Amino acid dipepetide frequency for Natronorubrum sulfidifaciens JCM 14089

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.196AlaAla: 12.196 ± 0.139	0.708AlaCys: 0.708 ± 0.027	9.821AlaAsp: 9.821 ± 0.117	7.94AlaGlu: 7.94 ± 0.107	3.815AlaPhe: 3.815 ± 0.076	8.748AlaGly: 8.748 ± 0.104	1.937AlaHis: 1.937 ± 0.046	5.573AlaIle: 5.573 ± 0.1	1.833AlaLys: 1.833 ± 0.049	9.969AlaLeu: 9.969 ± 0.141	2.078AlaMet: 2.078 ± 0.045	2.299AlaAsn: 2.299 ± 0.044	3.5AlaPro: 3.5 ± 0.063	2.247AlaGln: 2.247 ± 0.05	5.7AlaArg: 5.7 ± 0.095	5.114AlaSer: 5.114 ± 0.076	7.292AlaThr: 7.292 ± 0.105	10.076AlaVal: 10.076 ± 0.138	0.943AlaTrp: 0.943 ± 0.034	2.648AlaTyr: 2.648 ± 0.057	0.003AlaXaa: 0.003 ± 0.002
Cys	0.631CysAla: 0.631 ± 0.029	0.117CysCys: 0.117 ± 0.011	0.627CysAsp: 0.627 ± 0.028	0.624CysGlu: 0.624 ± 0.027	0.188CysPhe: 0.188 ± 0.014	0.819CysGly: 0.819 ± 0.033	0.211CysHis: 0.211 ± 0.013	0.28CysIle: 0.28 ± 0.013	0.137CysLys: 0.137 ± 0.011	0.628CysLeu: 0.628 ± 0.023	0.121CysMet: 0.121 ± 0.012	0.191CysAsn: 0.191 ± 0.013	0.552CysPro: 0.552 ± 0.029	0.193CysGln: 0.193 ± 0.014	0.511CysArg: 0.511 ± 0.023	0.478CysSer: 0.478 ± 0.021	0.479CysThr: 0.479 ± 0.024	0.473CysVal: 0.473 ± 0.025	0.111CysTrp: 0.111 ± 0.01	0.25CysTyr: 0.25 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	9.453AspAla: 9.453 ± 0.121	0.718AspCys: 0.718 ± 0.028	9.428AspAsp: 9.428 ± 0.169	8.761AspGlu: 8.761 ± 0.112	1.772AspPhe: 1.772 ± 0.049	7.895AspGly: 7.895 ± 0.125	2.092AspHis: 2.092 ± 0.047	3.36AspIle: 3.36 ± 0.069	0.985AspLys: 0.985 ± 0.036	7.22AspLeu: 7.22 ± 0.105	1.146AspMet: 1.146 ± 0.033	1.444AspAsn: 1.444 ± 0.04	4.325AspPro: 4.325 ± 0.069	1.893AspGln: 1.893 ± 0.052	6.219AspArg: 6.219 ± 0.092	3.993AspSer: 3.993 ± 0.084	4.39AspThr: 4.39 ± 0.081	7.783AspVal: 7.783 ± 0.104	0.96AspTrp: 0.96 ± 0.038	1.834AspTyr: 1.834 ± 0.047	0.002AspXaa: 0.002 ± 0.002
Glu	8.929GluAla: 8.929 ± 0.101	0.591GluCys: 0.591 ± 0.024	6.255GluAsp: 6.255 ± 0.098	6.31GluGlu: 6.31 ± 0.131	3.125GluPhe: 3.125 ± 0.059	5.306GluGly: 5.306 ± 0.086	2.18GluHis: 2.18 ± 0.055	4.501GluIle: 4.501 ± 0.08	1.887GluLys: 1.887 ± 0.054	7.998GluLeu: 7.998 ± 0.104	1.957GluMet: 1.957 ± 0.048	2.4GluAsn: 2.4 ± 0.057	4.654GluPro: 4.654 ± 0.085	3.274GluGln: 3.274 ± 0.065	7.414GluArg: 7.414 ± 0.1	5.394GluSer: 5.394 ± 0.089	7.877GluThr: 7.877 ± 0.104	5.117GluVal: 5.117 ± 0.079	1.146GluTrp: 1.146 ± 0.037	2.953GluTyr: 2.953 ± 0.053	0.004GluXaa: 0.004 ± 0.002
Phe	3.419PheAla: 3.419 ± 0.075	0.287PheCys: 0.287 ± 0.02	3.278PheAsp: 3.278 ± 0.065	3.258PheGlu: 3.258 ± 0.059	1.069PhePhe: 1.069 ± 0.037	3.126PheGly: 3.126 ± 0.07	0.641PheHis: 0.641 ± 0.026	1.251PheIle: 1.251 ± 0.045	0.509PheLys: 0.509 ± 0.021	2.773PheLeu: 2.773 ± 0.07	0.538PheMet: 0.538 ± 0.025	0.676PheAsn: 0.676 ± 0.024	1.326PhePro: 1.326 ± 0.038	0.77PheGln: 0.77 ± 0.03	1.649PheArg: 1.649 ± 0.046	1.653PheSer: 1.653 ± 0.045	1.851PheThr: 1.851 ± 0.048	3.203PheVal: 3.203 ± 0.068	0.391PheTrp: 0.391 ± 0.022	0.875PheTyr: 0.875 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	7.261GlyAla: 7.261 ± 0.11	0.726GlyCys: 0.726 ± 0.035	6.423GlyAsp: 6.423 ± 0.1	6.638GlyGlu: 6.638 ± 0.097	2.948GlyPhe: 2.948 ± 0.063	6.495GlyGly: 6.495 ± 0.121	1.724GlyHis: 1.724 ± 0.044	4.404GlyIle: 4.404 ± 0.079	1.794GlyLys: 1.794 ± 0.044	7.391GlyLeu: 7.391 ± 0.11	1.655GlyMet: 1.655 ± 0.041	1.81GlyAsn: 1.81 ± 0.053	3.147GlyPro: 3.147 ± 0.057	2.083GlyGln: 2.083 ± 0.047	4.442GlyArg: 4.442 ± 0.077	4.877GlySer: 4.877 ± 0.074	5.882GlyThr: 5.882 ± 0.074	7.082GlyVal: 7.082 ± 0.091	1.113GlyTrp: 1.113 ± 0.039	2.664GlyTyr: 2.664 ± 0.046	0.004GlyXaa: 0.004 ± 0.002
His	2.041HisAla: 2.041 ± 0.042	0.246HisCys: 0.246 ± 0.016	2.033HisAsp: 2.033 ± 0.051	1.916HisGlu: 1.916 ± 0.043	0.494HisPhe: 0.494 ± 0.023	2.097HisGly: 2.097 ± 0.051	0.592HisHis: 0.592 ± 0.028	0.829HisIle: 0.829 ± 0.029	0.3HisLys: 0.3 ± 0.017	1.789HisLeu: 1.789 ± 0.046	0.31HisMet: 0.31 ± 0.018	0.475HisAsn: 0.475 ± 0.023	1.27HisPro: 1.27 ± 0.036	0.503HisGln: 0.503 ± 0.025	1.339HisArg: 1.339 ± 0.036	0.965HisSer: 0.965 ± 0.035	1.191HisThr: 1.191 ± 0.039	1.89HisVal: 1.89 ± 0.042	0.248HisTrp: 0.248 ± 0.015	0.587HisTyr: 0.587 ± 0.027	0.001HisXaa: 0.001 ± 0.001
Ile	5.467IleAla: 5.467 ± 0.086	0.301IleCys: 0.301 ± 0.019	5.009IleAsp: 5.009 ± 0.087	4.731IleGlu: 4.731 ± 0.077	1.089IlePhe: 1.089 ± 0.034	4.347IleGly: 4.347 ± 0.087	0.908IleHis: 0.908 ± 0.032	1.824IleIle: 1.824 ± 0.042	0.798IleLys: 0.798 ± 0.033	3.299IleLeu: 3.299 ± 0.067	0.602IleMet: 0.602 ± 0.028	1.082IleAsn: 1.082 ± 0.038	2.217IlePro: 2.217 ± 0.049	1.225IleGln: 1.225 ± 0.04	2.619IleArg: 2.619 ± 0.053	2.502IleSer: 2.502 ± 0.058	2.874IleThr: 2.874 ± 0.057	4.329IleVal: 4.329 ± 0.08	0.393IleTrp: 0.393 ± 0.02	1.116IleTyr: 1.116 ± 0.03	0.002IleXaa: 0.002 ± 0.001
Lys	1.846LysAla: 1.846 ± 0.05	0.125LysCys: 0.125 ± 0.012	1.125LysAsp: 1.125 ± 0.04	1.245LysGlu: 1.245 ± 0.043	0.478LysPhe: 0.478 ± 0.021	1.229LysGly: 1.229 ± 0.035	0.541LysHis: 0.541 ± 0.026	0.855LysIle: 0.855 ± 0.03	0.552LysLys: 0.552 ± 0.028	1.737LysLeu: 1.737 ± 0.044	0.38LysMet: 0.38 ± 0.02	0.562LysAsn: 0.562 ± 0.027	1.032LysPro: 1.032 ± 0.039	0.788LysGln: 0.788 ± 0.032	1.676LysArg: 1.676 ± 0.049	1.1LysSer: 1.1 ± 0.035	1.376LysThr: 1.376 ± 0.04	1.081LysVal: 1.081 ± 0.033	0.224LysTrp: 0.224 ± 0.017	0.544LysTyr: 0.544 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	10.374LeuAla: 10.374 ± 0.158	0.709LeuCys: 0.709 ± 0.028	5.731LeuAsp: 5.731 ± 0.083	12.735LeuGlu: 12.735 ± 0.142	3.157LeuPhe: 3.157 ± 0.075	7.066LeuGly: 7.066 ± 0.111	1.461LeuHis: 1.461 ± 0.038	3.465LeuIle: 3.465 ± 0.074	1.496LeuLys: 1.496 ± 0.046	8.631LeuLeu: 8.631 ± 0.16	1.273LeuMet: 1.273 ± 0.039	1.73LeuAsn: 1.73 ± 0.046	3.8LeuPro: 3.8 ± 0.064	2.052LeuGln: 2.052 ± 0.045	4.685LeuArg: 4.685 ± 0.077	5.536LeuSer: 5.536 ± 0.079	5.348LeuThr: 5.348 ± 0.083	8.042LeuVal: 8.042 ± 0.129	0.865LeuTrp: 0.865 ± 0.03	2.208LeuTyr: 2.208 ± 0.054	0.001LeuXaa: 0.001 ± 0.001
Met	1.886MetAla: 1.886 ± 0.047	0.12MetCys: 0.12 ± 0.011	1.231MetAsp: 1.231 ± 0.035	1.102MetGlu: 1.102 ± 0.039	0.549MetPhe: 0.549 ± 0.025	1.458MetGly: 1.458 ± 0.04	0.37MetHis: 0.37 ± 0.02	0.804MetIle: 0.804 ± 0.03	0.417MetLys: 0.417 ± 0.022	1.651MetLeu: 1.651 ± 0.042	0.344MetMet: 0.344 ± 0.02	0.615MetAsn: 0.615 ± 0.026	0.829MetPro: 0.829 ± 0.031	0.542MetGln: 0.542 ± 0.027	1.009MetArg: 1.009 ± 0.033	1.502MetSer: 1.502 ± 0.041	1.678MetThr: 1.678 ± 0.044	1.283MetVal: 1.283 ± 0.038	0.177MetTrp: 0.177 ± 0.013	0.407MetTyr: 0.407 ± 0.022	0.001MetXaa: 0.001 ± 0.001
Asn	2.561AsnAla: 2.561 ± 0.045	0.21AsnCys: 0.21 ± 0.017	1.765AsnAsp: 1.765 ± 0.044	1.929AsnGlu: 1.929 ± 0.048	0.615AsnPhe: 0.615 ± 0.023	2.086AsnGly: 2.086 ± 0.047	0.547AsnHis: 0.547 ± 0.024	0.991AsnIle: 0.991 ± 0.032	0.485AsnLys: 0.485 ± 0.025	1.792AsnLeu: 1.792 ± 0.048	0.454AsnMet: 0.454 ± 0.022	0.56AsnAsn: 0.56 ± 0.028	1.478AsnPro: 1.478 ± 0.044	0.638AsnGln: 0.638 ± 0.026	1.633AsnArg: 1.633 ± 0.039	0.988AsnSer: 0.988 ± 0.035	1.37AsnThr: 1.37 ± 0.042	2.147AsnVal: 2.147 ± 0.051	0.355AsnTrp: 0.355 ± 0.018	0.66AsnTyr: 0.66 ± 0.029	0.001AsnXaa: 0.001 ± 0.001
Pro	4.596ProAla: 4.596 ± 0.079	0.25ProCys: 0.25 ± 0.016	4.798ProAsp: 4.798 ± 0.074	4.399ProGlu: 4.399 ± 0.073	1.572ProPhe: 1.572 ± 0.047	3.283ProGly: 3.283 ± 0.064	0.953ProHis: 0.953 ± 0.032	2.302ProIle: 2.302 ± 0.05	0.88ProLys: 0.88 ± 0.031	3.696ProLeu: 3.696 ± 0.074	0.882ProMet: 0.882 ± 0.029	1.208ProAsn: 1.208 ± 0.035	2.041ProPro: 2.041 ± 0.048	1.049ProGln: 1.049 ± 0.031	2.132ProArg: 2.132 ± 0.051	2.65ProSer: 2.65 ± 0.058	3.454ProThr: 3.454 ± 0.059	3.904ProVal: 3.904 ± 0.066	0.497ProTrp: 0.497 ± 0.023	1.065ProTyr: 1.065 ± 0.036	0.002ProXaa: 0.002 ± 0.001
Gln	2.644GlnAla: 2.644 ± 0.054	0.186GlnCys: 0.186 ± 0.013	1.437GlnAsp: 1.437 ± 0.039	1.787GlnGlu: 1.787 ± 0.048	1.114GlnPhe: 1.114 ± 0.03	1.684GlnGly: 1.684 ± 0.041	0.578GlnHis: 0.578 ± 0.021	1.19GlnIle: 1.19 ± 0.035	0.558GlnLys: 0.558 ± 0.028	2.749GlnLeu: 2.749 ± 0.045	0.59GlnMet: 0.59 ± 0.025	0.735GlnAsn: 0.735 ± 0.027	1.348GlnPro: 1.348 ± 0.038	1.2GlnGln: 1.2 ± 0.049	2.074GlnArg: 2.074 ± 0.049	1.676GlnSer: 1.676 ± 0.046	1.887GlnThr: 1.887 ± 0.049	1.808GlnVal: 1.808 ± 0.051	0.355GlnTrp: 0.355 ± 0.018	0.959GlnTyr: 0.959 ± 0.039	0.001GlnXaa: 0.001 ± 0.001
Arg	5.954ArgAla: 5.954 ± 0.099	0.483ArgCys: 0.483 ± 0.022	4.762ArgAsp: 4.762 ± 0.081	6.157ArgGlu: 6.157 ± 0.096	2.142ArgPhe: 2.142 ± 0.044	4.076ArgGly: 4.076 ± 0.059	1.25ArgHis: 1.25 ± 0.038	3.054ArgIle: 3.054 ± 0.057	1.432ArgLys: 1.432 ± 0.043	6.093ArgLeu: 6.093 ± 0.088	1.256ArgMet: 1.256 ± 0.038	1.605ArgAsn: 1.605 ± 0.035	2.396ArgPro: 2.396 ± 0.052	1.915ArgGln: 1.915 ± 0.048	4.434ArgArg: 4.434 ± 0.078	3.514ArgSer: 3.514 ± 0.069	4.093ArgThr: 4.093 ± 0.072	4.624ArgVal: 4.624 ± 0.066	0.728ArgTrp: 0.728 ± 0.03	1.865ArgTyr: 1.865 ± 0.042	0.004ArgXaa: 0.004 ± 0.002
Ser	5.151SerAla: 5.151 ± 0.072	0.341SerCys: 0.341 ± 0.019	4.516SerAsp: 4.516 ± 0.096	4.421SerGlu: 4.421 ± 0.08	1.897SerPhe: 1.897 ± 0.043	4.713SerGly: 4.713 ± 0.073	1.113SerHis: 1.113 ± 0.034	2.837SerIle: 2.837 ± 0.059	1.28SerLys: 1.28 ± 0.037	4.989SerLeu: 4.989 ± 0.091	1.209SerMet: 1.209 ± 0.034	1.391SerAsn: 1.391 ± 0.037	2.509SerPro: 2.509 ± 0.055	1.489SerGln: 1.489 ± 0.044	3.316SerArg: 3.316 ± 0.054	3.539SerSer: 3.539 ± 0.066	3.721SerThr: 3.721 ± 0.065	4.884SerVal: 4.884 ± 0.086	0.596SerTrp: 0.596 ± 0.022	1.471SerTyr: 1.471 ± 0.039	0.003SerXaa: 0.003 ± 0.002
Thr	7.405ThrAla: 7.405 ± 0.095	0.45ThrCys: 0.45 ± 0.019	6.195ThrAsp: 6.195 ± 0.106	5.075ThrGlu: 5.075 ± 0.078	2.215ThrPhe: 2.215 ± 0.044	5.711ThrGly: 5.711 ± 0.079	1.338ThrHis: 1.338 ± 0.04	3.767ThrIle: 3.767 ± 0.074	1.12ThrLys: 1.12 ± 0.034	6.119ThrLeu: 6.119 ± 0.082	1.149ThrMet: 1.149 ± 0.036	1.613ThrAsn: 1.613 ± 0.046	3.411ThrPro: 3.411 ± 0.058	1.617ThrGln: 1.617 ± 0.043	3.438ThrArg: 3.438 ± 0.065	3.072ThrSer: 3.072 ± 0.053	4.712ThrThr: 4.712 ± 0.081	7.129ThrVal: 7.129 ± 0.114	0.665ThrTrp: 0.665 ± 0.028	1.819ThrTyr: 1.819 ± 0.049	0.001ThrXaa: 0.001 ± 0.001
Val	9.051ValAla: 9.051 ± 0.118	0.703ValCys: 0.703 ± 0.027	7.68ValAsp: 7.68 ± 0.094	6.915ValGlu: 6.915 ± 0.109	2.982ValPhe: 2.982 ± 0.067	7.274ValGly: 7.274 ± 0.101	1.712ValHis: 1.712 ± 0.047	3.958ValIle: 3.958 ± 0.068	1.299ValLys: 1.299 ± 0.034	8.068ValLeu: 8.068 ± 0.109	1.364ValMet: 1.364 ± 0.037	1.841ValAsn: 1.841 ± 0.043	4.087ValPro: 4.087 ± 0.067	1.901ValGln: 1.901 ± 0.045	4.935ValArg: 4.935 ± 0.09	5.059ValSer: 5.059 ± 0.067	6.194ValThr: 6.194 ± 0.098	8.376ValVal: 8.376 ± 0.111	0.776ValTrp: 0.776 ± 0.029	2.064ValTyr: 2.064 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	0.879TrpAla: 0.879 ± 0.035	0.092TrpCys: 0.092 ± 0.009	0.777TrpAsp: 0.777 ± 0.034	0.774TrpGlu: 0.774 ± 0.033	0.464TrpPhe: 0.464 ± 0.022	0.819TrpGly: 0.819 ± 0.03	0.273TrpHis: 0.273 ± 0.017	0.592TrpIle: 0.592 ± 0.031	0.264TrpLys: 0.264 ± 0.018	1.284TrpLeu: 1.284 ± 0.043	0.247TrpMet: 0.247 ± 0.015	0.373TrpAsn: 0.373 ± 0.019	0.432TrpPro: 0.432 ± 0.024	0.387TrpGln: 0.387 ± 0.021	0.77TrpArg: 0.77 ± 0.033	0.571TrpSer: 0.571 ± 0.023	0.773TrpThr: 0.773 ± 0.026	0.754TrpVal: 0.754 ± 0.028	0.173TrpTrp: 0.173 ± 0.013	0.353TrpTyr: 0.353 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.691TyrAla: 2.691 ± 0.061	0.258TyrCys: 0.258 ± 0.014	2.779TyrAsp: 2.779 ± 0.059	2.556TyrGlu: 2.556 ± 0.053	0.856TyrPhe: 0.856 ± 0.034	2.329TyrGly: 2.329 ± 0.048	0.697TyrHis: 0.697 ± 0.031	0.897TyrIle: 0.897 ± 0.035	0.47TyrLys: 0.47 ± 0.027	2.483TyrLeu: 2.483 ± 0.057	0.419TyrMet: 0.419 ± 0.02	0.655TyrAsn: 0.655 ± 0.028	1.258TyrPro: 1.258 ± 0.039	0.792TyrGln: 0.792 ± 0.032	1.837TyrArg: 1.837 ± 0.048	1.198TyrSer: 1.198 ± 0.037	1.577TyrThr: 1.577 ± 0.042	2.252TyrVal: 2.252 ± 0.044	0.336TyrTrp: 0.336 ± 0.019	0.863TyrTyr: 0.863 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.002XaaCys: 0.002 ± 0.002	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.002XaaPhe: 0.002 ± 0.001	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.002XaaLys: 0.002 ± 0.001	0.004XaaLeu: 0.004 ± 0.002	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.001XaaGln: 0.001 ± 0.001	0.004XaaArg: 0.004 ± 0.002	0.003XaaSer: 0.003 ± 0.002	0.002XaaThr: 0.002 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3428 proteins (967963 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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