Amino acid dipepetide frequency for Paenibacillus naphthalenovorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.183AlaAla: 9.183 ± 0.111	0.787AlaCys: 0.787 ± 0.023	4.196AlaAsp: 4.196 ± 0.056	5.695AlaGlu: 5.695 ± 0.077	3.294AlaPhe: 3.294 ± 0.047	6.965AlaGly: 6.965 ± 0.081	1.493AlaHis: 1.493 ± 0.031	5.302AlaIle: 5.302 ± 0.071	4.516AlaLys: 4.516 ± 0.057	8.601AlaLeu: 8.601 ± 0.084	2.309AlaMet: 2.309 ± 0.04	2.604AlaAsn: 2.604 ± 0.04	2.79AlaPro: 2.79 ± 0.055	2.837AlaGln: 2.837 ± 0.057	3.758AlaArg: 3.758 ± 0.059	4.688AlaSer: 4.688 ± 0.069	3.201AlaThr: 3.201 ± 0.051	6.892AlaVal: 6.892 ± 0.083	0.923AlaTrp: 0.923 ± 0.028	2.6AlaTyr: 2.6 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.576CysAla: 0.576 ± 0.022	0.126CysCys: 0.126 ± 0.01	0.388CysAsp: 0.388 ± 0.019	0.458CysGlu: 0.458 ± 0.021	0.333CysPhe: 0.333 ± 0.016	0.893CysGly: 0.893 ± 0.03	0.196CysHis: 0.196 ± 0.011	0.566CysIle: 0.566 ± 0.019	0.37CysLys: 0.37 ± 0.015	0.768CysLeu: 0.768 ± 0.023	0.216CysMet: 0.216 ± 0.012	0.264CysAsn: 0.264 ± 0.011	0.399CysPro: 0.399 ± 0.02	0.235CysGln: 0.235 ± 0.012	0.527CysArg: 0.527 ± 0.021	0.584CysSer: 0.584 ± 0.018	0.453CysThr: 0.453 ± 0.018	0.511CysVal: 0.511 ± 0.02	0.091CysTrp: 0.091 ± 0.008	0.255CysTyr: 0.255 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	3.878AspAla: 3.878 ± 0.057	0.4AspCys: 0.4 ± 0.015	2.247AspAsp: 2.247 ± 0.047	3.687AspGlu: 3.687 ± 0.051	1.987AspPhe: 1.987 ± 0.039	3.656AspGly: 3.656 ± 0.053	1.155AspHis: 1.155 ± 0.028	3.559AspIle: 3.559 ± 0.06	2.783AspLys: 2.783 ± 0.052	4.858AspLeu: 4.858 ± 0.061	1.314AspMet: 1.314 ± 0.032	1.577AspAsn: 1.577 ± 0.034	2.477AspPro: 2.477 ± 0.043	1.888AspGln: 1.888 ± 0.037	2.936AspArg: 2.936 ± 0.045	2.551AspSer: 2.551 ± 0.049	2.241AspThr: 2.241 ± 0.038	3.588AspVal: 3.588 ± 0.056	0.712AspTrp: 0.712 ± 0.024	1.939AspTyr: 1.939 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	6.138GluAla: 6.138 ± 0.08	0.398GluCys: 0.398 ± 0.017	3.145GluAsp: 3.145 ± 0.049	5.517GluGlu: 5.517 ± 0.076	2.271GluPhe: 2.271 ± 0.041	4.247GluGly: 4.247 ± 0.058	1.625GluHis: 1.625 ± 0.044	4.545GluIle: 4.545 ± 0.059	4.424GluLys: 4.424 ± 0.063	7.324GluLeu: 7.324 ± 0.086	2.06GluMet: 2.06 ± 0.045	2.572GluAsn: 2.572 ± 0.048	2.43GluPro: 2.43 ± 0.039	3.614GluGln: 3.614 ± 0.058	4.252GluArg: 4.252 ± 0.06	3.364GluSer: 3.364 ± 0.049	3.413GluThr: 3.413 ± 0.048	4.558GluVal: 4.558 ± 0.06	0.935GluTrp: 0.935 ± 0.029	2.007GluTyr: 2.007 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.189PheAla: 3.189 ± 0.049	0.38PheCys: 0.38 ± 0.016	2.15PheAsp: 2.15 ± 0.034	2.435PheGlu: 2.435 ± 0.042	1.792PhePhe: 1.792 ± 0.04	3.311PheGly: 3.311 ± 0.048	0.919PheHis: 0.919 ± 0.025	2.982PheIle: 2.982 ± 0.048	1.915PheLys: 1.915 ± 0.041	3.913PheLeu: 3.913 ± 0.059	1.124PheMet: 1.124 ± 0.027	1.401PheAsn: 1.401 ± 0.033	1.72PhePro: 1.72 ± 0.036	1.45PheGln: 1.45 ± 0.033	1.917PheArg: 1.917 ± 0.037	2.62PheSer: 2.62 ± 0.043	2.32PheThr: 2.32 ± 0.039	2.967PheVal: 2.967 ± 0.051	0.477PheTrp: 0.477 ± 0.02	1.425PheTyr: 1.425 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	5.774GlyAla: 5.774 ± 0.094	0.808GlyCys: 0.808 ± 0.026	3.226GlyAsp: 3.226 ± 0.048	4.548GlyGlu: 4.548 ± 0.063	3.292GlyPhe: 3.292 ± 0.052	5.734GlyGly: 5.734 ± 0.068	1.573GlyHis: 1.573 ± 0.038	5.873GlyIle: 5.873 ± 0.06	4.786GlyLys: 4.786 ± 0.066	7.633GlyLeu: 7.633 ± 0.08	2.437GlyMet: 2.437 ± 0.048	2.49GlyAsn: 2.49 ± 0.045	2.166GlyPro: 2.166 ± 0.04	2.656GlyGln: 2.656 ± 0.04	3.832GlyArg: 3.832 ± 0.057	4.618GlySer: 4.618 ± 0.071	4.46GlyThr: 4.46 ± 0.059	5.381GlyVal: 5.381 ± 0.062	0.989GlyTrp: 0.989 ± 0.029	2.851GlyTyr: 2.851 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.652HisAla: 1.652 ± 0.032	0.221HisCys: 0.221 ± 0.012	0.985HisAsp: 0.985 ± 0.027	1.298HisGlu: 1.298 ± 0.031	0.963HisPhe: 0.963 ± 0.023	1.573HisGly: 1.573 ± 0.034	0.661HisHis: 0.661 ± 0.027	1.504HisIle: 1.504 ± 0.033	0.993HisLys: 0.993 ± 0.029	2.243HisLeu: 2.243 ± 0.053	0.619HisMet: 0.619 ± 0.019	0.692HisAsn: 0.692 ± 0.024	1.342HisPro: 1.342 ± 0.032	0.834HisGln: 0.834 ± 0.027	1.251HisArg: 1.251 ± 0.03	1.197HisSer: 1.197 ± 0.032	1.1HisThr: 1.1 ± 0.028	1.521HisVal: 1.521 ± 0.031	0.321HisTrp: 0.321 ± 0.015	0.905HisTyr: 0.905 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.996IleAla: 5.996 ± 0.068	0.663IleCys: 0.663 ± 0.022	3.756IleAsp: 3.756 ± 0.051	4.585IleGlu: 4.585 ± 0.063	2.423IlePhe: 2.423 ± 0.046	5.759IleGly: 5.759 ± 0.069	1.619IleHis: 1.619 ± 0.031	4.383IleIle: 4.383 ± 0.064	3.29IleLys: 3.29 ± 0.061	5.975IleLeu: 5.975 ± 0.075	1.698IleMet: 1.698 ± 0.032	2.413IleAsn: 2.413 ± 0.05	3.425IlePro: 3.425 ± 0.049	2.554IleGln: 2.554 ± 0.042	4.181IleArg: 4.181 ± 0.054	4.276IleSer: 4.276 ± 0.052	3.637IleThr: 3.637 ± 0.053	5.267IleVal: 5.267 ± 0.06	0.688IleTrp: 0.688 ± 0.024	2.098IleTyr: 2.098 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.653LysAla: 4.653 ± 0.068	0.299LysCys: 0.299 ± 0.013	2.979LysAsp: 2.979 ± 0.054	4.893LysGlu: 4.893 ± 0.067	1.616LysPhe: 1.616 ± 0.032	3.809LysGly: 3.809 ± 0.057	1.293LysHis: 1.293 ± 0.033	3.558LysIle: 3.558 ± 0.053	3.874LysLys: 3.874 ± 0.062	5.474LysLeu: 5.474 ± 0.058	1.657LysMet: 1.657 ± 0.035	2.237LysAsn: 2.237 ± 0.047	2.542LysPro: 2.542 ± 0.047	2.66LysGln: 2.66 ± 0.044	3.095LysArg: 3.095 ± 0.045	3.025LysSer: 3.025 ± 0.048	2.995LysThr: 2.995 ± 0.043	3.899LysVal: 3.899 ± 0.044	0.677LysTrp: 0.677 ± 0.023	1.812LysTyr: 1.812 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	8.484LeuAla: 8.484 ± 0.091	0.821LeuCys: 0.821 ± 0.021	4.946LeuAsp: 4.946 ± 0.064	6.59LeuGlu: 6.59 ± 0.079	4.512LeuPhe: 4.512 ± 0.064	7.08LeuGly: 7.08 ± 0.068	2.109LeuHis: 2.109 ± 0.043	6.617LeuIle: 6.617 ± 0.076	5.798LeuLys: 5.798 ± 0.077	10.809LeuLeu: 10.809 ± 0.115	2.739LeuMet: 2.739 ± 0.043	3.788LeuAsn: 3.788 ± 0.054	4.521LeuPro: 4.521 ± 0.062	4.168LeuGln: 4.168 ± 0.065	5.065LeuArg: 5.065 ± 0.064	6.752LeuSer: 6.752 ± 0.07	5.549LeuThr: 5.549 ± 0.066	6.373LeuVal: 6.373 ± 0.072	1.068LeuTrp: 1.068 ± 0.027	2.989LeuTyr: 2.989 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.323MetAla: 2.323 ± 0.041	0.17MetCys: 0.17 ± 0.012	1.448MetAsp: 1.448 ± 0.032	2.063MetGlu: 2.063 ± 0.042	1.05MetPhe: 1.05 ± 0.027	1.87MetGly: 1.87 ± 0.034	0.487MetHis: 0.487 ± 0.016	2.081MetIle: 2.081 ± 0.039	2.159MetLys: 2.159 ± 0.038	2.847MetLeu: 2.847 ± 0.049	0.916MetMet: 0.916 ± 0.028	1.483MetAsn: 1.483 ± 0.03	1.112MetPro: 1.112 ± 0.024	0.965MetGln: 0.965 ± 0.024	1.301MetArg: 1.301 ± 0.029	1.725MetSer: 1.725 ± 0.033	1.715MetThr: 1.715 ± 0.037	1.847MetVal: 1.847 ± 0.036	0.223MetTrp: 0.223 ± 0.012	0.711MetTyr: 0.711 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.716AsnAla: 2.716 ± 0.045	0.263AsnCys: 0.263 ± 0.015	1.781AsnAsp: 1.781 ± 0.037	2.498AsnGlu: 2.498 ± 0.041	1.165AsnPhe: 1.165 ± 0.03	3.079AsnGly: 3.079 ± 0.04	0.874AsnHis: 0.874 ± 0.027	2.433AsnIle: 2.433 ± 0.046	2.188AsnLys: 2.188 ± 0.049	3.199AsnLeu: 3.199 ± 0.053	0.963AsnMet: 0.963 ± 0.021	1.474AsnAsn: 1.474 ± 0.041	2.078AsnPro: 2.078 ± 0.038	1.531AsnGln: 1.531 ± 0.036	2.169AsnArg: 2.169 ± 0.041	1.811AsnSer: 1.811 ± 0.041	1.8AsnThr: 1.8 ± 0.032	2.677AsnVal: 2.677 ± 0.049	0.428AsnTrp: 0.428 ± 0.017	1.267AsnTyr: 1.267 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	3.358ProAla: 3.358 ± 0.057	0.253ProCys: 0.253 ± 0.013	2.662ProAsp: 2.662 ± 0.053	3.525ProGlu: 3.525 ± 0.052	1.887ProPhe: 1.887 ± 0.039	3.391ProGly: 3.391 ± 0.055	0.972ProHis: 0.972 ± 0.024	2.521ProIle: 2.521 ± 0.045	2.094ProLys: 2.094 ± 0.042	4.09ProLeu: 4.09 ± 0.06	1.096ProMet: 1.096 ± 0.023	1.52ProAsn: 1.52 ± 0.035	1.463ProPro: 1.463 ± 0.035	1.531ProGln: 1.531 ± 0.033	1.616ProArg: 1.616 ± 0.035	2.507ProSer: 2.507 ± 0.048	1.89ProThr: 1.89 ± 0.035	3.656ProVal: 3.656 ± 0.051	0.547ProTrp: 0.547 ± 0.022	1.58ProTyr: 1.58 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.559GlnAla: 3.559 ± 0.06	0.248GlnCys: 0.248 ± 0.014	1.626GlnAsp: 1.626 ± 0.033	2.731GlnGlu: 2.731 ± 0.044	1.413GlnPhe: 1.413 ± 0.028	2.693GlnGly: 2.693 ± 0.044	0.85GlnHis: 0.85 ± 0.026	2.632GlnIle: 2.632 ± 0.039	2.199GlnLys: 2.199 ± 0.043	4.056GlnLeu: 4.056 ± 0.065	1.208GlnMet: 1.208 ± 0.032	1.328GlnAsn: 1.328 ± 0.031	1.539GlnPro: 1.539 ± 0.038	1.875GlnGln: 1.875 ± 0.043	2.032GlnArg: 2.032 ± 0.04	2.271GlnSer: 2.271 ± 0.042	2.103GlnThr: 2.103 ± 0.041	2.602GlnVal: 2.602 ± 0.042	0.564GlnTrp: 0.564 ± 0.022	1.29GlnTyr: 1.29 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	3.403ArgAla: 3.403 ± 0.049	0.414ArgCys: 0.414 ± 0.017	2.431ArgAsp: 2.431 ± 0.04	4.023ArgGlu: 4.023 ± 0.056	2.372ArgPhe: 2.372 ± 0.04	3.189ArgGly: 3.189 ± 0.05	1.164ArgHis: 1.164 ± 0.031	3.944ArgIle: 3.944 ± 0.056	3.413ArgLys: 3.413 ± 0.05	5.748ArgLeu: 5.748 ± 0.072	1.789ArgMet: 1.789 ± 0.039	2.003ArgAsn: 2.003 ± 0.035	1.965ArgPro: 1.965 ± 0.04	2.219ArgGln: 2.219 ± 0.044	2.947ArgArg: 2.947 ± 0.043	3.132ArgSer: 3.132 ± 0.049	2.709ArgThr: 2.709 ± 0.043	3.274ArgVal: 3.274 ± 0.049	0.699ArgTrp: 0.699 ± 0.022	1.927ArgTyr: 1.927 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.522SerAla: 4.522 ± 0.061	0.474SerCys: 0.474 ± 0.021	2.829SerAsp: 2.829 ± 0.044	3.569SerGlu: 3.569 ± 0.056	2.767SerPhe: 2.767 ± 0.043	5.331SerGly: 5.331 ± 0.062	1.199SerHis: 1.199 ± 0.034	4.244SerIle: 4.244 ± 0.056	3.107SerLys: 3.107 ± 0.05	6.043SerLeu: 6.043 ± 0.063	1.714SerMet: 1.714 ± 0.036	2.025SerAsn: 2.025 ± 0.037	2.499SerPro: 2.499 ± 0.042	1.905SerGln: 1.905 ± 0.036	3.241SerArg: 3.241 ± 0.043	3.874SerSer: 3.874 ± 0.06	2.843SerThr: 2.843 ± 0.041	4.376SerVal: 4.376 ± 0.066	0.697SerTrp: 0.697 ± 0.023	1.943SerTyr: 1.943 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	4.658ThrAla: 4.658 ± 0.071	0.378ThrCys: 0.378 ± 0.016	2.603ThrAsp: 2.603 ± 0.041	3.145ThrGlu: 3.145 ± 0.046	2.288ThrPhe: 2.288 ± 0.04	4.514ThrGly: 4.514 ± 0.06	1.031ThrHis: 1.031 ± 0.027	3.676ThrIle: 3.676 ± 0.051	2.487ThrLys: 2.487 ± 0.036	5.186ThrLeu: 5.186 ± 0.055	1.336ThrMet: 1.336 ± 0.03	1.795ThrAsn: 1.795 ± 0.038	2.518ThrPro: 2.518 ± 0.044	1.51ThrGln: 1.51 ± 0.032	2.308ThrArg: 2.308 ± 0.033	2.892ThrSer: 2.892 ± 0.05	2.57ThrThr: 2.57 ± 0.045	4.467ThrVal: 4.467 ± 0.056	0.571ThrTrp: 0.571 ± 0.021	1.663ThrTyr: 1.663 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	5.268ValAla: 5.268 ± 0.068	0.669ValCys: 0.669 ± 0.026	3.558ValAsp: 3.558 ± 0.054	4.64ValGlu: 4.64 ± 0.064	2.962ValPhe: 2.962 ± 0.047	4.663ValGly: 4.663 ± 0.062	1.589ValHis: 1.589 ± 0.036	5.203ValIle: 5.203 ± 0.053	4.193ValLys: 4.193 ± 0.066	7.443ValLeu: 7.443 ± 0.07	2.028ValMet: 2.028 ± 0.036	2.815ValAsn: 2.815 ± 0.05	3.241ValPro: 3.241 ± 0.052	2.735ValGln: 2.735 ± 0.047	3.707ValArg: 3.707 ± 0.056	4.671ValSer: 4.671 ± 0.062	4.255ValThr: 4.255 ± 0.057	5.158ValVal: 5.158 ± 0.069	0.856ValTrp: 0.856 ± 0.024	2.459ValTyr: 2.459 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.802TrpAla: 0.802 ± 0.025	0.094TrpCys: 0.094 ± 0.008	0.626TrpAsp: 0.626 ± 0.023	0.713TrpGlu: 0.713 ± 0.023	0.582TrpPhe: 0.582 ± 0.023	0.8TrpGly: 0.8 ± 0.024	0.259TrpHis: 0.259 ± 0.014	0.922TrpIle: 0.922 ± 0.026	0.747TrpLys: 0.747 ± 0.021	1.344TrpLeu: 1.344 ± 0.036	0.443TrpMet: 0.443 ± 0.017	0.618TrpAsn: 0.618 ± 0.022	0.372TrpPro: 0.372 ± 0.018	0.416TrpGln: 0.416 ± 0.015	0.606TrpArg: 0.606 ± 0.025	0.705TrpSer: 0.705 ± 0.021	0.599TrpThr: 0.599 ± 0.024	0.82TrpVal: 0.82 ± 0.024	0.153TrpTrp: 0.153 ± 0.012	0.39TrpTyr: 0.39 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.499TyrAla: 2.499 ± 0.041	0.345TyrCys: 0.345 ± 0.018	1.852TyrAsp: 1.852 ± 0.039	2.223TyrGlu: 2.223 ± 0.035	1.439TyrPhe: 1.439 ± 0.033	2.57TyrGly: 2.57 ± 0.047	0.806TyrHis: 0.806 ± 0.024	2.143TyrIle: 2.143 ± 0.037	1.712TyrLys: 1.712 ± 0.037	3.225TyrLeu: 3.225 ± 0.044	0.832TyrMet: 0.832 ± 0.022	1.294TyrAsn: 1.294 ± 0.032	1.56TyrPro: 1.56 ± 0.033	1.235TyrGln: 1.235 ± 0.03	2.024TyrArg: 2.024 ± 0.036	1.94TyrSer: 1.94 ± 0.035	1.742TyrThr: 1.742 ± 0.037	2.281TyrVal: 2.281 ± 0.036	0.391TyrTrp: 0.391 ± 0.015	1.301TyrTyr: 1.301 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5049 proteins (1504056 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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