Amino acid dipepetide frequency for Thermomonospora umbrina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.078AlaAla: 20.078 ± 0.146	1.0AlaCys: 1.0 ± 0.026	8.285AlaAsp: 8.285 ± 0.075	8.793AlaGlu: 8.793 ± 0.088	3.608AlaPhe: 3.608 ± 0.044	12.94AlaGly: 12.94 ± 0.095	2.76AlaHis: 2.76 ± 0.042	3.869AlaIle: 3.869 ± 0.046	2.315AlaLys: 2.315 ± 0.042	14.367AlaLeu: 14.367 ± 0.108	2.591AlaMet: 2.591 ± 0.038	1.773AlaAsn: 1.773 ± 0.035	6.924AlaPro: 6.924 ± 0.071	3.197AlaGln: 3.197 ± 0.037	11.003AlaArg: 11.003 ± 0.09	5.418AlaSer: 5.418 ± 0.059	6.6AlaThr: 6.6 ± 0.063	11.94AlaVal: 11.94 ± 0.119	1.925AlaTrp: 1.925 ± 0.035	2.542AlaTyr: 2.542 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	1.021CysAla: 1.021 ± 0.022	0.105CysCys: 0.105 ± 0.007	0.534CysAsp: 0.534 ± 0.016	0.402CysGlu: 0.402 ± 0.014	0.228CysPhe: 0.228 ± 0.011	0.98CysGly: 0.98 ± 0.022	0.205CysHis: 0.205 ± 0.01	0.151CysIle: 0.151 ± 0.008	0.112CysLys: 0.112 ± 0.009	0.706CysLeu: 0.706 ± 0.018	0.129CysMet: 0.129 ± 0.008	0.132CysAsn: 0.132 ± 0.009	0.521CysPro: 0.521 ± 0.018	0.146CysGln: 0.146 ± 0.008	0.73CysArg: 0.73 ± 0.021	0.399CysSer: 0.399 ± 0.013	0.447CysThr: 0.447 ± 0.015	0.651CysVal: 0.651 ± 0.017	0.114CysTrp: 0.114 ± 0.007	0.155CysTyr: 0.155 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.548AspAla: 7.548 ± 0.069	0.412AspCys: 0.412 ± 0.016	4.166AspAsp: 4.166 ± 0.051	3.985AspGlu: 3.985 ± 0.048	1.513AspPhe: 1.513 ± 0.034	6.468AspGly: 6.468 ± 0.073	1.613AspHis: 1.613 ± 0.027	1.745AspIle: 1.745 ± 0.032	0.942AspLys: 0.942 ± 0.023	6.92AspLeu: 6.92 ± 0.057	0.873AspMet: 0.873 ± 0.022	0.852AspAsn: 0.852 ± 0.022	5.089AspPro: 5.089 ± 0.062	1.402AspGln: 1.402 ± 0.031	5.707AspArg: 5.707 ± 0.059	2.111AspSer: 2.111 ± 0.04	2.951AspThr: 2.951 ± 0.034	5.234AspVal: 5.234 ± 0.054	0.894AspTrp: 0.894 ± 0.024	1.034AspTyr: 1.034 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.239GluAla: 7.239 ± 0.082	0.4GluCys: 0.4 ± 0.014	2.889GluAsp: 2.889 ± 0.038	3.333GluGlu: 3.333 ± 0.055	1.439GluPhe: 1.439 ± 0.026	4.476GluGly: 4.476 ± 0.049	1.586GluHis: 1.586 ± 0.028	2.492GluIle: 2.492 ± 0.037	1.065GluLys: 1.065 ± 0.028	6.284GluLeu: 6.284 ± 0.074	0.96GluMet: 0.96 ± 0.022	0.891GluAsn: 0.891 ± 0.019	3.807GluPro: 3.807 ± 0.062	1.904GluGln: 1.904 ± 0.033	6.433GluArg: 6.433 ± 0.063	2.486GluSer: 2.486 ± 0.039	2.931GluThr: 2.931 ± 0.033	4.826GluVal: 4.826 ± 0.056	0.764GluTrp: 0.764 ± 0.022	1.082GluTyr: 1.082 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.63PheAla: 3.63 ± 0.046	0.277PheCys: 0.277 ± 0.011	1.892PheAsp: 1.892 ± 0.028	1.436PheGlu: 1.436 ± 0.028	0.786PhePhe: 0.786 ± 0.022	3.035PheGly: 3.035 ± 0.043	0.614PheHis: 0.614 ± 0.019	0.709PheIle: 0.709 ± 0.017	0.483PheLys: 0.483 ± 0.015	2.599PheLeu: 2.599 ± 0.039	0.407PheMet: 0.407 ± 0.014	0.527PheAsn: 0.527 ± 0.017	1.401PhePro: 1.401 ± 0.028	0.659PheGln: 0.659 ± 0.017	1.946PheArg: 1.946 ± 0.028	1.273PheSer: 1.273 ± 0.025	1.971PheThr: 1.971 ± 0.033	2.304PheVal: 2.304 ± 0.035	0.412PheTrp: 0.412 ± 0.013	0.558PheTyr: 0.558 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	10.731GlyAla: 10.731 ± 0.076	0.877GlyCys: 0.877 ± 0.021	5.793GlyAsp: 5.793 ± 0.057	5.231GlyGlu: 5.231 ± 0.058	2.833GlyPhe: 2.833 ± 0.037	9.718GlyGly: 9.718 ± 0.105	2.408GlyHis: 2.408 ± 0.035	3.079GlyIle: 3.079 ± 0.042	1.937GlyLys: 1.937 ± 0.034	10.052GlyLeu: 10.052 ± 0.073	1.998GlyMet: 1.998 ± 0.028	1.592GlyAsn: 1.592 ± 0.032	6.142GlyPro: 6.142 ± 0.064	2.318GlyGln: 2.318 ± 0.05	9.232GlyArg: 9.232 ± 0.068	4.9GlySer: 4.9 ± 0.06	5.743GlyThr: 5.743 ± 0.06	8.102GlyVal: 8.102 ± 0.078	1.715GlyTrp: 1.715 ± 0.031	2.083GlyTyr: 2.083 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.641HisAla: 2.641 ± 0.038	0.219HisCys: 0.219 ± 0.01	1.496HisAsp: 1.496 ± 0.027	1.178HisGlu: 1.178 ± 0.025	0.605HisPhe: 0.605 ± 0.018	2.491HisGly: 2.491 ± 0.037	0.701HisHis: 0.701 ± 0.021	0.609HisIle: 0.609 ± 0.017	0.296HisLys: 0.296 ± 0.012	2.473HisLeu: 2.473 ± 0.042	0.36HisMet: 0.36 ± 0.013	0.347HisAsn: 0.347 ± 0.013	1.775HisPro: 1.775 ± 0.029	0.554HisGln: 0.554 ± 0.017	2.342HisArg: 2.342 ± 0.034	0.911HisSer: 0.911 ± 0.026	1.112HisThr: 1.112 ± 0.025	1.785HisVal: 1.785 ± 0.028	0.386HisTrp: 0.386 ± 0.014	0.465HisTyr: 0.465 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.904IleAla: 4.904 ± 0.058	0.282IleCys: 0.282 ± 0.012	2.462IleAsp: 2.462 ± 0.039	2.177IleGlu: 2.177 ± 0.036	0.71IlePhe: 0.71 ± 0.017	3.565IleGly: 3.565 ± 0.046	0.577IleHis: 0.577 ± 0.016	1.022IleIle: 1.022 ± 0.025	0.721IleLys: 0.721 ± 0.021	2.473IleLeu: 2.473 ± 0.041	0.518IleMet: 0.518 ± 0.015	0.672IleAsn: 0.672 ± 0.02	1.834IlePro: 1.834 ± 0.03	0.716IleGln: 0.716 ± 0.02	2.526IleArg: 2.526 ± 0.041	1.612IleSer: 1.612 ± 0.026	2.284IleThr: 2.284 ± 0.038	3.069IleVal: 3.069 ± 0.04	0.377IleTrp: 0.377 ± 0.014	0.551IleTyr: 0.551 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.429LysAla: 2.429 ± 0.043	0.106LysCys: 0.106 ± 0.009	1.059LysAsp: 1.059 ± 0.027	0.976LysGlu: 0.976 ± 0.024	0.375LysPhe: 0.375 ± 0.014	1.648LysGly: 1.648 ± 0.037	0.339LysHis: 0.339 ± 0.011	0.815LysIle: 0.815 ± 0.024	0.545LysLys: 0.545 ± 0.021	1.485LysLeu: 1.485 ± 0.027	0.322LysMet: 0.322 ± 0.013	0.417LysAsn: 0.417 ± 0.015	1.138LysPro: 1.138 ± 0.027	0.467LysGln: 0.467 ± 0.017	1.375LysArg: 1.375 ± 0.028	0.93LysSer: 0.93 ± 0.025	1.105LysThr: 1.105 ± 0.027	1.764LysVal: 1.764 ± 0.035	0.231LysTrp: 0.231 ± 0.011	0.368LysTyr: 0.368 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.893LeuAla: 14.893 ± 0.124	0.79LeuCys: 0.79 ± 0.023	6.785LeuAsp: 6.785 ± 0.065	5.041LeuGlu: 5.041 ± 0.054	2.521LeuPhe: 2.521 ± 0.042	9.404LeuGly: 9.404 ± 0.069	2.136LeuHis: 2.136 ± 0.033	3.51LeuIle: 3.51 ± 0.045	1.735LeuLys: 1.735 ± 0.033	10.845LeuLeu: 10.845 ± 0.106	1.644LeuMet: 1.644 ± 0.029	1.783LeuAsn: 1.783 ± 0.031	6.381LeuPro: 6.381 ± 0.064	2.032LeuGln: 2.032 ± 0.036	9.473LeuArg: 9.473 ± 0.085	5.202LeuSer: 5.202 ± 0.054	6.736LeuThr: 6.736 ± 0.053	8.825LeuVal: 8.825 ± 0.08	1.35LeuTrp: 1.35 ± 0.027	1.739LeuTyr: 1.739 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.451MetAla: 2.451 ± 0.033	0.122MetCys: 0.122 ± 0.008	0.917MetAsp: 0.917 ± 0.023	0.807MetGlu: 0.807 ± 0.021	0.492MetPhe: 0.492 ± 0.015	1.412MetGly: 1.412 ± 0.029	0.338MetHis: 0.338 ± 0.012	0.747MetIle: 0.747 ± 0.021	0.387MetLys: 0.387 ± 0.016	1.835MetLeu: 1.835 ± 0.032	0.315MetMet: 0.315 ± 0.012	0.468MetAsn: 0.468 ± 0.017	1.176MetPro: 1.176 ± 0.024	0.401MetGln: 0.401 ± 0.014	1.629MetArg: 1.629 ± 0.031	1.331MetSer: 1.331 ± 0.024	1.611MetThr: 1.611 ± 0.029	1.405MetVal: 1.405 ± 0.027	0.2MetTrp: 0.2 ± 0.01	0.283MetTyr: 0.283 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.213AsnAla: 2.213 ± 0.04	0.159AsnCys: 0.159 ± 0.009	1.04AsnAsp: 1.04 ± 0.022	0.874AsnGlu: 0.874 ± 0.021	0.408AsnPhe: 0.408 ± 0.015	1.951AsnGly: 1.951 ± 0.042	0.352AsnHis: 0.352 ± 0.015	0.546AsnIle: 0.546 ± 0.018	0.328AsnLys: 0.328 ± 0.014	1.544AsnLeu: 1.544 ± 0.029	0.268AsnMet: 0.268 ± 0.011	0.337AsnAsn: 0.337 ± 0.014	1.281AsnPro: 1.281 ± 0.029	0.384AsnGln: 0.384 ± 0.016	1.226AsnArg: 1.226 ± 0.025	0.69AsnSer: 0.69 ± 0.02	1.023AsnThr: 1.023 ± 0.024	1.497AsnVal: 1.497 ± 0.027	0.247AsnTrp: 0.247 ± 0.011	0.334AsnTyr: 0.334 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	8.574ProAla: 8.574 ± 0.083	0.376ProCys: 0.376 ± 0.015	4.812ProAsp: 4.812 ± 0.056	4.539ProGlu: 4.539 ± 0.062	1.716ProPhe: 1.716 ± 0.032	7.32ProGly: 7.32 ± 0.083	1.41ProHis: 1.41 ± 0.031	1.699ProIle: 1.699 ± 0.027	1.1ProLys: 1.1 ± 0.026	5.312ProLeu: 5.312 ± 0.057	1.199ProMet: 1.199 ± 0.021	0.993ProAsn: 0.993 ± 0.024	4.859ProPro: 4.859 ± 0.084	1.684ProGln: 1.684 ± 0.035	4.608ProArg: 4.608 ± 0.061	3.543ProSer: 3.543 ± 0.053	3.514ProThr: 3.514 ± 0.053	5.428ProVal: 5.428 ± 0.058	0.98ProTrp: 0.98 ± 0.021	1.347ProTyr: 1.347 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.216GlnAla: 3.216 ± 0.045	0.156GlnCys: 0.156 ± 0.009	1.12GlnAsp: 1.12 ± 0.021	1.221GlnGlu: 1.221 ± 0.028	0.579GlnPhe: 0.579 ± 0.017	2.242GlnGly: 2.242 ± 0.044	0.506GlnHis: 0.506 ± 0.017	1.102GlnIle: 1.102 ± 0.024	0.435GlnLys: 0.435 ± 0.016	2.173GlnLeu: 2.173 ± 0.043	0.489GlnMet: 0.489 ± 0.017	0.462GlnAsn: 0.462 ± 0.017	1.526GlnPro: 1.526 ± 0.041	0.859GlnGln: 0.859 ± 0.029	2.351GlnArg: 2.351 ± 0.037	1.082GlnSer: 1.082 ± 0.024	1.271GlnThr: 1.271 ± 0.028	2.33GlnVal: 2.33 ± 0.032	0.413GlnTrp: 0.413 ± 0.014	0.476GlnTyr: 0.476 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.745ArgAla: 10.745 ± 0.096	0.707ArgCys: 0.707 ± 0.02	5.091ArgAsp: 5.091 ± 0.056	5.102ArgGlu: 5.102 ± 0.053	2.573ArgPhe: 2.573 ± 0.04	6.357ArgGly: 6.357 ± 0.056	2.389ArgHis: 2.389 ± 0.035	3.372ArgIle: 3.372 ± 0.039	1.46ArgLys: 1.46 ± 0.028	10.341ArgLeu: 10.341 ± 0.078	2.055ArgMet: 2.055 ± 0.033	1.441ArgAsn: 1.441 ± 0.029	6.252ArgPro: 6.252 ± 0.069	2.237ArgGln: 2.237 ± 0.033	10.08ArgArg: 10.08 ± 0.09	4.445ArgSer: 4.445 ± 0.047	5.276ArgThr: 5.276 ± 0.05	6.847ArgVal: 6.847 ± 0.053	1.617ArgTrp: 1.617 ± 0.028	1.917ArgTyr: 1.917 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.056SerAla: 6.056 ± 0.053	0.384SerCys: 0.384 ± 0.014	2.483SerAsp: 2.483 ± 0.04	2.264SerGlu: 2.264 ± 0.033	1.432SerPhe: 1.432 ± 0.028	5.663SerGly: 5.663 ± 0.064	0.966SerHis: 0.966 ± 0.023	1.437SerIle: 1.437 ± 0.027	0.864SerLys: 0.864 ± 0.024	4.608SerLeu: 4.608 ± 0.048	1.052SerMet: 1.052 ± 0.024	0.747SerAsn: 0.747 ± 0.023	3.419SerPro: 3.419 ± 0.058	1.053SerGln: 1.053 ± 0.025	3.98SerArg: 3.98 ± 0.045	2.469SerSer: 2.469 ± 0.045	2.715SerThr: 2.715 ± 0.045	3.913SerVal: 3.913 ± 0.043	0.867SerTrp: 0.867 ± 0.02	1.023SerTyr: 1.023 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	8.08ThrAla: 8.08 ± 0.074	0.429ThrCys: 0.429 ± 0.014	3.312ThrAsp: 3.312 ± 0.039	3.009ThrGlu: 3.009 ± 0.039	1.638ThrPhe: 1.638 ± 0.028	6.42ThrGly: 6.42 ± 0.063	1.128ThrHis: 1.128 ± 0.025	1.876ThrIle: 1.876 ± 0.036	0.973ThrLys: 0.973 ± 0.025	5.777ThrLeu: 5.777 ± 0.058	1.07ThrMet: 1.07 ± 0.023	0.896ThrAsn: 0.896 ± 0.022	4.118ThrPro: 4.118 ± 0.049	1.124ThrGln: 1.124 ± 0.028	4.411ThrArg: 4.411 ± 0.044	2.803ThrSer: 2.803 ± 0.038	3.569ThrThr: 3.569 ± 0.058	5.811ThrVal: 5.811 ± 0.064	0.943ThrTrp: 0.943 ± 0.025	1.16ThrTyr: 1.16 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	11.3ValAla: 11.3 ± 0.091	0.713ValCys: 0.713 ± 0.017	5.13ValAsp: 5.13 ± 0.051	4.911ValGlu: 4.911 ± 0.065	2.396ValPhe: 2.396 ± 0.036	7.092ValGly: 7.092 ± 0.069	1.928ValHis: 1.928 ± 0.032	3.278ValIle: 3.278 ± 0.045	1.574ValLys: 1.574 ± 0.035	9.285ValLeu: 9.285 ± 0.083	1.54ValMet: 1.54 ± 0.024	1.617ValAsn: 1.617 ± 0.031	5.518ValPro: 5.518 ± 0.049	1.918ValGln: 1.918 ± 0.03	7.703ValArg: 7.703 ± 0.066	4.075ValSer: 4.075 ± 0.047	5.679ValThr: 5.679 ± 0.068	8.176ValVal: 8.176 ± 0.084	1.157ValTrp: 1.157 ± 0.025	1.567ValTyr: 1.567 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.713TrpAla: 1.713 ± 0.034	0.158TrpCys: 0.158 ± 0.008	0.8TrpAsp: 0.8 ± 0.02	0.779TrpGlu: 0.779 ± 0.018	0.489TrpPhe: 0.489 ± 0.014	1.15TrpGly: 1.15 ± 0.027	0.401TrpHis: 0.401 ± 0.016	0.544TrpIle: 0.544 ± 0.016	0.305TrpLys: 0.305 ± 0.013	1.718TrpLeu: 1.718 ± 0.03	0.278TrpMet: 0.278 ± 0.011	0.386TrpAsn: 0.386 ± 0.013	0.862TrpPro: 0.862 ± 0.02	0.445TrpGln: 0.445 ± 0.014	1.668TrpArg: 1.668 ± 0.027	0.899TrpSer: 0.899 ± 0.022	0.977TrpThr: 0.977 ± 0.023	1.02TrpVal: 1.02 ± 0.023	0.375TrpTrp: 0.375 ± 0.013	0.325TrpTyr: 0.325 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.466TyrAla: 2.466 ± 0.034	0.198TyrCys: 0.198 ± 0.01	1.395TyrAsp: 1.395 ± 0.029	1.227TyrGlu: 1.227 ± 0.026	0.579TyrPhe: 0.579 ± 0.015	2.15TyrGly: 2.15 ± 0.04	0.387TyrHis: 0.387 ± 0.014	0.45TyrIle: 0.45 ± 0.013	0.318TyrLys: 0.318 ± 0.014	2.029TyrLeu: 2.029 ± 0.031	0.257TyrMet: 0.257 ± 0.011	0.37TyrAsn: 0.37 ± 0.014	0.991TyrPro: 0.991 ± 0.025	0.508TyrGln: 0.508 ± 0.017	1.879TyrArg: 1.879 ± 0.034	0.817TyrSer: 0.817 ± 0.02	1.035TyrThr: 1.035 ± 0.022	1.63TyrVal: 1.63 ± 0.029	0.324TyrTrp: 0.324 ± 0.012	0.379TyrTyr: 0.379 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6565 proteins (2119970 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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