Amino acid dipepetide frequency for Bacteroidales bacterium KA00251

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.992AlaAla: 3.992 ± 0.119	0.764AlaCys: 0.764 ± 0.043	3.339AlaAsp: 3.339 ± 0.086	4.538AlaGlu: 4.538 ± 0.1	3.353AlaPhe: 3.353 ± 0.081	4.133AlaGly: 4.133 ± 0.101	1.313AlaHis: 1.313 ± 0.045	5.424AlaIle: 5.424 ± 0.114	4.843AlaLys: 4.843 ± 0.111	8.216AlaLeu: 8.216 ± 0.135	1.878AlaMet: 1.878 ± 0.061	2.817AlaAsn: 2.817 ± 0.075	2.701AlaPro: 2.701 ± 0.071	2.947AlaGln: 2.947 ± 0.066	3.281AlaArg: 3.281 ± 0.086	4.774AlaSer: 4.774 ± 0.095	4.948AlaThr: 4.948 ± 0.104	4.252AlaVal: 4.252 ± 0.09	0.585AlaTrp: 0.585 ± 0.028	2.719AlaTyr: 2.719 ± 0.072	0.0AlaXaa: 0.0 ± 0.0
Cys	0.632CysAla: 0.632 ± 0.037	0.184CysCys: 0.184 ± 0.019	0.565CysAsp: 0.565 ± 0.033	0.688CysGlu: 0.688 ± 0.036	0.603CysPhe: 0.603 ± 0.035	0.872CysGly: 0.872 ± 0.047	0.329CysHis: 0.329 ± 0.025	0.688CysIle: 0.688 ± 0.038	0.706CysLys: 0.706 ± 0.037	0.999CysLeu: 0.999 ± 0.041	0.209CysMet: 0.209 ± 0.021	0.545CysAsn: 0.545 ± 0.035	0.542CysPro: 0.542 ± 0.036	0.381CysGln: 0.381 ± 0.029	0.619CysArg: 0.619 ± 0.036	0.757CysSer: 0.757 ± 0.042	0.634CysThr: 0.634 ± 0.032	0.567CysVal: 0.567 ± 0.035	0.101CysTrp: 0.101 ± 0.014	0.54CysTyr: 0.54 ± 0.034	0.0CysXaa: 0.0 ± 0.0
Asp	3.492AspAla: 3.492 ± 0.081	0.594AspCys: 0.594 ± 0.036	2.01AspAsp: 2.01 ± 0.072	3.335AspGlu: 3.335 ± 0.096	2.961AspPhe: 2.961 ± 0.071	3.106AspGly: 3.106 ± 0.088	0.89AspHis: 0.89 ± 0.044	3.192AspIle: 3.192 ± 0.08	3.709AspLys: 3.709 ± 0.091	5.184AspLeu: 5.184 ± 0.106	1.087AspMet: 1.087 ± 0.045	2.216AspAsn: 2.216 ± 0.07	2.295AspPro: 2.295 ± 0.069	1.334AspGln: 1.334 ± 0.054	2.495AspArg: 2.495 ± 0.069	3.129AspSer: 3.129 ± 0.102	2.539AspThr: 2.539 ± 0.067	2.692AspVal: 2.692 ± 0.071	0.63AspTrp: 0.63 ± 0.036	2.241AspTyr: 2.241 ± 0.078	0.0AspXaa: 0.0 ± 0.0
Glu	5.349GluAla: 5.349 ± 0.115	0.58GluCys: 0.58 ± 0.034	3.449GluAsp: 3.449 ± 0.087	7.06GluGlu: 7.06 ± 0.165	1.974GluPhe: 1.974 ± 0.062	5.267GluGly: 5.267 ± 0.137	1.206GluHis: 1.206 ± 0.05	4.67GluIle: 4.67 ± 0.097	5.932GluLys: 5.932 ± 0.108	6.318GluLeu: 6.318 ± 0.123	1.793GluMet: 1.793 ± 0.066	2.86GluAsn: 2.86 ± 0.071	1.827GluPro: 1.827 ± 0.051	2.676GluGln: 2.676 ± 0.081	3.716GluArg: 3.716 ± 0.097	3.837GluSer: 3.837 ± 0.087	3.304GluThr: 3.304 ± 0.077	5.19GluVal: 5.19 ± 0.101	0.666GluTrp: 0.666 ± 0.037	2.36GluTyr: 2.36 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	3.256PheAla: 3.256 ± 0.084	0.616PheCys: 0.616 ± 0.03	2.548PheAsp: 2.548 ± 0.074	2.523PheGlu: 2.523 ± 0.065	2.588PhePhe: 2.588 ± 0.085	2.844PheGly: 2.844 ± 0.078	0.825PheHis: 0.825 ± 0.039	2.978PheIle: 2.978 ± 0.09	2.291PheLys: 2.291 ± 0.075	4.583PheLeu: 4.583 ± 0.101	0.968PheMet: 0.968 ± 0.04	1.878PheAsn: 1.878 ± 0.054	2.006PhePro: 2.006 ± 0.062	1.287PheGln: 1.287 ± 0.048	2.228PheArg: 2.228 ± 0.072	3.817PheSer: 3.817 ± 0.088	2.716PheThr: 2.716 ± 0.081	3.153PheVal: 3.153 ± 0.078	0.486PheTrp: 0.486 ± 0.032	1.726PheTyr: 1.726 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	4.684GlyAla: 4.684 ± 0.1	0.863GlyCys: 0.863 ± 0.049	3.333GlyAsp: 3.333 ± 0.077	4.476GlyGlu: 4.476 ± 0.092	2.938GlyPhe: 2.938 ± 0.076	4.577GlyGly: 4.577 ± 0.113	1.262GlyHis: 1.262 ± 0.046	4.937GlyIle: 4.937 ± 0.114	5.424GlyLys: 5.424 ± 0.099	5.63GlyLeu: 5.63 ± 0.113	1.683GlyMet: 1.683 ± 0.06	2.963GlyAsn: 2.963 ± 0.083	1.183GlyPro: 1.183 ± 0.043	1.795GlyGln: 1.795 ± 0.051	2.913GlyArg: 2.913 ± 0.079	4.122GlySer: 4.122 ± 0.09	3.702GlyThr: 3.702 ± 0.091	4.801GlyVal: 4.801 ± 0.095	0.679GlyTrp: 0.679 ± 0.035	3.044GlyTyr: 3.044 ± 0.083	0.0GlyXaa: 0.0 ± 0.0
His	1.161HisAla: 1.161 ± 0.044	0.321HisCys: 0.321 ± 0.026	0.863HisAsp: 0.863 ± 0.038	1.094HisGlu: 1.094 ± 0.045	1.284HisPhe: 1.284 ± 0.046	1.143HisGly: 1.143 ± 0.047	0.538HisHis: 0.538 ± 0.034	1.369HisIle: 1.369 ± 0.054	1.278HisLys: 1.278 ± 0.049	2.331HisLeu: 2.331 ± 0.07	0.388HisMet: 0.388 ± 0.026	0.849HisAsn: 0.849 ± 0.037	1.237HisPro: 1.237 ± 0.047	0.616HisGln: 0.616 ± 0.034	1.069HisArg: 1.069 ± 0.05	1.434HisSer: 1.434 ± 0.05	1.138HisThr: 1.138 ± 0.042	0.908HisVal: 0.908 ± 0.042	0.251HisTrp: 0.251 ± 0.025	0.991HisTyr: 0.991 ± 0.045	0.0HisXaa: 0.0 ± 0.0
Ile	5.923IleAla: 5.923 ± 0.121	0.674IleCys: 0.674 ± 0.038	4.117IleAsp: 4.117 ± 0.082	4.996IleGlu: 4.996 ± 0.102	2.553IlePhe: 2.553 ± 0.08	4.319IleGly: 4.319 ± 0.089	1.315IleHis: 1.315 ± 0.055	3.821IleIle: 3.821 ± 0.093	3.985IleLys: 3.985 ± 0.101	6.381IleLeu: 6.381 ± 0.119	1.12IleMet: 1.12 ± 0.05	2.678IleAsn: 2.678 ± 0.067	3.411IlePro: 3.411 ± 0.083	2.098IleGln: 2.098 ± 0.064	3.276IleArg: 3.276 ± 0.089	4.568IleSer: 4.568 ± 0.083	3.868IleThr: 3.868 ± 0.085	4.473IleVal: 4.473 ± 0.093	0.477IleTrp: 0.477 ± 0.028	2.255IleTyr: 2.255 ± 0.064	0.0IleXaa: 0.0 ± 0.0
Lys	5.125LysAla: 5.125 ± 0.122	0.469LysCys: 0.469 ± 0.032	3.458LysAsp: 3.458 ± 0.086	6.867LysGlu: 6.867 ± 0.125	1.526LysPhe: 1.526 ± 0.058	5.114LysGly: 5.114 ± 0.097	1.143LysHis: 1.143 ± 0.051	4.112LysIle: 4.112 ± 0.081	5.811LysLys: 5.811 ± 0.111	6.109LysLeu: 6.109 ± 0.116	1.894LysMet: 1.894 ± 0.062	2.932LysAsn: 2.932 ± 0.086	2.449LysPro: 2.449 ± 0.064	2.631LysGln: 2.631 ± 0.068	3.801LysArg: 3.801 ± 0.097	4.115LysSer: 4.115 ± 0.094	3.323LysThr: 3.323 ± 0.085	4.821LysVal: 4.821 ± 0.103	0.627LysTrp: 0.627 ± 0.041	2.196LysTyr: 2.196 ± 0.067	0.0LysXaa: 0.0 ± 0.0
Leu	7.346LeuAla: 7.346 ± 0.123	1.365LeuCys: 1.365 ± 0.055	4.538LeuAsp: 4.538 ± 0.087	6.046LeuGlu: 6.046 ± 0.135	5.628LeuPhe: 5.628 ± 0.119	6.199LeuGly: 6.199 ± 0.114	2.452LeuHis: 2.452 ± 0.071	5.8LeuIle: 5.8 ± 0.115	6.004LeuLys: 6.004 ± 0.106	11.905LeuLeu: 11.905 ± 0.18	2.217LeuMet: 2.217 ± 0.066	3.866LeuAsn: 3.866 ± 0.085	5.107LeuPro: 5.107 ± 0.115	4.328LeuGln: 4.328 ± 0.097	5.41LeuArg: 5.41 ± 0.11	9.005LeuSer: 9.005 ± 0.148	5.572LeuThr: 5.572 ± 0.118	6.062LeuVal: 6.062 ± 0.098	0.941LeuTrp: 0.941 ± 0.042	4.196LeuTyr: 4.196 ± 0.105	0.0LeuXaa: 0.0 ± 0.0
Met	1.862MetAla: 1.862 ± 0.065	0.15MetCys: 0.15 ± 0.016	1.083MetAsp: 1.083 ± 0.042	1.542MetGlu: 1.542 ± 0.053	0.585MetPhe: 0.585 ± 0.032	1.71MetGly: 1.71 ± 0.073	0.482MetHis: 0.482 ± 0.03	1.334MetIle: 1.334 ± 0.046	1.95MetLys: 1.95 ± 0.059	2.407MetLeu: 2.407 ± 0.075	0.692MetMet: 0.692 ± 0.032	0.99MetAsn: 0.99 ± 0.04	1.221MetPro: 1.221 ± 0.053	0.995MetGln: 0.995 ± 0.043	1.204MetArg: 1.204 ± 0.049	1.34MetSer: 1.34 ± 0.054	1.242MetThr: 1.242 ± 0.047	1.372MetVal: 1.372 ± 0.05	0.161MetTrp: 0.161 ± 0.018	0.553MetTyr: 0.553 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.922AsnAla: 2.922 ± 0.08	0.493AsnCys: 0.493 ± 0.036	1.986AsnAsp: 1.986 ± 0.069	2.887AsnGlu: 2.887 ± 0.064	1.874AsnPhe: 1.874 ± 0.063	2.759AsnGly: 2.759 ± 0.079	0.841AsnHis: 0.841 ± 0.044	2.687AsnIle: 2.687 ± 0.072	2.893AsnLys: 2.893 ± 0.082	4.28AsnLeu: 4.28 ± 0.09	0.964AsnMet: 0.964 ± 0.035	2.015AsnAsn: 2.015 ± 0.072	2.293AsnPro: 2.293 ± 0.072	1.362AsnGln: 1.362 ± 0.049	2.212AsnArg: 2.212 ± 0.062	2.835AsnSer: 2.835 ± 0.072	2.315AsnThr: 2.315 ± 0.061	2.485AsnVal: 2.485 ± 0.071	0.441AsnTrp: 0.441 ± 0.027	1.753AsnTyr: 1.753 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	2.367ProAla: 2.367 ± 0.062	0.379ProCys: 0.379 ± 0.026	1.99ProAsp: 1.99 ± 0.06	3.118ProGlu: 3.118 ± 0.076	2.259ProPhe: 2.259 ± 0.068	1.88ProGly: 1.88 ± 0.063	1.033ProHis: 1.033 ± 0.043	3.109ProIle: 3.109 ± 0.077	2.506ProLys: 2.506 ± 0.068	4.975ProLeu: 4.975 ± 0.089	0.901ProMet: 0.901 ± 0.034	1.851ProAsn: 1.851 ± 0.066	1.253ProPro: 1.253 ± 0.054	1.966ProGln: 1.966 ± 0.065	1.784ProArg: 1.784 ± 0.059	3.409ProSer: 3.409 ± 0.097	2.38ProThr: 2.38 ± 0.064	2.084ProVal: 2.084 ± 0.061	0.403ProTrp: 0.403 ± 0.03	1.878ProTyr: 1.878 ± 0.062	0.0ProXaa: 0.0 ± 0.0
Gln	2.443GlnAla: 2.443 ± 0.081	0.347GlnCys: 0.347 ± 0.021	1.701GlnAsp: 1.701 ± 0.057	2.969GlnGlu: 2.969 ± 0.075	1.394GlnPhe: 1.394 ± 0.051	2.331GlnGly: 2.331 ± 0.063	0.771GlnHis: 0.771 ± 0.04	2.272GlnIle: 2.272 ± 0.063	2.875GlnLys: 2.875 ± 0.084	3.776GlnLeu: 3.776 ± 0.079	0.894GlnMet: 0.894 ± 0.042	1.508GlnAsn: 1.508 ± 0.055	1.226GlnPro: 1.226 ± 0.045	1.598GlnGln: 1.598 ± 0.064	2.004GlnArg: 2.004 ± 0.073	2.264GlnSer: 2.264 ± 0.06	1.706GlnThr: 1.706 ± 0.048	2.096GlnVal: 2.096 ± 0.057	0.372GlnTrp: 0.372 ± 0.027	1.343GlnTyr: 1.343 ± 0.055	0.0GlnXaa: 0.0 ± 0.0
Arg	3.102ArgAla: 3.102 ± 0.079	0.488ArgCys: 0.488 ± 0.028	2.329ArgAsp: 2.329 ± 0.067	3.57ArgGlu: 3.57 ± 0.092	2.497ArgPhe: 2.497 ± 0.064	3.046ArgGly: 3.046 ± 0.079	1.114ArgHis: 1.114 ± 0.05	3.821ArgIle: 3.821 ± 0.078	3.774ArgLys: 3.774 ± 0.089	5.365ArgLeu: 5.365 ± 0.108	1.273ArgMet: 1.273 ± 0.049	2.281ArgAsn: 2.281 ± 0.072	1.811ArgPro: 1.811 ± 0.053	1.853ArgGln: 1.853 ± 0.064	2.806ArgArg: 2.806 ± 0.086	2.965ArgSer: 2.965 ± 0.088	2.31ArgThr: 2.31 ± 0.063	2.896ArgVal: 2.896 ± 0.078	0.466ArgTrp: 0.466 ± 0.032	2.331ArgTyr: 2.331 ± 0.076	0.0ArgXaa: 0.0 ± 0.0
Ser	4.196SerAla: 4.196 ± 0.075	0.975SerCys: 0.975 ± 0.043	3.247SerAsp: 3.247 ± 0.085	4.126SerGlu: 4.126 ± 0.097	3.929SerPhe: 3.929 ± 0.096	4.323SerGly: 4.323 ± 0.087	1.49SerHis: 1.49 ± 0.057	4.924SerIle: 4.924 ± 0.09	4.016SerLys: 4.016 ± 0.089	8.254SerLeu: 8.254 ± 0.144	1.417SerMet: 1.417 ± 0.057	2.833SerAsn: 2.833 ± 0.075	3.127SerPro: 3.127 ± 0.073	2.546SerGln: 2.546 ± 0.066	3.339SerArg: 3.339 ± 0.075	5.659SerSer: 5.659 ± 0.105	3.978SerThr: 3.978 ± 0.099	3.817SerVal: 3.817 ± 0.085	0.657SerTrp: 0.657 ± 0.037	3.01SerTyr: 3.01 ± 0.089	0.0SerXaa: 0.0 ± 0.0
Thr	3.889ThrAla: 3.889 ± 0.087	0.473ThrCys: 0.473 ± 0.034	2.577ThrAsp: 2.577 ± 0.07	3.095ThrGlu: 3.095 ± 0.075	2.691ThrPhe: 2.691 ± 0.08	3.57ThrGly: 3.57 ± 0.084	1.058ThrHis: 1.058 ± 0.051	4.325ThrIle: 4.325 ± 0.096	3.472ThrLys: 3.472 ± 0.083	6.773ThrLeu: 6.773 ± 0.12	1.062ThrMet: 1.062 ± 0.05	2.196ThrAsn: 2.196 ± 0.063	3.341ThrPro: 3.341 ± 0.088	1.856ThrGln: 1.856 ± 0.057	2.288ThrArg: 2.288 ± 0.058	3.873ThrSer: 3.873 ± 0.08	3.375ThrThr: 3.375 ± 0.089	3.106ThrVal: 3.106 ± 0.089	0.41ThrTrp: 0.41 ± 0.026	2.077ThrTyr: 2.077 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	5.757ValAla: 5.757 ± 0.109	0.789ValCys: 0.789 ± 0.04	3.362ValAsp: 3.362 ± 0.072	4.364ValGlu: 4.364 ± 0.093	2.4ValPhe: 2.4 ± 0.071	4.395ValGly: 4.395 ± 0.104	1.0ValHis: 1.0 ± 0.044	3.723ValIle: 3.723 ± 0.094	3.886ValLys: 3.886 ± 0.089	5.798ValLeu: 5.798 ± 0.111	1.392ValMet: 1.392 ± 0.052	2.447ValAsn: 2.447 ± 0.077	2.568ValPro: 2.568 ± 0.067	1.78ValGln: 1.78 ± 0.058	2.853ValArg: 2.853 ± 0.077	4.516ValSer: 4.516 ± 0.089	3.525ValThr: 3.525 ± 0.085	4.973ValVal: 4.973 ± 0.112	0.574ValTrp: 0.574 ± 0.033	2.248ValTyr: 2.248 ± 0.069	0.0ValXaa: 0.0 ± 0.0
Trp	0.538TrpAla: 0.538 ± 0.036	0.132TrpCys: 0.132 ± 0.016	0.486TrpAsp: 0.486 ± 0.031	0.592TrpGlu: 0.592 ± 0.033	0.345TrpPhe: 0.345 ± 0.026	0.791TrpGly: 0.791 ± 0.049	0.249TrpHis: 0.249 ± 0.021	0.634TrpIle: 0.634 ± 0.037	0.697TrpLys: 0.697 ± 0.032	0.975TrpLeu: 0.975 ± 0.049	0.296TrpMet: 0.296 ± 0.022	0.457TrpAsn: 0.457 ± 0.034	0.172TrpPro: 0.172 ± 0.018	0.444TrpGln: 0.444 ± 0.029	0.516TrpArg: 0.516 ± 0.032	0.567TrpSer: 0.567 ± 0.033	0.471TrpThr: 0.471 ± 0.029	0.58TrpVal: 0.58 ± 0.034	0.094TrpTrp: 0.094 ± 0.013	0.349TrpTyr: 0.349 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.783TyrAla: 2.783 ± 0.07	0.506TyrCys: 0.506 ± 0.032	2.154TyrAsp: 2.154 ± 0.063	2.147TyrGlu: 2.147 ± 0.065	1.934TyrPhe: 1.934 ± 0.068	2.631TyrGly: 2.631 ± 0.076	0.952TyrHis: 0.952 ± 0.041	2.488TyrIle: 2.488 ± 0.068	2.468TyrLys: 2.468 ± 0.062	3.729TyrLeu: 3.729 ± 0.089	0.744TyrMet: 0.744 ± 0.037	2.116TyrAsn: 2.116 ± 0.08	1.757TyrPro: 1.757 ± 0.06	1.396TyrGln: 1.396 ± 0.051	2.282TyrArg: 2.282 ± 0.075	2.876TyrSer: 2.876 ± 0.081	2.461TyrThr: 2.461 ± 0.064	2.022TyrVal: 2.022 ± 0.063	0.365TyrTrp: 0.365 ± 0.026	1.844TyrTyr: 1.844 ± 0.065	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1795 proteins (553800 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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