Amino acid dipepetide frequency for Marek s disease virus serotype 2 MDV2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.075AlaAla: 9.075 ± 0.997
2.132AlaCys: 2.132 ± 0.264
5.071AlaAsp: 5.071 ± 0.5
4.927AlaGlu: 4.927 ± 0.423
3.688AlaPhe: 3.688 ± 0.344
4.984AlaGly: 4.984 ± 0.411
2.046AlaHis: 2.046 ± 0.268
5.676AlaIle: 5.676 ± 0.359
3.083AlaLys: 3.083 ± 0.324
9.306AlaLeu: 9.306 ± 0.535
1.959AlaMet: 1.959 ± 0.187
3.371AlaAsn: 3.371 ± 0.255
4.437AlaPro: 4.437 ± 0.379
1.815AlaGln: 1.815 ± 0.208
6.425AlaArg: 6.425 ± 0.479
8.125AlaSer: 8.125 ± 0.49
5.561AlaThr: 5.561 ± 0.486
6.482AlaVal: 6.482 ± 0.523
0.98AlaTrp: 0.98 ± 0.152
2.852AlaTyr: 2.852 ± 0.267
0.0AlaXaa: 0.0 ± 0.0
Cys
2.046CysAla: 2.046 ± 0.25
0.576CysCys: 0.576 ± 0.141
1.786CysAsp: 1.786 ± 0.264
1.268CysGlu: 1.268 ± 0.197
1.008CysPhe: 1.008 ± 0.197
1.585CysGly: 1.585 ± 0.256
0.519CysHis: 0.519 ± 0.117
1.585CysIle: 1.585 ± 0.343
0.605CysLys: 0.605 ± 0.147
2.132CysLeu: 2.132 ± 0.229
0.778CysMet: 0.778 ± 0.155
1.152CysAsn: 1.152 ± 0.232
1.152CysPro: 1.152 ± 0.165
0.49CysGln: 0.49 ± 0.116
1.556CysArg: 1.556 ± 0.192
1.383CysSer: 1.383 ± 0.232
1.383CysThr: 1.383 ± 0.202
1.757CysVal: 1.757 ± 0.245
0.144CysTrp: 0.144 ± 0.063
0.807CysTyr: 0.807 ± 0.146
0.0CysXaa: 0.0 ± 0.0
Asp
6.137AspAla: 6.137 ± 0.58
1.296AspCys: 1.296 ± 0.257
3.918AspAsp: 3.918 ± 0.408
2.737AspGlu: 2.737 ± 0.223
1.757AspPhe: 1.757 ± 0.204
4.091AspGly: 4.091 ± 0.305
1.152AspHis: 1.152 ± 0.179
3.63AspIle: 3.63 ± 0.383
1.527AspLys: 1.527 ± 0.23
4.869AspLeu: 4.869 ± 0.364
1.527AspMet: 1.527 ± 0.279
1.786AspAsn: 1.786 ± 0.236
3.112AspPro: 3.112 ± 0.358
0.778AspGln: 0.778 ± 0.197
3.889AspArg: 3.889 ± 0.433
4.523AspSer: 4.523 ± 0.413
3.544AspThr: 3.544 ± 0.309
4.466AspVal: 4.466 ± 0.395
0.864AspTrp: 0.864 ± 0.165
1.642AspTyr: 1.642 ± 0.249
0.0AspXaa: 0.0 ± 0.0
Glu
4.466GluAla: 4.466 ± 0.332
1.527GluCys: 1.527 ± 0.22
2.823GluAsp: 2.823 ± 0.252
3.284GluGlu: 3.284 ± 0.292
1.642GluPhe: 1.642 ± 0.267
2.478GluGly: 2.478 ± 0.289
1.181GluHis: 1.181 ± 0.178
2.708GluIle: 2.708 ± 0.227
2.218GluLys: 2.218 ± 0.26
5.733GluLeu: 5.733 ± 0.537
1.124GluMet: 1.124 ± 0.18
2.247GluAsn: 2.247 ± 0.316
2.132GluPro: 2.132 ± 0.212
1.441GluGln: 1.441 ± 0.212
4.206GluArg: 4.206 ± 0.343
4.293GluSer: 4.293 ± 0.338
3.774GluThr: 3.774 ± 0.372
2.622GluVal: 2.622 ± 0.234
0.72GluTrp: 0.72 ± 0.155
1.815GluTyr: 1.815 ± 0.221
0.0GluXaa: 0.0 ± 0.0
Phe
3.429PheAla: 3.429 ± 0.24
0.691PheCys: 0.691 ± 0.174
2.507PheAsp: 2.507 ± 0.304
1.873PheGlu: 1.873 ± 0.241
1.873PhePhe: 1.873 ± 0.248
1.902PheGly: 1.902 ± 0.273
0.922PheHis: 0.922 ± 0.184
2.19PheIle: 2.19 ± 0.233
1.815PheLys: 1.815 ± 0.232
3.515PheLeu: 3.515 ± 0.435
0.951PheMet: 0.951 ± 0.197
1.325PheAsn: 1.325 ± 0.171
1.815PhePro: 1.815 ± 0.248
1.095PheGln: 1.095 ± 0.22
1.93PheArg: 1.93 ± 0.219
4.034PheSer: 4.034 ± 0.29
2.017PheThr: 2.017 ± 0.258
3.025PheVal: 3.025 ± 0.276
0.547PheTrp: 0.547 ± 0.134
1.354PheTyr: 1.354 ± 0.206
0.0PheXaa: 0.0 ± 0.0
Gly
5.215GlyAla: 5.215 ± 0.401
1.037GlyCys: 1.037 ± 0.212
3.601GlyAsp: 3.601 ± 0.293
3.63GlyGlu: 3.63 ± 0.425
2.132GlyPhe: 2.132 ± 0.236
3.573GlyGly: 3.573 ± 0.305
1.037GlyHis: 1.037 ± 0.159
3.198GlyIle: 3.198 ± 0.249
2.305GlyLys: 2.305 ± 0.225
5.186GlyLeu: 5.186 ± 0.469
1.527GlyMet: 1.527 ± 0.222
2.046GlyAsn: 2.046 ± 0.184
2.593GlyPro: 2.593 ± 0.325
2.046GlyGln: 2.046 ± 0.292
5.157GlyArg: 5.157 ± 0.555
5.1GlySer: 5.1 ± 0.363
4.581GlyThr: 4.581 ± 0.418
2.881GlyVal: 2.881 ± 0.305
0.749GlyTrp: 0.749 ± 0.137
1.786GlyTyr: 1.786 ± 0.208
0.0GlyXaa: 0.0 ± 0.0
His
2.593HisAla: 2.593 ± 0.234
0.375HisCys: 0.375 ± 0.128
1.095HisAsp: 1.095 ± 0.196
0.951HisGlu: 0.951 ± 0.193
1.181HisPhe: 1.181 ± 0.184
1.902HisGly: 1.902 ± 0.219
0.403HisHis: 0.403 ± 0.091
1.354HisIle: 1.354 ± 0.173
0.864HisLys: 0.864 ± 0.137
2.247HisLeu: 2.247 ± 0.256
0.749HisMet: 0.749 ± 0.166
0.519HisAsn: 0.519 ± 0.125
1.239HisPro: 1.239 ± 0.23
0.346HisGln: 0.346 ± 0.111
1.873HisArg: 1.873 ± 0.252
1.786HisSer: 1.786 ± 0.229
0.807HisThr: 0.807 ± 0.14
1.729HisVal: 1.729 ± 0.199
0.173HisTrp: 0.173 ± 0.081
0.663HisTyr: 0.663 ± 0.125
0.0HisXaa: 0.0 ± 0.0
Ile
5.676IleAla: 5.676 ± 0.397
1.354IleCys: 1.354 ± 0.205
3.256IleAsp: 3.256 ± 0.304
3.256IleGlu: 3.256 ± 0.281
2.362IlePhe: 2.362 ± 0.273
3.198IleGly: 3.198 ± 0.305
1.095IleHis: 1.095 ± 0.155
2.737IleIle: 2.737 ± 0.253
2.103IleLys: 2.103 ± 0.232
4.84IleLeu: 4.84 ± 0.348
1.066IleMet: 1.066 ± 0.192
2.334IleAsn: 2.334 ± 0.268
2.852IlePro: 2.852 ± 0.248
1.786IleGln: 1.786 ± 0.276
3.803IleArg: 3.803 ± 0.304
4.408IleSer: 4.408 ± 0.346
3.054IleThr: 3.054 ± 0.286
3.227IleVal: 3.227 ± 0.31
0.346IleTrp: 0.346 ± 0.096
1.786IleTyr: 1.786 ± 0.219
0.0IleXaa: 0.0 ± 0.0
Lys
2.881LysAla: 2.881 ± 0.303
0.691LysCys: 0.691 ± 0.168
1.7LysAsp: 1.7 ± 0.199
1.902LysGlu: 1.902 ± 0.234
1.412LysPhe: 1.412 ± 0.172
1.441LysGly: 1.441 ± 0.203
1.268LysHis: 1.268 ± 0.227
2.017LysIle: 2.017 ± 0.276
1.959LysLys: 1.959 ± 0.242
3.688LysLeu: 3.688 ± 0.394
0.951LysMet: 0.951 ± 0.147
1.469LysAsn: 1.469 ± 0.236
1.7LysPro: 1.7 ± 0.25
1.21LysGln: 1.21 ± 0.184
3.573LysArg: 3.573 ± 0.349
2.737LysSer: 2.737 ± 0.307
2.968LysThr: 2.968 ± 0.358
2.19LysVal: 2.19 ± 0.285
0.605LysTrp: 0.605 ± 0.122
1.498LysTyr: 1.498 ± 0.217
0.0LysXaa: 0.0 ± 0.0
Leu
8.47LeuAla: 8.47 ± 0.48
2.535LeuCys: 2.535 ± 0.251
5.013LeuAsp: 5.013 ± 0.434
5.445LeuGlu: 5.445 ± 0.437
3.832LeuPhe: 3.832 ± 0.332
5.186LeuGly: 5.186 ± 0.367
2.218LeuHis: 2.218 ± 0.258
4.696LeuIle: 4.696 ± 0.42
4.12LeuLys: 4.12 ± 0.439
10.228LeuLeu: 10.228 ± 0.54
2.535LeuMet: 2.535 ± 0.364
3.054LeuAsn: 3.054 ± 0.3
4.495LeuPro: 4.495 ± 0.332
2.852LeuGln: 2.852 ± 0.267
6.799LeuArg: 6.799 ± 0.407
8.643LeuSer: 8.643 ± 0.496
5.445LeuThr: 5.445 ± 0.398
5.128LeuVal: 5.128 ± 0.426
1.066LeuTrp: 1.066 ± 0.196
2.996LeuTyr: 2.996 ± 0.356
0.0LeuXaa: 0.0 ± 0.0
Met
2.651MetAla: 2.651 ± 0.247
0.346MetCys: 0.346 ± 0.103
1.325MetAsp: 1.325 ± 0.192
1.181MetGlu: 1.181 ± 0.198
0.893MetPhe: 0.893 ± 0.156
1.757MetGly: 1.757 ± 0.235
0.749MetHis: 0.749 ± 0.16
1.066MetIle: 1.066 ± 0.167
0.72MetLys: 0.72 ± 0.14
2.305MetLeu: 2.305 ± 0.301
0.807MetMet: 0.807 ± 0.166
1.008MetAsn: 1.008 ± 0.164
1.268MetPro: 1.268 ± 0.185
0.547MetGln: 0.547 ± 0.127
1.441MetArg: 1.441 ± 0.203
2.535MetSer: 2.535 ± 0.236
1.469MetThr: 1.469 ± 0.18
1.441MetVal: 1.441 ± 0.186
0.259MetTrp: 0.259 ± 0.081
0.749MetTyr: 0.749 ± 0.125
0.0MetXaa: 0.0 ± 0.0
Asn
3.774AsnAla: 3.774 ± 0.338
0.951AsnCys: 0.951 ± 0.174
1.902AsnAsp: 1.902 ± 0.206
1.7AsnGlu: 1.7 ± 0.185
1.325AsnPhe: 1.325 ± 0.174
2.218AsnGly: 2.218 ± 0.238
0.663AsnHis: 0.663 ± 0.119
2.074AsnIle: 2.074 ± 0.255
1.469AsnLys: 1.469 ± 0.244
3.14AsnLeu: 3.14 ± 0.334
0.893AsnMet: 0.893 ± 0.123
1.383AsnAsn: 1.383 ± 0.214
1.902AsnPro: 1.902 ± 0.206
0.836AsnGln: 0.836 ± 0.133
1.815AsnArg: 1.815 ± 0.226
2.737AsnSer: 2.737 ± 0.286
2.535AsnThr: 2.535 ± 0.258
2.881AsnVal: 2.881 ± 0.291
0.346AsnTrp: 0.346 ± 0.107
1.296AsnTyr: 1.296 ± 0.178
0.0AsnXaa: 0.0 ± 0.0
Pro
3.688ProAla: 3.688 ± 0.328
1.066ProCys: 1.066 ± 0.187
2.823ProAsp: 2.823 ± 0.288
3.083ProGlu: 3.083 ± 0.346
1.556ProPhe: 1.556 ± 0.162
3.371ProGly: 3.371 ± 0.352
1.556ProHis: 1.556 ± 0.218
2.766ProIle: 2.766 ± 0.245
1.498ProLys: 1.498 ± 0.211
4.35ProLeu: 4.35 ± 0.514
1.152ProMet: 1.152 ± 0.206
1.498ProAsn: 1.498 ± 0.201
4.091ProPro: 4.091 ± 0.438
0.98ProGln: 0.98 ± 0.201
3.515ProArg: 3.515 ± 0.43
4.84ProSer: 4.84 ± 0.52
3.284ProThr: 3.284 ± 0.322
3.573ProVal: 3.573 ± 0.27
0.576ProTrp: 0.576 ± 0.14
1.296ProTyr: 1.296 ± 0.214
0.0ProXaa: 0.0 ± 0.0
Gln
2.391GlnAla: 2.391 ± 0.2
0.778GlnCys: 0.778 ± 0.177
1.066GlnAsp: 1.066 ± 0.169
1.354GlnGlu: 1.354 ± 0.219
1.239GlnPhe: 1.239 ± 0.223
1.268GlnGly: 1.268 ± 0.17
0.634GlnHis: 0.634 ± 0.121
1.325GlnIle: 1.325 ± 0.209
1.383GlnLys: 1.383 ± 0.169
2.449GlnLeu: 2.449 ± 0.235
0.864GlnMet: 0.864 ± 0.136
0.836GlnAsn: 0.836 ± 0.182
1.037GlnPro: 1.037 ± 0.22
1.066GlnGln: 1.066 ± 0.152
2.017GlnArg: 2.017 ± 0.199
2.19GlnSer: 2.19 ± 0.248
1.902GlnThr: 1.902 ± 0.313
1.354GlnVal: 1.354 ± 0.181
0.144GlnTrp: 0.144 ± 0.071
1.037GlnTyr: 1.037 ± 0.173
0.0GlnXaa: 0.0 ± 0.0
Arg
7.289ArgAla: 7.289 ± 0.39
1.988ArgCys: 1.988 ± 0.276
4.35ArgAsp: 4.35 ± 0.42
3.342ArgGlu: 3.342 ± 0.278
2.795ArgPhe: 2.795 ± 0.283
4.379ArgGly: 4.379 ± 0.448
2.132ArgHis: 2.132 ± 0.264
3.371ArgIle: 3.371 ± 0.267
2.679ArgLys: 2.679 ± 0.397
6.482ArgLeu: 6.482 ± 0.424
1.613ArgMet: 1.613 ± 0.189
2.91ArgAsn: 2.91 ± 0.314
3.803ArgPro: 3.803 ± 0.335
2.161ArgGln: 2.161 ± 0.251
6.943ArgArg: 6.943 ± 0.69
5.935ArgSer: 5.935 ± 0.635
4.379ArgThr: 4.379 ± 0.363
4.149ArgVal: 4.149 ± 0.268
0.605ArgTrp: 0.605 ± 0.143
1.815ArgTyr: 1.815 ± 0.206
0.0ArgXaa: 0.0 ± 0.0
Ser
7.52SerAla: 7.52 ± 0.53
1.93SerCys: 1.93 ± 0.22
5.071SerAsp: 5.071 ± 0.448
4.61SerGlu: 4.61 ± 0.332
2.362SerPhe: 2.362 ± 0.285
5.618SerGly: 5.618 ± 0.393
1.498SerHis: 1.498 ± 0.18
4.293SerIle: 4.293 ± 0.326
3.371SerLys: 3.371 ± 0.331
7.376SerLeu: 7.376 ± 0.427
2.074SerMet: 2.074 ± 0.293
3.169SerAsn: 3.169 ± 0.264
4.206SerPro: 4.206 ± 0.355
2.362SerGln: 2.362 ± 0.267
6.54SerArg: 6.54 ± 0.491
7.347SerSer: 7.347 ± 0.648
5.993SerThr: 5.993 ± 0.563
6.367SerVal: 6.367 ± 0.503
0.605SerTrp: 0.605 ± 0.129
2.276SerTyr: 2.276 ± 0.217
0.0SerXaa: 0.0 ± 0.0
Thr
6.108ThrAla: 6.108 ± 0.523
1.7ThrCys: 1.7 ± 0.224
3.486ThrAsp: 3.486 ± 0.288
3.025ThrGlu: 3.025 ± 0.351
2.939ThrPhe: 2.939 ± 0.301
3.832ThrGly: 3.832 ± 0.322
1.498ThrHis: 1.498 ± 0.203
3.63ThrIle: 3.63 ± 0.267
1.93ThrLys: 1.93 ± 0.218
5.935ThrLeu: 5.935 ± 0.461
1.152ThrMet: 1.152 ± 0.219
2.218ThrAsn: 2.218 ± 0.262
3.198ThrPro: 3.198 ± 0.359
1.613ThrGln: 1.613 ± 0.236
4.523ThrArg: 4.523 ± 0.349
5.359ThrSer: 5.359 ± 0.505
4.178ThrThr: 4.178 ± 0.432
4.754ThrVal: 4.754 ± 0.418
0.634ThrTrp: 0.634 ± 0.16
2.132ThrTyr: 2.132 ± 0.279
0.0ThrXaa: 0.0 ± 0.0
Val
5.157ValAla: 5.157 ± 0.409
1.757ValCys: 1.757 ± 0.298
4.235ValAsp: 4.235 ± 0.286
3.083ValGlu: 3.083 ± 0.294
3.054ValPhe: 3.054 ± 0.356
3.515ValGly: 3.515 ± 0.282
1.124ValHis: 1.124 ± 0.166
3.486ValIle: 3.486 ± 0.425
2.593ValLys: 2.593 ± 0.289
6.598ValLeu: 6.598 ± 0.436
1.671ValMet: 1.671 ± 0.218
1.902ValAsn: 1.902 ± 0.228
3.601ValPro: 3.601 ± 0.347
1.959ValGln: 1.959 ± 0.276
4.322ValArg: 4.322 ± 0.323
5.186ValSer: 5.186 ± 0.39
4.062ValThr: 4.062 ± 0.276
4.062ValVal: 4.062 ± 0.438
0.922ValTrp: 0.922 ± 0.179
2.737ValTyr: 2.737 ± 0.274
0.0ValXaa: 0.0 ± 0.0
Trp
0.605TrpAla: 0.605 ± 0.129
0.259TrpCys: 0.259 ± 0.089
0.49TrpAsp: 0.49 ± 0.104
0.403TrpGlu: 0.403 ± 0.1
0.432TrpPhe: 0.432 ± 0.125
0.691TrpGly: 0.691 ± 0.15
0.403TrpHis: 0.403 ± 0.115
0.663TrpIle: 0.663 ± 0.146
0.634TrpLys: 0.634 ± 0.132
1.152TrpLeu: 1.152 ± 0.172
0.23TrpMet: 0.23 ± 0.081
0.375TrpAsn: 0.375 ± 0.097
0.576TrpPro: 0.576 ± 0.151
0.317TrpGln: 0.317 ± 0.094
0.893TrpArg: 0.893 ± 0.185
0.691TrpSer: 0.691 ± 0.131
0.893TrpThr: 0.893 ± 0.152
0.49TrpVal: 0.49 ± 0.091
0.144TrpTrp: 0.144 ± 0.064
0.317TrpTyr: 0.317 ± 0.078
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.823TyrAla: 2.823 ± 0.238
0.72TyrCys: 0.72 ± 0.168
1.729TyrAsp: 1.729 ± 0.231
1.412TyrGlu: 1.412 ± 0.188
1.325TyrPhe: 1.325 ± 0.207
2.391TyrGly: 2.391 ± 0.312
0.749TyrHis: 0.749 ± 0.17
2.074TyrIle: 2.074 ± 0.238
0.98TyrLys: 0.98 ± 0.194
3.227TyrLeu: 3.227 ± 0.328
0.864TyrMet: 0.864 ± 0.183
1.239TyrAsn: 1.239 ± 0.166
1.354TyrPro: 1.354 ± 0.219
0.634TyrGln: 0.634 ± 0.163
1.902TyrArg: 1.902 ± 0.235
2.737TyrSer: 2.737 ± 0.266
2.017TyrThr: 2.017 ± 0.248
2.449TyrVal: 2.449 ± 0.242
0.23TyrTrp: 0.23 ± 0.069
1.066TyrTyr: 1.066 ± 0.158
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 65 proteins (34710 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski