Amino acid dipepetide frequency for Lactococcus virus 712

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.9AlaAla: 0.9 ± 0.37
0.225AlaCys: 0.225 ± 0.163
3.039AlaAsp: 3.039 ± 0.552
4.502AlaGlu: 4.502 ± 0.774
3.152AlaPhe: 3.152 ± 0.715
3.827AlaGly: 3.827 ± 0.678
0.788AlaHis: 0.788 ± 0.393
4.39AlaIle: 4.39 ± 1.028
5.065AlaLys: 5.065 ± 0.821
6.754AlaLeu: 6.754 ± 0.849
1.801AlaMet: 1.801 ± 0.563
4.052AlaAsn: 4.052 ± 0.726
1.576AlaPro: 1.576 ± 0.414
1.801AlaGln: 1.801 ± 0.464
1.801AlaArg: 1.801 ± 0.387
3.152AlaSer: 3.152 ± 0.61
2.927AlaThr: 2.927 ± 0.71
4.39AlaVal: 4.39 ± 1.107
1.914AlaTrp: 1.914 ± 0.739
2.251AlaTyr: 2.251 ± 0.451
0.0AlaXaa: 0.0 ± 0.0
Cys
0.225CysAla: 0.225 ± 0.169
0.225CysCys: 0.225 ± 0.245
0.113CysAsp: 0.113 ± 0.135
0.45CysGlu: 0.45 ± 0.205
0.225CysPhe: 0.225 ± 0.176
0.9CysGly: 0.9 ± 0.359
0.225CysHis: 0.225 ± 0.184
0.225CysIle: 0.225 ± 0.172
0.675CysLys: 0.675 ± 0.301
0.563CysLeu: 0.563 ± 0.35
0.0CysMet: 0.0 ± 0.0
0.45CysAsn: 0.45 ± 0.235
0.113CysPro: 0.113 ± 0.12
0.225CysGln: 0.225 ± 0.159
0.563CysArg: 0.563 ± 0.255
0.45CysSer: 0.45 ± 0.238
0.338CysThr: 0.338 ± 0.195
0.45CysVal: 0.45 ± 0.213
0.225CysTrp: 0.225 ± 0.196
0.338CysTyr: 0.338 ± 0.206
0.0CysXaa: 0.0 ± 0.0
Asp
1.688AspAla: 1.688 ± 0.578
0.225AspCys: 0.225 ± 0.163
3.94AspAsp: 3.94 ± 0.961
3.602AspGlu: 3.602 ± 0.752
3.827AspPhe: 3.827 ± 0.512
4.165AspGly: 4.165 ± 0.926
0.788AspHis: 0.788 ± 0.309
3.827AspIle: 3.827 ± 0.784
6.191AspLys: 6.191 ± 0.658
6.191AspLeu: 6.191 ± 0.791
1.013AspMet: 1.013 ± 0.297
4.728AspAsn: 4.728 ± 0.829
1.351AspPro: 1.351 ± 0.46
0.788AspGln: 0.788 ± 0.343
2.251AspArg: 2.251 ± 0.565
2.701AspSer: 2.701 ± 0.588
4.953AspThr: 4.953 ± 0.651
3.602AspVal: 3.602 ± 0.685
1.238AspTrp: 1.238 ± 0.337
3.152AspTyr: 3.152 ± 0.616
0.0AspXaa: 0.0 ± 0.0
Glu
2.814GluAla: 2.814 ± 0.429
0.563GluCys: 0.563 ± 0.328
3.602GluAsp: 3.602 ± 0.532
6.303GluGlu: 6.303 ± 1.263
4.277GluPhe: 4.277 ± 0.564
2.364GluGly: 2.364 ± 0.474
1.463GluHis: 1.463 ± 0.522
5.741GluIle: 5.741 ± 1.032
6.641GluLys: 6.641 ± 1.057
9.568GluLeu: 9.568 ± 1.335
2.364GluMet: 2.364 ± 0.556
5.29GluAsn: 5.29 ± 0.786
1.463GluPro: 1.463 ± 0.351
3.039GluGln: 3.039 ± 0.711
2.364GluArg: 2.364 ± 0.465
3.827GluSer: 3.827 ± 0.625
4.728GluThr: 4.728 ± 0.812
4.615GluVal: 4.615 ± 0.782
0.788GluTrp: 0.788 ± 0.313
3.489GluTyr: 3.489 ± 0.823
0.0GluXaa: 0.0 ± 0.0
Phe
2.814PheAla: 2.814 ± 0.614
0.225PheCys: 0.225 ± 0.173
3.377PheAsp: 3.377 ± 0.595
2.139PheGlu: 2.139 ± 0.475
2.026PhePhe: 2.026 ± 0.72
2.364PheGly: 2.364 ± 0.707
0.338PheHis: 0.338 ± 0.25
2.701PheIle: 2.701 ± 0.673
4.502PheLys: 4.502 ± 0.703
3.264PheLeu: 3.264 ± 0.592
0.9PheMet: 0.9 ± 0.318
3.264PheAsn: 3.264 ± 0.687
0.675PhePro: 0.675 ± 0.354
1.238PheGln: 1.238 ± 0.321
1.576PheArg: 1.576 ± 0.33
4.502PheSer: 4.502 ± 0.862
3.039PheThr: 3.039 ± 0.491
2.814PheVal: 2.814 ± 0.521
0.45PheTrp: 0.45 ± 0.208
2.026PheTyr: 2.026 ± 0.488
0.0PheXaa: 0.0 ± 0.0
Gly
3.602GlyAla: 3.602 ± 1.264
0.338GlyCys: 0.338 ± 0.198
3.152GlyAsp: 3.152 ± 0.649
3.489GlyGlu: 3.489 ± 0.5
1.801GlyPhe: 1.801 ± 0.605
3.602GlyGly: 3.602 ± 0.881
1.013GlyHis: 1.013 ± 0.359
3.715GlyIle: 3.715 ± 1.187
5.853GlyLys: 5.853 ± 0.791
6.191GlyLeu: 6.191 ± 1.053
1.126GlyMet: 1.126 ± 0.398
3.377GlyAsn: 3.377 ± 0.562
0.225GlyPro: 0.225 ± 0.175
2.026GlyGln: 2.026 ± 0.461
2.251GlyArg: 2.251 ± 0.365
5.178GlySer: 5.178 ± 1.053
3.602GlyThr: 3.602 ± 0.984
5.628GlyVal: 5.628 ± 1.272
1.351GlyTrp: 1.351 ± 0.38
3.489GlyTyr: 3.489 ± 0.669
0.0GlyXaa: 0.0 ± 0.0
His
0.788HisAla: 0.788 ± 0.276
0.788HisCys: 0.788 ± 0.452
0.563HisAsp: 0.563 ± 0.284
0.675HisGlu: 0.675 ± 0.333
0.563HisPhe: 0.563 ± 0.233
1.463HisGly: 1.463 ± 0.404
0.113HisHis: 0.113 ± 0.089
1.013HisIle: 1.013 ± 0.397
1.013HisLys: 1.013 ± 0.31
1.013HisLeu: 1.013 ± 0.394
0.338HisMet: 0.338 ± 0.198
0.9HisAsn: 0.9 ± 0.324
0.113HisPro: 0.113 ± 0.101
0.225HisGln: 0.225 ± 0.183
0.338HisArg: 0.338 ± 0.219
0.225HisSer: 0.225 ± 0.169
0.788HisThr: 0.788 ± 0.317
0.788HisVal: 0.788 ± 0.313
0.225HisTrp: 0.225 ± 0.147
0.675HisTyr: 0.675 ± 0.346
0.0HisXaa: 0.0 ± 0.0
Ile
4.84IleAla: 4.84 ± 0.638
0.338IleCys: 0.338 ± 0.229
4.165IleAsp: 4.165 ± 0.649
6.529IleGlu: 6.529 ± 1.007
2.814IlePhe: 2.814 ± 0.595
3.489IleGly: 3.489 ± 1.014
0.788IleHis: 0.788 ± 0.305
4.502IleIle: 4.502 ± 0.71
6.979IleLys: 6.979 ± 1.017
5.065IleLeu: 5.065 ± 0.989
1.463IleMet: 1.463 ± 0.459
4.39IleAsn: 4.39 ± 0.648
1.351IlePro: 1.351 ± 0.401
2.251IleGln: 2.251 ± 0.429
2.251IleArg: 2.251 ± 0.46
3.94IleSer: 3.94 ± 0.616
4.953IleThr: 4.953 ± 0.708
4.84IleVal: 4.84 ± 0.814
1.463IleTrp: 1.463 ± 0.435
2.476IleTyr: 2.476 ± 0.516
0.0IleXaa: 0.0 ± 0.0
Lys
7.542LysAla: 7.542 ± 1.053
0.45LysCys: 0.45 ± 0.213
4.84LysAsp: 4.84 ± 0.613
9.23LysGlu: 9.23 ± 1.505
2.476LysPhe: 2.476 ± 0.514
5.516LysGly: 5.516 ± 1.073
0.788LysHis: 0.788 ± 0.308
5.966LysIle: 5.966 ± 0.755
9.343LysLys: 9.343 ± 1.235
6.866LysLeu: 6.866 ± 0.95
3.489LysMet: 3.489 ± 0.579
4.052LysAsn: 4.052 ± 0.674
1.688LysPro: 1.688 ± 0.461
3.715LysGln: 3.715 ± 0.775
4.165LysArg: 4.165 ± 0.798
5.29LysSer: 5.29 ± 0.871
5.065LysThr: 5.065 ± 0.668
6.641LysVal: 6.641 ± 0.666
1.914LysTrp: 1.914 ± 0.371
3.152LysTyr: 3.152 ± 0.78
0.0LysXaa: 0.0 ± 0.0
Leu
3.715LeuAla: 3.715 ± 0.582
0.338LeuCys: 0.338 ± 0.198
5.628LeuAsp: 5.628 ± 0.741
5.853LeuGlu: 5.853 ± 0.736
3.602LeuPhe: 3.602 ± 0.77
3.94LeuGly: 3.94 ± 0.8
1.238LeuHis: 1.238 ± 0.423
6.866LeuIle: 6.866 ± 0.997
8.104LeuLys: 8.104 ± 0.847
6.529LeuLeu: 6.529 ± 1.107
1.914LeuMet: 1.914 ± 0.615
5.741LeuAsn: 5.741 ± 0.747
2.814LeuPro: 2.814 ± 0.449
3.152LeuGln: 3.152 ± 0.565
3.152LeuArg: 3.152 ± 0.648
5.29LeuSer: 5.29 ± 0.71
6.303LeuThr: 6.303 ± 0.864
5.29LeuVal: 5.29 ± 0.703
1.463LeuTrp: 1.463 ± 0.388
4.502LeuTyr: 4.502 ± 0.869
0.0LeuXaa: 0.0 ± 0.0
Met
2.139MetAla: 2.139 ± 0.546
0.0MetCys: 0.0 ± 0.0
1.801MetAsp: 1.801 ± 0.539
2.927MetGlu: 2.927 ± 0.639
0.45MetPhe: 0.45 ± 0.242
0.788MetGly: 0.788 ± 0.307
0.338MetHis: 0.338 ± 0.189
1.914MetIle: 1.914 ± 0.538
2.364MetLys: 2.364 ± 0.484
1.914MetLeu: 1.914 ± 0.57
0.338MetMet: 0.338 ± 0.214
2.026MetAsn: 2.026 ± 0.495
0.788MetPro: 0.788 ± 0.306
1.688MetGln: 1.688 ± 0.477
0.45MetArg: 0.45 ± 0.206
1.351MetSer: 1.351 ± 0.397
1.576MetThr: 1.576 ± 0.456
1.351MetVal: 1.351 ± 0.303
0.338MetTrp: 0.338 ± 0.195
1.463MetTyr: 1.463 ± 0.405
0.0MetXaa: 0.0 ± 0.0
Asn
4.728AsnAla: 4.728 ± 1.203
0.225AsnCys: 0.225 ± 0.186
4.165AsnAsp: 4.165 ± 0.621
4.277AsnGlu: 4.277 ± 0.744
1.914AsnPhe: 1.914 ± 0.497
5.966AsnGly: 5.966 ± 0.946
0.563AsnHis: 0.563 ± 0.203
4.728AsnIle: 4.728 ± 0.648
5.628AsnLys: 5.628 ± 1.122
5.741AsnLeu: 5.741 ± 1.022
1.801AsnMet: 1.801 ± 0.432
3.377AsnAsn: 3.377 ± 0.59
2.026AsnPro: 2.026 ± 0.458
2.026AsnGln: 2.026 ± 0.494
2.139AsnArg: 2.139 ± 0.371
4.502AsnSer: 4.502 ± 0.726
3.827AsnThr: 3.827 ± 0.659
3.489AsnVal: 3.489 ± 0.698
1.126AsnTrp: 1.126 ± 0.353
2.251AsnTyr: 2.251 ± 0.542
0.0AsnXaa: 0.0 ± 0.0
Pro
1.914ProAla: 1.914 ± 0.467
0.113ProCys: 0.113 ± 0.117
1.463ProAsp: 1.463 ± 0.401
1.463ProGlu: 1.463 ± 0.47
1.126ProPhe: 1.126 ± 0.346
0.0ProGly: 0.0 ± 0.0
0.225ProHis: 0.225 ± 0.147
1.351ProIle: 1.351 ± 0.404
1.914ProLys: 1.914 ± 0.374
1.801ProLeu: 1.801 ± 0.383
0.563ProMet: 0.563 ± 0.246
2.476ProAsn: 2.476 ± 0.668
0.45ProPro: 0.45 ± 0.25
0.563ProGln: 0.563 ± 0.27
0.563ProArg: 0.563 ± 0.242
1.351ProSer: 1.351 ± 0.557
1.914ProThr: 1.914 ± 0.453
1.463ProVal: 1.463 ± 0.443
0.225ProTrp: 0.225 ± 0.183
0.9ProTyr: 0.9 ± 0.279
0.0ProXaa: 0.0 ± 0.0
Gln
3.377GlnAla: 3.377 ± 0.863
0.225GlnCys: 0.225 ± 0.166
2.026GlnAsp: 2.026 ± 0.59
2.139GlnGlu: 2.139 ± 0.54
1.126GlnPhe: 1.126 ± 0.331
2.476GlnGly: 2.476 ± 0.523
0.225GlnHis: 0.225 ± 0.163
1.801GlnIle: 1.801 ± 0.439
2.251GlnLys: 2.251 ± 0.555
3.152GlnLeu: 3.152 ± 0.676
1.238GlnMet: 1.238 ± 0.301
2.026GlnAsn: 2.026 ± 0.436
0.9GlnPro: 0.9 ± 0.337
1.351GlnGln: 1.351 ± 0.416
1.351GlnArg: 1.351 ± 0.419
2.251GlnSer: 2.251 ± 0.492
2.589GlnThr: 2.589 ± 0.518
1.801GlnVal: 1.801 ± 0.38
0.675GlnTrp: 0.675 ± 0.301
0.788GlnTyr: 0.788 ± 0.286
0.0GlnXaa: 0.0 ± 0.0
Arg
2.251ArgAla: 2.251 ± 0.551
0.563ArgCys: 0.563 ± 0.275
2.139ArgAsp: 2.139 ± 0.5
2.476ArgGlu: 2.476 ± 0.549
1.238ArgPhe: 1.238 ± 0.334
2.026ArgGly: 2.026 ± 0.438
0.9ArgHis: 0.9 ± 0.268
2.476ArgIle: 2.476 ± 0.478
4.277ArgLys: 4.277 ± 0.82
3.152ArgLeu: 3.152 ± 0.498
0.675ArgMet: 0.675 ± 0.336
2.026ArgAsn: 2.026 ± 0.522
0.675ArgPro: 0.675 ± 0.253
1.463ArgGln: 1.463 ± 0.359
1.801ArgArg: 1.801 ± 0.479
1.688ArgSer: 1.688 ± 0.388
1.801ArgThr: 1.801 ± 0.431
1.914ArgVal: 1.914 ± 0.488
0.45ArgTrp: 0.45 ± 0.225
1.914ArgTyr: 1.914 ± 0.547
0.0ArgXaa: 0.0 ± 0.0
Ser
4.615SerAla: 4.615 ± 1.286
0.788SerCys: 0.788 ± 0.37
3.827SerAsp: 3.827 ± 0.711
3.827SerGlu: 3.827 ± 0.577
3.489SerPhe: 3.489 ± 0.587
6.078SerGly: 6.078 ± 1.436
0.563SerHis: 0.563 ± 0.248
4.277SerIle: 4.277 ± 0.758
4.84SerLys: 4.84 ± 0.809
4.39SerLeu: 4.39 ± 0.618
2.026SerMet: 2.026 ± 0.413
3.715SerAsn: 3.715 ± 0.634
1.351SerPro: 1.351 ± 0.385
1.801SerGln: 1.801 ± 0.453
2.026SerArg: 2.026 ± 0.396
5.065SerSer: 5.065 ± 0.941
3.152SerThr: 3.152 ± 0.497
4.277SerVal: 4.277 ± 0.664
1.013SerTrp: 1.013 ± 0.307
2.251SerTyr: 2.251 ± 0.597
0.0SerXaa: 0.0 ± 0.0
Thr
4.84ThrAla: 4.84 ± 0.827
0.225ThrCys: 0.225 ± 0.16
4.277ThrAsp: 4.277 ± 0.896
5.178ThrGlu: 5.178 ± 0.751
3.489ThrPhe: 3.489 ± 0.791
4.615ThrGly: 4.615 ± 0.794
0.225ThrHis: 0.225 ± 0.18
3.827ThrIle: 3.827 ± 0.666
4.728ThrLys: 4.728 ± 0.611
5.29ThrLeu: 5.29 ± 0.673
0.788ThrMet: 0.788 ± 0.277
4.277ThrAsn: 4.277 ± 0.732
1.914ThrPro: 1.914 ± 0.392
2.364ThrGln: 2.364 ± 0.5
1.914ThrArg: 1.914 ± 0.455
4.165ThrSer: 4.165 ± 0.797
3.94ThrThr: 3.94 ± 0.782
4.84ThrVal: 4.84 ± 0.832
1.126ThrTrp: 1.126 ± 0.392
2.251ThrTyr: 2.251 ± 0.548
0.0ThrXaa: 0.0 ± 0.0
Val
3.377ValAla: 3.377 ± 0.54
0.45ValCys: 0.45 ± 0.243
4.615ValAsp: 4.615 ± 0.738
5.29ValGlu: 5.29 ± 0.74
3.264ValPhe: 3.264 ± 0.706
3.715ValGly: 3.715 ± 0.644
0.788ValHis: 0.788 ± 0.308
4.615ValIle: 4.615 ± 0.582
7.091ValLys: 7.091 ± 0.755
3.377ValLeu: 3.377 ± 0.516
2.026ValMet: 2.026 ± 0.442
2.814ValAsn: 2.814 ± 0.574
1.238ValPro: 1.238 ± 0.391
1.576ValGln: 1.576 ± 0.427
3.152ValArg: 3.152 ± 0.787
5.29ValSer: 5.29 ± 1.409
5.29ValThr: 5.29 ± 0.821
3.489ValVal: 3.489 ± 0.612
0.563ValTrp: 0.563 ± 0.221
2.927ValTyr: 2.927 ± 0.485
0.0ValXaa: 0.0 ± 0.0
Trp
0.788TrpAla: 0.788 ± 0.244
0.338TrpCys: 0.338 ± 0.2
0.9TrpAsp: 0.9 ± 0.453
1.013TrpGlu: 1.013 ± 0.312
0.9TrpPhe: 0.9 ± 0.405
1.576TrpGly: 1.576 ± 0.456
0.338TrpHis: 0.338 ± 0.207
0.9TrpIle: 0.9 ± 0.298
0.9TrpLys: 0.9 ± 0.304
1.238TrpLeu: 1.238 ± 0.325
0.338TrpMet: 0.338 ± 0.221
2.251TrpAsn: 2.251 ± 0.717
0.0TrpPro: 0.0 ± 0.0
1.013TrpGln: 1.013 ± 0.27
0.563TrpArg: 0.563 ± 0.295
1.238TrpSer: 1.238 ± 0.338
1.013TrpThr: 1.013 ± 0.326
0.675TrpVal: 0.675 ± 0.363
0.225TrpTrp: 0.225 ± 0.145
0.9TrpTyr: 0.9 ± 0.305
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.351TyrAla: 1.351 ± 0.475
0.338TyrCys: 0.338 ± 0.267
2.589TyrAsp: 2.589 ± 0.705
3.94TyrGlu: 3.94 ± 0.709
2.476TyrPhe: 2.476 ± 0.465
2.139TyrGly: 2.139 ± 0.422
0.9TyrHis: 0.9 ± 0.301
4.052TyrIle: 4.052 ± 0.819
3.94TyrLys: 3.94 ± 0.822
3.377TyrLeu: 3.377 ± 0.703
1.688TyrMet: 1.688 ± 0.39
3.264TyrAsn: 3.264 ± 0.537
1.126TyrPro: 1.126 ± 0.439
1.463TyrGln: 1.463 ± 0.571
1.238TyrArg: 1.238 ± 0.402
1.914TyrSer: 1.914 ± 0.407
2.476TyrThr: 2.476 ± 0.764
2.589TyrVal: 2.589 ± 0.572
0.338TyrTrp: 0.338 ± 0.198
1.914TyrTyr: 1.914 ± 0.6
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (8885 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski