Amino acid dipepetide frequency for Peruvian horse sickness virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.179AlaAla: 4.179 ± 1.019
0.964AlaCys: 0.964 ± 0.363
1.125AlaAsp: 1.125 ± 0.269
4.982AlaGlu: 4.982 ± 0.906
1.125AlaPhe: 1.125 ± 0.431
3.375AlaGly: 3.375 ± 1.201
1.446AlaHis: 1.446 ± 0.425
2.732AlaIle: 2.732 ± 0.646
3.054AlaLys: 3.054 ± 0.401
8.036AlaLeu: 8.036 ± 1.022
0.804AlaMet: 0.804 ± 0.263
1.607AlaAsn: 1.607 ± 0.46
2.411AlaPro: 2.411 ± 0.626
1.929AlaGln: 1.929 ± 0.365
3.697AlaArg: 3.697 ± 0.709
3.697AlaSer: 3.697 ± 0.611
3.375AlaThr: 3.375 ± 1.04
3.536AlaVal: 3.536 ± 0.721
0.643AlaTrp: 0.643 ± 0.23
1.768AlaTyr: 1.768 ± 0.609
0.0AlaXaa: 0.0 ± 0.0
Cys
0.482CysAla: 0.482 ± 0.208
0.161CysCys: 0.161 ± 0.16
0.643CysAsp: 0.643 ± 0.259
0.804CysGlu: 0.804 ± 0.258
0.964CysPhe: 0.964 ± 0.393
0.321CysGly: 0.321 ± 0.161
0.321CysHis: 0.321 ± 0.181
0.964CysIle: 0.964 ± 0.356
0.964CysLys: 0.964 ± 0.21
1.768CysLeu: 1.768 ± 0.662
0.482CysMet: 0.482 ± 0.283
0.321CysAsn: 0.321 ± 0.315
0.0CysPro: 0.0 ± 0.0
0.321CysGln: 0.321 ± 0.18
0.804CysArg: 0.804 ± 0.175
1.286CysSer: 1.286 ± 0.538
0.482CysThr: 0.482 ± 0.278
0.482CysVal: 0.482 ± 0.221
0.161CysTrp: 0.161 ± 0.118
1.286CysTyr: 1.286 ± 0.543
0.0CysXaa: 0.0 ± 0.0
Asp
3.375AspAla: 3.375 ± 0.592
0.482AspCys: 0.482 ± 0.251
2.893AspAsp: 2.893 ± 0.588
4.661AspGlu: 4.661 ± 1.232
1.929AspPhe: 1.929 ± 0.454
2.893AspGly: 2.893 ± 0.682
0.643AspHis: 0.643 ± 0.247
4.179AspIle: 4.179 ± 0.978
2.089AspLys: 2.089 ± 0.604
5.304AspLeu: 5.304 ± 0.883
1.446AspMet: 1.446 ± 0.467
0.804AspAsn: 0.804 ± 0.255
2.732AspPro: 2.732 ± 0.399
1.446AspGln: 1.446 ± 0.277
3.375AspArg: 3.375 ± 0.628
3.697AspSer: 3.697 ± 0.718
2.732AspThr: 2.732 ± 0.543
6.107AspVal: 6.107 ± 1.098
0.643AspTrp: 0.643 ± 0.199
1.929AspTyr: 1.929 ± 0.354
0.0AspXaa: 0.0 ± 0.0
Glu
5.304GluAla: 5.304 ± 0.745
1.286GluCys: 1.286 ± 0.36
2.732GluAsp: 2.732 ± 0.759
6.429GluGlu: 6.429 ± 1.177
2.572GluPhe: 2.572 ± 0.774
2.893GluGly: 2.893 ± 0.528
1.446GluHis: 1.446 ± 0.597
5.947GluIle: 5.947 ± 0.93
6.59GluLys: 6.59 ± 0.97
6.429GluLeu: 6.429 ± 0.911
1.607GluMet: 1.607 ± 0.447
5.625GluAsn: 5.625 ± 0.606
1.607GluPro: 1.607 ± 0.488
1.768GluGln: 1.768 ± 0.437
4.982GluArg: 4.982 ± 1.089
5.143GluSer: 5.143 ± 0.737
4.018GluThr: 4.018 ± 0.597
4.339GluVal: 4.339 ± 0.683
0.643GluTrp: 0.643 ± 0.51
1.768GluTyr: 1.768 ± 0.346
0.0GluXaa: 0.0 ± 0.0
Phe
2.089PheAla: 2.089 ± 0.572
0.482PheCys: 0.482 ± 0.289
2.411PheAsp: 2.411 ± 0.471
3.697PheGlu: 3.697 ± 0.716
0.964PhePhe: 0.964 ± 0.316
2.732PheGly: 2.732 ± 0.605
1.286PheHis: 1.286 ± 0.374
3.857PheIle: 3.857 ± 0.508
2.572PheLys: 2.572 ± 0.477
2.893PheLeu: 2.893 ± 0.646
1.125PheMet: 1.125 ± 0.589
3.054PheAsn: 3.054 ± 0.852
0.964PhePro: 0.964 ± 0.243
0.964PheGln: 0.964 ± 0.316
2.25PheArg: 2.25 ± 0.638
3.697PheSer: 3.697 ± 0.842
1.929PheThr: 1.929 ± 0.566
2.732PheVal: 2.732 ± 0.705
0.321PheTrp: 0.321 ± 0.272
1.607PheTyr: 1.607 ± 0.435
0.0PheXaa: 0.0 ± 0.0
Gly
2.411GlyAla: 2.411 ± 0.666
0.643GlyCys: 0.643 ± 0.291
5.143GlyAsp: 5.143 ± 1.326
2.732GlyGlu: 2.732 ± 0.377
3.054GlyPhe: 3.054 ± 0.67
2.572GlyGly: 2.572 ± 0.604
0.643GlyHis: 0.643 ± 0.218
3.857GlyIle: 3.857 ± 0.799
3.536GlyLys: 3.536 ± 1.026
4.661GlyLeu: 4.661 ± 0.774
2.089GlyMet: 2.089 ± 0.534
2.893GlyAsn: 2.893 ± 0.556
2.089GlyPro: 2.089 ± 0.556
2.572GlyGln: 2.572 ± 0.626
3.214GlyArg: 3.214 ± 0.476
3.375GlySer: 3.375 ± 0.581
2.732GlyThr: 2.732 ± 0.811
2.893GlyVal: 2.893 ± 0.769
0.643GlyTrp: 0.643 ± 0.314
2.25GlyTyr: 2.25 ± 0.537
0.0GlyXaa: 0.0 ± 0.0
His
1.446HisAla: 1.446 ± 0.416
0.161HisCys: 0.161 ± 0.136
0.804HisAsp: 0.804 ± 0.271
1.446HisGlu: 1.446 ± 0.389
1.125HisPhe: 1.125 ± 0.426
1.446HisGly: 1.446 ± 0.523
0.321HisHis: 0.321 ± 0.188
2.25HisIle: 2.25 ± 0.457
1.286HisLys: 1.286 ± 0.428
2.089HisLeu: 2.089 ± 0.612
0.804HisMet: 0.804 ± 0.219
0.643HisAsn: 0.643 ± 0.213
0.161HisPro: 0.161 ± 0.118
0.643HisGln: 0.643 ± 0.188
1.446HisArg: 1.446 ± 0.396
1.607HisSer: 1.607 ± 0.499
0.804HisThr: 0.804 ± 0.309
1.607HisVal: 1.607 ± 0.529
0.321HisTrp: 0.321 ± 0.18
0.643HisTyr: 0.643 ± 0.303
0.0HisXaa: 0.0 ± 0.0
Ile
4.179IleAla: 4.179 ± 0.837
0.964IleCys: 0.964 ± 0.288
3.857IleAsp: 3.857 ± 0.463
3.697IleGlu: 3.697 ± 0.698
2.893IlePhe: 2.893 ± 0.591
5.143IleGly: 5.143 ± 0.925
1.768IleHis: 1.768 ± 0.269
4.661IleIle: 4.661 ± 0.719
5.464IleLys: 5.464 ± 1.054
6.75IleLeu: 6.75 ± 0.987
1.768IleMet: 1.768 ± 0.301
3.054IleAsn: 3.054 ± 0.652
1.125IlePro: 1.125 ± 0.429
3.214IleGln: 3.214 ± 0.604
4.339IleArg: 4.339 ± 0.778
5.786IleSer: 5.786 ± 0.852
5.625IleThr: 5.625 ± 0.847
3.536IleVal: 3.536 ± 0.593
1.125IleTrp: 1.125 ± 0.438
2.732IleTyr: 2.732 ± 0.492
0.0IleXaa: 0.0 ± 0.0
Lys
3.375LysAla: 3.375 ± 0.522
1.125LysCys: 1.125 ± 0.375
3.375LysAsp: 3.375 ± 0.795
4.822LysGlu: 4.822 ± 0.955
2.572LysPhe: 2.572 ± 0.704
3.697LysGly: 3.697 ± 0.592
2.089LysHis: 2.089 ± 0.537
5.947LysIle: 5.947 ± 0.996
5.143LysLys: 5.143 ± 1.311
6.429LysLeu: 6.429 ± 0.903
2.572LysMet: 2.572 ± 0.656
3.375LysAsn: 3.375 ± 0.818
1.286LysPro: 1.286 ± 0.436
2.25LysGln: 2.25 ± 0.919
3.697LysArg: 3.697 ± 0.765
3.536LysSer: 3.536 ± 0.519
3.857LysThr: 3.857 ± 0.952
4.822LysVal: 4.822 ± 0.774
0.482LysTrp: 0.482 ± 0.321
2.572LysTyr: 2.572 ± 0.907
0.0LysXaa: 0.0 ± 0.0
Leu
4.822LeuAla: 4.822 ± 0.695
1.607LeuCys: 1.607 ± 0.318
4.339LeuAsp: 4.339 ± 0.764
6.107LeuGlu: 6.107 ± 0.786
4.018LeuPhe: 4.018 ± 0.645
4.661LeuGly: 4.661 ± 0.615
1.768LeuHis: 1.768 ± 0.478
6.59LeuIle: 6.59 ± 1.37
6.911LeuLys: 6.911 ± 1.001
8.036LeuLeu: 8.036 ± 0.912
3.697LeuMet: 3.697 ± 0.656
5.304LeuAsn: 5.304 ± 1.12
5.464LeuPro: 5.464 ± 1.298
4.339LeuGln: 4.339 ± 1.283
6.75LeuArg: 6.75 ± 1.987
6.75LeuSer: 6.75 ± 0.741
5.143LeuThr: 5.143 ± 0.949
4.5LeuVal: 4.5 ± 0.526
0.804LeuTrp: 0.804 ± 0.319
2.411LeuTyr: 2.411 ± 0.603
0.0LeuXaa: 0.0 ± 0.0
Met
1.446MetAla: 1.446 ± 0.382
0.482MetCys: 0.482 ± 0.26
1.768MetAsp: 1.768 ± 0.488
1.768MetGlu: 1.768 ± 0.41
1.125MetPhe: 1.125 ± 0.319
0.964MetGly: 0.964 ± 0.48
1.125MetHis: 1.125 ± 0.436
2.411MetIle: 2.411 ± 0.625
2.089MetLys: 2.089 ± 0.61
3.214MetLeu: 3.214 ± 0.486
1.768MetMet: 1.768 ± 0.605
1.607MetAsn: 1.607 ± 0.488
1.286MetPro: 1.286 ± 0.539
1.286MetGln: 1.286 ± 0.506
1.929MetArg: 1.929 ± 0.442
3.054MetSer: 3.054 ± 0.544
1.768MetThr: 1.768 ± 0.411
1.768MetVal: 1.768 ± 0.553
0.161MetTrp: 0.161 ± 0.136
0.643MetTyr: 0.643 ± 0.328
0.0MetXaa: 0.0 ± 0.0
Asn
2.893AsnAla: 2.893 ± 0.667
0.643AsnCys: 0.643 ± 0.324
3.536AsnAsp: 3.536 ± 0.382
3.857AsnGlu: 3.857 ± 0.709
2.411AsnPhe: 2.411 ± 0.48
2.893AsnGly: 2.893 ± 0.421
1.286AsnHis: 1.286 ± 0.414
4.018AsnIle: 4.018 ± 0.751
1.929AsnLys: 1.929 ± 0.46
4.339AsnLeu: 4.339 ± 0.719
1.125AsnMet: 1.125 ± 0.295
1.446AsnAsn: 1.446 ± 0.553
1.607AsnPro: 1.607 ± 0.288
1.286AsnGln: 1.286 ± 0.515
2.572AsnArg: 2.572 ± 0.694
2.411AsnSer: 2.411 ± 0.455
3.214AsnThr: 3.214 ± 0.572
4.339AsnVal: 4.339 ± 0.601
0.804AsnTrp: 0.804 ± 0.381
1.929AsnTyr: 1.929 ± 0.521
0.0AsnXaa: 0.0 ± 0.0
Pro
1.607ProAla: 1.607 ± 0.473
0.161ProCys: 0.161 ± 0.165
2.089ProAsp: 2.089 ± 0.665
3.054ProGlu: 3.054 ± 0.878
1.929ProPhe: 1.929 ± 0.449
2.089ProGly: 2.089 ± 0.537
0.643ProHis: 0.643 ± 0.29
2.893ProIle: 2.893 ± 0.602
1.768ProLys: 1.768 ± 0.364
3.214ProLeu: 3.214 ± 0.648
0.482ProMet: 0.482 ± 0.292
2.25ProAsn: 2.25 ± 0.749
1.768ProPro: 1.768 ± 0.596
1.446ProGln: 1.446 ± 0.525
1.607ProArg: 1.607 ± 0.382
2.25ProSer: 2.25 ± 0.569
2.572ProThr: 2.572 ± 0.611
2.25ProVal: 2.25 ± 0.577
0.643ProTrp: 0.643 ± 0.269
1.929ProTyr: 1.929 ± 0.377
0.0ProXaa: 0.0 ± 0.0
Gln
1.607GlnAla: 1.607 ± 0.355
0.482GlnCys: 0.482 ± 0.244
1.768GlnAsp: 1.768 ± 0.541
2.893GlnGlu: 2.893 ± 0.787
0.804GlnPhe: 0.804 ± 0.378
1.607GlnGly: 1.607 ± 0.516
0.643GlnHis: 0.643 ± 0.315
2.572GlnIle: 2.572 ± 0.762
2.411GlnLys: 2.411 ± 0.624
3.054GlnLeu: 3.054 ± 0.524
0.964GlnMet: 0.964 ± 0.486
1.929GlnAsn: 1.929 ± 0.316
1.768GlnPro: 1.768 ± 0.561
0.964GlnGln: 0.964 ± 0.351
2.411GlnArg: 2.411 ± 0.747
3.375GlnSer: 3.375 ± 0.763
2.411GlnThr: 2.411 ± 0.525
1.607GlnVal: 1.607 ± 0.313
0.321GlnTrp: 0.321 ± 0.197
1.125GlnTyr: 1.125 ± 0.342
0.0GlnXaa: 0.0 ± 0.0
Arg
4.179ArgAla: 4.179 ± 0.685
0.643ArgCys: 0.643 ± 0.19
2.893ArgAsp: 2.893 ± 0.698
4.5ArgGlu: 4.5 ± 0.619
4.179ArgPhe: 4.179 ± 0.653
3.857ArgGly: 3.857 ± 0.632
0.964ArgHis: 0.964 ± 0.464
3.697ArgIle: 3.697 ± 0.725
4.661ArgLys: 4.661 ± 1.164
4.179ArgLeu: 4.179 ± 0.899
2.411ArgMet: 2.411 ± 0.615
4.018ArgAsn: 4.018 ± 0.905
1.446ArgPro: 1.446 ± 0.385
2.572ArgGln: 2.572 ± 0.5
4.822ArgArg: 4.822 ± 0.784
3.857ArgSer: 3.857 ± 0.789
3.536ArgThr: 3.536 ± 0.653
5.304ArgVal: 5.304 ± 0.794
0.643ArgTrp: 0.643 ± 0.287
0.643ArgTyr: 0.643 ± 0.273
0.0ArgXaa: 0.0 ± 0.0
Ser
4.018SerAla: 4.018 ± 0.654
0.161SerCys: 0.161 ± 0.158
3.536SerAsp: 3.536 ± 0.628
6.59SerGlu: 6.59 ± 0.727
3.375SerPhe: 3.375 ± 0.641
4.822SerGly: 4.822 ± 0.948
1.286SerHis: 1.286 ± 0.463
4.982SerIle: 4.982 ± 0.471
5.625SerLys: 5.625 ± 0.853
7.072SerLeu: 7.072 ± 1.303
2.732SerMet: 2.732 ± 0.719
2.411SerAsn: 2.411 ± 0.399
2.893SerPro: 2.893 ± 0.64
1.768SerGln: 1.768 ± 0.604
4.661SerArg: 4.661 ± 0.472
4.982SerSer: 4.982 ± 1.053
4.822SerThr: 4.822 ± 0.772
3.857SerVal: 3.857 ± 0.561
0.964SerTrp: 0.964 ± 0.26
2.089SerTyr: 2.089 ± 0.58
0.0SerXaa: 0.0 ± 0.0
Thr
3.214ThrAla: 3.214 ± 0.959
0.804ThrCys: 0.804 ± 0.382
3.375ThrAsp: 3.375 ± 0.815
3.857ThrGlu: 3.857 ± 0.798
2.25ThrPhe: 2.25 ± 0.78
3.054ThrGly: 3.054 ± 0.607
1.768ThrHis: 1.768 ± 0.354
2.732ThrIle: 2.732 ± 0.587
3.375ThrLys: 3.375 ± 0.587
5.143ThrLeu: 5.143 ± 0.832
2.411ThrMet: 2.411 ± 0.649
3.214ThrAsn: 3.214 ± 0.471
2.411ThrPro: 2.411 ± 0.535
2.25ThrGln: 2.25 ± 0.5
5.625ThrArg: 5.625 ± 0.951
4.179ThrSer: 4.179 ± 0.597
4.018ThrThr: 4.018 ± 0.923
4.018ThrVal: 4.018 ± 0.838
0.321ThrTrp: 0.321 ± 0.161
1.607ThrTyr: 1.607 ± 0.446
0.0ThrXaa: 0.0 ± 0.0
Val
2.25ValAla: 2.25 ± 0.472
1.125ValCys: 1.125 ± 0.238
3.697ValAsp: 3.697 ± 0.966
5.304ValGlu: 5.304 ± 0.975
2.411ValPhe: 2.411 ± 0.509
2.893ValGly: 2.893 ± 0.616
0.643ValHis: 0.643 ± 0.239
4.018ValIle: 4.018 ± 0.477
3.857ValLys: 3.857 ± 0.871
6.59ValLeu: 6.59 ± 0.907
2.411ValMet: 2.411 ± 0.453
3.054ValAsn: 3.054 ± 0.552
3.697ValPro: 3.697 ± 0.502
2.572ValGln: 2.572 ± 0.719
2.893ValArg: 2.893 ± 0.541
5.786ValSer: 5.786 ± 0.867
3.536ValThr: 3.536 ± 0.452
4.018ValVal: 4.018 ± 1.056
0.964ValTrp: 0.964 ± 0.226
3.214ValTyr: 3.214 ± 0.614
0.0ValXaa: 0.0 ± 0.0
Trp
0.161TrpAla: 0.161 ± 0.16
0.321TrpCys: 0.321 ± 0.18
1.125TrpAsp: 1.125 ± 0.337
0.643TrpGlu: 0.643 ± 0.415
0.643TrpPhe: 0.643 ± 0.216
0.482TrpGly: 0.482 ± 0.317
0.482TrpHis: 0.482 ± 0.153
1.607TrpIle: 1.607 ± 0.569
1.125TrpLys: 1.125 ± 0.436
0.643TrpLeu: 0.643 ± 0.374
0.161TrpMet: 0.161 ± 0.16
0.804TrpAsn: 0.804 ± 0.305
0.161TrpPro: 0.161 ± 0.179
0.482TrpGln: 0.482 ± 0.262
0.321TrpArg: 0.321 ± 0.203
0.643TrpSer: 0.643 ± 0.333
0.161TrpThr: 0.161 ± 0.158
0.321TrpVal: 0.321 ± 0.161
0.161TrpTrp: 0.161 ± 0.16
0.482TrpTyr: 0.482 ± 0.391
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.446TyrAla: 1.446 ± 0.546
0.321TyrCys: 0.321 ± 0.203
2.25TyrAsp: 2.25 ± 0.339
1.286TyrGlu: 1.286 ± 0.529
1.286TyrPhe: 1.286 ± 0.274
1.607TyrGly: 1.607 ± 0.449
0.482TyrHis: 0.482 ± 0.327
1.768TyrIle: 1.768 ± 0.427
2.572TyrLys: 2.572 ± 0.648
4.339TyrLeu: 4.339 ± 1.311
0.643TyrMet: 0.643 ± 0.275
1.125TyrAsn: 1.125 ± 0.381
1.768TyrPro: 1.768 ± 0.461
0.643TyrGln: 0.643 ± 0.286
1.607TyrArg: 1.607 ± 0.622
3.536TyrSer: 3.536 ± 0.56
2.893TyrThr: 2.893 ± 0.284
2.893TyrVal: 2.893 ± 0.683
0.161TyrTrp: 0.161 ± 0.158
1.286TyrTyr: 1.286 ± 0.386
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (6223 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski