Amino acid dipepetide frequency for Legionella worsleiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.515AlaAla: 6.515 ± 0.117	1.116AlaCys: 1.116 ± 0.044	3.649AlaAsp: 3.649 ± 0.067	4.352AlaGlu: 4.352 ± 0.072	3.063AlaPhe: 3.063 ± 0.061	5.017AlaGly: 5.017 ± 0.096	2.062AlaHis: 2.062 ± 0.053	5.614AlaIle: 5.614 ± 0.078	4.573AlaLys: 4.573 ± 0.076	9.799AlaLeu: 9.799 ± 0.12	2.048AlaMet: 2.048 ± 0.053	3.417AlaAsn: 3.417 ± 0.079	2.542AlaPro: 2.542 ± 0.05	4.009AlaGln: 4.009 ± 0.08	3.327AlaArg: 3.327 ± 0.073	4.782AlaSer: 4.782 ± 0.076	3.965AlaThr: 3.965 ± 0.08	5.239AlaVal: 5.239 ± 0.092	0.781AlaTrp: 0.781 ± 0.035	2.477AlaTyr: 2.477 ± 0.051	0.003AlaXaa: 0.003 ± 0.002
Cys	0.944CysAla: 0.944 ± 0.032	0.197CysCys: 0.197 ± 0.017	0.687CysAsp: 0.687 ± 0.033	0.63CysGlu: 0.63 ± 0.028	0.67CysPhe: 0.67 ± 0.031	0.905CysGly: 0.905 ± 0.035	0.384CysHis: 0.384 ± 0.021	0.842CysIle: 0.842 ± 0.029	0.612CysLys: 0.612 ± 0.028	1.38CysLeu: 1.38 ± 0.048	0.281CysMet: 0.281 ± 0.019	0.513CysAsn: 0.513 ± 0.025	0.509CysPro: 0.509 ± 0.028	0.551CysGln: 0.551 ± 0.02	0.525CysArg: 0.525 ± 0.027	0.976CysSer: 0.976 ± 0.039	0.626CysThr: 0.626 ± 0.029	0.757CysVal: 0.757 ± 0.031	0.129CysTrp: 0.129 ± 0.012	0.494CysTyr: 0.494 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.005AspAla: 4.005 ± 0.072	0.609AspCys: 0.609 ± 0.025	2.635AspAsp: 2.635 ± 0.06	3.66AspGlu: 3.66 ± 0.074	2.493AspPhe: 2.493 ± 0.055	2.828AspGly: 2.828 ± 0.066	1.081AspHis: 1.081 ± 0.035	3.499AspIle: 3.499 ± 0.06	3.241AspLys: 3.241 ± 0.067	5.118AspLeu: 5.118 ± 0.08	1.142AspMet: 1.142 ± 0.038	2.281AspAsn: 2.281 ± 0.054	1.935AspPro: 1.935 ± 0.045	1.649AspGln: 1.649 ± 0.042	1.9AspArg: 1.9 ± 0.051	3.249AspSer: 3.249 ± 0.065	2.47AspThr: 2.47 ± 0.061	3.236AspVal: 3.236 ± 0.068	0.691AspTrp: 0.691 ± 0.023	2.178AspTyr: 2.178 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.035GluAla: 4.035 ± 0.072	0.642GluCys: 0.642 ± 0.026	2.34GluAsp: 2.34 ± 0.058	3.772GluGlu: 3.772 ± 0.075	2.476GluPhe: 2.476 ± 0.055	2.786GluGly: 2.786 ± 0.056	2.123GluHis: 2.123 ± 0.063	3.987GluIle: 3.987 ± 0.075	3.598GluLys: 3.598 ± 0.074	6.982GluLeu: 6.982 ± 0.1	1.371GluMet: 1.371 ± 0.041	2.281GluAsn: 2.281 ± 0.05	1.865GluPro: 1.865 ± 0.051	3.889GluGln: 3.889 ± 0.075	2.937GluArg: 2.937 ± 0.075	3.461GluSer: 3.461 ± 0.061	2.758GluThr: 2.758 ± 0.059	3.261GluVal: 3.261 ± 0.066	0.641GluTrp: 0.641 ± 0.026	1.915GluTyr: 1.915 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.466PheAla: 3.466 ± 0.069	0.664PheCys: 0.664 ± 0.031	2.434PheAsp: 2.434 ± 0.05	2.064PheGlu: 2.064 ± 0.053	2.403PhePhe: 2.403 ± 0.06	2.562PheGly: 2.562 ± 0.067	1.013PheHis: 1.013 ± 0.038	3.508PheIle: 3.508 ± 0.079	2.563PheLys: 2.563 ± 0.053	4.333PheLeu: 4.333 ± 0.071	1.032PheMet: 1.032 ± 0.031	2.493PheAsn: 2.493 ± 0.053	1.584PhePro: 1.584 ± 0.048	1.389PheGln: 1.389 ± 0.041	1.585PheArg: 1.585 ± 0.05	3.439PheSer: 3.439 ± 0.073	2.457PheThr: 2.457 ± 0.053	2.507PheVal: 2.507 ± 0.061	0.518PheTrp: 0.518 ± 0.023	1.711PheTyr: 1.711 ± 0.048	0.001PheXaa: 0.001 ± 0.001
Gly	4.392GlyAla: 4.392 ± 0.087	0.844GlyCys: 0.844 ± 0.032	2.773GlyAsp: 2.773 ± 0.06	3.081GlyGlu: 3.081 ± 0.061	3.2GlyPhe: 3.2 ± 0.066	3.961GlyGly: 3.961 ± 0.14	1.567GlyHis: 1.567 ± 0.049	4.828GlyIle: 4.828 ± 0.091	3.399GlyLys: 3.399 ± 0.08	6.577GlyLeu: 6.577 ± 0.091	1.754GlyMet: 1.754 ± 0.056	2.467GlyAsn: 2.467 ± 0.065	1.464GlyPro: 1.464 ± 0.047	2.405GlyGln: 2.405 ± 0.057	2.516GlyArg: 2.516 ± 0.064	3.914GlySer: 3.914 ± 0.085	3.452GlyThr: 3.452 ± 0.071	4.271GlyVal: 4.271 ± 0.078	0.779GlyTrp: 0.779 ± 0.032	2.391GlyTyr: 2.391 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	2.018HisAla: 2.018 ± 0.047	0.434HisCys: 0.434 ± 0.024	1.284HisAsp: 1.284 ± 0.036	1.49HisGlu: 1.49 ± 0.044	1.367HisPhe: 1.367 ± 0.044	1.682HisGly: 1.682 ± 0.049	1.067HisHis: 1.067 ± 0.039	1.696HisIle: 1.696 ± 0.039	1.136HisLys: 1.136 ± 0.036	3.007HisLeu: 3.007 ± 0.066	0.553HisMet: 0.553 ± 0.024	1.077HisAsn: 1.077 ± 0.034	1.424HisPro: 1.424 ± 0.041	1.533HisGln: 1.533 ± 0.045	1.153HisArg: 1.153 ± 0.034	1.743HisSer: 1.743 ± 0.044	1.256HisThr: 1.256 ± 0.037	1.518HisVal: 1.518 ± 0.042	0.377HisTrp: 0.377 ± 0.019	1.313HisTyr: 1.313 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	6.239IleAla: 6.239 ± 0.097	0.839IleCys: 0.839 ± 0.033	4.067IleAsp: 4.067 ± 0.076	4.365IleGlu: 4.365 ± 0.081	2.344IlePhe: 2.344 ± 0.063	4.199IleGly: 4.199 ± 0.081	1.917IleHis: 1.917 ± 0.053	5.052IleIle: 5.052 ± 0.09	4.938IleLys: 4.938 ± 0.088	6.605IleLeu: 6.605 ± 0.106	1.401IleMet: 1.401 ± 0.036	4.369IleAsn: 4.369 ± 0.073	3.44IlePro: 3.44 ± 0.068	2.799IleGln: 2.799 ± 0.051	2.907IleArg: 2.907 ± 0.067	4.812IleSer: 4.812 ± 0.066	4.241IleThr: 4.241 ± 0.068	3.745IleVal: 3.745 ± 0.067	0.556IleTrp: 0.556 ± 0.024	2.015IleTyr: 2.015 ± 0.051	0.001IleXaa: 0.001 ± 0.001
Lys	4.589LysAla: 4.589 ± 0.079	0.405LysCys: 0.405 ± 0.024	2.824LysAsp: 2.824 ± 0.066	4.025LysGlu: 4.025 ± 0.075	1.431LysPhe: 1.431 ± 0.044	3.177LysGly: 3.177 ± 0.065	1.453LysHis: 1.453 ± 0.04	4.19LysIle: 4.19 ± 0.082	4.495LysLys: 4.495 ± 0.082	5.373LysLeu: 5.373 ± 0.071	1.443LysMet: 1.443 ± 0.042	3.557LysAsn: 3.557 ± 0.068	2.739LysPro: 2.739 ± 0.057	3.118LysGln: 3.118 ± 0.063	2.709LysArg: 2.709 ± 0.067	3.866LysSer: 3.866 ± 0.065	3.627LysThr: 3.627 ± 0.067	3.033LysVal: 3.033 ± 0.067	0.442LysTrp: 0.442 ± 0.019	1.557LysTyr: 1.557 ± 0.047	0.0LysXaa: 0.0 ± 0.0
Leu	9.239LeuAla: 9.239 ± 0.113	1.498LeuCys: 1.498 ± 0.044	5.547LeuAsp: 5.547 ± 0.075	5.606LeuGlu: 5.606 ± 0.107	5.164LeuPhe: 5.164 ± 0.089	6.453LeuGly: 6.453 ± 0.104	2.843LeuHis: 2.843 ± 0.065	8.223LeuIle: 8.223 ± 0.11	6.579LeuLys: 6.579 ± 0.102	11.695LeuLeu: 11.695 ± 0.178	2.778LeuMet: 2.778 ± 0.06	5.849LeuAsn: 5.849 ± 0.098	4.803LeuPro: 4.803 ± 0.097	4.242LeuGln: 4.242 ± 0.065	4.509LeuArg: 4.509 ± 0.073	8.344LeuSer: 8.344 ± 0.1	6.278LeuThr: 6.278 ± 0.081	6.368LeuVal: 6.368 ± 0.1	1.108LeuTrp: 1.108 ± 0.036	3.274LeuTyr: 3.274 ± 0.064	0.001LeuXaa: 0.001 ± 0.001
Met	2.011MetAla: 2.011 ± 0.051	0.205MetCys: 0.205 ± 0.015	1.222MetAsp: 1.222 ± 0.039	1.2MetGlu: 1.2 ± 0.036	0.775MetPhe: 0.775 ± 0.032	1.511MetGly: 1.511 ± 0.042	0.586MetHis: 0.586 ± 0.024	1.567MetIle: 1.567 ± 0.04	1.415MetLys: 1.415 ± 0.045	2.45MetLeu: 2.45 ± 0.054	0.72MetMet: 0.72 ± 0.033	1.47MetAsn: 1.47 ± 0.039	1.086MetPro: 1.086 ± 0.034	1.177MetGln: 1.177 ± 0.037	1.184MetArg: 1.184 ± 0.041	1.726MetSer: 1.726 ± 0.047	1.559MetThr: 1.559 ± 0.042	1.477MetVal: 1.477 ± 0.046	0.139MetTrp: 0.139 ± 0.012	0.65MetTyr: 0.65 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.828AsnAla: 3.828 ± 0.069	0.537AsnCys: 0.537 ± 0.03	2.377AsnAsp: 2.377 ± 0.06	2.994AsnGlu: 2.994 ± 0.06	1.795AsnPhe: 1.795 ± 0.05	2.819AsnGly: 2.819 ± 0.077	1.383AsnHis: 1.383 ± 0.043	3.039AsnIle: 3.039 ± 0.062	3.114AsnLys: 3.114 ± 0.067	4.673AsnLeu: 4.673 ± 0.077	0.973AsnMet: 0.973 ± 0.033	2.697AsnAsn: 2.697 ± 0.067	2.829AsnPro: 2.829 ± 0.052	2.825AsnGln: 2.825 ± 0.06	2.08AsnArg: 2.08 ± 0.048	3.116AsnSer: 3.116 ± 0.065	2.926AsnThr: 2.926 ± 0.066	2.27AsnVal: 2.27 ± 0.048	0.583AsnTrp: 0.583 ± 0.027	1.81AsnTyr: 1.81 ± 0.049	0.001AsnXaa: 0.001 ± 0.001
Pro	2.947ProAla: 2.947 ± 0.068	0.449ProCys: 0.449 ± 0.025	2.491ProAsp: 2.491 ± 0.058	3.248ProGlu: 3.248 ± 0.064	1.831ProPhe: 1.831 ± 0.042	2.692ProGly: 2.692 ± 0.064	1.045ProHis: 1.045 ± 0.038	2.466ProIle: 2.466 ± 0.05	2.19ProLys: 2.19 ± 0.055	4.482ProLeu: 4.482 ± 0.073	0.968ProMet: 0.968 ± 0.03	1.783ProAsn: 1.783 ± 0.046	1.445ProPro: 1.445 ± 0.046	1.909ProGln: 1.909 ± 0.046	1.443ProArg: 1.443 ± 0.044	2.505ProSer: 2.505 ± 0.055	1.878ProThr: 1.878 ± 0.05	3.53ProVal: 3.53 ± 0.066	0.489ProTrp: 0.489 ± 0.024	1.361ProTyr: 1.361 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.65GlnAla: 3.65 ± 0.077	0.557GlnCys: 0.557 ± 0.026	1.938GlnAsp: 1.938 ± 0.048	2.535GlnGlu: 2.535 ± 0.051	2.152GlnPhe: 2.152 ± 0.047	2.677GlnGly: 2.677 ± 0.067	1.4GlnHis: 1.4 ± 0.042	3.288GlnIle: 3.288 ± 0.069	2.782GlnLys: 2.782 ± 0.057	5.64GlnLeu: 5.64 ± 0.091	1.073GlnMet: 1.073 ± 0.037	2.178GlnAsn: 2.178 ± 0.047	1.701GlnPro: 1.701 ± 0.049	2.638GlnGln: 2.638 ± 0.076	2.141GlnArg: 2.141 ± 0.055	3.079GlnSer: 3.079 ± 0.063	2.452GlnThr: 2.452 ± 0.056	2.645GlnVal: 2.645 ± 0.055	0.644GlnTrp: 0.644 ± 0.029	1.526GlnTyr: 1.526 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.94ArgAla: 2.94 ± 0.062	0.534ArgCys: 0.534 ± 0.023	2.095ArgAsp: 2.095 ± 0.05	2.41ArgGlu: 2.41 ± 0.059	2.163ArgPhe: 2.163 ± 0.057	2.186ArgGly: 2.186 ± 0.053	1.179ArgHis: 1.179 ± 0.035	3.364ArgIle: 3.364 ± 0.063	2.283ArgLys: 2.283 ± 0.049	5.151ArgLeu: 5.151 ± 0.075	1.135ArgMet: 1.135 ± 0.038	2.049ArgAsn: 2.049 ± 0.052	1.461ArgPro: 1.461 ± 0.038	1.993ArgGln: 1.993 ± 0.052	1.868ArgArg: 1.868 ± 0.059	2.542ArgSer: 2.542 ± 0.051	2.15ArgThr: 2.15 ± 0.052	2.662ArgVal: 2.662 ± 0.055	0.527ArgTrp: 0.527 ± 0.027	1.802ArgTyr: 1.802 ± 0.054	0.002ArgXaa: 0.002 ± 0.002
Ser	5.054SerAla: 5.054 ± 0.091	0.93SerCys: 0.93 ± 0.035	3.303SerAsp: 3.303 ± 0.064	3.536SerGlu: 3.536 ± 0.069	3.129SerPhe: 3.129 ± 0.065	4.691SerGly: 4.691 ± 0.083	1.686SerHis: 1.686 ± 0.043	4.616SerIle: 4.616 ± 0.077	3.219SerLys: 3.219 ± 0.067	8.077SerLeu: 8.077 ± 0.108	1.677SerMet: 1.677 ± 0.043	2.659SerAsn: 2.659 ± 0.06	2.966SerPro: 2.966 ± 0.071	2.97SerGln: 2.97 ± 0.063	2.805SerArg: 2.805 ± 0.056	5.461SerSer: 5.461 ± 0.122	3.53SerThr: 3.53 ± 0.064	4.249SerVal: 4.249 ± 0.085	0.823SerTrp: 0.823 ± 0.028	2.253SerTyr: 2.253 ± 0.056	0.002SerXaa: 0.002 ± 0.002
Thr	4.455ThrAla: 4.455 ± 0.093	0.601ThrCys: 0.601 ± 0.028	2.629ThrAsp: 2.629 ± 0.054	2.791ThrGlu: 2.791 ± 0.055	1.981ThrPhe: 1.981 ± 0.049	3.657ThrGly: 3.657 ± 0.082	1.536ThrHis: 1.536 ± 0.043	3.631ThrIle: 3.631 ± 0.075	2.551ThrLys: 2.551 ± 0.058	6.56ThrLeu: 6.56 ± 0.093	1.196ThrMet: 1.196 ± 0.038	2.407ThrAsn: 2.407 ± 0.061	2.961ThrPro: 2.961 ± 0.059	2.78ThrGln: 2.78 ± 0.055	2.268ThrArg: 2.268 ± 0.052	3.348ThrSer: 3.348 ± 0.07	2.939ThrThr: 2.939 ± 0.072	3.939ThrVal: 3.939 ± 0.081	0.487ThrTrp: 0.487 ± 0.024	1.673ThrTyr: 1.673 ± 0.05	0.002ThrXaa: 0.002 ± 0.002
Val	4.826ValAla: 4.826 ± 0.087	0.796ValCys: 0.796 ± 0.029	3.32ValAsp: 3.32 ± 0.06	3.134ValGlu: 3.134 ± 0.062	2.947ValPhe: 2.947 ± 0.068	3.518ValGly: 3.518 ± 0.077	1.456ValHis: 1.456 ± 0.042	4.722ValIle: 4.722 ± 0.085	3.152ValLys: 3.152 ± 0.066	6.953ValLeu: 6.953 ± 0.104	1.654ValMet: 1.654 ± 0.046	3.139ValAsn: 3.139 ± 0.073	2.413ValPro: 2.413 ± 0.049	2.156ValGln: 2.156 ± 0.054	2.458ValArg: 2.458 ± 0.049	4.217ValSer: 4.217 ± 0.08	3.616ValThr: 3.616 ± 0.074	4.269ValVal: 4.269 ± 0.09	0.611ValTrp: 0.611 ± 0.027	2.065ValTyr: 2.065 ± 0.047	0.001ValXaa: 0.001 ± 0.001
Trp	0.657TrpAla: 0.657 ± 0.031	0.157TrpCys: 0.157 ± 0.013	0.515TrpAsp: 0.515 ± 0.027	0.487TrpGlu: 0.487 ± 0.025	0.553TrpPhe: 0.553 ± 0.025	0.683TrpGly: 0.683 ± 0.031	0.365TrpHis: 0.365 ± 0.019	0.768TrpIle: 0.768 ± 0.033	0.488TrpLys: 0.488 ± 0.025	1.42TrpLeu: 1.42 ± 0.045	0.327TrpMet: 0.327 ± 0.018	0.589TrpAsn: 0.589 ± 0.026	0.404TrpPro: 0.404 ± 0.022	0.632TrpGln: 0.632 ± 0.026	0.533TrpArg: 0.533 ± 0.023	0.651TrpSer: 0.651 ± 0.027	0.486TrpThr: 0.486 ± 0.023	0.697TrpVal: 0.697 ± 0.03	0.139TrpTrp: 0.139 ± 0.012	0.397TrpTyr: 0.397 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.542TyrAla: 2.542 ± 0.055	0.597TyrCys: 0.597 ± 0.026	1.766TyrAsp: 1.766 ± 0.098	1.74TyrGlu: 1.74 ± 0.049	1.789TyrPhe: 1.789 ± 0.049	2.029TyrGly: 2.029 ± 0.051	0.979TyrHis: 0.979 ± 0.034	1.953TyrIle: 1.953 ± 0.048	1.724TyrLys: 1.724 ± 0.043	4.125TyrLeu: 4.125 ± 0.071	0.602TyrMet: 0.602 ± 0.024	1.393TyrAsn: 1.393 ± 0.047	1.581TyrPro: 1.581 ± 0.047	2.031TyrGln: 2.031 ± 0.046	1.65TyrArg: 1.65 ± 0.048	2.404TyrSer: 2.404 ± 0.057	1.724TyrThr: 1.724 ± 0.046	1.749TyrVal: 1.749 ± 0.04	0.484TyrTrp: 0.484 ± 0.023	1.372TyrTyr: 1.372 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.002XaaThr: 0.002 ± 0.002	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.002	0.043XaaXaa: 0.043 ± 0.013

Statistics based on 2614 proteins (893477 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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