Amino acid dipepetide frequency for Desulfovibrio carbinoliphilus subsp. oakridgensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.788AlaAla: 19.788 ± 0.248	1.755AlaCys: 1.755 ± 0.04	6.537AlaAsp: 6.537 ± 0.079	7.072AlaGlu: 7.072 ± 0.091	4.615AlaPhe: 4.615 ± 0.068	13.171AlaGly: 13.171 ± 0.139	1.975AlaHis: 1.975 ± 0.042	4.684AlaIle: 4.684 ± 0.067	4.572AlaLys: 4.572 ± 0.07	14.072AlaLeu: 14.072 ± 0.134	3.64AlaMet: 3.64 ± 0.054	2.467AlaAsn: 2.467 ± 0.051	6.311AlaPro: 6.311 ± 0.12	2.842AlaGln: 2.842 ± 0.05	9.13AlaArg: 9.13 ± 0.106	5.928AlaSer: 5.928 ± 0.076	6.087AlaThr: 6.087 ± 0.087	10.421AlaVal: 10.421 ± 0.116	1.465AlaTrp: 1.465 ± 0.042	2.761AlaTyr: 2.761 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.316CysAla: 1.316 ± 0.032	0.249CysCys: 0.249 ± 0.014	0.716CysAsp: 0.716 ± 0.025	0.503CysGlu: 0.503 ± 0.022	0.385CysPhe: 0.385 ± 0.019	1.456CysGly: 1.456 ± 0.042	0.366CysHis: 0.366 ± 0.024	0.511CysIle: 0.511 ± 0.021	0.322CysLys: 0.322 ± 0.019	1.624CysLeu: 1.624 ± 0.041	0.213CysMet: 0.213 ± 0.012	0.299CysAsn: 0.299 ± 0.014	0.993CysPro: 0.993 ± 0.031	0.402CysGln: 0.402 ± 0.018	1.204CysArg: 1.204 ± 0.034	0.573CysSer: 0.573 ± 0.022	0.444CysThr: 0.444 ± 0.019	0.831CysVal: 0.831 ± 0.027	0.118CysTrp: 0.118 ± 0.009	0.288CysTyr: 0.288 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	6.766AspAla: 6.766 ± 0.078	0.659AspCys: 0.659 ± 0.024	2.634AspAsp: 2.634 ± 0.044	2.866AspGlu: 2.866 ± 0.052	2.35AspPhe: 2.35 ± 0.048	4.729AspGly: 4.729 ± 0.078	1.051AspHis: 1.051 ± 0.028	3.065AspIle: 3.065 ± 0.061	2.01AspLys: 2.01 ± 0.049	6.024AspLeu: 6.024 ± 0.074	1.428AspMet: 1.428 ± 0.035	1.187AspAsn: 1.187 ± 0.034	3.612AspPro: 3.612 ± 0.068	1.435AspGln: 1.435 ± 0.037	4.155AspArg: 4.155 ± 0.058	1.921AspSer: 1.921 ± 0.042	2.595AspThr: 2.595 ± 0.054	4.075AspVal: 4.075 ± 0.059	0.737AspTrp: 0.737 ± 0.027	1.501AspTyr: 1.501 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	8.77GluAla: 8.77 ± 0.1	0.532GluCys: 0.532 ± 0.02	2.897GluAsp: 2.897 ± 0.056	3.59GluGlu: 3.59 ± 0.069	1.79GluPhe: 1.79 ± 0.039	3.942GluGly: 3.942 ± 0.054	1.035GluHis: 1.035 ± 0.034	2.952GluIle: 2.952 ± 0.05	2.94GluLys: 2.94 ± 0.054	5.8GluLeu: 5.8 ± 0.071	1.471GluMet: 1.471 ± 0.042	1.704GluAsn: 1.704 ± 0.04	2.664GluPro: 2.664 ± 0.063	1.735GluGln: 1.735 ± 0.043	4.362GluArg: 4.362 ± 0.073	2.49GluSer: 2.49 ± 0.044	3.344GluThr: 3.344 ± 0.06	3.887GluVal: 3.887 ± 0.065	0.474GluTrp: 0.474 ± 0.021	1.226GluTyr: 1.226 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.585PheAla: 4.585 ± 0.057	0.643PheCys: 0.643 ± 0.024	2.385PheAsp: 2.385 ± 0.044	2.115PheGlu: 2.115 ± 0.04	1.945PhePhe: 1.945 ± 0.051	3.406PheGly: 3.406 ± 0.056	0.736PheHis: 0.736 ± 0.028	1.389PheIle: 1.389 ± 0.038	1.186PheLys: 1.186 ± 0.032	4.559PheLeu: 4.559 ± 0.07	0.794PheMet: 0.794 ± 0.027	0.915PheAsn: 0.915 ± 0.027	1.921PhePro: 1.921 ± 0.038	0.924PheGln: 0.924 ± 0.032	2.276PheArg: 2.276 ± 0.044	2.427PheSer: 2.427 ± 0.044	2.222PheThr: 2.222 ± 0.05	2.733PheVal: 2.733 ± 0.044	0.519PheTrp: 0.519 ± 0.023	1.039PheTyr: 1.039 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.477GlyAla: 8.477 ± 0.117	1.32GlyCys: 1.32 ± 0.032	4.433GlyAsp: 4.433 ± 0.068	5.065GlyGlu: 5.065 ± 0.067	3.45GlyPhe: 3.45 ± 0.061	7.391GlyGly: 7.391 ± 0.098	1.984GlyHis: 1.984 ± 0.042	3.996GlyIle: 3.996 ± 0.069	3.774GlyLys: 3.774 ± 0.065	10.862GlyLeu: 10.862 ± 0.135	2.279GlyMet: 2.279 ± 0.045	2.045GlyAsn: 2.045 ± 0.038	4.501GlyPro: 4.501 ± 0.077	3.362GlyGln: 3.362 ± 0.053	7.332GlyArg: 7.332 ± 0.078	3.922GlySer: 3.922 ± 0.056	4.124GlyThr: 4.124 ± 0.07	6.113GlyVal: 6.113 ± 0.08	1.044GlyTrp: 1.044 ± 0.034	2.358GlyTyr: 2.358 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.959HisAla: 1.959 ± 0.044	0.305HisCys: 0.305 ± 0.015	1.133HisAsp: 1.133 ± 0.035	0.984HisGlu: 0.984 ± 0.031	0.896HisPhe: 0.896 ± 0.027	1.835HisGly: 1.835 ± 0.04	0.474HisHis: 0.474 ± 0.019	0.846HisIle: 0.846 ± 0.028	0.614HisLys: 0.614 ± 0.025	2.125HisLeu: 2.125 ± 0.039	0.377HisMet: 0.377 ± 0.018	0.436HisAsn: 0.436 ± 0.018	1.326HisPro: 1.326 ± 0.034	0.54HisGln: 0.54 ± 0.023	1.179HisArg: 1.179 ± 0.03	0.733HisSer: 0.733 ± 0.026	0.839HisThr: 0.839 ± 0.026	1.363HisVal: 1.363 ± 0.035	0.213HisTrp: 0.213 ± 0.013	0.527HisTyr: 0.527 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	4.297IleAla: 4.297 ± 0.069	0.496IleCys: 0.496 ± 0.021	2.429IleAsp: 2.429 ± 0.051	2.755IleGlu: 2.755 ± 0.054	1.63IlePhe: 1.63 ± 0.041	3.654IleGly: 3.654 ± 0.06	0.889IleHis: 0.889 ± 0.028	1.812IleIle: 1.812 ± 0.048	1.673IleLys: 1.673 ± 0.039	4.977IleLeu: 4.977 ± 0.066	0.994IleMet: 0.994 ± 0.033	1.289IleAsn: 1.289 ± 0.034	2.282IlePro: 2.282 ± 0.044	1.093IleGln: 1.093 ± 0.038	2.968IleArg: 2.968 ± 0.047	2.207IleSer: 2.207 ± 0.05	2.151IleThr: 2.151 ± 0.051	3.341IleVal: 3.341 ± 0.059	0.355IleTrp: 0.355 ± 0.016	0.94IleTyr: 0.94 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.806LysAla: 4.806 ± 0.074	0.308LysCys: 0.308 ± 0.018	2.126LysAsp: 2.126 ± 0.046	2.32LysGlu: 2.32 ± 0.047	1.096LysPhe: 1.096 ± 0.032	2.937LysGly: 2.937 ± 0.046	0.615LysHis: 0.615 ± 0.023	1.792LysIle: 1.792 ± 0.046	2.138LysLys: 2.138 ± 0.05	3.282LysLeu: 3.282 ± 0.054	0.904LysMet: 0.904 ± 0.024	1.3LysAsn: 1.3 ± 0.035	1.944LysPro: 1.944 ± 0.046	0.898LysGln: 0.898 ± 0.031	2.416LysArg: 2.416 ± 0.046	1.9LysSer: 1.9 ± 0.045	2.185LysThr: 2.185 ± 0.042	2.554LysVal: 2.554 ± 0.057	0.329LysTrp: 0.329 ± 0.018	0.834LysTyr: 0.834 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	18.144LeuAla: 18.144 ± 0.184	1.502LeuCys: 1.502 ± 0.039	6.434LeuAsp: 6.434 ± 0.075	6.053LeuGlu: 6.053 ± 0.075	4.417LeuPhe: 4.417 ± 0.067	9.836LeuGly: 9.836 ± 0.117	1.772LeuHis: 1.772 ± 0.043	3.461LeuIle: 3.461 ± 0.068	3.318LeuLys: 3.318 ± 0.054	11.531LeuLeu: 11.531 ± 0.148	1.92LeuMet: 1.92 ± 0.039	2.066LeuAsn: 2.066 ± 0.044	6.562LeuPro: 6.562 ± 0.088	2.195LeuGln: 2.195 ± 0.047	7.545LeuArg: 7.545 ± 0.095	6.631LeuSer: 6.631 ± 0.089	6.015LeuThr: 6.015 ± 0.076	8.193LeuVal: 8.193 ± 0.087	1.194LeuTrp: 1.194 ± 0.038	2.445LeuTyr: 2.445 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	3.504MetAla: 3.504 ± 0.054	0.196MetCys: 0.196 ± 0.012	1.468MetAsp: 1.468 ± 0.04	1.468MetGlu: 1.468 ± 0.035	0.629MetPhe: 0.629 ± 0.022	1.92MetGly: 1.92 ± 0.04	0.405MetHis: 0.405 ± 0.021	0.857MetIle: 0.857 ± 0.029	0.84MetLys: 0.84 ± 0.03	2.293MetLeu: 2.293 ± 0.048	0.431MetMet: 0.431 ± 0.021	0.56MetAsn: 0.56 ± 0.021	1.421MetPro: 1.421 ± 0.036	0.645MetGln: 0.645 ± 0.021	1.74MetArg: 1.74 ± 0.04	1.226MetSer: 1.226 ± 0.032	1.458MetThr: 1.458 ± 0.033	1.709MetVal: 1.709 ± 0.04	0.153MetTrp: 0.153 ± 0.012	0.348MetTyr: 0.348 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.62AsnAla: 2.62 ± 0.063	0.335AsnCys: 0.335 ± 0.017	1.157AsnAsp: 1.157 ± 0.029	1.043AsnGlu: 1.043 ± 0.034	0.933AsnPhe: 0.933 ± 0.033	1.742AsnGly: 1.742 ± 0.044	0.428AsnHis: 0.428 ± 0.02	1.372AsnIle: 1.372 ± 0.033	0.79AsnLys: 0.79 ± 0.028	2.778AsnLeu: 2.778 ± 0.048	0.638AsnMet: 0.638 ± 0.022	0.645AsnAsn: 0.645 ± 0.025	1.771AsnPro: 1.771 ± 0.041	0.682AsnGln: 0.682 ± 0.02	1.603AsnArg: 1.603 ± 0.037	0.973AsnSer: 0.973 ± 0.032	1.147AsnThr: 1.147 ± 0.036	1.7AsnVal: 1.7 ± 0.042	0.292AsnTrp: 0.292 ± 0.015	0.651AsnTyr: 0.651 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	8.068ProAla: 8.068 ± 0.151	0.617ProCys: 0.617 ± 0.021	4.172ProAsp: 4.172 ± 0.073	4.271ProGlu: 4.271 ± 0.077	2.084ProPhe: 2.084 ± 0.037	6.061ProGly: 6.061 ± 0.098	0.977ProHis: 0.977 ± 0.028	1.73ProIle: 1.73 ± 0.036	1.82ProLys: 1.82 ± 0.046	5.233ProLeu: 5.233 ± 0.071	1.175ProMet: 1.175 ± 0.027	0.982ProAsn: 0.982 ± 0.032	3.362ProPro: 3.362 ± 0.092	1.449ProGln: 1.449 ± 0.035	3.163ProArg: 3.163 ± 0.067	2.529ProSer: 2.529 ± 0.043	2.265ProThr: 2.265 ± 0.055	4.508ProVal: 4.508 ± 0.071	0.727ProTrp: 0.727 ± 0.025	1.257ProTyr: 1.257 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.473GlnAla: 4.473 ± 0.064	0.307GlnCys: 0.307 ± 0.018	1.299GlnAsp: 1.299 ± 0.036	1.693GlnGlu: 1.693 ± 0.043	0.864GlnPhe: 0.864 ± 0.029	2.477GlnGly: 2.477 ± 0.049	0.44GlnHis: 0.44 ± 0.022	1.261GlnIle: 1.261 ± 0.034	1.31GlnLys: 1.31 ± 0.033	2.088GlnLeu: 2.088 ± 0.049	0.665GlnMet: 0.665 ± 0.025	0.855GlnAsn: 0.855 ± 0.029	1.335GlnPro: 1.335 ± 0.041	0.813GlnGln: 0.813 ± 0.035	1.57GlnArg: 1.57 ± 0.037	1.465GlnSer: 1.465 ± 0.04	1.6GlnThr: 1.6 ± 0.041	2.038GlnVal: 2.038 ± 0.045	0.28GlnTrp: 0.28 ± 0.014	0.623GlnTyr: 0.623 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.137ArgAla: 7.137 ± 0.078	0.765ArgCys: 0.765 ± 0.027	4.063ArgAsp: 4.063 ± 0.06	5.164ArgGlu: 5.164 ± 0.076	3.091ArgPhe: 3.091 ± 0.05	4.572ArgGly: 4.572 ± 0.068	1.726ArgHis: 1.726 ± 0.038	3.582ArgIle: 3.582 ± 0.062	2.498ArgLys: 2.498 ± 0.047	9.47ArgLeu: 9.47 ± 0.104	1.66ArgMet: 1.66 ± 0.037	1.561ArgAsn: 1.561 ± 0.041	4.167ArgPro: 4.167 ± 0.07	2.983ArgGln: 2.983 ± 0.051	5.781ArgArg: 5.781 ± 0.094	2.877ArgSer: 2.877 ± 0.054	3.28ArgThr: 3.28 ± 0.054	4.787ArgVal: 4.787 ± 0.067	0.653ArgTrp: 0.653 ± 0.023	1.802ArgTyr: 1.802 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.59SerAla: 4.59 ± 0.068	0.609SerCys: 0.609 ± 0.024	2.382SerAsp: 2.382 ± 0.045	2.344SerGlu: 2.344 ± 0.05	1.953SerPhe: 1.953 ± 0.042	5.231SerGly: 5.231 ± 0.065	0.997SerHis: 0.997 ± 0.03	2.267SerIle: 2.267 ± 0.049	1.585SerLys: 1.585 ± 0.04	6.096SerLeu: 6.096 ± 0.074	1.242SerMet: 1.242 ± 0.029	0.981SerAsn: 0.981 ± 0.032	3.007SerPro: 3.007 ± 0.06	1.494SerGln: 1.494 ± 0.036	3.895SerArg: 3.895 ± 0.066	2.315SerSer: 2.315 ± 0.058	2.13SerThr: 2.13 ± 0.049	3.442SerVal: 3.442 ± 0.058	0.599SerTrp: 0.599 ± 0.023	1.075SerTyr: 1.075 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.235ThrAla: 6.235 ± 0.082	0.616ThrCys: 0.616 ± 0.025	2.719ThrAsp: 2.719 ± 0.053	2.431ThrGlu: 2.431 ± 0.044	1.88ThrPhe: 1.88 ± 0.037	5.21ThrGly: 5.21 ± 0.069	0.869ThrHis: 0.869 ± 0.027	2.213ThrIle: 2.213 ± 0.052	1.419ThrLys: 1.419 ± 0.041	5.853ThrLeu: 5.853 ± 0.072	1.107ThrMet: 1.107 ± 0.027	1.075ThrAsn: 1.075 ± 0.038	3.496ThrPro: 3.496 ± 0.063	1.127ThrGln: 1.127 ± 0.033	3.164ThrArg: 3.164 ± 0.056	2.27ThrSer: 2.27 ± 0.052	2.521ThrThr: 2.521 ± 0.055	4.395ThrVal: 4.395 ± 0.071	0.516ThrTrp: 0.516 ± 0.02	1.203ThrTyr: 1.203 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	10.088ValAla: 10.088 ± 0.108	1.089ValCys: 1.089 ± 0.029	3.813ValAsp: 3.813 ± 0.057	4.075ValGlu: 4.075 ± 0.067	3.172ValPhe: 3.172 ± 0.061	5.409ValGly: 5.409 ± 0.081	1.248ValHis: 1.248 ± 0.036	3.093ValIle: 3.093 ± 0.053	2.577ValLys: 2.577 ± 0.053	8.473ValLeu: 8.473 ± 0.092	1.611ValMet: 1.611 ± 0.033	1.947ValAsn: 1.947 ± 0.049	3.831ValPro: 3.831 ± 0.058	1.593ValGln: 1.593 ± 0.04	5.324ValArg: 5.324 ± 0.068	4.261ValSer: 4.261 ± 0.061	4.275ValThr: 4.275 ± 0.062	6.313ValVal: 6.313 ± 0.085	0.89ValTrp: 0.89 ± 0.026	1.687ValTyr: 1.687 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.948TrpAla: 0.948 ± 0.027	0.132TrpCys: 0.132 ± 0.01	0.574TrpAsp: 0.574 ± 0.022	0.565TrpGlu: 0.565 ± 0.021	0.441TrpPhe: 0.441 ± 0.018	0.784TrpGly: 0.784 ± 0.027	0.256TrpHis: 0.256 ± 0.015	0.488TrpIle: 0.488 ± 0.021	0.461TrpLys: 0.461 ± 0.021	1.407TrpLeu: 1.407 ± 0.037	0.3TrpMet: 0.3 ± 0.016	0.347TrpAsn: 0.347 ± 0.02	0.697TrpPro: 0.697 ± 0.028	0.452TrpGln: 0.452 ± 0.021	1.039TrpArg: 1.039 ± 0.034	0.517TrpSer: 0.517 ± 0.023	0.599TrpThr: 0.599 ± 0.023	0.638TrpVal: 0.638 ± 0.023	0.206TrpTrp: 0.206 ± 0.013	0.231TrpTyr: 0.231 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.723TyrAla: 2.723 ± 0.053	0.377TyrCys: 0.377 ± 0.018	1.427TyrAsp: 1.427 ± 0.04	1.23TyrGlu: 1.23 ± 0.033	1.097TyrPhe: 1.097 ± 0.036	2.07TyrGly: 2.07 ± 0.042	0.461TyrHis: 0.461 ± 0.02	0.862TyrIle: 0.862 ± 0.028	0.839TyrLys: 0.839 ± 0.029	2.687TyrLeu: 2.687 ± 0.058	0.419TyrMet: 0.419 ± 0.017	0.641TyrAsn: 0.641 ± 0.029	1.243TyrPro: 1.243 ± 0.03	0.791TyrGln: 0.791 ± 0.03	1.773TyrArg: 1.773 ± 0.04	1.07TyrSer: 1.07 ± 0.031	1.039TyrThr: 1.039 ± 0.036	1.728TyrVal: 1.728 ± 0.035	0.321TyrTrp: 0.321 ± 0.018	0.791TyrTyr: 0.791 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3713 proteins (1225608 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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