Amino acid dipepetide frequency for SAR11 cluster bacterium PRT-SC02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.785AlaAla: 3.785 ± 0.212
0.579AlaCys: 0.579 ± 0.065
2.409AlaAsp: 2.409 ± 0.159
2.862AlaGlu: 2.862 ± 0.133
2.38AlaPhe: 2.38 ± 0.142
3.911AlaGly: 3.911 ± 0.189
0.694AlaHis: 0.694 ± 0.06
4.904AlaIle: 4.904 ± 0.185
5.024AlaLys: 5.024 ± 0.194
5.07AlaLeu: 5.07 ± 0.186
1.491AlaMet: 1.491 ± 0.088
2.529AlaAsn: 2.529 ± 0.125
1.199AlaPro: 1.199 ± 0.089
1.308AlaGln: 1.308 ± 0.092
1.835AlaArg: 1.835 ± 0.119
3.539AlaSer: 3.539 ± 0.155
2.495AlaThr: 2.495 ± 0.15
3.194AlaVal: 3.194 ± 0.151
0.47AlaTrp: 0.47 ± 0.058
1.858AlaTyr: 1.858 ± 0.114
0.0AlaXaa: 0.0 ± 0.0
Cys
0.619CysAla: 0.619 ± 0.053
0.132CysCys: 0.132 ± 0.027
0.442CysAsp: 0.442 ± 0.053
0.608CysGlu: 0.608 ± 0.063
0.574CysPhe: 0.574 ± 0.057
0.849CysGly: 0.849 ± 0.075
0.149CysHis: 0.149 ± 0.029
0.769CysIle: 0.769 ± 0.066
0.86CysLys: 0.86 ± 0.083
1.044CysLeu: 1.044 ± 0.086
0.161CysMet: 0.161 ± 0.027
0.51CysAsn: 0.51 ± 0.054
0.344CysPro: 0.344 ± 0.05
0.258CysGln: 0.258 ± 0.041
0.298CysArg: 0.298 ± 0.039
0.774CysSer: 0.774 ± 0.079
0.39CysThr: 0.39 ± 0.049
0.631CysVal: 0.631 ± 0.068
0.063CysTrp: 0.063 ± 0.02
0.315CysTyr: 0.315 ± 0.043
0.0CysXaa: 0.0 ± 0.0
Asp
2.139AspAla: 2.139 ± 0.118
0.465AspCys: 0.465 ± 0.053
2.197AspAsp: 2.197 ± 0.133
3.143AspGlu: 3.143 ± 0.15
2.799AspPhe: 2.799 ± 0.118
2.759AspGly: 2.759 ± 0.135
0.872AspHis: 0.872 ± 0.07
4.645AspIle: 4.645 ± 0.169
5.879AspLys: 5.879 ± 0.203
5.643AspLeu: 5.643 ± 0.201
0.935AspMet: 0.935 ± 0.061
2.902AspAsn: 2.902 ± 0.127
1.589AspPro: 1.589 ± 0.107
1.589AspGln: 1.589 ± 0.101
1.703AspArg: 1.703 ± 0.11
2.558AspSer: 2.558 ± 0.11
2.059AspThr: 2.059 ± 0.111
2.736AspVal: 2.736 ± 0.136
0.516AspTrp: 0.516 ± 0.06
2.156AspTyr: 2.156 ± 0.12
0.0AspXaa: 0.0 ± 0.0
Glu
2.994GluAla: 2.994 ± 0.14
0.413GluCys: 0.413 ± 0.047
2.558GluAsp: 2.558 ± 0.128
3.533GluGlu: 3.533 ± 0.171
2.799GluPhe: 2.799 ± 0.138
2.661GluGly: 2.661 ± 0.127
0.849GluHis: 0.849 ± 0.067
6.624GluIle: 6.624 ± 0.221
8.081GluLys: 8.081 ± 0.223
5.076GluLeu: 5.076 ± 0.179
1.204GluMet: 1.204 ± 0.098
4.582GluAsn: 4.582 ± 0.185
1.434GluPro: 1.434 ± 0.097
1.376GluGln: 1.376 ± 0.101
1.996GluArg: 1.996 ± 0.104
2.925GluSer: 2.925 ± 0.126
2.592GluThr: 2.592 ± 0.131
3.521GluVal: 3.521 ± 0.16
0.424GluTrp: 0.424 ± 0.053
1.761GluTyr: 1.761 ± 0.109
0.0GluXaa: 0.0 ± 0.0
Phe
2.478PheAla: 2.478 ± 0.129
0.654PheCys: 0.654 ± 0.061
2.787PheAsp: 2.787 ± 0.121
2.959PheGlu: 2.959 ± 0.137
3.865PhePhe: 3.865 ± 0.237
3.556PheGly: 3.556 ± 0.15
0.642PheHis: 0.642 ± 0.063
4.737PheIle: 4.737 ± 0.21
6.274PheLys: 6.274 ± 0.219
5.953PheLeu: 5.953 ± 0.225
0.855PheMet: 0.855 ± 0.069
3.602PheAsn: 3.602 ± 0.145
1.445PhePro: 1.445 ± 0.09
1.25PheGln: 1.25 ± 0.072
1.801PheArg: 1.801 ± 0.115
4.187PheSer: 4.187 ± 0.148
2.397PheThr: 2.397 ± 0.142
2.845PheVal: 2.845 ± 0.147
0.539PheTrp: 0.539 ± 0.062
2.334PheTyr: 2.334 ± 0.132
0.0PheXaa: 0.0 ± 0.0
Gly
3.516GlyAla: 3.516 ± 0.18
0.769GlyCys: 0.769 ± 0.074
2.833GlyAsp: 2.833 ± 0.155
3.074GlyGlu: 3.074 ± 0.124
3.16GlyPhe: 3.16 ± 0.142
4.485GlyGly: 4.485 ± 0.276
1.204GlyHis: 1.204 ± 0.076
5.46GlyIle: 5.46 ± 0.151
5.861GlyLys: 5.861 ± 0.198
5.454GlyLeu: 5.454 ± 0.22
1.353GlyMet: 1.353 ± 0.106
2.879GlyAsn: 2.879 ± 0.126
1.726GlyPro: 1.726 ± 0.099
1.612GlyGln: 1.612 ± 0.1
2.088GlyArg: 2.088 ± 0.129
4.112GlySer: 4.112 ± 0.157
3.166GlyThr: 3.166 ± 0.154
3.814GlyVal: 3.814 ± 0.18
0.763GlyTrp: 0.763 ± 0.069
2.26GlyTyr: 2.26 ± 0.115
0.0GlyXaa: 0.0 ± 0.0
His
0.803HisAla: 0.803 ± 0.067
0.178HisCys: 0.178 ± 0.033
0.688HisAsp: 0.688 ± 0.07
0.774HisGlu: 0.774 ± 0.066
0.694HisPhe: 0.694 ± 0.059
1.101HisGly: 1.101 ± 0.079
0.384HisHis: 0.384 ± 0.056
1.159HisIle: 1.159 ± 0.077
1.417HisLys: 1.417 ± 0.086
1.503HisLeu: 1.503 ± 0.09
0.292HisMet: 0.292 ± 0.039
0.883HisAsn: 0.883 ± 0.09
0.677HisPro: 0.677 ± 0.062
0.533HisGln: 0.533 ± 0.065
0.602HisArg: 0.602 ± 0.063
1.027HisSer: 1.027 ± 0.064
0.642HisThr: 0.642 ± 0.054
0.746HisVal: 0.746 ± 0.068
0.172HisTrp: 0.172 ± 0.033
0.625HisTyr: 0.625 ± 0.065
0.0HisXaa: 0.0 ± 0.0
Ile
5.018IleAla: 5.018 ± 0.195
1.17IleCys: 1.17 ± 0.086
5.248IleAsp: 5.248 ± 0.189
5.724IleGlu: 5.724 ± 0.18
5.861IlePhe: 5.861 ± 0.263
5.856IleGly: 5.856 ± 0.192
1.233IleHis: 1.233 ± 0.082
10.111IleIle: 10.111 ± 0.303
11.837IleLys: 11.837 ± 0.313
9.669IleLeu: 9.669 ± 0.278
1.761IleMet: 1.761 ± 0.103
6.704IleAsn: 6.704 ± 0.194
3.166IlePro: 3.166 ± 0.136
2.3IleGln: 2.3 ± 0.106
2.81IleArg: 2.81 ± 0.124
7.857IleSer: 7.857 ± 0.212
4.227IleThr: 4.227 ± 0.151
4.978IleVal: 4.978 ± 0.192
0.711IleTrp: 0.711 ± 0.061
3.292IleTyr: 3.292 ± 0.15
0.0IleXaa: 0.0 ± 0.0
Lys
4.428LysAla: 4.428 ± 0.178
0.786LysCys: 0.786 ± 0.068
5.833LysAsp: 5.833 ± 0.196
7.249LysGlu: 7.249 ± 0.214
6.028LysPhe: 6.028 ± 0.214
4.898LysGly: 4.898 ± 0.177
1.29LysHis: 1.29 ± 0.086
14.349LysIle: 14.349 ± 0.371
17.865LysLys: 17.865 ± 0.504
9.492LysLeu: 9.492 ± 0.261
2.26LysMet: 2.26 ± 0.114
11.419LysAsn: 11.419 ± 0.399
2.868LysPro: 2.868 ± 0.142
2.415LysGln: 2.415 ± 0.11
3.871LysArg: 3.871 ± 0.15
7.416LysSer: 7.416 ± 0.212
4.944LysThr: 4.944 ± 0.19
5.684LysVal: 5.684 ± 0.189
0.803LysTrp: 0.803 ± 0.07
4.101LysTyr: 4.101 ± 0.166
0.0LysXaa: 0.0 ± 0.0
Leu
5.351LeuAla: 5.351 ± 0.198
0.74LeuCys: 0.74 ± 0.063
4.921LeuAsp: 4.921 ± 0.166
5.225LeuGlu: 5.225 ± 0.167
4.732LeuPhe: 4.732 ± 0.22
5.712LeuGly: 5.712 ± 0.201
1.376LeuHis: 1.376 ± 0.096
9.503LeuIle: 9.503 ± 0.283
11.516LeuLys: 11.516 ± 0.334
7.84LeuLeu: 7.84 ± 0.253
2.38LeuMet: 2.38 ± 0.123
6.882LeuAsn: 6.882 ± 0.233
3.166LeuPro: 3.166 ± 0.132
2.191LeuGln: 2.191 ± 0.106
3.258LeuArg: 3.258 ± 0.13
7.347LeuSer: 7.347 ± 0.212
4.147LeuThr: 4.147 ± 0.145
5.047LeuVal: 5.047 ± 0.197
0.671LeuTrp: 0.671 ± 0.06
2.713LeuTyr: 2.713 ± 0.131
0.0LeuXaa: 0.0 ± 0.0
Met
1.319MetAla: 1.319 ± 0.099
0.172MetCys: 0.172 ± 0.031
0.791MetAsp: 0.791 ± 0.078
1.009MetGlu: 1.009 ± 0.069
0.969MetPhe: 0.969 ± 0.068
1.417MetGly: 1.417 ± 0.104
0.304MetHis: 0.304 ± 0.044
1.87MetIle: 1.87 ± 0.102
2.231MetLys: 2.231 ± 0.128
1.646MetLeu: 1.646 ± 0.093
0.396MetMet: 0.396 ± 0.05
1.308MetAsn: 1.308 ± 0.078
0.866MetPro: 0.866 ± 0.066
0.591MetGln: 0.591 ± 0.055
0.786MetArg: 0.786 ± 0.07
1.83MetSer: 1.83 ± 0.088
1.038MetThr: 1.038 ± 0.078
1.038MetVal: 1.038 ± 0.071
0.155MetTrp: 0.155 ± 0.025
0.442MetTyr: 0.442 ± 0.047
0.0MetXaa: 0.0 ± 0.0
Asn
2.535AsnAla: 2.535 ± 0.107
0.682AsnCys: 0.682 ± 0.071
2.919AsnAsp: 2.919 ± 0.137
3.957AsnGlu: 3.957 ± 0.153
4.508AsnPhe: 4.508 ± 0.212
2.833AsnGly: 2.833 ± 0.156
0.929AsnHis: 0.929 ± 0.079
6.94AsnIle: 6.94 ± 0.202
8.591AsnLys: 8.591 ± 0.309
7.519AsnLeu: 7.519 ± 0.199
1.181AsnMet: 1.181 ± 0.079
5.013AsnAsn: 5.013 ± 0.19
2.202AsnPro: 2.202 ± 0.104
2.07AsnGln: 2.07 ± 0.128
2.007AsnArg: 2.007 ± 0.109
4.582AsnSer: 4.582 ± 0.185
2.764AsnThr: 2.764 ± 0.124
3.068AsnVal: 3.068 ± 0.136
0.602AsnTrp: 0.602 ± 0.058
3.16AsnTyr: 3.16 ± 0.16
0.0AsnXaa: 0.0 ± 0.0
Pro
1.629ProAla: 1.629 ± 0.102
0.27ProCys: 0.27 ± 0.043
1.698ProAsp: 1.698 ± 0.1
1.938ProGlu: 1.938 ± 0.119
1.629ProPhe: 1.629 ± 0.106
1.99ProGly: 1.99 ± 0.127
0.574ProHis: 0.574 ± 0.057
3.051ProIle: 3.051 ± 0.148
2.959ProLys: 2.959 ± 0.116
2.873ProLeu: 2.873 ± 0.129
0.476ProMet: 0.476 ± 0.051
2.036ProAsn: 2.036 ± 0.125
0.843ProPro: 0.843 ± 0.079
0.809ProGln: 0.809 ± 0.067
0.958ProArg: 0.958 ± 0.071
2.099ProSer: 2.099 ± 0.106
1.468ProThr: 1.468 ± 0.088
1.956ProVal: 1.956 ± 0.1
0.333ProTrp: 0.333 ± 0.044
0.849ProTyr: 0.849 ± 0.082
0.0ProXaa: 0.0 ± 0.0
Gln
1.468GlnAla: 1.468 ± 0.103
0.212GlnCys: 0.212 ± 0.041
1.199GlnAsp: 1.199 ± 0.078
1.365GlnGlu: 1.365 ± 0.105
0.998GlnPhe: 0.998 ± 0.074
1.302GlnGly: 1.302 ± 0.089
0.407GlnHis: 0.407 ± 0.05
2.799GlnIle: 2.799 ± 0.129
3.258GlnLys: 3.258 ± 0.133
2.128GlnLeu: 2.128 ± 0.091
0.528GlnMet: 0.528 ± 0.057
1.973GlnAsn: 1.973 ± 0.104
0.78GlnPro: 0.78 ± 0.071
0.711GlnGln: 0.711 ± 0.069
1.124GlnArg: 1.124 ± 0.079
1.652GlnSer: 1.652 ± 0.095
1.222GlnThr: 1.222 ± 0.085
1.382GlnVal: 1.382 ± 0.101
0.264GlnTrp: 0.264 ± 0.036
0.751GlnTyr: 0.751 ± 0.064
0.0GlnXaa: 0.0 ± 0.0
Arg
1.87ArgAla: 1.87 ± 0.107
0.356ArgCys: 0.356 ± 0.045
1.847ArgAsp: 1.847 ± 0.109
2.03ArgGlu: 2.03 ± 0.111
1.726ArgPhe: 1.726 ± 0.093
1.818ArgGly: 1.818 ± 0.108
0.642ArgHis: 0.642 ± 0.059
3.005ArgIle: 3.005 ± 0.141
3.762ArgLys: 3.762 ± 0.152
2.971ArgLeu: 2.971 ± 0.128
0.711ArgMet: 0.711 ± 0.062
1.944ArgAsn: 1.944 ± 0.103
1.113ArgPro: 1.113 ± 0.092
0.877ArgGln: 0.877 ± 0.081
1.365ArgArg: 1.365 ± 0.092
2.483ArgSer: 2.483 ± 0.129
1.6ArgThr: 1.6 ± 0.085
2.093ArgVal: 2.093 ± 0.116
0.344ArgTrp: 0.344 ± 0.046
1.113ArgTyr: 1.113 ± 0.093
0.0ArgXaa: 0.0 ± 0.0
Ser
3.556SerAla: 3.556 ± 0.154
0.705SerCys: 0.705 ± 0.068
3.487SerAsp: 3.487 ± 0.132
3.963SerGlu: 3.963 ± 0.191
4.06SerPhe: 4.06 ± 0.181
4.72SerGly: 4.72 ± 0.162
1.118SerHis: 1.118 ± 0.07
6.779SerIle: 6.779 ± 0.244
8.465SerLys: 8.465 ± 0.245
6.991SerLeu: 6.991 ± 0.18
1.434SerMet: 1.434 ± 0.079
4.319SerAsn: 4.319 ± 0.164
1.95SerPro: 1.95 ± 0.098
1.824SerGln: 1.824 ± 0.101
2.254SerArg: 2.254 ± 0.115
4.886SerSer: 4.886 ± 0.204
2.873SerThr: 2.873 ± 0.122
3.659SerVal: 3.659 ± 0.167
0.608SerTrp: 0.608 ± 0.056
2.133SerTyr: 2.133 ± 0.121
0.0SerXaa: 0.0 ± 0.0
Thr
2.592ThrAla: 2.592 ± 0.139
0.419ThrCys: 0.419 ± 0.048
2.133ThrAsp: 2.133 ± 0.117
2.3ThrGlu: 2.3 ± 0.113
2.472ThrPhe: 2.472 ± 0.114
3.458ThrGly: 3.458 ± 0.15
0.728ThrHis: 0.728 ± 0.062
4.25ThrIle: 4.25 ± 0.153
4.422ThrLys: 4.422 ± 0.143
4.129ThrLeu: 4.129 ± 0.15
0.803ThrMet: 0.803 ± 0.076
2.793ThrAsn: 2.793 ± 0.123
1.698ThrPro: 1.698 ± 0.091
1.153ThrGln: 1.153 ± 0.085
1.583ThrArg: 1.583 ± 0.102
3.263ThrSer: 3.263 ± 0.13
2.317ThrThr: 2.317 ± 0.13
2.592ThrVal: 2.592 ± 0.126
0.442ThrTrp: 0.442 ± 0.05
1.313ThrTyr: 1.313 ± 0.087
0.0ThrXaa: 0.0 ± 0.0
Val
3.412ValAla: 3.412 ± 0.174
0.671ValCys: 0.671 ± 0.069
2.896ValAsp: 2.896 ± 0.125
3.223ValGlu: 3.223 ± 0.142
2.816ValPhe: 2.816 ± 0.153
3.613ValGly: 3.613 ± 0.148
0.763ValHis: 0.763 ± 0.066
5.236ValIle: 5.236 ± 0.204
5.076ValLys: 5.076 ± 0.172
5.013ValLeu: 5.013 ± 0.167
1.187ValMet: 1.187 ± 0.079
3.149ValAsn: 3.149 ± 0.136
1.996ValPro: 1.996 ± 0.114
1.319ValGln: 1.319 ± 0.081
1.881ValArg: 1.881 ± 0.1
4.175ValSer: 4.175 ± 0.145
2.65ValThr: 2.65 ± 0.119
3.453ValVal: 3.453 ± 0.15
0.482ValTrp: 0.482 ± 0.059
1.531ValTyr: 1.531 ± 0.096
0.0ValXaa: 0.0 ± 0.0
Trp
0.419TrpAla: 0.419 ± 0.051
0.08TrpCys: 0.08 ± 0.021
0.373TrpAsp: 0.373 ± 0.044
0.453TrpGlu: 0.453 ± 0.057
0.545TrpPhe: 0.545 ± 0.053
0.551TrpGly: 0.551 ± 0.055
0.161TrpHis: 0.161 ± 0.03
0.723TrpIle: 0.723 ± 0.06
0.969TrpLys: 0.969 ± 0.078
0.877TrpLeu: 0.877 ± 0.084
0.264TrpMet: 0.264 ± 0.036
0.482TrpAsn: 0.482 ± 0.058
0.287TrpPro: 0.287 ± 0.051
0.315TrpGln: 0.315 ± 0.04
0.447TrpArg: 0.447 ± 0.052
0.562TrpSer: 0.562 ± 0.06
0.459TrpThr: 0.459 ± 0.056
0.47TrpVal: 0.47 ± 0.056
0.086TrpTrp: 0.086 ± 0.023
0.321TrpTyr: 0.321 ± 0.045
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.606TyrAla: 1.606 ± 0.085
0.338TyrCys: 0.338 ± 0.044
2.025TyrAsp: 2.025 ± 0.106
2.013TyrGlu: 2.013 ± 0.102
2.546TyrPhe: 2.546 ± 0.124
2.099TyrGly: 2.099 ± 0.114
0.579TyrHis: 0.579 ± 0.053
2.621TyrIle: 2.621 ± 0.123
3.648TyrLys: 3.648 ± 0.153
3.825TyrLeu: 3.825 ± 0.177
0.499TyrMet: 0.499 ± 0.058
2.162TyrAsn: 2.162 ± 0.13
1.09TyrPro: 1.09 ± 0.082
1.021TyrGln: 1.021 ± 0.079
1.004TyrArg: 1.004 ± 0.083
2.512TyrSer: 2.512 ± 0.13
1.411TyrThr: 1.411 ± 0.093
1.635TyrVal: 1.635 ± 0.095
0.396TyrTrp: 0.396 ± 0.049
1.164TyrTyr: 1.164 ± 0.091
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 632 proteins (174364 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski