Amino acid dipepetide frequency for Streptococcus phage Javan522

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.705AlaAla: 4.705 ± 1.061
0.66AlaCys: 0.66 ± 0.262
3.962AlaAsp: 3.962 ± 0.581
4.953AlaGlu: 4.953 ± 0.984
1.486AlaPhe: 1.486 ± 0.346
4.457AlaGly: 4.457 ± 0.801
0.66AlaHis: 0.66 ± 0.21
5.613AlaIle: 5.613 ± 0.605
6.768AlaLys: 6.768 ± 0.817
6.603AlaLeu: 6.603 ± 1.173
2.311AlaMet: 2.311 ± 0.413
3.549AlaAsn: 3.549 ± 0.554
1.568AlaPro: 1.568 ± 0.297
3.467AlaGln: 3.467 ± 0.668
2.559AlaArg: 2.559 ± 0.442
5.035AlaSer: 5.035 ± 0.783
4.457AlaThr: 4.457 ± 0.886
4.705AlaVal: 4.705 ± 0.702
0.825AlaTrp: 0.825 ± 0.249
2.146AlaTyr: 2.146 ± 0.412
0.0AlaXaa: 0.0 ± 0.0
Cys
0.413CysAla: 0.413 ± 0.178
0.083CysCys: 0.083 ± 0.086
0.33CysAsp: 0.33 ± 0.149
0.908CysGlu: 0.908 ± 0.312
0.413CysPhe: 0.413 ± 0.206
0.991CysGly: 0.991 ± 0.308
0.083CysHis: 0.083 ± 0.072
0.165CysIle: 0.165 ± 0.131
0.33CysLys: 0.33 ± 0.182
0.413CysLeu: 0.413 ± 0.165
0.248CysMet: 0.248 ± 0.149
0.248CysAsn: 0.248 ± 0.144
0.083CysPro: 0.083 ± 0.083
0.248CysGln: 0.248 ± 0.131
0.33CysArg: 0.33 ± 0.176
0.248CysSer: 0.248 ± 0.159
0.33CysThr: 0.33 ± 0.133
0.413CysVal: 0.413 ± 0.194
0.165CysTrp: 0.165 ± 0.117
0.248CysTyr: 0.248 ± 0.147
0.0CysXaa: 0.0 ± 0.0
Asp
3.467AspAla: 3.467 ± 0.415
0.66AspCys: 0.66 ± 0.208
4.54AspAsp: 4.54 ± 0.538
5.613AspGlu: 5.613 ± 0.823
3.302AspPhe: 3.302 ± 0.6
4.87AspGly: 4.87 ± 0.704
0.66AspHis: 0.66 ± 0.25
4.127AspIle: 4.127 ± 0.667
6.108AspLys: 6.108 ± 0.589
7.016AspLeu: 7.016 ± 0.685
1.651AspMet: 1.651 ± 0.309
4.375AspAsn: 4.375 ± 0.455
1.733AspPro: 1.733 ± 0.433
0.908AspGln: 0.908 ± 0.325
2.146AspArg: 2.146 ± 0.314
3.962AspSer: 3.962 ± 0.595
3.797AspThr: 3.797 ± 0.497
4.21AspVal: 4.21 ± 0.518
0.908AspTrp: 0.908 ± 0.267
3.054AspTyr: 3.054 ± 0.538
0.0AspXaa: 0.0 ± 0.0
Glu
5.2GluAla: 5.2 ± 0.714
0.495GluCys: 0.495 ± 0.218
3.714GluAsp: 3.714 ± 0.698
5.53GluGlu: 5.53 ± 0.895
2.972GluPhe: 2.972 ± 0.434
2.559GluGly: 2.559 ± 0.422
1.156GluHis: 1.156 ± 0.343
6.603GluIle: 6.603 ± 0.67
6.356GluLys: 6.356 ± 0.758
7.346GluLeu: 7.346 ± 0.845
2.146GluMet: 2.146 ± 0.395
2.889GluAsn: 2.889 ± 0.546
1.733GluPro: 1.733 ± 0.376
3.384GluGln: 3.384 ± 0.561
3.219GluArg: 3.219 ± 0.579
4.375GluSer: 4.375 ± 0.526
4.457GluThr: 4.457 ± 0.614
5.035GluVal: 5.035 ± 0.836
0.825GluTrp: 0.825 ± 0.232
2.641GluTyr: 2.641 ± 0.572
0.0GluXaa: 0.0 ± 0.0
Phe
2.972PheAla: 2.972 ± 0.568
0.413PheCys: 0.413 ± 0.193
3.302PheAsp: 3.302 ± 0.547
2.972PheGlu: 2.972 ± 0.532
1.073PhePhe: 1.073 ± 0.381
2.972PheGly: 2.972 ± 0.561
0.248PheHis: 0.248 ± 0.14
2.311PheIle: 2.311 ± 0.504
3.962PheLys: 3.962 ± 0.584
2.229PheLeu: 2.229 ± 0.487
1.073PheMet: 1.073 ± 0.295
2.476PheAsn: 2.476 ± 0.493
0.825PhePro: 0.825 ± 0.238
0.991PheGln: 0.991 ± 0.24
1.733PheArg: 1.733 ± 0.521
2.889PheSer: 2.889 ± 0.399
2.229PheThr: 2.229 ± 0.473
1.981PheVal: 1.981 ± 0.399
0.413PheTrp: 0.413 ± 0.194
1.651PheTyr: 1.651 ± 0.396
0.0PheXaa: 0.0 ± 0.0
Gly
3.632GlyAla: 3.632 ± 0.588
0.413GlyCys: 0.413 ± 0.187
4.21GlyAsp: 4.21 ± 0.582
3.714GlyGlu: 3.714 ± 0.568
2.394GlyPhe: 2.394 ± 0.449
4.87GlyGly: 4.87 ± 0.655
1.073GlyHis: 1.073 ± 0.259
4.622GlyIle: 4.622 ± 0.593
6.026GlyLys: 6.026 ± 0.687
5.118GlyLeu: 5.118 ± 0.926
1.898GlyMet: 1.898 ± 0.434
3.714GlyAsn: 3.714 ± 0.432
0.825GlyPro: 0.825 ± 0.284
2.559GlyGln: 2.559 ± 0.456
2.889GlyArg: 2.889 ± 0.387
3.549GlySer: 3.549 ± 0.527
3.054GlyThr: 3.054 ± 0.498
4.705GlyVal: 4.705 ± 0.565
1.156GlyTrp: 1.156 ± 0.394
3.467GlyTyr: 3.467 ± 0.58
0.0GlyXaa: 0.0 ± 0.0
His
1.238HisAla: 1.238 ± 0.435
0.165HisCys: 0.165 ± 0.119
0.991HisAsp: 0.991 ± 0.301
1.156HisGlu: 1.156 ± 0.281
0.66HisPhe: 0.66 ± 0.257
0.743HisGly: 0.743 ± 0.224
0.0HisHis: 0.0 ± 0.0
0.743HisIle: 0.743 ± 0.284
0.66HisLys: 0.66 ± 0.235
0.908HisLeu: 0.908 ± 0.241
0.165HisMet: 0.165 ± 0.118
0.743HisAsn: 0.743 ± 0.21
0.495HisPro: 0.495 ± 0.181
0.578HisGln: 0.578 ± 0.211
0.578HisArg: 0.578 ± 0.185
0.578HisSer: 0.578 ± 0.196
0.908HisThr: 0.908 ± 0.302
0.825HisVal: 0.825 ± 0.215
0.33HisTrp: 0.33 ± 0.159
0.743HisTyr: 0.743 ± 0.254
0.0HisXaa: 0.0 ± 0.0
Ile
4.705IleAla: 4.705 ± 0.636
0.413IleCys: 0.413 ± 0.186
5.943IleAsp: 5.943 ± 1.006
6.026IleGlu: 6.026 ± 0.575
2.064IlePhe: 2.064 ± 0.397
3.714IleGly: 3.714 ± 0.636
0.991IleHis: 0.991 ± 0.265
4.457IleIle: 4.457 ± 0.789
7.594IleLys: 7.594 ± 0.724
6.026IleLeu: 6.026 ± 0.772
0.908IleMet: 0.908 ± 0.254
4.953IleAsn: 4.953 ± 0.719
1.816IlePro: 1.816 ± 0.499
1.651IleGln: 1.651 ± 0.325
2.641IleArg: 2.641 ± 0.426
4.21IleSer: 4.21 ± 0.82
5.2IleThr: 5.2 ± 0.642
3.714IleVal: 3.714 ± 0.514
0.743IleTrp: 0.743 ± 0.249
2.806IleTyr: 2.806 ± 0.552
0.0IleXaa: 0.0 ± 0.0
Lys
6.934LysAla: 6.934 ± 0.872
0.578LysCys: 0.578 ± 0.213
6.191LysAsp: 6.191 ± 1.098
7.264LysGlu: 7.264 ± 0.958
2.972LysPhe: 2.972 ± 0.467
4.87LysGly: 4.87 ± 0.738
1.568LysHis: 1.568 ± 0.367
7.429LysIle: 7.429 ± 1.03
8.667LysLys: 8.667 ± 1.08
6.851LysLeu: 6.851 ± 0.699
2.146LysMet: 2.146 ± 0.365
5.283LysAsn: 5.283 ± 0.647
3.219LysPro: 3.219 ± 0.616
4.705LysGln: 4.705 ± 0.692
3.384LysArg: 3.384 ± 0.564
4.54LysSer: 4.54 ± 0.542
5.53LysThr: 5.53 ± 0.689
5.448LysVal: 5.448 ± 0.709
0.578LysTrp: 0.578 ± 0.196
3.137LysTyr: 3.137 ± 0.52
0.0LysXaa: 0.0 ± 0.0
Leu
6.356LeuAla: 6.356 ± 1.063
0.413LeuCys: 0.413 ± 0.183
6.686LeuAsp: 6.686 ± 0.7
7.264LeuGlu: 7.264 ± 0.905
3.302LeuPhe: 3.302 ± 0.604
5.695LeuGly: 5.695 ± 0.896
0.66LeuHis: 0.66 ± 0.248
5.778LeuIle: 5.778 ± 0.859
8.832LeuLys: 8.832 ± 1.159
6.768LeuLeu: 6.768 ± 0.839
1.733LeuMet: 1.733 ± 0.353
5.2LeuAsn: 5.2 ± 0.735
2.476LeuPro: 2.476 ± 0.428
3.714LeuGln: 3.714 ± 0.561
4.21LeuArg: 4.21 ± 0.56
4.87LeuSer: 4.87 ± 0.786
5.035LeuThr: 5.035 ± 0.672
4.953LeuVal: 4.953 ± 0.672
0.413LeuTrp: 0.413 ± 0.189
2.724LeuTyr: 2.724 ± 0.542
0.0LeuXaa: 0.0 ± 0.0
Met
1.898MetAla: 1.898 ± 0.432
0.083MetCys: 0.083 ± 0.084
1.321MetAsp: 1.321 ± 0.399
1.238MetGlu: 1.238 ± 0.266
1.073MetPhe: 1.073 ± 0.262
1.238MetGly: 1.238 ± 0.315
0.248MetHis: 0.248 ± 0.143
2.146MetIle: 2.146 ± 0.472
1.568MetLys: 1.568 ± 0.325
1.981MetLeu: 1.981 ± 0.417
0.413MetMet: 0.413 ± 0.188
1.238MetAsn: 1.238 ± 0.302
0.66MetPro: 0.66 ± 0.243
0.825MetGln: 0.825 ± 0.241
1.816MetArg: 1.816 ± 0.358
2.064MetSer: 2.064 ± 0.443
2.146MetThr: 2.146 ± 0.466
1.156MetVal: 1.156 ± 0.313
0.083MetTrp: 0.083 ± 0.079
0.578MetTyr: 0.578 ± 0.278
0.0MetXaa: 0.0 ± 0.0
Asn
3.714AsnAla: 3.714 ± 0.703
0.0AsnCys: 0.0 ± 0.0
3.797AsnAsp: 3.797 ± 0.428
3.384AsnGlu: 3.384 ± 0.492
2.476AsnPhe: 2.476 ± 0.41
4.457AsnGly: 4.457 ± 0.641
0.825AsnHis: 0.825 ± 0.319
3.714AsnIle: 3.714 ± 0.641
4.87AsnLys: 4.87 ± 0.618
5.448AsnLeu: 5.448 ± 0.69
1.651AsnMet: 1.651 ± 0.323
3.549AsnAsn: 3.549 ± 0.58
2.229AsnPro: 2.229 ± 0.433
2.476AsnGln: 2.476 ± 0.497
2.394AsnArg: 2.394 ± 0.464
3.549AsnSer: 3.549 ± 0.614
2.724AsnThr: 2.724 ± 0.483
3.219AsnVal: 3.219 ± 0.495
0.743AsnTrp: 0.743 ± 0.245
1.981AsnTyr: 1.981 ± 0.404
0.0AsnXaa: 0.0 ± 0.0
Pro
1.568ProAla: 1.568 ± 0.412
0.165ProCys: 0.165 ± 0.123
1.898ProAsp: 1.898 ± 0.37
1.981ProGlu: 1.981 ± 0.444
1.321ProPhe: 1.321 ± 0.347
0.495ProGly: 0.495 ± 0.192
0.578ProHis: 0.578 ± 0.228
1.816ProIle: 1.816 ± 0.356
2.972ProLys: 2.972 ± 0.609
2.559ProLeu: 2.559 ± 0.439
0.413ProMet: 0.413 ± 0.226
1.486ProAsn: 1.486 ± 0.434
0.495ProPro: 0.495 ± 0.198
1.238ProGln: 1.238 ± 0.312
0.908ProArg: 0.908 ± 0.366
1.486ProSer: 1.486 ± 0.306
2.064ProThr: 2.064 ± 0.389
1.403ProVal: 1.403 ± 0.432
0.165ProTrp: 0.165 ± 0.142
1.651ProTyr: 1.651 ± 0.534
0.0ProXaa: 0.0 ± 0.0
Gln
2.559GlnAla: 2.559 ± 0.417
0.33GlnCys: 0.33 ± 0.175
1.651GlnAsp: 1.651 ± 0.32
3.137GlnGlu: 3.137 ± 0.569
2.146GlnPhe: 2.146 ± 0.381
2.229GlnGly: 2.229 ± 0.46
0.413GlnHis: 0.413 ± 0.159
3.054GlnIle: 3.054 ± 0.518
3.632GlnLys: 3.632 ± 0.563
4.705GlnLeu: 4.705 ± 0.751
1.486GlnMet: 1.486 ± 0.416
2.559GlnAsn: 2.559 ± 0.513
0.413GlnPro: 0.413 ± 0.183
1.568GlnGln: 1.568 ± 0.485
1.651GlnArg: 1.651 ± 0.38
3.302GlnSer: 3.302 ± 0.594
2.146GlnThr: 2.146 ± 0.436
1.156GlnVal: 1.156 ± 0.275
0.578GlnTrp: 0.578 ± 0.239
1.073GlnTyr: 1.073 ± 0.257
0.0GlnXaa: 0.0 ± 0.0
Arg
3.302ArgAla: 3.302 ± 0.519
0.413ArgCys: 0.413 ± 0.239
2.806ArgAsp: 2.806 ± 0.548
2.972ArgGlu: 2.972 ± 0.44
1.321ArgPhe: 1.321 ± 0.261
3.137ArgGly: 3.137 ± 0.53
0.578ArgHis: 0.578 ± 0.243
2.972ArgIle: 2.972 ± 0.421
3.467ArgLys: 3.467 ± 0.569
3.879ArgLeu: 3.879 ± 0.556
0.66ArgMet: 0.66 ± 0.244
2.394ArgAsn: 2.394 ± 0.398
0.578ArgPro: 0.578 ± 0.226
2.229ArgGln: 2.229 ± 0.366
2.064ArgArg: 2.064 ± 0.529
1.816ArgSer: 1.816 ± 0.311
2.394ArgThr: 2.394 ± 0.439
2.146ArgVal: 2.146 ± 0.458
0.578ArgTrp: 0.578 ± 0.208
1.898ArgTyr: 1.898 ± 0.417
0.0ArgXaa: 0.0 ± 0.0
Ser
4.705SerAla: 4.705 ± 1.048
0.165SerCys: 0.165 ± 0.114
4.54SerAsp: 4.54 ± 0.596
3.797SerGlu: 3.797 ± 0.475
2.972SerPhe: 2.972 ± 0.472
4.953SerGly: 4.953 ± 0.768
1.238SerHis: 1.238 ± 0.367
4.127SerIle: 4.127 ± 0.677
4.953SerLys: 4.953 ± 0.654
4.045SerLeu: 4.045 ± 0.679
1.403SerMet: 1.403 ± 0.361
3.632SerAsn: 3.632 ± 0.539
1.733SerPro: 1.733 ± 0.412
2.972SerGln: 2.972 ± 0.468
2.311SerArg: 2.311 ± 0.406
3.879SerSer: 3.879 ± 0.704
2.559SerThr: 2.559 ± 0.575
3.549SerVal: 3.549 ± 0.545
0.743SerTrp: 0.743 ± 0.326
2.889SerTyr: 2.889 ± 0.53
0.0SerXaa: 0.0 ± 0.0
Thr
5.613ThrAla: 5.613 ± 1.01
0.165ThrCys: 0.165 ± 0.111
3.632ThrAsp: 3.632 ± 0.455
2.806ThrGlu: 2.806 ± 0.64
2.559ThrPhe: 2.559 ± 0.404
5.283ThrGly: 5.283 ± 0.52
0.908ThrHis: 0.908 ± 0.255
4.127ThrIle: 4.127 ± 0.471
4.375ThrLys: 4.375 ± 0.516
4.787ThrLeu: 4.787 ± 0.547
1.321ThrMet: 1.321 ± 0.359
2.806ThrAsn: 2.806 ± 0.459
2.559ThrPro: 2.559 ± 0.496
2.311ThrGln: 2.311 ± 0.403
1.898ThrArg: 1.898 ± 0.456
4.375ThrSer: 4.375 ± 0.601
4.21ThrThr: 4.21 ± 0.58
3.714ThrVal: 3.714 ± 0.526
0.743ThrTrp: 0.743 ± 0.191
1.568ThrTyr: 1.568 ± 0.379
0.0ThrXaa: 0.0 ± 0.0
Val
4.045ValAla: 4.045 ± 0.951
0.33ValCys: 0.33 ± 0.186
3.797ValAsp: 3.797 ± 0.636
5.118ValGlu: 5.118 ± 0.663
2.311ValPhe: 2.311 ± 0.515
4.045ValGly: 4.045 ± 0.515
0.825ValHis: 0.825 ± 0.292
3.632ValIle: 3.632 ± 0.572
5.365ValLys: 5.365 ± 0.67
6.108ValLeu: 6.108 ± 0.752
1.238ValMet: 1.238 ± 0.368
3.632ValAsn: 3.632 ± 0.525
1.486ValPro: 1.486 ± 0.287
1.156ValGln: 1.156 ± 0.285
2.311ValArg: 2.311 ± 0.435
3.962ValSer: 3.962 ± 0.501
4.045ValThr: 4.045 ± 0.531
3.797ValVal: 3.797 ± 0.432
0.413ValTrp: 0.413 ± 0.23
1.568ValTyr: 1.568 ± 0.425
0.0ValXaa: 0.0 ± 0.0
Trp
0.495TrpAla: 0.495 ± 0.219
0.083TrpCys: 0.083 ± 0.087
0.825TrpAsp: 0.825 ± 0.228
0.495TrpGlu: 0.495 ± 0.212
0.495TrpPhe: 0.495 ± 0.239
0.66TrpGly: 0.66 ± 0.301
0.165TrpHis: 0.165 ± 0.119
1.073TrpIle: 1.073 ± 0.315
1.321TrpLys: 1.321 ± 0.283
0.991TrpLeu: 0.991 ± 0.354
0.083TrpMet: 0.083 ± 0.086
0.495TrpAsn: 0.495 ± 0.221
0.33TrpPro: 0.33 ± 0.128
0.413TrpGln: 0.413 ± 0.167
0.578TrpArg: 0.578 ± 0.247
0.66TrpSer: 0.66 ± 0.18
0.495TrpThr: 0.495 ± 0.193
0.578TrpVal: 0.578 ± 0.211
0.0TrpTrp: 0.0 ± 0.0
0.578TrpTyr: 0.578 ± 0.22
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.972TyrAla: 2.972 ± 0.368
0.66TyrCys: 0.66 ± 0.245
2.972TyrAsp: 2.972 ± 0.695
2.311TyrGlu: 2.311 ± 0.548
1.403TyrPhe: 1.403 ± 0.406
1.651TyrGly: 1.651 ± 0.305
0.33TyrHis: 0.33 ± 0.154
2.146TyrIle: 2.146 ± 0.554
3.467TyrLys: 3.467 ± 0.589
3.302TyrLeu: 3.302 ± 0.538
0.743TyrMet: 0.743 ± 0.268
1.981TyrAsn: 1.981 ± 0.581
1.403TyrPro: 1.403 ± 0.464
2.394TyrGln: 2.394 ± 0.527
1.981TyrArg: 1.981 ± 0.381
1.816TyrSer: 1.816 ± 0.367
1.981TyrThr: 1.981 ± 0.468
2.476TyrVal: 2.476 ± 0.478
0.413TyrTrp: 0.413 ± 0.168
1.981TyrTyr: 1.981 ± 0.353
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 60 proteins (12116 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski