeuGln: 3.766 ± 0.073	2.756LeuArg: 2.756 ± 0.061	6.909LeuSer: 6.909 ± 0.107	4.997LeuThr: 4.997 ± 0.081	5.364LeuVal: 5.364 ± 0.089	0.662LeuTrp: 0.662 ± 0.034	3.617LeuTyr: 3.617 ± 0.081	0.0LeuXaa: 0.0 ± 0.0
Met	1.727MetAla: 1.727 ± 0.056	0.227MetCys: 0.227 ± 0.017	1.422MetAsp: 1.422 ± 0.045	1.203MetGlu: 1.203 ± 0.042	1.22MetPhe: 1.22 ± 0.046	1.577MetGly: 1.577 ± 0.04	0.532MetHis: 0.532 ± 0.028	2.16MetIle: 2.16 ± 0.066	2.241MetLys: 2.241 ± 0.053	2.495MetLeu: 2.495 ± 0.062	0.722MetMet: 0.722 ± 0.033	1.493MetAsn: 1.493 ± 0.046	1.0MetPro: 1.0 ± 0.037	1.221MetGln: 1.221 ± 0.046	0.761MetArg: 0.761 ± 0.031	1.83MetSer: 1.83 ± 0.046	1.243MetThr: 1.243 ± 0.039	1.628MetVal: 1.628 ± 0.054	0.174MetTrp: 0.174 ± 0.014	0.808MetTyr: 0.808 ± 0.037	0.0MetXaa: 0.0 ± 0.0
Asn	3.658AsnAla: 3.658 ± 0.073	0.464AsnCys: 0.464 ± 0.028	3.03AsnAsp: 3.03 ± 0.067	4.565AsnGlu: 4.565 ± 0.088	2.603AsnPhe: 2.603 ± 0.057	2.912AsnGly: 2.912 ± 0.065	1.072AsnHis: 1.072 ± 0.038	5.651AsnIle: 5.651 ± 0.1	4.545AsnLys: 4.545 ± 0.081	5.086AsnLeu: 5.086 ± 0.089	1.377AsnMet: 1.377 ± 0.037	3.269AsnAsn: 3.269 ± 0.077	2.048AsnPro: 2.048 ± 0.051	2.12AsnGln: 2.12 ± 0.054	2.006AsnArg: 2.006 ± 0.057	3.593AsnSer: 3.593 ± 0.079	2.903AsnThr: 2.903 ± 0.063	3.094AsnVal: 3.094 ± 0.062	0.396AsnTrp: 0.396 ± 0.024	2.236AsnTyr: 2.236 ± 0.061	0.0AsnXaa: 0.0 ± 0.0
Pro	1.535ProAla: 1.535 ± 0.052	0.239ProCys: 0.239 ± 0.016	1.32ProAsp: 1.32 ± 0.038	1.882ProGlu: 1.882 ± 0.053	1.786ProPhe: 1.786 ± 0.049	1.237ProGly: 1.237 ± 0.043	0.704ProHis: 0.704 ± 0.03	2.458ProIle: 2.458 ± 0.056	2.542ProLys: 2.542 ± 0.052	3.016ProLeu: 3.016 ± 0.066	0.776ProMet: 0.776 ± 0.03	1.677ProAsn: 1.677 ± 0.05	0.602ProPro: 0.602 ± 0.029	1.118ProGln: 1.118 ± 0.039	0.752ProArg: 0.752 ± 0.032	1.896ProSer: 1.896 ± 0.055	1.86ProThr: 1.86 ± 0.06	1.854ProVal: 1.854 ± 0.052	0.238ProTrp: 0.238 ± 0.017	1.466ProTyr: 1.466 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.417GlnAla: 2.417 ± 0.063	0.253GlnCys: 0.253 ± 0.017	1.655GlnAsp: 1.655 ± 0.043	3.143GlnGlu: 3.143 ± 0.072	1.512GlnPhe: 1.512 ± 0.043	1.719GlnGly: 1.719 ± 0.046	0.786GlnHis: 0.786 ± 0.033	2.887GlnIle: 2.887 ± 0.066	3.682GlnLys: 3.682 ± 0.07	3.297GlnLeu: 3.297 ± 0.062	1.024GlnMet: 1.024 ± 0.04	2.491GlnAsn: 2.491 ± 0.066	0.954GlnPro: 0.954 ± 0.033	1.484GlnGln: 1.484 ± 0.049	1.408GlnArg: 1.408 ± 0.044	2.307GlnSer: 2.307 ± 0.06	2.378GlnThr: 2.378 ± 0.06	1.907GlnVal: 1.907 ± 0.048	0.354GlnTrp: 0.354 ± 0.021	1.295GlnTyr: 1.295 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	1.902ArgAla: 1.902 ± 0.055	0.276ArgCys: 0.276 ± 0.022	1.664ArgAsp: 1.664 ± 0.051	2.081ArgGlu: 2.081 ± 0.045	1.727ArgPhe: 1.727 ± 0.052	1.588ArgGly: 1.588 ± 0.049	0.652ArgHis: 0.652 ± 0.028	2.558ArgIle: 2.558 ± 0.059	2.26ArgLys: 2.26 ± 0.058	3.111ArgLeu: 3.111 ± 0.064	0.837ArgMet: 0.837 ± 0.032	1.675ArgAsn: 1.675 ± 0.046	0.839ArgPro: 0.839 ± 0.038	0.981ArgGln: 0.981 ± 0.038	1.146ArgArg: 1.146 ± 0.044	1.631ArgSer: 1.631 ± 0.048	1.484ArgThr: 1.484 ± 0.043	2.302ArgVal: 2.302 ± 0.053	0.259ArgTrp: 0.259 ± 0.021	1.357ArgTyr: 1.357 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.698SerAla: 3.698 ± 0.076	0.682SerCys: 0.682 ± 0.033	2.976SerAsp: 2.976 ± 0.063	3.472SerGlu: 3.472 ± 0.062	3.79SerPhe: 3.79 ± 0.077	3.672SerGly: 3.672 ± 0.076	1.312SerHis: 1.312 ± 0.044	5.565SerIle: 5.565 ± 0.086	5.458SerLys: 5.458 ± 0.094	6.541SerLeu: 6.541 ± 0.088	1.807SerMet: 1.807 ± 0.051	3.531SerAsn: 3.531 ± 0.064	1.404SerPro: 1.404 ± 0.043	2.339SerGln: 2.339 ± 0.058	1.85SerArg: 1.85 ± 0.05	4.358SerSer: 4.358 ± 0.085	3.221SerThr: 3.221 ± 0.069	3.987SerVal: 3.987 ± 0.084	0.515SerTrp: 0.515 ± 0.026	2.624SerTyr: 2.624 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	3.4ThrAla: 3.4 ± 0.073	0.412ThrCys: 0.412 ± 0.028	2.269ThrAsp: 2.269 ± 0.059	2.248ThrGlu: 2.248 ± 0.061	2.8ThrPhe: 2.8 ± 0.065	2.981ThrGly: 2.981 ± 0.068	1.332ThrHis: 1.332 ± 0.044	4.888ThrIle: 4.888 ± 0.081	4.09ThrLys: 4.09 ± 0.084	6.156ThrLeu: 6.156 ± 0.1	1.208ThrMet: 1.208 ± 0.041	2.69ThrAsn: 2.69 ± 0.061	2.207ThrPro: 2.207 ± 0.054	2.566ThrGln: 2.566 ± 0.069	1.456ThrArg: 1.456 ± 0.044	3.316ThrSer: 3.316 ± 0.071	3.259ThrThr: 3.259 ± 0.077	3.208ThrVal: 3.208 ± 0.078	0.34ThrTrp: 0.34 ± 0.024	2.159ThrTyr: 2.159 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	4.458ValAla: 4.458 ± 0.093	0.816ValCys: 0.816 ± 0.035	3.429ValAsp: 3.429 ± 0.069	4.235ValGlu: 4.235 ± 0.076	2.972ValPhe: 2.972 ± 0.073	3.705ValGly: 3.705 ± 0.08	1.131ValHis: 1.131 ± 0.039	5.402ValIle: 5.402 ± 0.09	4.832ValLys: 4.832 ± 0.08	6.21ValLeu: 6.21 ± 0.097	1.573ValMet: 1.573 ± 0.05	3.438ValAsn: 3.438 ± 0.074	1.946ValPro: 1.946 ± 0.052	2.272ValGln: 2.272 ± 0.051	1.752ValArg: 1.752 ± 0.051	3.944ValSer: 3.944 ± 0.083	3.16ValThr: 3.16 ± 0.067	4.583ValVal: 4.583 ± 0.098	0.473ValTrp: 0.473 ± 0.022	2.348ValTyr: 2.348 ± 0.063	0.0ValXaa: 0.0 ± 0.0
Trp	0.435TrpAla: 0.435 ± 0.024	0.1TrpCys: 0.1 ± 0.011	0.39TrpAsp: 0.39 ± 0.025	0.442TrpGlu: 0.442 ± 0.024	0.419TrpPhe: 0.419 ± 0.024	0.494TrpGly: 0.494 ± 0.026	0.178TrpHis: 0.178 ± 0.014	0.631TrpIle: 0.631 ± 0.031	0.459TrpLys: 0.459 ± 0.026	0.731TrpLeu: 0.731 ± 0.03	0.26TrpMet: 0.26 ± 0.021	0.385TrpAsn: 0.385 ± 0.023	0.163TrpPro: 0.163 ± 0.015	0.293TrpGln: 0.293 ± 0.019	0.235TrpArg: 0.235 ± 0.017	0.465TrpSer: 0.465 ± 0.029	0.287TrpThr: 0.287 ± 0.02	0.493TrpVal: 0.493 ± 0.025	0.08TrpTrp: 0.08 ± 0.011	0.297TrpTyr: 0.297 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.483TyrAla: 2.483 ± 0.058	0.38TyrCys: 0.38 ± 0.025	2.55TyrAsp: 2.55 ± 0.064	3.199TyrGlu: 3.199 ± 0.073	2.348TyrPhe: 2.348 ± 0.059	2.157TyrGly: 2.157 ± 0.049	0.795TyrHis: 0.795 ± 0.033	3.171TyrIle: 3.171 ± 0.061	3.418TyrLys: 3.418 ± 0.074	3.883TyrLeu: 3.883 ± 0.08	0.955TyrMet: 0.955 ± 0.039	2.26TyrAsn: 2.26 ± 0.051	1.231TyrPro: 1.231 ± 0.039	1.208TyrGln: 1.208 ± 0.041	1.222TyrArg: 1.222 ± 0.048	2.433TyrSer: 2.433 ± 0.065	2.109TyrThr: 2.109 ± 0.059	2.148TyrVal: 2.148 ± 0.051	0.346TyrTrp: 0.346 ± 0.022	1.719TyrTyr: 1.719 ± 0.05	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2486 proteins (787083 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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