Amino acid dipepetide frequency for Vibrio phage ICP2_2013_A_Haiti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.571AlaAla: 7.571 ± 1.06
0.655AlaCys: 0.655 ± 0.295
4.95AlaAsp: 4.95 ± 0.517
5.46AlaGlu: 5.46 ± 0.807
2.111AlaPhe: 2.111 ± 0.363
5.97AlaGly: 5.97 ± 1.004
0.874AlaHis: 0.874 ± 0.206
4.077AlaIle: 4.077 ± 0.563
4.514AlaLys: 4.514 ± 0.665
6.188AlaLeu: 6.188 ± 0.859
2.912AlaMet: 2.912 ± 0.548
3.713AlaAsn: 3.713 ± 0.565
3.058AlaPro: 3.058 ± 0.498
3.203AlaGln: 3.203 ± 0.454
3.931AlaArg: 3.931 ± 0.523
4.222AlaSer: 4.222 ± 0.686
5.824AlaThr: 5.824 ± 0.617
5.533AlaVal: 5.533 ± 0.671
1.238AlaTrp: 1.238 ± 0.295
3.567AlaTyr: 3.567 ± 0.524
0.0AlaXaa: 0.0 ± 0.0
Cys
0.437CysAla: 0.437 ± 0.223
0.073CysCys: 0.073 ± 0.077
0.51CysAsp: 0.51 ± 0.206
0.728CysGlu: 0.728 ± 0.287
0.218CysPhe: 0.218 ± 0.145
0.728CysGly: 0.728 ± 0.216
0.218CysHis: 0.218 ± 0.162
0.582CysIle: 0.582 ± 0.209
0.728CysLys: 0.728 ± 0.207
0.874CysLeu: 0.874 ± 0.271
0.218CysMet: 0.218 ± 0.153
0.291CysAsn: 0.291 ± 0.17
0.218CysPro: 0.218 ± 0.139
0.146CysGln: 0.146 ± 0.102
0.437CysArg: 0.437 ± 0.219
0.364CysSer: 0.364 ± 0.167
0.51CysThr: 0.51 ± 0.209
0.874CysVal: 0.874 ± 0.237
0.073CysTrp: 0.073 ± 0.076
0.801CysTyr: 0.801 ± 0.287
0.0CysXaa: 0.0 ± 0.0
Asp
5.169AspAla: 5.169 ± 0.821
1.165AspCys: 1.165 ± 0.334
3.931AspAsp: 3.931 ± 0.483
4.368AspGlu: 4.368 ± 0.584
2.038AspPhe: 2.038 ± 0.419
5.315AspGly: 5.315 ± 0.672
1.019AspHis: 1.019 ± 0.27
3.786AspIle: 3.786 ± 0.656
4.659AspLys: 4.659 ± 0.574
4.077AspLeu: 4.077 ± 0.54
1.82AspMet: 1.82 ± 0.363
2.912AspAsn: 2.912 ± 0.463
2.912AspPro: 2.912 ± 0.381
1.747AspGln: 1.747 ± 0.293
2.621AspArg: 2.621 ± 0.465
3.786AspSer: 3.786 ± 0.54
3.931AspThr: 3.931 ± 0.418
5.169AspVal: 5.169 ± 0.617
1.165AspTrp: 1.165 ± 0.356
2.766AspTyr: 2.766 ± 0.417
0.0AspXaa: 0.0 ± 0.0
Glu
5.606GluAla: 5.606 ± 0.686
1.019GluCys: 1.019 ± 0.335
4.586GluAsp: 4.586 ± 0.7
5.97GluGlu: 5.97 ± 0.853
3.567GluPhe: 3.567 ± 0.405
5.023GluGly: 5.023 ± 0.728
0.874GluHis: 0.874 ± 0.199
3.786GluIle: 3.786 ± 0.523
3.858GluLys: 3.858 ± 0.56
4.878GluLeu: 4.878 ± 0.513
2.33GluMet: 2.33 ± 0.429
3.058GluAsn: 3.058 ± 0.424
1.456GluPro: 1.456 ± 0.31
3.422GluGln: 3.422 ± 0.56
3.349GluArg: 3.349 ± 0.548
4.295GluSer: 4.295 ± 0.453
2.839GluThr: 2.839 ± 0.476
4.95GluVal: 4.95 ± 0.589
1.019GluTrp: 1.019 ± 0.262
2.694GluTyr: 2.694 ± 0.419
0.0GluXaa: 0.0 ± 0.0
Phe
3.349PheAla: 3.349 ± 0.517
0.291PheCys: 0.291 ± 0.123
2.839PheAsp: 2.839 ± 0.388
2.184PheGlu: 2.184 ± 0.345
1.456PhePhe: 1.456 ± 0.322
2.766PheGly: 2.766 ± 0.438
0.582PheHis: 0.582 ± 0.192
2.33PheIle: 2.33 ± 0.575
2.985PheLys: 2.985 ± 0.432
2.184PheLeu: 2.184 ± 0.371
1.165PheMet: 1.165 ± 0.302
1.456PheAsn: 1.456 ± 0.301
1.456PhePro: 1.456 ± 0.374
1.747PheGln: 1.747 ± 0.428
1.966PheArg: 1.966 ± 0.365
2.766PheSer: 2.766 ± 0.525
2.257PheThr: 2.257 ± 0.444
2.621PheVal: 2.621 ± 0.384
0.437PheTrp: 0.437 ± 0.151
1.383PheTyr: 1.383 ± 0.367
0.0PheXaa: 0.0 ± 0.0
Gly
5.096GlyAla: 5.096 ± 0.689
0.655GlyCys: 0.655 ± 0.258
5.096GlyAsp: 5.096 ± 0.709
5.387GlyGlu: 5.387 ± 0.602
3.058GlyPhe: 3.058 ± 0.439
7.062GlyGly: 7.062 ± 1.535
0.946GlyHis: 0.946 ± 0.248
4.441GlyIle: 4.441 ± 0.715
4.368GlyLys: 4.368 ± 0.618
5.315GlyLeu: 5.315 ± 0.547
1.966GlyMet: 1.966 ± 0.422
3.349GlyAsn: 3.349 ± 0.586
4.077GlyPro: 4.077 ± 3.081
2.694GlyGln: 2.694 ± 0.48
3.422GlyArg: 3.422 ± 0.467
5.169GlySer: 5.169 ± 0.832
5.606GlyThr: 5.606 ± 0.868
5.315GlyVal: 5.315 ± 0.7
1.165GlyTrp: 1.165 ± 0.291
3.422GlyTyr: 3.422 ± 0.448
0.0GlyXaa: 0.0 ± 0.0
His
0.582HisAla: 0.582 ± 0.208
0.291HisCys: 0.291 ± 0.174
0.655HisAsp: 0.655 ± 0.179
1.31HisGlu: 1.31 ± 0.285
0.946HisPhe: 0.946 ± 0.194
0.801HisGly: 0.801 ± 0.254
0.291HisHis: 0.291 ± 0.153
0.582HisIle: 0.582 ± 0.191
0.946HisLys: 0.946 ± 0.353
0.874HisLeu: 0.874 ± 0.265
0.582HisMet: 0.582 ± 0.191
0.728HisAsn: 0.728 ± 0.244
1.019HisPro: 1.019 ± 0.349
0.437HisGln: 0.437 ± 0.164
0.728HisArg: 0.728 ± 0.224
1.456HisSer: 1.456 ± 0.372
0.874HisThr: 0.874 ± 0.253
0.874HisVal: 0.874 ± 0.234
0.146HisTrp: 0.146 ± 0.11
0.218HisTyr: 0.218 ± 0.133
0.0HisXaa: 0.0 ± 0.0
Ile
3.858IleAla: 3.858 ± 0.598
0.146IleCys: 0.146 ± 0.1
4.077IleAsp: 4.077 ± 0.599
3.276IleGlu: 3.276 ± 0.456
1.674IlePhe: 1.674 ± 0.299
4.15IleGly: 4.15 ± 0.533
0.728IleHis: 0.728 ± 0.218
3.422IleIle: 3.422 ± 0.462
3.567IleLys: 3.567 ± 0.504
3.203IleLeu: 3.203 ± 0.487
1.31IleMet: 1.31 ± 0.308
3.64IleAsn: 3.64 ± 0.468
2.184IlePro: 2.184 ± 0.364
3.058IleGln: 3.058 ± 0.623
3.276IleArg: 3.276 ± 0.471
4.004IleSer: 4.004 ± 0.575
3.64IleThr: 3.64 ± 0.636
3.858IleVal: 3.858 ± 0.537
0.655IleTrp: 0.655 ± 0.194
1.674IleTyr: 1.674 ± 0.389
0.0IleXaa: 0.0 ± 0.0
Lys
6.407LysAla: 6.407 ± 0.947
0.291LysCys: 0.291 ± 0.166
4.222LysAsp: 4.222 ± 0.507
4.441LysGlu: 4.441 ± 0.544
2.839LysPhe: 2.839 ± 0.506
4.95LysGly: 4.95 ± 0.626
0.946LysHis: 0.946 ± 0.196
4.15LysIle: 4.15 ± 0.497
2.766LysLys: 2.766 ± 0.64
4.732LysLeu: 4.732 ± 0.625
0.946LysMet: 0.946 ± 0.285
1.893LysAsn: 1.893 ± 0.392
1.82LysPro: 1.82 ± 0.46
2.694LysGln: 2.694 ± 0.432
2.985LysArg: 2.985 ± 0.586
3.422LysSer: 3.422 ± 0.506
3.494LysThr: 3.494 ± 0.523
5.315LysVal: 5.315 ± 0.614
1.019LysTrp: 1.019 ± 0.279
2.985LysTyr: 2.985 ± 0.455
0.0LysXaa: 0.0 ± 0.0
Leu
6.407LeuAla: 6.407 ± 0.749
0.655LeuCys: 0.655 ± 0.277
4.878LeuAsp: 4.878 ± 0.539
6.261LeuGlu: 6.261 ± 0.566
2.257LeuPhe: 2.257 ± 0.441
4.004LeuGly: 4.004 ± 0.584
1.31LeuHis: 1.31 ± 0.354
4.295LeuIle: 4.295 ± 0.61
4.004LeuLys: 4.004 ± 0.594
6.043LeuLeu: 6.043 ± 0.616
2.038LeuMet: 2.038 ± 0.389
3.931LeuAsn: 3.931 ± 0.51
2.33LeuPro: 2.33 ± 0.44
3.13LeuGln: 3.13 ± 0.463
3.931LeuArg: 3.931 ± 0.502
5.242LeuSer: 5.242 ± 0.671
5.242LeuThr: 5.242 ± 0.648
3.858LeuVal: 3.858 ± 0.495
0.874LeuTrp: 0.874 ± 0.243
2.912LeuTyr: 2.912 ± 0.344
0.0LeuXaa: 0.0 ± 0.0
Met
2.694MetAla: 2.694 ± 0.399
0.291MetCys: 0.291 ± 0.157
1.165MetAsp: 1.165 ± 0.429
2.038MetGlu: 2.038 ± 0.372
0.946MetPhe: 0.946 ± 0.249
2.184MetGly: 2.184 ± 0.428
0.291MetHis: 0.291 ± 0.142
1.165MetIle: 1.165 ± 0.293
2.257MetLys: 2.257 ± 0.415
2.621MetLeu: 2.621 ± 0.616
1.092MetMet: 1.092 ± 0.32
1.238MetAsn: 1.238 ± 0.3
1.165MetPro: 1.165 ± 0.298
0.582MetGln: 0.582 ± 0.269
0.874MetArg: 0.874 ± 0.254
1.966MetSer: 1.966 ± 0.551
1.966MetThr: 1.966 ± 0.407
1.31MetVal: 1.31 ± 0.329
0.51MetTrp: 0.51 ± 0.185
0.801MetTyr: 0.801 ± 0.274
0.0MetXaa: 0.0 ± 0.0
Asn
3.567AsnAla: 3.567 ± 0.503
0.51AsnCys: 0.51 ± 0.19
2.621AsnAsp: 2.621 ± 0.473
2.475AsnGlu: 2.475 ± 0.365
1.966AsnPhe: 1.966 ± 0.342
3.858AsnGly: 3.858 ± 0.699
1.165AsnHis: 1.165 ± 0.314
2.694AsnIle: 2.694 ± 0.421
2.839AsnLys: 2.839 ± 0.414
4.878AsnLeu: 4.878 ± 0.689
1.529AsnMet: 1.529 ± 0.396
2.038AsnAsn: 2.038 ± 0.394
2.621AsnPro: 2.621 ± 0.429
2.038AsnGln: 2.038 ± 0.337
1.674AsnArg: 1.674 ± 0.264
2.985AsnSer: 2.985 ± 0.431
2.257AsnThr: 2.257 ± 0.387
4.004AsnVal: 4.004 ± 0.591
0.801AsnTrp: 0.801 ± 0.244
1.747AsnTyr: 1.747 ± 0.374
0.0AsnXaa: 0.0 ± 0.0
Pro
2.839ProAla: 2.839 ± 0.431
0.218ProCys: 0.218 ± 0.126
2.621ProAsp: 2.621 ± 0.323
4.222ProGlu: 4.222 ± 0.424
1.674ProPhe: 1.674 ± 0.442
0.51ProGly: 0.51 ± 0.192
0.728ProHis: 0.728 ± 0.217
2.184ProIle: 2.184 ± 0.332
2.475ProLys: 2.475 ± 0.414
2.038ProLeu: 2.038 ± 0.352
0.946ProMet: 0.946 ± 0.235
2.475ProAsn: 2.475 ± 0.424
0.946ProPro: 0.946 ± 0.37
2.985ProGln: 2.985 ± 1.625
1.82ProArg: 1.82 ± 0.421
2.548ProSer: 2.548 ± 0.568
3.422ProThr: 3.422 ± 0.894
3.349ProVal: 3.349 ± 0.549
0.437ProTrp: 0.437 ± 0.166
0.946ProTyr: 0.946 ± 0.268
0.0ProXaa: 0.0 ± 0.0
Gln
4.514GlnAla: 4.514 ± 0.789
0.291GlnCys: 0.291 ± 0.142
2.402GlnAsp: 2.402 ± 0.408
1.893GlnGlu: 1.893 ± 0.294
1.529GlnPhe: 1.529 ± 0.411
5.242GlnGly: 5.242 ± 2.766
0.51GlnHis: 0.51 ± 0.198
2.184GlnIle: 2.184 ± 0.5
1.238GlnLys: 1.238 ± 0.285
3.567GlnLeu: 3.567 ± 0.559
1.383GlnMet: 1.383 ± 0.265
1.747GlnAsn: 1.747 ± 0.483
1.383GlnPro: 1.383 ± 0.341
2.038GlnGln: 2.038 ± 0.449
2.111GlnArg: 2.111 ± 0.385
2.184GlnSer: 2.184 ± 0.517
2.33GlnThr: 2.33 ± 0.516
2.548GlnVal: 2.548 ± 0.335
0.582GlnTrp: 0.582 ± 0.233
2.038GlnTyr: 2.038 ± 0.396
0.0GlnXaa: 0.0 ± 0.0
Arg
3.203ArgAla: 3.203 ± 0.634
0.364ArgCys: 0.364 ± 0.166
3.64ArgAsp: 3.64 ± 0.516
4.295ArgGlu: 4.295 ± 0.569
1.383ArgPhe: 1.383 ± 0.29
3.567ArgGly: 3.567 ± 0.545
0.51ArgHis: 0.51 ± 0.165
3.13ArgIle: 3.13 ± 0.494
3.276ArgLys: 3.276 ± 0.601
3.422ArgLeu: 3.422 ± 0.563
1.31ArgMet: 1.31 ± 0.259
2.839ArgAsn: 2.839 ± 0.447
1.82ArgPro: 1.82 ± 0.361
2.038ArgGln: 2.038 ± 0.358
2.475ArgArg: 2.475 ± 0.457
2.548ArgSer: 2.548 ± 0.371
2.111ArgThr: 2.111 ± 0.306
3.276ArgVal: 3.276 ± 0.444
0.946ArgTrp: 0.946 ± 0.196
1.893ArgTyr: 1.893 ± 0.41
0.0ArgXaa: 0.0 ± 0.0
Ser
4.95SerAla: 4.95 ± 0.617
0.437SerCys: 0.437 ± 0.178
4.15SerAsp: 4.15 ± 0.589
3.494SerGlu: 3.494 ± 0.569
2.621SerPhe: 2.621 ± 0.528
5.97SerGly: 5.97 ± 0.946
0.582SerHis: 0.582 ± 0.173
3.276SerIle: 3.276 ± 0.503
5.315SerLys: 5.315 ± 0.615
4.15SerLeu: 4.15 ± 0.558
1.383SerMet: 1.383 ± 0.312
3.276SerAsn: 3.276 ± 0.491
2.839SerPro: 2.839 ± 0.385
2.839SerGln: 2.839 ± 0.484
2.985SerArg: 2.985 ± 0.484
4.659SerSer: 4.659 ± 0.675
4.441SerThr: 4.441 ± 0.721
4.077SerVal: 4.077 ± 0.457
0.874SerTrp: 0.874 ± 0.209
1.602SerTyr: 1.602 ± 0.337
0.0SerXaa: 0.0 ± 0.0
Thr
4.15ThrAla: 4.15 ± 0.49
0.364ThrCys: 0.364 ± 0.231
3.422ThrAsp: 3.422 ± 0.57
3.276ThrGlu: 3.276 ± 0.555
2.621ThrPhe: 2.621 ± 0.407
5.533ThrGly: 5.533 ± 0.937
0.728ThrHis: 0.728 ± 0.271
3.64ThrIle: 3.64 ± 0.629
3.931ThrLys: 3.931 ± 0.665
4.878ThrLeu: 4.878 ± 0.478
1.165ThrMet: 1.165 ± 0.303
3.422ThrAsn: 3.422 ± 0.61
3.713ThrPro: 3.713 ± 0.473
2.475ThrGln: 2.475 ± 0.381
2.548ThrArg: 2.548 ± 0.385
4.222ThrSer: 4.222 ± 0.625
5.46ThrThr: 5.46 ± 0.608
4.732ThrVal: 4.732 ± 0.611
0.801ThrTrp: 0.801 ± 0.259
2.33ThrTyr: 2.33 ± 0.474
0.0ThrXaa: 0.0 ± 0.0
Val
5.606ValAla: 5.606 ± 0.697
0.728ValCys: 0.728 ± 0.228
4.514ValAsp: 4.514 ± 0.586
4.222ValGlu: 4.222 ± 0.543
2.985ValPhe: 2.985 ± 0.576
6.552ValGly: 6.552 ± 1.16
1.31ValHis: 1.31 ± 0.41
3.858ValIle: 3.858 ± 0.393
4.95ValLys: 4.95 ± 0.534
5.315ValLeu: 5.315 ± 0.755
1.602ValMet: 1.602 ± 0.308
3.422ValAsn: 3.422 ± 0.511
2.548ValPro: 2.548 ± 0.471
2.402ValGln: 2.402 ± 0.356
3.786ValArg: 3.786 ± 0.602
4.659ValSer: 4.659 ± 0.665
4.222ValThr: 4.222 ± 0.652
5.315ValVal: 5.315 ± 0.55
1.31ValTrp: 1.31 ± 0.284
2.621ValTyr: 2.621 ± 0.41
0.0ValXaa: 0.0 ± 0.0
Trp
1.31TrpAla: 1.31 ± 0.298
0.146TrpCys: 0.146 ± 0.104
0.946TrpAsp: 0.946 ± 0.213
0.874TrpGlu: 0.874 ± 0.22
1.092TrpPhe: 1.092 ± 0.292
1.019TrpGly: 1.019 ± 0.253
0.146TrpHis: 0.146 ± 0.137
0.582TrpIle: 0.582 ± 0.173
1.165TrpLys: 1.165 ± 0.277
1.31TrpLeu: 1.31 ± 0.302
0.437TrpMet: 0.437 ± 0.184
0.655TrpAsn: 0.655 ± 0.274
0.437TrpPro: 0.437 ± 0.181
1.019TrpGln: 1.019 ± 0.209
0.364TrpArg: 0.364 ± 0.166
0.801TrpSer: 0.801 ± 0.269
0.728TrpThr: 0.728 ± 0.271
0.946TrpVal: 0.946 ± 0.29
0.291TrpTrp: 0.291 ± 0.128
0.51TrpTyr: 0.51 ± 0.205
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.33TyrAla: 2.33 ± 0.358
0.437TyrCys: 0.437 ± 0.172
3.13TyrAsp: 3.13 ± 0.383
2.402TyrGlu: 2.402 ± 0.493
1.238TyrPhe: 1.238 ± 0.264
2.402TyrGly: 2.402 ± 0.343
0.582TyrHis: 0.582 ± 0.188
1.238TyrIle: 1.238 ± 0.307
2.475TyrLys: 2.475 ± 0.45
3.058TyrLeu: 3.058 ± 0.495
0.946TyrMet: 0.946 ± 0.228
2.184TyrAsn: 2.184 ± 0.312
1.383TyrPro: 1.383 ± 0.312
1.019TyrGln: 1.019 ± 0.272
2.766TyrArg: 2.766 ± 0.477
2.621TyrSer: 2.621 ± 0.389
2.257TyrThr: 2.257 ± 0.427
4.004TyrVal: 4.004 ± 0.677
0.437TyrTrp: 0.437 ± 0.192
1.456TyrTyr: 1.456 ± 0.406
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (13737 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski