Amino acid dipepetide frequency for Pararhizobium antarcticum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.43AlaAla: 15.43 ± 0.149	1.001AlaCys: 1.001 ± 0.025	6.992AlaAsp: 6.992 ± 0.076	6.903AlaGlu: 6.903 ± 0.079	4.72AlaPhe: 4.72 ± 0.061	10.177AlaGly: 10.177 ± 0.093	2.159AlaHis: 2.159 ± 0.039	6.962AlaIle: 6.962 ± 0.077	4.247AlaLys: 4.247 ± 0.069	12.656AlaLeu: 12.656 ± 0.12	3.678AlaMet: 3.678 ± 0.052	3.046AlaAsn: 3.046 ± 0.045	4.532AlaPro: 4.532 ± 0.067	3.686AlaGln: 3.686 ± 0.058	7.648AlaArg: 7.648 ± 0.089	6.696AlaSer: 6.696 ± 0.085	6.079AlaThr: 6.079 ± 0.068	8.594AlaVal: 8.594 ± 0.085	1.322AlaTrp: 1.322 ± 0.029	2.493AlaTyr: 2.493 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.897CysAla: 0.897 ± 0.026	0.117CysCys: 0.117 ± 0.008	0.546CysAsp: 0.546 ± 0.02	0.451CysGlu: 0.451 ± 0.016	0.355CysPhe: 0.355 ± 0.014	0.949CysGly: 0.949 ± 0.026	0.226CysHis: 0.226 ± 0.012	0.433CysIle: 0.433 ± 0.017	0.204CysLys: 0.204 ± 0.011	0.811CysLeu: 0.811 ± 0.022	0.167CysMet: 0.167 ± 0.01	0.213CysAsn: 0.213 ± 0.011	0.386CysPro: 0.386 ± 0.016	0.231CysGln: 0.231 ± 0.012	0.577CysArg: 0.577 ± 0.021	0.461CysSer: 0.461 ± 0.018	0.4CysThr: 0.4 ± 0.017	0.612CysVal: 0.612 ± 0.021	0.108CysTrp: 0.108 ± 0.009	0.2CysTyr: 0.2 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.877AspAla: 6.877 ± 0.08	0.522AspCys: 0.522 ± 0.019	3.249AspAsp: 3.249 ± 0.059	3.292AspGlu: 3.292 ± 0.053	2.453AspPhe: 2.453 ± 0.046	5.397AspGly: 5.397 ± 0.07	1.322AspHis: 1.322 ± 0.032	3.624AspIle: 3.624 ± 0.045	1.88AspLys: 1.88 ± 0.043	5.975AspLeu: 5.975 ± 0.061	1.595AspMet: 1.595 ± 0.032	1.529AspAsn: 1.529 ± 0.034	3.281AspPro: 3.281 ± 0.049	1.741AspGln: 1.741 ± 0.038	4.205AspArg: 4.205 ± 0.052	2.296AspSer: 2.296 ± 0.041	2.821AspThr: 2.821 ± 0.057	4.268AspVal: 4.268 ± 0.055	1.001AspTrp: 1.001 ± 0.024	1.518AspTyr: 1.518 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	6.975GluAla: 6.975 ± 0.081	0.318GluCys: 0.318 ± 0.017	2.806GluAsp: 2.806 ± 0.052	2.928GluGlu: 2.928 ± 0.059	1.739GluPhe: 1.739 ± 0.032	3.986GluGly: 3.986 ± 0.053	1.122GluHis: 1.122 ± 0.027	3.829GluIle: 3.829 ± 0.056	2.688GluLys: 2.688 ± 0.051	4.768GluLeu: 4.768 ± 0.062	1.606GluMet: 1.606 ± 0.037	1.839GluAsn: 1.839 ± 0.032	2.544GluPro: 2.544 ± 0.05	2.065GluGln: 2.065 ± 0.04	4.289GluArg: 4.289 ± 0.056	2.36GluSer: 2.36 ± 0.04	4.098GluThr: 4.098 ± 0.056	3.384GluVal: 3.384 ± 0.061	0.654GluTrp: 0.654 ± 0.023	1.003GluTyr: 1.003 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.59PheAla: 4.59 ± 0.062	0.434PheCys: 0.434 ± 0.018	2.841PheAsp: 2.841 ± 0.049	2.235PheGlu: 2.235 ± 0.035	1.602PhePhe: 1.602 ± 0.041	3.816PheGly: 3.816 ± 0.058	0.768PheHis: 0.768 ± 0.02	2.001PheIle: 2.001 ± 0.044	1.213PheLys: 1.213 ± 0.03	3.683PheLeu: 3.683 ± 0.06	0.914PheMet: 0.914 ± 0.023	1.172PheAsn: 1.172 ± 0.029	1.639PhePro: 1.639 ± 0.034	1.141PheGln: 1.141 ± 0.031	2.244PheArg: 2.244 ± 0.037	2.706PheSer: 2.706 ± 0.047	2.029PheThr: 2.029 ± 0.039	2.915PheVal: 2.915 ± 0.049	0.566PheTrp: 0.566 ± 0.021	0.965PheTyr: 0.965 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.464GlyAla: 8.464 ± 0.08	0.839GlyCys: 0.839 ± 0.023	4.472GlyAsp: 4.472 ± 0.056	4.506GlyGlu: 4.506 ± 0.052	3.794GlyPhe: 3.794 ± 0.058	6.774GlyGly: 6.774 ± 0.078	1.909GlyHis: 1.909 ± 0.04	5.201GlyIle: 5.201 ± 0.06	3.649GlyLys: 3.649 ± 0.05	8.807GlyLeu: 8.807 ± 0.089	2.414GlyMet: 2.414 ± 0.045	2.467GlyAsn: 2.467 ± 0.052	3.093GlyPro: 3.093 ± 0.047	2.793GlyGln: 2.793 ± 0.049	5.495GlyArg: 5.495 ± 0.062	4.636GlySer: 4.636 ± 0.054	4.808GlyThr: 4.808 ± 0.063	5.797GlyVal: 5.797 ± 0.076	1.249GlyTrp: 1.249 ± 0.03	2.35GlyTyr: 2.35 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	2.292HisAla: 2.292 ± 0.042	0.234HisCys: 0.234 ± 0.013	1.269HisAsp: 1.269 ± 0.03	0.978HisGlu: 0.978 ± 0.028	0.935HisPhe: 0.935 ± 0.024	1.889HisGly: 1.889 ± 0.036	0.577HisHis: 0.577 ± 0.019	1.061HisIle: 1.061 ± 0.027	0.533HisLys: 0.533 ± 0.02	2.059HisLeu: 2.059 ± 0.042	0.562HisMet: 0.562 ± 0.02	0.454HisAsn: 0.454 ± 0.016	1.257HisPro: 1.257 ± 0.029	0.606HisGln: 0.606 ± 0.02	1.375HisArg: 1.375 ± 0.036	0.962HisSer: 0.962 ± 0.024	0.851HisThr: 0.851 ± 0.023	1.539HisVal: 1.539 ± 0.036	0.292HisTrp: 0.292 ± 0.012	0.546HisTyr: 0.546 ± 0.018	0.0HisXaa: 0.0 ± 0.0
Ile	8.116IleAla: 8.116 ± 0.083	0.617IleCys: 0.617 ± 0.021	4.084IleAsp: 4.084 ± 0.05	3.785IleGlu: 3.785 ± 0.052	1.976IlePhe: 1.976 ± 0.04	5.497IleGly: 5.497 ± 0.077	1.037IleHis: 1.037 ± 0.03	2.927IleIle: 2.927 ± 0.048	1.749IleLys: 1.749 ± 0.039	5.234IleLeu: 5.234 ± 0.063	1.133IleMet: 1.133 ± 0.028	1.69IleAsn: 1.69 ± 0.036	2.466IlePro: 2.466 ± 0.043	1.309IleGln: 1.309 ± 0.032	3.619IleArg: 3.619 ± 0.056	3.43IleSer: 3.43 ± 0.054	3.003IleThr: 3.003 ± 0.044	4.546IleVal: 4.546 ± 0.057	0.615IleTrp: 0.615 ± 0.02	1.242IleTyr: 1.242 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.821LysAla: 4.821 ± 0.071	0.165LysCys: 0.165 ± 0.01	2.032LysAsp: 2.032 ± 0.045	1.691LysGlu: 1.691 ± 0.043	1.005LysPhe: 1.005 ± 0.026	2.864LysGly: 2.864 ± 0.051	0.679LysHis: 0.679 ± 0.023	2.122LysIle: 2.122 ± 0.046	1.491LysLys: 1.491 ± 0.034	3.453LysLeu: 3.453 ± 0.046	0.952LysMet: 0.952 ± 0.027	1.042LysAsn: 1.042 ± 0.027	2.227LysPro: 2.227 ± 0.044	1.157LysGln: 1.157 ± 0.029	2.482LysArg: 2.482 ± 0.041	2.238LysSer: 2.238 ± 0.04	2.485LysThr: 2.485 ± 0.042	2.583LysVal: 2.583 ± 0.045	0.373LysTrp: 0.373 ± 0.015	0.663LysTyr: 0.663 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	12.461LeuAla: 12.461 ± 0.101	0.931LeuCys: 0.931 ± 0.026	5.987LeuAsp: 5.987 ± 0.061	5.264LeuGlu: 5.264 ± 0.066	3.879LeuPhe: 3.879 ± 0.058	7.836LeuGly: 7.836 ± 0.095	1.828LeuHis: 1.828 ± 0.039	5.259LeuIle: 5.259 ± 0.067	4.129LeuLys: 4.129 ± 0.058	9.295LeuLeu: 9.295 ± 0.094	2.527LeuMet: 2.527 ± 0.044	2.681LeuAsn: 2.681 ± 0.04	5.184LeuPro: 5.184 ± 0.062	2.908LeuGln: 2.908 ± 0.046	5.924LeuArg: 5.924 ± 0.074	7.254LeuSer: 7.254 ± 0.089	5.611LeuThr: 5.611 ± 0.073	7.385LeuVal: 7.385 ± 0.088	1.08LeuTrp: 1.08 ± 0.032	2.166LeuTyr: 2.166 ± 0.037	0.0LeuXaa: 0.0 ± 0.0
Met	3.362MetAla: 3.362 ± 0.054	0.137MetCys: 0.137 ± 0.01	1.273MetAsp: 1.273 ± 0.027	1.249MetGlu: 1.249 ± 0.028	0.78MetPhe: 0.78 ± 0.026	1.849MetGly: 1.849 ± 0.036	0.438MetHis: 0.438 ± 0.018	1.659MetIle: 1.659 ± 0.041	1.182MetLys: 1.182 ± 0.029	2.683MetLeu: 2.683 ± 0.047	0.803MetMet: 0.803 ± 0.024	0.899MetAsn: 0.899 ± 0.023	1.556MetPro: 1.556 ± 0.034	0.921MetGln: 0.921 ± 0.029	1.84MetArg: 1.84 ± 0.034	1.786MetSer: 1.786 ± 0.037	2.149MetThr: 2.149 ± 0.035	1.838MetVal: 1.838 ± 0.034	0.199MetTrp: 0.199 ± 0.012	0.329MetTyr: 0.329 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.376AsnAla: 3.376 ± 0.05	0.24AsnCys: 0.24 ± 0.014	1.656AsnAsp: 1.656 ± 0.034	1.367AsnGlu: 1.367 ± 0.031	1.031AsnPhe: 1.031 ± 0.025	2.593AsnGly: 2.593 ± 0.049	0.566AsnHis: 0.566 ± 0.02	1.593AsnIle: 1.593 ± 0.036	0.806AsnLys: 0.806 ± 0.027	2.742AsnLeu: 2.742 ± 0.046	0.704AsnMet: 0.704 ± 0.023	0.75AsnAsn: 0.75 ± 0.024	1.836AsnPro: 1.836 ± 0.033	0.809AsnGln: 0.809 ± 0.021	2.01AsnArg: 2.01 ± 0.039	1.387AsnSer: 1.387 ± 0.031	1.43AsnThr: 1.43 ± 0.033	1.97AsnVal: 1.97 ± 0.035	0.468AsnTrp: 0.468 ± 0.018	0.702AsnTyr: 0.702 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.391ProAla: 5.391 ± 0.077	0.3ProCys: 0.3 ± 0.014	3.59ProAsp: 3.59 ± 0.056	3.374ProGlu: 3.374 ± 0.057	2.03ProPhe: 2.03 ± 0.035	4.024ProGly: 4.024 ± 0.059	1.028ProHis: 1.028 ± 0.027	2.403ProIle: 2.403 ± 0.043	1.737ProLys: 1.737 ± 0.036	4.537ProLeu: 4.537 ± 0.055	1.242ProMet: 1.242 ± 0.025	1.225ProAsn: 1.225 ± 0.031	1.912ProPro: 1.912 ± 0.043	1.646ProGln: 1.646 ± 0.032	2.336ProArg: 2.336 ± 0.043	2.662ProSer: 2.662 ± 0.044	2.3ProThr: 2.3 ± 0.041	4.235ProVal: 4.235 ± 0.051	0.629ProTrp: 0.629 ± 0.025	1.145ProTyr: 1.145 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.052GlnAla: 4.052 ± 0.06	0.196GlnCys: 0.196 ± 0.012	1.527GlnAsp: 1.527 ± 0.033	1.471GlnGlu: 1.471 ± 0.029	1.118GlnPhe: 1.118 ± 0.026	2.257GlnGly: 2.257 ± 0.04	0.615GlnHis: 0.615 ± 0.02	1.968GlnIle: 1.968 ± 0.054	1.251GlnLys: 1.251 ± 0.03	2.726GlnLeu: 2.726 ± 0.051	1.036GlnMet: 1.036 ± 0.027	0.941GlnAsn: 0.941 ± 0.027	1.702GlnPro: 1.702 ± 0.038	1.236GlnGln: 1.236 ± 0.034	2.213GlnArg: 2.213 ± 0.042	2.022GlnSer: 2.022 ± 0.037	1.93GlnThr: 1.93 ± 0.036	2.126GlnVal: 2.126 ± 0.041	0.413GlnTrp: 0.413 ± 0.017	0.602GlnTyr: 0.602 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	6.759ArgAla: 6.759 ± 0.082	0.436ArgCys: 0.436 ± 0.02	3.874ArgAsp: 3.874 ± 0.06	3.546ArgGlu: 3.546 ± 0.054	2.887ArgPhe: 2.887 ± 0.042	4.25ArgGly: 4.25 ± 0.053	1.64ArgHis: 1.64 ± 0.034	4.195ArgIle: 4.195 ± 0.053	2.531ArgLys: 2.531 ± 0.045	7.206ArgLeu: 7.206 ± 0.077	1.916ArgMet: 1.916 ± 0.035	1.992ArgAsn: 1.992 ± 0.036	3.061ArgPro: 3.061 ± 0.046	2.552ArgGln: 2.552 ± 0.05	4.833ArgArg: 4.833 ± 0.067	3.703ArgSer: 3.703 ± 0.052	3.293ArgThr: 3.293 ± 0.047	4.085ArgVal: 4.085 ± 0.055	0.86ArgTrp: 0.86 ± 0.024	1.638ArgTyr: 1.638 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.43SerAla: 6.43 ± 0.082	0.417SerCys: 0.417 ± 0.018	3.353SerAsp: 3.353 ± 0.052	3.07SerGlu: 3.07 ± 0.048	2.471SerPhe: 2.471 ± 0.045	6.002SerGly: 6.002 ± 0.068	1.184SerHis: 1.184 ± 0.03	3.271SerIle: 3.271 ± 0.047	1.852SerLys: 1.852 ± 0.036	5.926SerLeu: 5.926 ± 0.073	1.534SerMet: 1.534 ± 0.032	1.546SerAsn: 1.546 ± 0.032	2.661SerPro: 2.661 ± 0.046	1.719SerGln: 1.719 ± 0.034	3.725SerArg: 3.725 ± 0.057	3.301SerSer: 3.301 ± 0.054	3.025SerThr: 3.025 ± 0.047	4.308SerVal: 4.308 ± 0.049	0.774SerTrp: 0.774 ± 0.022	1.371SerTyr: 1.371 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	6.549ThrAla: 6.549 ± 0.07	0.422ThrCys: 0.422 ± 0.019	3.075ThrAsp: 3.075 ± 0.05	2.801ThrGlu: 2.801 ± 0.044	2.188ThrPhe: 2.188 ± 0.035	5.39ThrGly: 5.39 ± 0.064	1.045ThrHis: 1.045 ± 0.026	3.463ThrIle: 3.463 ± 0.05	1.669ThrLys: 1.669 ± 0.033	5.946ThrLeu: 5.946 ± 0.061	1.35ThrMet: 1.35 ± 0.027	1.384ThrAsn: 1.384 ± 0.03	3.087ThrPro: 3.087 ± 0.045	1.586ThrGln: 1.586 ± 0.034	3.187ThrArg: 3.187 ± 0.051	3.07ThrSer: 3.07 ± 0.043	3.191ThrThr: 3.191 ± 0.051	4.634ThrVal: 4.634 ± 0.053	0.656ThrTrp: 0.656 ± 0.021	1.237ThrTyr: 1.237 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.512ValAla: 8.512 ± 0.078	0.645ValCys: 0.645 ± 0.023	4.097ValAsp: 4.097 ± 0.055	4.344ValGlu: 4.344 ± 0.058	2.985ValPhe: 2.985 ± 0.051	5.076ValGly: 5.076 ± 0.07	1.34ValHis: 1.34 ± 0.027	4.331ValIle: 4.331 ± 0.054	2.462ValLys: 2.462 ± 0.041	7.31ValLeu: 7.31 ± 0.082	1.947ValMet: 1.947 ± 0.037	2.072ValAsn: 2.072 ± 0.045	3.584ValPro: 3.584 ± 0.053	1.959ValGln: 1.959 ± 0.033	4.625ValArg: 4.625 ± 0.059	4.897ValSer: 4.897 ± 0.058	4.551ValThr: 4.551 ± 0.06	5.627ValVal: 5.627 ± 0.072	0.88ValTrp: 0.88 ± 0.024	1.545ValTyr: 1.545 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.184TrpAla: 1.184 ± 0.03	0.138TrpCys: 0.138 ± 0.01	0.617TrpAsp: 0.617 ± 0.023	0.533TrpGlu: 0.533 ± 0.019	0.548TrpPhe: 0.548 ± 0.021	0.785TrpGly: 0.785 ± 0.019	0.311TrpHis: 0.311 ± 0.015	0.7TrpIle: 0.7 ± 0.023	0.51TrpLys: 0.51 ± 0.018	1.537TrpLeu: 1.537 ± 0.041	0.367TrpMet: 0.367 ± 0.016	0.454TrpAsn: 0.454 ± 0.016	0.646TrpPro: 0.646 ± 0.023	0.596TrpGln: 0.596 ± 0.02	0.92TrpArg: 0.92 ± 0.027	0.826TrpSer: 0.826 ± 0.02	0.765TrpThr: 0.765 ± 0.025	0.74TrpVal: 0.74 ± 0.024	0.213TrpTrp: 0.213 ± 0.012	0.304TrpTyr: 0.304 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.482TyrAla: 2.482 ± 0.047	0.236TyrCys: 0.236 ± 0.012	1.506TyrAsp: 1.506 ± 0.033	1.211TyrGlu: 1.211 ± 0.03	0.978TyrPhe: 0.978 ± 0.026	2.107TyrGly: 2.107 ± 0.042	0.473TyrHis: 0.473 ± 0.019	1.073TyrIle: 1.073 ± 0.032	0.741TyrLys: 0.741 ± 0.024	2.239TyrLeu: 2.239 ± 0.042	0.487TyrMet: 0.487 ± 0.021	0.641TyrAsn: 0.641 ± 0.021	1.093TyrPro: 1.093 ± 0.027	0.741TyrGln: 0.741 ± 0.021	1.709TyrArg: 1.709 ± 0.039	1.25TyrSer: 1.25 ± 0.031	1.111TyrThr: 1.111 ± 0.027	1.605TyrVal: 1.605 ± 0.037	0.34TyrTrp: 0.34 ± 0.015	0.594TyrTyr: 0.594 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4832 proteins (1519063 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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