Amino acid dipepetide frequency for Spiroplasma eriocheiris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.58AlaAla: 3.58 ± 0.111
0.655AlaCys: 0.655 ± 0.04
2.713AlaAsp: 2.713 ± 0.09
2.777AlaGlu: 2.777 ± 0.085
2.559AlaPhe: 2.559 ± 0.09
3.445AlaGly: 3.445 ± 0.111
0.919AlaHis: 0.919 ± 0.051
6.301AlaIle: 6.301 ± 0.151
5.313AlaLys: 5.313 ± 0.14
5.689AlaLeu: 5.689 ± 0.123
1.336AlaMet: 1.336 ± 0.065
4.056AlaAsn: 4.056 ± 0.102
1.541AlaPro: 1.541 ± 0.07
2.275AlaGln: 2.275 ± 0.08
1.776AlaArg: 1.776 ± 0.075
3.273AlaSer: 3.273 ± 0.095
3.593AlaThr: 3.593 ± 0.109
3.527AlaVal: 3.527 ± 0.104
0.545AlaTrp: 0.545 ± 0.043
2.063AlaTyr: 2.063 ± 0.069
0.0AlaXaa: 0.0 ± 0.0
Cys
0.522CysAla: 0.522 ± 0.034
0.113CysCys: 0.113 ± 0.019
0.366CysAsp: 0.366 ± 0.029
0.427CysGlu: 0.427 ± 0.035
0.494CysPhe: 0.494 ± 0.038
0.479CysGly: 0.479 ± 0.037
0.223CysHis: 0.223 ± 0.026
0.468CysIle: 0.468 ± 0.036
0.438CysLys: 0.438 ± 0.037
0.85CysLeu: 0.85 ± 0.048
0.118CysMet: 0.118 ± 0.016
0.361CysAsn: 0.361 ± 0.03
0.235CysPro: 0.235 ± 0.026
0.392CysGln: 0.392 ± 0.036
0.228CysArg: 0.228 ± 0.028
0.481CysSer: 0.481 ± 0.035
0.356CysThr: 0.356 ± 0.031
0.392CysVal: 0.392 ± 0.031
0.118CysTrp: 0.118 ± 0.019
0.392CysTyr: 0.392 ± 0.035
0.0CysXaa: 0.0 ± 0.0
Asp
2.293AspAla: 2.293 ± 0.073
0.294AspCys: 0.294 ± 0.032
2.969AspAsp: 2.969 ± 0.097
3.609AspGlu: 3.609 ± 0.093
2.938AspPhe: 2.938 ± 0.091
2.613AspGly: 2.613 ± 0.12
1.208AspHis: 1.208 ± 0.062
4.737AspIle: 4.737 ± 0.12
3.939AspLys: 3.939 ± 0.118
5.884AspLeu: 5.884 ± 0.123
0.842AspMet: 0.842 ± 0.045
4.1AspAsn: 4.1 ± 0.107
2.076AspPro: 2.076 ± 0.072
2.283AspGln: 2.283 ± 0.083
1.303AspArg: 1.303 ± 0.068
2.662AspSer: 2.662 ± 0.083
2.019AspThr: 2.019 ± 0.07
2.9AspVal: 2.9 ± 0.098
0.617AspTrp: 0.617 ± 0.041
2.864AspTyr: 2.864 ± 0.092
0.0AspXaa: 0.0 ± 0.0
Glu
2.861GluAla: 2.861 ± 0.094
0.292GluCys: 0.292 ± 0.026
2.457GluAsp: 2.457 ± 0.087
3.916GluGlu: 3.916 ± 0.14
2.723GluPhe: 2.723 ± 0.101
2.306GluGly: 2.306 ± 0.091
1.057GluHis: 1.057 ± 0.06
6.229GluIle: 6.229 ± 0.161
5.221GluLys: 5.221 ± 0.162
6.416GluLeu: 6.416 ± 0.148
1.326GluMet: 1.326 ± 0.057
3.923GluAsn: 3.923 ± 0.124
1.518GluPro: 1.518 ± 0.085
2.733GluGln: 2.733 ± 0.097
1.784GluArg: 1.784 ± 0.081
2.301GluSer: 2.301 ± 0.092
2.777GluThr: 2.777 ± 0.08
3.591GluVal: 3.591 ± 0.111
0.663GluTrp: 0.663 ± 0.043
2.603GluTyr: 2.603 ± 0.078
0.0GluXaa: 0.0 ± 0.0
Phe
3.171PheAla: 3.171 ± 0.101
0.491PheCys: 0.491 ± 0.037
2.989PheAsp: 2.989 ± 0.091
2.396PheGlu: 2.396 ± 0.096
2.59PhePhe: 2.59 ± 0.103
2.864PheGly: 2.864 ± 0.104
0.683PheHis: 0.683 ± 0.041
4.799PheIle: 4.799 ± 0.134
3.952PheLys: 3.952 ± 0.096
5.426PheLeu: 5.426 ± 0.143
1.049PheMet: 1.049 ± 0.052
4.144PheAsn: 4.144 ± 0.125
1.303PhePro: 1.303 ± 0.06
1.597PheGln: 1.597 ± 0.079
1.244PheArg: 1.244 ± 0.057
3.281PheSer: 3.281 ± 0.105
2.785PheThr: 2.785 ± 0.092
2.787PheVal: 2.787 ± 0.095
0.571PheTrp: 0.571 ± 0.042
2.255PheTyr: 2.255 ± 0.087
0.0PheXaa: 0.0 ± 0.0
Gly
3.161GlyAla: 3.161 ± 0.101
0.417GlyCys: 0.417 ± 0.037
2.618GlyAsp: 2.618 ± 0.088
2.703GlyGlu: 2.703 ± 0.095
2.761GlyPhe: 2.761 ± 0.089
3.125GlyGly: 3.125 ± 0.134
0.937GlyHis: 0.937 ± 0.055
4.855GlyIle: 4.855 ± 0.131
3.936GlyLys: 3.936 ± 0.122
5.001GlyLeu: 5.001 ± 0.111
1.305GlyMet: 1.305 ± 0.054
2.636GlyAsn: 2.636 ± 0.087
1.259GlyPro: 1.259 ± 0.053
1.733GlyGln: 1.733 ± 0.074
1.472GlyArg: 1.472 ± 0.07
2.984GlySer: 2.984 ± 0.091
3.294GlyThr: 3.294 ± 0.104
3.632GlyVal: 3.632 ± 0.116
0.729GlyTrp: 0.729 ± 0.046
2.554GlyTyr: 2.554 ± 0.074
0.0GlyXaa: 0.0 ± 0.0
His
0.95HisAla: 0.95 ± 0.045
0.171HisCys: 0.171 ± 0.024
0.919HisAsp: 0.919 ± 0.039
0.926HisGlu: 0.926 ± 0.052
0.898HisPhe: 0.898 ± 0.045
0.919HisGly: 0.919 ± 0.053
0.822HisHis: 0.822 ± 0.061
1.257HisIle: 1.257 ± 0.059
1.164HisLys: 1.164 ± 0.059
2.024HisLeu: 2.024 ± 0.072
0.264HisMet: 0.264 ± 0.026
1.385HisAsn: 1.385 ± 0.067
0.865HisPro: 0.865 ± 0.048
1.428HisGln: 1.428 ± 0.075
0.604HisArg: 0.604 ± 0.044
0.965HisSer: 0.965 ± 0.052
0.735HisThr: 0.735 ± 0.045
0.819HisVal: 0.819 ± 0.048
0.246HisTrp: 0.246 ± 0.024
0.896HisTyr: 0.896 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
6.234IleAla: 6.234 ± 0.163
0.942IleCys: 0.942 ± 0.053
4.95IleAsp: 4.95 ± 0.104
4.466IleGlu: 4.466 ± 0.14
5.009IlePhe: 5.009 ± 0.138
4.765IleGly: 4.765 ± 0.134
1.216IleHis: 1.216 ± 0.052
10.601IleIle: 10.601 ± 0.227
8.661IleLys: 8.661 ± 0.16
9.229IleLeu: 9.229 ± 0.19
1.886IleMet: 1.886 ± 0.074
8.151IleAsn: 8.151 ± 0.162
3.12IlePro: 3.12 ± 0.103
2.413IleGln: 2.413 ± 0.077
2.513IleArg: 2.513 ± 0.085
6.165IleSer: 6.165 ± 0.117
5.797IleThr: 5.797 ± 0.124
5.444IleVal: 5.444 ± 0.13
0.988IleTrp: 0.988 ± 0.054
3.496IleTyr: 3.496 ± 0.092
0.0IleXaa: 0.0 ± 0.0
Lys
4.399LysAla: 4.399 ± 0.109
0.346LysCys: 0.346 ± 0.029
4.269LysAsp: 4.269 ± 0.113
5.871LysGlu: 5.871 ± 0.14
3.24LysPhe: 3.24 ± 0.108
3.191LysGly: 3.191 ± 0.114
1.282LysHis: 1.282 ± 0.057
8.878LysIle: 8.878 ± 0.173
7.68LysLys: 7.68 ± 0.19
8.126LysLeu: 8.126 ± 0.165
2.36LysMet: 2.36 ± 0.078
6.647LysAsn: 6.647 ± 0.183
2.572LysPro: 2.572 ± 0.068
3.253LysGln: 3.253 ± 0.088
2.383LysArg: 2.383 ± 0.093
3.586LysSer: 3.586 ± 0.101
5.28LysThr: 5.28 ± 0.131
4.962LysVal: 4.962 ± 0.126
1.006LysTrp: 1.006 ± 0.051
3.954LysTyr: 3.954 ± 0.118
0.0LysXaa: 0.0 ± 0.0
Leu
7.322LeuAla: 7.322 ± 0.154
0.678LeuCys: 0.678 ± 0.044
5.032LeuAsp: 5.032 ± 0.106
5.346LeuGlu: 5.346 ± 0.145
4.993LeuPhe: 4.993 ± 0.128
5.262LeuGly: 5.262 ± 0.14
1.597LeuHis: 1.597 ± 0.063
9.577LeuIle: 9.577 ± 0.166
8.535LeuLys: 8.535 ± 0.156
9.905LeuLeu: 9.905 ± 0.196
2.163LeuMet: 2.163 ± 0.078
7.089LeuAsn: 7.089 ± 0.151
3.14LeuPro: 3.14 ± 0.093
3.742LeuGln: 3.742 ± 0.094
2.772LeuArg: 2.772 ± 0.093
6.306LeuSer: 6.306 ± 0.122
7.465LeuThr: 7.465 ± 0.16
6.429LeuVal: 6.429 ± 0.145
1.016LeuTrp: 1.016 ± 0.056
3.383LeuTyr: 3.383 ± 0.107
0.0LeuXaa: 0.0 ± 0.0
Met
1.561MetAla: 1.561 ± 0.067
0.146MetCys: 0.146 ± 0.021
0.804MetAsp: 0.804 ± 0.049
0.95MetGlu: 0.95 ± 0.051
1.037MetPhe: 1.037 ± 0.05
1.269MetGly: 1.269 ± 0.061
0.404MetHis: 0.404 ± 0.03
1.935MetIle: 1.935 ± 0.077
2.009MetLys: 2.009 ± 0.067
2.372MetLeu: 2.372 ± 0.085
0.609MetMet: 0.609 ± 0.042
1.469MetAsn: 1.469 ± 0.057
0.699MetPro: 0.699 ± 0.044
0.883MetGln: 0.883 ± 0.051
0.612MetArg: 0.612 ± 0.039
1.203MetSer: 1.203 ± 0.051
1.116MetThr: 1.116 ± 0.058
1.292MetVal: 1.292 ± 0.058
0.23MetTrp: 0.23 ± 0.025
0.604MetTyr: 0.604 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
3.342AsnAla: 3.342 ± 0.093
0.433AsnCys: 0.433 ± 0.038
4.312AsnAsp: 4.312 ± 0.101
4.087AsnGlu: 4.087 ± 0.115
4.289AsnPhe: 4.289 ± 0.12
3.166AsnGly: 3.166 ± 0.101
1.451AsnHis: 1.451 ± 0.078
6.81AsnIle: 6.81 ± 0.148
6.524AsnLys: 6.524 ± 0.139
7.806AsnLeu: 7.806 ± 0.171
1.344AsnMet: 1.344 ± 0.052
7.225AsnAsn: 7.225 ± 0.223
2.966AsnPro: 2.966 ± 0.089
3.263AsnGln: 3.263 ± 0.105
1.83AsnArg: 1.83 ± 0.063
4.341AsnSer: 4.341 ± 0.138
2.907AsnThr: 2.907 ± 0.098
3.673AsnVal: 3.673 ± 0.099
0.921AsnTrp: 0.921 ± 0.045
3.916AsnTyr: 3.916 ± 0.111
0.0AsnXaa: 0.0 ± 0.0
Pro
1.779ProAla: 1.779 ± 0.075
0.192ProCys: 0.192 ± 0.022
1.738ProAsp: 1.738 ± 0.065
2.009ProGlu: 2.009 ± 0.063
1.628ProPhe: 1.628 ± 0.069
1.743ProGly: 1.743 ± 0.069
0.74ProHis: 0.74 ± 0.051
2.751ProIle: 2.751 ± 0.073
2.045ProLys: 2.045 ± 0.083
2.946ProLeu: 2.946 ± 0.087
0.599ProMet: 0.599 ± 0.043
2.483ProAsn: 2.483 ± 0.081
0.926ProPro: 0.926 ± 0.06
1.469ProGln: 1.469 ± 0.058
0.799ProArg: 0.799 ± 0.05
2.055ProSer: 2.055 ± 0.068
2.357ProThr: 2.357 ± 0.105
2.278ProVal: 2.278 ± 0.09
0.34ProTrp: 0.34 ± 0.03
1.221ProTyr: 1.221 ± 0.06
0.0ProXaa: 0.0 ± 0.0
Gln
2.303GlnAla: 2.303 ± 0.082
0.195GlnCys: 0.195 ± 0.025
2.104GlnAsp: 2.104 ± 0.083
2.943GlnGlu: 2.943 ± 0.107
1.687GlnPhe: 1.687 ± 0.072
1.692GlnGly: 1.692 ± 0.062
0.845GlnHis: 0.845 ± 0.048
3.652GlnIle: 3.652 ± 0.099
3.637GlnLys: 3.637 ± 0.098
4.044GlnLeu: 4.044 ± 0.109
0.809GlnMet: 0.809 ± 0.056
2.708GlnAsn: 2.708 ± 0.093
1.53GlnPro: 1.53 ± 0.087
2.306GlnGln: 2.306 ± 0.099
1.205GlnArg: 1.205 ± 0.051
1.656GlnSer: 1.656 ± 0.062
2.467GlnThr: 2.467 ± 0.076
2.275GlnVal: 2.275 ± 0.086
0.507GlnTrp: 0.507 ± 0.036
1.84GlnTyr: 1.84 ± 0.084
0.0GlnXaa: 0.0 ± 0.0
Arg
1.472ArgAla: 1.472 ± 0.066
0.251ArgCys: 0.251 ± 0.026
1.474ArgAsp: 1.474 ± 0.064
1.96ArgGlu: 1.96 ± 0.08
1.28ArgPhe: 1.28 ± 0.067
1.449ArgGly: 1.449 ± 0.066
0.566ArgHis: 0.566 ± 0.04
2.746ArgIle: 2.746 ± 0.094
2.559ArgLys: 2.559 ± 0.096
2.685ArgLeu: 2.685 ± 0.089
0.793ArgMet: 0.793 ± 0.042
1.835ArgAsn: 1.835 ± 0.076
0.801ArgPro: 0.801 ± 0.051
1.216ArgGln: 1.216 ± 0.055
1.088ArgArg: 1.088 ± 0.061
1.377ArgSer: 1.377 ± 0.06
1.495ArgThr: 1.495 ± 0.062
1.587ArgVal: 1.587 ± 0.064
0.317ArgTrp: 0.317 ± 0.027
1.241ArgTyr: 1.241 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
3.312SerAla: 3.312 ± 0.094
0.466SerCys: 0.466 ± 0.035
3.063SerAsp: 3.063 ± 0.1
3.325SerGlu: 3.325 ± 0.109
3.363SerPhe: 3.363 ± 0.101
3.363SerGly: 3.363 ± 0.106
1.159SerHis: 1.159 ± 0.058
4.348SerIle: 4.348 ± 0.1
4.12SerLys: 4.12 ± 0.113
6.035SerLeu: 6.035 ± 0.146
1.121SerMet: 1.121 ± 0.059
3.703SerAsn: 3.703 ± 0.11
1.853SerPro: 1.853 ± 0.082
2.416SerGln: 2.416 ± 0.091
1.507SerArg: 1.507 ± 0.065
3.767SerSer: 3.767 ± 0.114
3.115SerThr: 3.115 ± 0.096
3.135SerVal: 3.135 ± 0.098
0.758SerTrp: 0.758 ± 0.044
2.746SerTyr: 2.746 ± 0.086
0.0SerXaa: 0.0 ± 0.0
Thr
3.217ThrAla: 3.217 ± 0.095
0.381ThrCys: 0.381 ± 0.035
2.746ThrAsp: 2.746 ± 0.085
2.48ThrGlu: 2.48 ± 0.082
2.746ThrPhe: 2.746 ± 0.082
3.271ThrGly: 3.271 ± 0.094
0.886ThrHis: 0.886 ± 0.052
6.194ThrIle: 6.194 ± 0.135
4.906ThrLys: 4.906 ± 0.114
5.28ThrLeu: 5.28 ± 0.119
1.175ThrMet: 1.175 ± 0.054
4.527ThrAsn: 4.527 ± 0.118
2.347ThrPro: 2.347 ± 0.085
1.62ThrGln: 1.62 ± 0.067
1.666ThrArg: 1.666 ± 0.078
3.788ThrSer: 3.788 ± 0.107
4.33ThrThr: 4.33 ± 0.128
3.342ThrVal: 3.342 ± 0.092
0.63ThrTrp: 0.63 ± 0.042
2.239ThrTyr: 2.239 ± 0.083
0.0ThrXaa: 0.0 ± 0.0
Val
3.77ValAla: 3.77 ± 0.121
0.54ValCys: 0.54 ± 0.035
3.248ValAsp: 3.248 ± 0.106
3.404ValGlu: 3.404 ± 0.105
2.657ValPhe: 2.657 ± 0.098
3.473ValGly: 3.473 ± 0.102
0.76ValHis: 0.76 ± 0.045
5.971ValIle: 5.971 ± 0.138
5.055ValLys: 5.055 ± 0.121
5.697ValLeu: 5.697 ± 0.138
1.226ValMet: 1.226 ± 0.054
4.328ValAsn: 4.328 ± 0.123
1.776ValPro: 1.776 ± 0.067
1.756ValGln: 1.756 ± 0.063
1.6ValArg: 1.6 ± 0.068
3.555ValSer: 3.555 ± 0.103
3.36ValThr: 3.36 ± 0.126
4.072ValVal: 4.072 ± 0.121
0.571ValTrp: 0.571 ± 0.039
2.209ValTyr: 2.209 ± 0.084
0.0ValXaa: 0.0 ± 0.0
Trp
0.591TrpAla: 0.591 ± 0.041
0.072TrpCys: 0.072 ± 0.013
0.617TrpAsp: 0.617 ± 0.045
0.64TrpGlu: 0.64 ± 0.045
0.742TrpPhe: 0.742 ± 0.051
0.535TrpGly: 0.535 ± 0.037
0.179TrpHis: 0.179 ± 0.02
1.083TrpIle: 1.083 ± 0.065
0.975TrpLys: 0.975 ± 0.049
1.144TrpLeu: 1.144 ± 0.062
0.251TrpMet: 0.251 ± 0.027
0.916TrpAsn: 0.916 ± 0.046
0.258TrpPro: 0.258 ± 0.025
0.412TrpGln: 0.412 ± 0.031
0.315TrpArg: 0.315 ± 0.028
0.612TrpSer: 0.612 ± 0.036
0.729TrpThr: 0.729 ± 0.042
0.663TrpVal: 0.663 ± 0.046
0.235TrpTrp: 0.235 ± 0.025
0.622TrpTyr: 0.622 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.096TyrAla: 2.096 ± 0.071
0.376TyrCys: 0.376 ± 0.03
2.761TyrAsp: 2.761 ± 0.096
2.462TyrGlu: 2.462 ± 0.091
2.741TyrPhe: 2.741 ± 0.089
2.183TyrGly: 2.183 ± 0.074
1.323TyrHis: 1.323 ± 0.059
2.854TyrIle: 2.854 ± 0.078
2.618TyrLys: 2.618 ± 0.09
5.195TyrLeu: 5.195 ± 0.128
0.627TyrMet: 0.627 ± 0.043
2.92TyrAsn: 2.92 ± 0.097
1.31TyrPro: 1.31 ± 0.061
3.214TyrGln: 3.214 ± 0.114
1.492TyrArg: 1.492 ± 0.072
2.319TyrSer: 2.319 ± 0.087
1.794TyrThr: 1.794 ± 0.075
2.227TyrVal: 2.227 ± 0.072
0.584TyrTrp: 0.584 ± 0.037
2.28TyrTyr: 2.28 ± 0.089
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1180 proteins (390732 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski