Amino acid dipepetide frequency for Mesocricetibacter intestinalis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.018AlaAla: 10.018 ± 0.383
1.221AlaCys: 1.221 ± 0.051
5.222AlaAsp: 5.222 ± 0.188
6.727AlaGlu: 6.727 ± 0.109
3.638AlaPhe: 3.638 ± 0.096
6.692AlaGly: 6.692 ± 0.148
1.56AlaHis: 1.56 ± 0.051
5.78AlaIle: 5.78 ± 0.12
5.138AlaLys: 5.138 ± 0.111
11.563AlaLeu: 11.563 ± 0.181
2.496AlaMet: 2.496 ± 0.075
3.302AlaAsn: 3.302 ± 0.115
3.217AlaPro: 3.217 ± 0.068
4.924AlaGln: 4.924 ± 0.151
4.425AlaArg: 4.425 ± 0.097
4.313AlaSer: 4.313 ± 0.142
4.318AlaThr: 4.318 ± 0.248
6.486AlaVal: 6.486 ± 0.118
0.894AlaTrp: 0.894 ± 0.034
2.673AlaTyr: 2.673 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
1.044CysAla: 1.044 ± 0.041
0.215CysCys: 0.215 ± 0.022
0.626CysAsp: 0.626 ± 0.037
0.64CysGlu: 0.64 ± 0.035
0.509CysPhe: 0.509 ± 0.03
1.171CysGly: 1.171 ± 0.049
0.287CysHis: 0.287 ± 0.024
0.667CysIle: 0.667 ± 0.038
0.448CysLys: 0.448 ± 0.033
1.203CysLeu: 1.203 ± 0.048
0.19CysMet: 0.19 ± 0.018
0.331CysAsn: 0.331 ± 0.024
0.538CysPro: 0.538 ± 0.036
0.367CysGln: 0.367 ± 0.025
0.783CysArg: 0.783 ± 0.042
0.707CysSer: 0.707 ± 0.032
0.474CysThr: 0.474 ± 0.029
0.64CysVal: 0.64 ± 0.036
0.135CysTrp: 0.135 ± 0.016
0.409CysTyr: 0.409 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.769AspAla: 3.769 ± 0.107
0.595AspCys: 0.595 ± 0.034
1.792AspAsp: 1.792 ± 0.06
3.14AspGlu: 3.14 ± 0.083
2.486AspPhe: 2.486 ± 0.069
3.104AspGly: 3.104 ± 0.223
0.763AspHis: 0.763 ± 0.037
3.889AspIle: 3.889 ± 0.098
3.483AspLys: 3.483 ± 0.085
4.909AspLeu: 4.909 ± 0.096
1.325AspMet: 1.325 ± 0.053
2.487AspAsn: 2.487 ± 0.091
2.111AspPro: 2.111 ± 0.06
1.759AspGln: 1.759 ± 0.063
2.148AspArg: 2.148 ± 0.062
2.853AspSer: 2.853 ± 0.115
2.063AspThr: 2.063 ± 0.064
2.608AspVal: 2.608 ± 0.073
0.773AspTrp: 0.773 ± 0.038
2.257AspTyr: 2.257 ± 0.067
0.0AspXaa: 0.0 ± 0.0
Glu
5.063GluAla: 5.063 ± 0.107
0.414GluCys: 0.414 ± 0.027
2.728GluAsp: 2.728 ± 0.08
3.984GluGlu: 3.984 ± 0.094
2.277GluPhe: 2.277 ± 0.068
3.949GluGly: 3.949 ± 0.099
1.321GluHis: 1.321 ± 0.049
4.539GluIle: 4.539 ± 0.106
4.447GluLys: 4.447 ± 0.099
6.333GluLeu: 6.333 ± 0.13
1.69GluMet: 1.69 ± 0.055
3.421GluAsn: 3.421 ± 0.093
1.734GluPro: 1.734 ± 0.065
4.002GluGln: 4.002 ± 0.101
3.678GluArg: 3.678 ± 0.096
2.908GluSer: 2.908 ± 0.07
2.639GluThr: 2.639 ± 0.076
3.996GluVal: 3.996 ± 0.088
0.575GluTrp: 0.575 ± 0.036
1.719GluTyr: 1.719 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.794PheAla: 3.794 ± 0.091
0.598PheCys: 0.598 ± 0.032
2.551PheAsp: 2.551 ± 0.074
2.407PheGlu: 2.407 ± 0.066
1.903PhePhe: 1.903 ± 0.075
3.438PheGly: 3.438 ± 0.089
0.824PheHis: 0.824 ± 0.036
3.331PheIle: 3.331 ± 0.089
1.821PheLys: 1.821 ± 0.06
3.907PheLeu: 3.907 ± 0.116
0.999PheMet: 0.999 ± 0.043
2.121PheAsn: 2.121 ± 0.062
1.523PhePro: 1.523 ± 0.05
1.196PheGln: 1.196 ± 0.046
1.829PheArg: 1.829 ± 0.065
3.408PheSer: 3.408 ± 0.087
2.023PheThr: 2.023 ± 0.054
2.691PheVal: 2.691 ± 0.08
0.518PheTrp: 0.518 ± 0.03
1.487PheTyr: 1.487 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
6.109GlyAla: 6.109 ± 0.14
0.937GlyCys: 0.937 ± 0.042
3.316GlyAsp: 3.316 ± 0.101
4.659GlyGlu: 4.659 ± 0.109
3.406GlyPhe: 3.406 ± 0.088
5.34GlyGly: 5.34 ± 0.125
1.403GlyHis: 1.403 ± 0.054
5.596GlyIle: 5.596 ± 0.11
4.786GlyLys: 4.786 ± 0.153
7.657GlyLeu: 7.657 ± 0.138
1.958GlyMet: 1.958 ± 0.06
2.953GlyAsn: 2.953 ± 0.143
1.518GlyPro: 1.518 ± 0.057
2.719GlyGln: 2.719 ± 0.074
3.476GlyArg: 3.476 ± 0.081
4.034GlySer: 4.034 ± 0.129
3.429GlyThr: 3.429 ± 0.108
5.048GlyVal: 5.048 ± 0.106
0.924GlyTrp: 0.924 ± 0.041
2.651GlyTyr: 2.651 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.385HisAla: 1.385 ± 0.045
0.376HisCys: 0.376 ± 0.025
0.763HisAsp: 0.763 ± 0.036
0.959HisGlu: 0.959 ± 0.042
0.994HisPhe: 0.994 ± 0.044
1.325HisGly: 1.325 ± 0.053
0.593HisHis: 0.593 ± 0.038
1.65HisIle: 1.65 ± 0.06
1.151HisLys: 1.151 ± 0.048
2.255HisLeu: 2.255 ± 0.077
0.431HisMet: 0.431 ± 0.025
0.964HisAsn: 0.964 ± 0.045
1.052HisPro: 1.052 ± 0.044
1.046HisGln: 1.046 ± 0.048
1.118HisArg: 1.118 ± 0.043
1.415HisSer: 1.415 ± 0.055
0.877HisThr: 0.877 ± 0.04
0.84HisVal: 0.84 ± 0.038
0.378HisTrp: 0.378 ± 0.025
0.867HisTyr: 0.867 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
7.23IleAla: 7.23 ± 0.125
0.887IleCys: 0.887 ± 0.039
3.595IleAsp: 3.595 ± 0.086
4.39IleGlu: 4.39 ± 0.101
2.775IlePhe: 2.775 ± 0.092
5.686IleGly: 5.686 ± 0.123
1.278IleHis: 1.278 ± 0.05
4.525IleIle: 4.525 ± 0.113
3.419IleLys: 3.419 ± 0.087
6.809IleLeu: 6.809 ± 0.138
1.381IleMet: 1.381 ± 0.05
2.953IleAsn: 2.953 ± 0.079
2.863IlePro: 2.863 ± 0.082
2.24IleGln: 2.24 ± 0.063
3.658IleArg: 3.658 ± 0.094
4.575IleSer: 4.575 ± 0.094
3.406IleThr: 3.406 ± 0.085
4.004IleVal: 4.004 ± 0.08
0.648IleTrp: 0.648 ± 0.034
2.011IleTyr: 2.011 ± 0.063
0.0IleXaa: 0.0 ± 0.0
Lys
5.252LysAla: 5.252 ± 0.114
0.389LysCys: 0.389 ± 0.029
2.795LysAsp: 2.795 ± 0.147
3.246LysGlu: 3.246 ± 0.085
1.804LysPhe: 1.804 ± 0.058
4.007LysGly: 4.007 ± 0.114
0.966LysHis: 0.966 ± 0.04
3.799LysIle: 3.799 ± 0.073
3.209LysLys: 3.209 ± 0.089
5.521LysLeu: 5.521 ± 0.108
1.403LysMet: 1.403 ± 0.05
2.699LysAsn: 2.699 ± 0.084
2.218LysPro: 2.218 ± 0.065
2.763LysGln: 2.763 ± 0.067
2.82LysArg: 2.82 ± 0.072
2.998LysSer: 2.998 ± 0.085
2.887LysThr: 2.887 ± 0.076
3.66LysVal: 3.66 ± 0.083
0.491LysTrp: 0.491 ± 0.03
1.612LysTyr: 1.612 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
10.629LeuAla: 10.629 ± 0.169
1.398LeuCys: 1.398 ± 0.049
5.093LeuAsp: 5.093 ± 0.098
5.903LeuGlu: 5.903 ± 0.139
4.914LeuPhe: 4.914 ± 0.126
7.55LeuGly: 7.55 ± 0.137
2.295LeuHis: 2.295 ± 0.068
7.34LeuIle: 7.34 ± 0.139
5.559LeuLys: 5.559 ± 0.1
12.106LeuLeu: 12.106 ± 0.246
2.489LeuMet: 2.489 ± 0.07
5.046LeuAsn: 5.046 ± 0.123
4.896LeuPro: 4.896 ± 0.099
5.033LeuGln: 5.033 ± 0.117
5.319LeuArg: 5.319 ± 0.117
8.152LeuSer: 8.152 ± 0.127
5.446LeuThr: 5.446 ± 0.111
6.231LeuVal: 6.231 ± 0.118
1.158LeuTrp: 1.158 ± 0.044
2.962LeuTyr: 2.962 ± 0.09
0.0LeuXaa: 0.0 ± 0.0
Met
2.439MetAla: 2.439 ± 0.074
0.164MetCys: 0.164 ± 0.016
0.967MetAsp: 0.967 ± 0.039
1.146MetGlu: 1.146 ± 0.051
0.788MetPhe: 0.788 ± 0.036
1.665MetGly: 1.665 ± 0.059
0.449MetHis: 0.449 ± 0.031
1.472MetIle: 1.472 ± 0.058
1.498MetLys: 1.498 ± 0.047
2.96MetLeu: 2.96 ± 0.086
0.661MetMet: 0.661 ± 0.035
1.071MetAsn: 1.071 ± 0.043
1.106MetPro: 1.106 ± 0.046
1.438MetGln: 1.438 ± 0.051
1.194MetArg: 1.194 ± 0.044
1.55MetSer: 1.55 ± 0.049
1.3MetThr: 1.3 ± 0.046
1.445MetVal: 1.445 ± 0.047
0.189MetTrp: 0.189 ± 0.021
0.473MetTyr: 0.473 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
3.742AsnAla: 3.742 ± 0.115
0.436AsnCys: 0.436 ± 0.029
1.754AsnAsp: 1.754 ± 0.05
2.242AsnGlu: 2.242 ± 0.063
1.647AsnPhe: 1.647 ± 0.059
3.105AsnGly: 3.105 ± 0.212
0.86AsnHis: 0.86 ± 0.037
3.516AsnIle: 3.516 ± 0.093
2.425AsnLys: 2.425 ± 0.069
4.784AsnLeu: 4.784 ± 0.111
1.102AsnMet: 1.102 ± 0.042
2.111AsnAsn: 2.111 ± 0.104
2.486AsnPro: 2.486 ± 0.06
2.035AsnGln: 2.035 ± 0.058
2.372AsnArg: 2.372 ± 0.074
2.419AsnSer: 2.419 ± 0.147
2.045AsnThr: 2.045 ± 0.082
2.504AsnVal: 2.504 ± 0.11
0.525AsnTrp: 0.525 ± 0.028
1.407AsnTyr: 1.407 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
3.51ProAla: 3.51 ± 0.073
0.337ProCys: 0.337 ± 0.025
2.073ProAsp: 2.073 ± 0.065
3.15ProGlu: 3.15 ± 0.084
1.848ProPhe: 1.848 ± 0.058
2.046ProGly: 2.046 ± 0.068
1.082ProHis: 1.082 ± 0.045
2.272ProIle: 2.272 ± 0.071
1.964ProLys: 1.964 ± 0.068
4.594ProLeu: 4.594 ± 0.115
0.945ProMet: 0.945 ± 0.044
1.684ProAsn: 1.684 ± 0.054
1.398ProPro: 1.398 ± 0.064
2.529ProGln: 2.529 ± 0.088
1.532ProArg: 1.532 ± 0.062
2.083ProSer: 2.083 ± 0.054
1.864ProThr: 1.864 ± 0.058
2.821ProVal: 2.821 ± 0.08
0.426ProTrp: 0.426 ± 0.03
1.353ProTyr: 1.353 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
4.772GlnAla: 4.772 ± 0.103
0.453GlnCys: 0.453 ± 0.027
2.083GlnAsp: 2.083 ± 0.062
2.733GlnGlu: 2.733 ± 0.083
1.554GlnPhe: 1.554 ± 0.053
3.608GlnGly: 3.608 ± 0.073
1.111GlnHis: 1.111 ± 0.051
2.871GlnIle: 2.871 ± 0.081
2.41GlnLys: 2.41 ± 0.067
4.739GlnLeu: 4.739 ± 0.104
0.925GlnMet: 0.925 ± 0.042
2.018GlnAsn: 2.018 ± 0.065
1.919GlnPro: 1.919 ± 0.078
3.406GlnGln: 3.406 ± 0.093
2.826GlnArg: 2.826 ± 0.085
2.724GlnSer: 2.724 ± 0.165
2.076GlnThr: 2.076 ± 0.061
2.773GlnVal: 2.773 ± 0.063
0.687GlnTrp: 0.687 ± 0.033
1.403GlnTyr: 1.403 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
4.019ArgAla: 4.019 ± 0.077
0.489ArgCys: 0.489 ± 0.028
2.456ArgAsp: 2.456 ± 0.075
3.53ArgGlu: 3.53 ± 0.096
2.539ArgPhe: 2.539 ± 0.073
3.039ArgGly: 3.039 ± 0.087
1.415ArgHis: 1.415 ± 0.061
3.745ArgIle: 3.745 ± 0.088
2.519ArgLys: 2.519 ± 0.073
6.156ArgLeu: 6.156 ± 0.125
1.099ArgMet: 1.099 ± 0.036
2.222ArgAsn: 2.222 ± 0.069
1.958ArgPro: 1.958 ± 0.061
2.75ArgGln: 2.75 ± 0.076
3.334ArgArg: 3.334 ± 0.106
2.606ArgSer: 2.606 ± 0.078
2.21ArgThr: 2.21 ± 0.058
3.002ArgVal: 3.002 ± 0.08
0.623ArgTrp: 0.623 ± 0.035
1.966ArgTyr: 1.966 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
6.882SerAla: 6.882 ± 0.525
0.626SerCys: 0.626 ± 0.035
2.81SerAsp: 2.81 ± 0.068
3.386SerGlu: 3.386 ± 0.075
2.614SerPhe: 2.614 ± 0.07
5.22SerGly: 5.22 ± 0.106
1.183SerHis: 1.183 ± 0.049
3.533SerIle: 3.533 ± 0.092
2.584SerLys: 2.584 ± 0.07
6.682SerLeu: 6.682 ± 0.125
1.423SerMet: 1.423 ± 0.052
2.08SerAsn: 2.08 ± 0.084
2.335SerPro: 2.335 ± 0.064
2.076SerGln: 2.076 ± 0.058
3.042SerArg: 3.042 ± 0.088
3.506SerSer: 3.506 ± 0.195
2.516SerThr: 2.516 ± 0.079
4.151SerVal: 4.151 ± 0.111
0.69SerTrp: 0.69 ± 0.035
1.849SerTyr: 1.849 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
5.0ThrAla: 5.0 ± 0.228
0.401ThrCys: 0.401 ± 0.023
2.644ThrAsp: 2.644 ± 0.09
3.317ThrGlu: 3.317 ± 0.076
1.943ThrPhe: 1.943 ± 0.072
3.53ThrGly: 3.53 ± 0.106
0.927ThrHis: 0.927 ± 0.038
2.521ThrIle: 2.521 ± 0.074
2.086ThrLys: 2.086 ± 0.066
5.564ThrLeu: 5.564 ± 0.101
0.954ThrMet: 0.954 ± 0.04
1.761ThrAsn: 1.761 ± 0.11
2.404ThrPro: 2.404 ± 0.072
1.929ThrGln: 1.929 ± 0.064
2.185ThrArg: 2.185 ± 0.069
2.435ThrSer: 2.435 ± 0.082
2.26ThrThr: 2.26 ± 0.116
3.06ThrVal: 3.06 ± 0.12
0.418ThrTrp: 0.418 ± 0.026
1.325ThrTyr: 1.325 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
6.112ValAla: 6.112 ± 0.121
0.798ValCys: 0.798 ± 0.04
3.027ValAsp: 3.027 ± 0.083
3.947ValGlu: 3.947 ± 0.091
2.623ValPhe: 2.623 ± 0.086
4.383ValGly: 4.383 ± 0.11
1.011ValHis: 1.011 ± 0.042
4.757ValIle: 4.757 ± 0.096
3.74ValLys: 3.74 ± 0.098
6.456ValLeu: 6.456 ± 0.116
1.647ValMet: 1.647 ± 0.057
2.713ValAsn: 2.713 ± 0.099
2.382ValPro: 2.382 ± 0.074
2.237ValGln: 2.237 ± 0.059
3.102ValArg: 3.102 ± 0.076
4.024ValSer: 4.024 ± 0.087
3.082ValThr: 3.082 ± 0.085
4.231ValVal: 4.231 ± 0.099
0.616ValTrp: 0.616 ± 0.033
1.749ValTyr: 1.749 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.837TrpAla: 0.837 ± 0.041
0.152TrpCys: 0.152 ± 0.016
0.496TrpAsp: 0.496 ± 0.03
0.509TrpGlu: 0.509 ± 0.028
0.573TrpPhe: 0.573 ± 0.029
0.762TrpGly: 0.762 ± 0.039
0.282TrpHis: 0.282 ± 0.021
0.672TrpIle: 0.672 ± 0.035
0.521TrpLys: 0.521 ± 0.027
1.675TrpLeu: 1.675 ± 0.052
0.229TrpMet: 0.229 ± 0.02
0.456TrpAsn: 0.456 ± 0.029
0.271TrpPro: 0.271 ± 0.02
0.874TrpGln: 0.874 ± 0.038
0.728TrpArg: 0.728 ± 0.036
0.54TrpSer: 0.54 ± 0.03
0.428TrpThr: 0.428 ± 0.029
0.725TrpVal: 0.725 ± 0.037
0.157TrpTrp: 0.157 ± 0.017
0.366TrpTyr: 0.366 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.003TyrAla: 3.003 ± 0.069
0.498TyrCys: 0.498 ± 0.035
1.523TyrAsp: 1.523 ± 0.053
1.401TyrGlu: 1.401 ± 0.053
1.535TyrPhe: 1.535 ± 0.064
2.3TyrGly: 2.3 ± 0.061
0.827TyrHis: 0.827 ± 0.04
1.861TyrIle: 1.861 ± 0.071
1.328TyrLys: 1.328 ± 0.051
3.647TyrLeu: 3.647 ± 0.103
0.625TyrMet: 0.625 ± 0.036
1.123TyrAsn: 1.123 ± 0.044
1.582TyrPro: 1.582 ± 0.056
1.769TyrGln: 1.769 ± 0.061
2.105TyrArg: 2.105 ± 0.066
1.938TyrSer: 1.938 ± 0.065
1.321TyrThr: 1.321 ± 0.048
1.722TyrVal: 1.722 ± 0.058
0.429TyrTrp: 0.429 ± 0.032
1.107TyrTyr: 1.107 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1827 proteins (598647 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski