Amino acid dipepetide frequency for Glycomyces sambucus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	25.382AlaAla: 25.382 ± 0.232	0.998AlaCys: 0.998 ± 0.025	9.337AlaAsp: 9.337 ± 0.091	9.628AlaGlu: 9.628 ± 0.101	4.214AlaPhe: 4.214 ± 0.052	13.034AlaGly: 13.034 ± 0.115	2.638AlaHis: 2.638 ± 0.043	4.845AlaIle: 4.845 ± 0.054	3.062AlaLys: 3.062 ± 0.05	14.478AlaLeu: 14.478 ± 0.135	2.877AlaMet: 2.877 ± 0.043	2.534AlaAsn: 2.534 ± 0.04	6.985AlaPro: 6.985 ± 0.09	3.517AlaGln: 3.517 ± 0.047	8.926AlaArg: 8.926 ± 0.098	6.306AlaSer: 6.306 ± 0.072	7.004AlaThr: 7.004 ± 0.073	13.201AlaVal: 13.201 ± 0.116	2.214AlaTrp: 2.214 ± 0.04	2.794AlaTyr: 2.794 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.934CysAla: 0.934 ± 0.026	0.092CysCys: 0.092 ± 0.007	0.485CysAsp: 0.485 ± 0.017	0.429CysGlu: 0.429 ± 0.016	0.218CysPhe: 0.218 ± 0.012	0.851CysGly: 0.851 ± 0.024	0.162CysHis: 0.162 ± 0.01	0.2CysIle: 0.2 ± 0.011	0.094CysLys: 0.094 ± 0.007	0.607CysLeu: 0.607 ± 0.02	0.133CysMet: 0.133 ± 0.01	0.152CysAsn: 0.152 ± 0.01	0.38CysPro: 0.38 ± 0.016	0.143CysGln: 0.143 ± 0.009	0.445CysArg: 0.445 ± 0.016	0.406CysSer: 0.406 ± 0.016	0.434CysThr: 0.434 ± 0.017	0.532CysVal: 0.532 ± 0.018	0.115CysTrp: 0.115 ± 0.008	0.154CysTyr: 0.154 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	8.751AspAla: 8.751 ± 0.089	0.417AspCys: 0.417 ± 0.018	4.086AspAsp: 4.086 ± 0.075	4.2AspGlu: 4.2 ± 0.055	1.997AspPhe: 1.997 ± 0.035	6.569AspGly: 6.569 ± 0.085	1.421AspHis: 1.421 ± 0.031	1.917AspIle: 1.917 ± 0.034	0.997AspLys: 0.997 ± 0.028	7.101AspLeu: 7.101 ± 0.072	0.984AspMet: 0.984 ± 0.025	1.042AspAsn: 1.042 ± 0.029	4.905AspPro: 4.905 ± 0.056	1.683AspGln: 1.683 ± 0.034	5.217AspArg: 5.217 ± 0.07	2.4AspSer: 2.4 ± 0.043	3.292AspThr: 3.292 ± 0.054	4.503AspVal: 4.503 ± 0.055	1.147AspTrp: 1.147 ± 0.027	1.495AspTyr: 1.495 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	8.762GluAla: 8.762 ± 0.093	0.403GluCys: 0.403 ± 0.016	3.532GluAsp: 3.532 ± 0.056	3.566GluGlu: 3.566 ± 0.065	1.807GluPhe: 1.807 ± 0.031	4.643GluGly: 4.643 ± 0.062	1.654GluHis: 1.654 ± 0.033	2.456GluIle: 2.456 ± 0.039	1.085GluLys: 1.085 ± 0.03	6.25GluLeu: 6.25 ± 0.073	0.967GluMet: 0.967 ± 0.024	1.027GluAsn: 1.027 ± 0.027	3.718GluPro: 3.718 ± 0.057	1.96GluGln: 1.96 ± 0.032	5.436GluArg: 5.436 ± 0.068	2.996GluSer: 2.996 ± 0.047	3.304GluThr: 3.304 ± 0.051	4.781GluVal: 4.781 ± 0.062	0.947GluTrp: 0.947 ± 0.028	1.398GluTyr: 1.398 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.597PheAla: 4.597 ± 0.058	0.237PheCys: 0.237 ± 0.013	2.456PheAsp: 2.456 ± 0.04	1.723PheGlu: 1.723 ± 0.034	0.932PhePhe: 0.932 ± 0.031	3.427PheGly: 3.427 ± 0.048	0.621PheHis: 0.621 ± 0.019	1.042PheIle: 1.042 ± 0.025	0.616PheLys: 0.616 ± 0.019	2.773PheLeu: 2.773 ± 0.046	0.518PheMet: 0.518 ± 0.018	0.743PheAsn: 0.743 ± 0.024	1.359PhePro: 1.359 ± 0.029	0.77PheGln: 0.77 ± 0.023	1.812PheArg: 1.812 ± 0.033	1.508PheSer: 1.508 ± 0.032	2.388PheThr: 2.388 ± 0.047	2.135PheVal: 2.135 ± 0.038	0.491PheTrp: 0.491 ± 0.018	0.691PheTyr: 0.691 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	11.488GlyAla: 11.488 ± 0.092	0.685GlyCys: 0.685 ± 0.019	5.886GlyAsp: 5.886 ± 0.083	5.539GlyGlu: 5.539 ± 0.068	3.213GlyPhe: 3.213 ± 0.049	8.483GlyGly: 8.483 ± 0.117	1.944GlyHis: 1.944 ± 0.039	3.746GlyIle: 3.746 ± 0.055	2.053GlyLys: 2.053 ± 0.041	9.662GlyLeu: 9.662 ± 0.085	1.95GlyMet: 1.95 ± 0.039	1.903GlyAsn: 1.903 ± 0.044	4.91GlyPro: 4.91 ± 0.057	2.369GlyGln: 2.369 ± 0.042	6.755GlyArg: 6.755 ± 0.063	4.834GlySer: 4.834 ± 0.062	5.936GlyThr: 5.936 ± 0.071	7.236GlyVal: 7.236 ± 0.061	1.779GlyTrp: 1.779 ± 0.032	2.328GlyTyr: 2.328 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.447HisAla: 2.447 ± 0.045	0.175HisCys: 0.175 ± 0.008	1.246HisAsp: 1.246 ± 0.029	1.162HisGlu: 1.162 ± 0.03	0.668HisPhe: 0.668 ± 0.023	2.016HisGly: 2.016 ± 0.036	0.588HisHis: 0.588 ± 0.021	0.606HisIle: 0.606 ± 0.02	0.295HisLys: 0.295 ± 0.012	2.502HisLeu: 2.502 ± 0.041	0.338HisMet: 0.338 ± 0.013	0.352HisAsn: 0.352 ± 0.013	1.54HisPro: 1.54 ± 0.03	0.548HisGln: 0.548 ± 0.021	1.901HisArg: 1.901 ± 0.037	0.902HisSer: 0.902 ± 0.024	1.037HisThr: 1.037 ± 0.027	1.519HisVal: 1.519 ± 0.03	0.392HisTrp: 0.392 ± 0.014	0.532HisTyr: 0.532 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.408IleAla: 6.408 ± 0.066	0.27IleCys: 0.27 ± 0.012	2.837IleAsp: 2.837 ± 0.046	2.609IleGlu: 2.609 ± 0.043	0.763IlePhe: 0.763 ± 0.022	4.214IleGly: 4.214 ± 0.06	0.584IleHis: 0.584 ± 0.021	1.159IleIle: 1.159 ± 0.027	0.68IleLys: 0.68 ± 0.02	2.9IleLeu: 2.9 ± 0.047	0.538IleMet: 0.538 ± 0.02	0.671IleAsn: 0.671 ± 0.022	1.83IlePro: 1.83 ± 0.033	0.793IleGln: 0.793 ± 0.023	2.19IleArg: 2.19 ± 0.043	1.534IleSer: 1.534 ± 0.035	2.231IleThr: 2.231 ± 0.038	3.211IleVal: 3.211 ± 0.056	0.457IleTrp: 0.457 ± 0.017	0.574IleTyr: 0.574 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.799LysAla: 2.799 ± 0.049	0.1LysCys: 0.1 ± 0.007	1.115LysAsp: 1.115 ± 0.028	1.079LysGlu: 1.079 ± 0.028	0.498LysPhe: 0.498 ± 0.019	1.599LysGly: 1.599 ± 0.033	0.468LysHis: 0.468 ± 0.017	0.841LysIle: 0.841 ± 0.024	0.585LysLys: 0.585 ± 0.027	1.863LysLeu: 1.863 ± 0.043	0.36LysMet: 0.36 ± 0.016	0.413LysAsn: 0.413 ± 0.017	1.205LysPro: 1.205 ± 0.028	0.584LysGln: 0.584 ± 0.018	1.737LysArg: 1.737 ± 0.032	1.038LysSer: 1.038 ± 0.029	1.212LysThr: 1.212 ± 0.029	1.604LysVal: 1.604 ± 0.033	0.294LysTrp: 0.294 ± 0.012	0.424LysTyr: 0.424 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	16.148LeuAla: 16.148 ± 0.139	0.728LeuCys: 0.728 ± 0.021	7.053LeuAsp: 7.053 ± 0.078	5.058LeuGlu: 5.058 ± 0.055	2.874LeuPhe: 2.874 ± 0.048	9.146LeuGly: 9.146 ± 0.083	2.087LeuHis: 2.087 ± 0.037	3.543LeuIle: 3.543 ± 0.051	1.986LeuLys: 1.986 ± 0.044	10.52LeuLeu: 10.52 ± 0.108	1.717LeuMet: 1.717 ± 0.036	1.841LeuAsn: 1.841 ± 0.036	5.764LeuPro: 5.764 ± 0.072	2.316LeuGln: 2.316 ± 0.037	7.581LeuArg: 7.581 ± 0.079	4.828LeuSer: 4.828 ± 0.055	6.142LeuThr: 6.142 ± 0.073	8.734LeuVal: 8.734 ± 0.08	1.415LeuTrp: 1.415 ± 0.03	1.858LeuTyr: 1.858 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.282MetAla: 2.282 ± 0.041	0.124MetCys: 0.124 ± 0.008	0.915MetAsp: 0.915 ± 0.024	0.838MetGlu: 0.838 ± 0.024	0.578MetPhe: 0.578 ± 0.017	1.345MetGly: 1.345 ± 0.03	0.375MetHis: 0.375 ± 0.015	0.784MetIle: 0.784 ± 0.023	0.423MetLys: 0.423 ± 0.018	1.871MetLeu: 1.871 ± 0.036	0.326MetMet: 0.326 ± 0.014	0.516MetAsn: 0.516 ± 0.018	1.114MetPro: 1.114 ± 0.031	0.473MetGln: 0.473 ± 0.016	1.543MetArg: 1.543 ± 0.03	1.362MetSer: 1.362 ± 0.027	1.556MetThr: 1.556 ± 0.027	1.384MetVal: 1.384 ± 0.032	0.26MetTrp: 0.26 ± 0.013	0.344MetTyr: 0.344 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.566AsnAla: 2.566 ± 0.039	0.148AsnCys: 0.148 ± 0.009	1.074AsnAsp: 1.074 ± 0.028	1.072AsnGlu: 1.072 ± 0.028	0.563AsnPhe: 0.563 ± 0.02	2.058AsnGly: 2.058 ± 0.042	0.391AsnHis: 0.391 ± 0.015	0.652AsnIle: 0.652 ± 0.022	0.328AsnLys: 0.328 ± 0.015	2.048AsnLeu: 2.048 ± 0.035	0.317AsnMet: 0.317 ± 0.013	0.454AsnAsn: 0.454 ± 0.02	1.549AsnPro: 1.549 ± 0.035	0.597AsnGln: 0.597 ± 0.021	1.407AsnArg: 1.407 ± 0.04	0.907AsnSer: 0.907 ± 0.027	1.15AsnThr: 1.15 ± 0.03	1.481AsnVal: 1.481 ± 0.035	0.406AsnTrp: 0.406 ± 0.015	0.498AsnTyr: 0.498 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.885ProAla: 7.885 ± 0.089	0.251ProCys: 0.251 ± 0.012	4.33ProAsp: 4.33 ± 0.054	4.566ProGlu: 4.566 ± 0.061	1.653ProPhe: 1.653 ± 0.03	5.991ProGly: 5.991 ± 0.071	1.173ProHis: 1.173 ± 0.029	1.709ProIle: 1.709 ± 0.034	1.135ProLys: 1.135 ± 0.029	4.852ProLeu: 4.852 ± 0.056	0.988ProMet: 0.988 ± 0.024	1.097ProAsn: 1.097 ± 0.026	3.029ProPro: 3.029 ± 0.08	1.635ProGln: 1.635 ± 0.042	3.399ProArg: 3.399 ± 0.052	2.796ProSer: 2.796 ± 0.043	2.831ProThr: 2.831 ± 0.049	5.224ProVal: 5.224 ± 0.059	0.943ProTrp: 0.943 ± 0.029	1.252ProTyr: 1.252 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.484GlnAla: 3.484 ± 0.048	0.161GlnCys: 0.161 ± 0.01	1.213GlnAsp: 1.213 ± 0.028	1.267GlnGlu: 1.267 ± 0.024	0.809GlnPhe: 0.809 ± 0.023	2.021GlnGly: 2.021 ± 0.033	0.54GlnHis: 0.54 ± 0.017	1.238GlnIle: 1.238 ± 0.029	0.45GlnLys: 0.45 ± 0.018	2.681GlnLeu: 2.681 ± 0.045	0.52GlnMet: 0.52 ± 0.017	0.528GlnAsn: 0.528 ± 0.022	1.485GlnPro: 1.485 ± 0.043	1.073GlnGln: 1.073 ± 0.036	2.244GlnArg: 2.244 ± 0.039	1.292GlnSer: 1.292 ± 0.03	1.456GlnThr: 1.456 ± 0.033	2.258GlnVal: 2.258 ± 0.042	0.538GlnTrp: 0.538 ± 0.019	0.659GlnTyr: 0.659 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.783ArgAla: 8.783 ± 0.085	0.442ArgCys: 0.442 ± 0.016	4.289ArgAsp: 4.289 ± 0.059	4.395ArgGlu: 4.395 ± 0.067	2.583ArgPhe: 2.583 ± 0.043	5.243ArgGly: 5.243 ± 0.071	1.763ArgHis: 1.763 ± 0.037	3.397ArgIle: 3.397 ± 0.048	1.55ArgLys: 1.55 ± 0.032	8.355ArgLeu: 8.355 ± 0.096	1.687ArgMet: 1.687 ± 0.033	1.341ArgAsn: 1.341 ± 0.029	4.204ArgPro: 4.204 ± 0.062	1.844ArgGln: 1.844 ± 0.033	7.029ArgArg: 7.029 ± 0.082	3.666ArgSer: 3.666 ± 0.053	4.48ArgThr: 4.48 ± 0.052	5.107ArgVal: 5.107 ± 0.061	1.26ArgTrp: 1.26 ± 0.031	1.716ArgTyr: 1.716 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	6.101SerAla: 6.101 ± 0.061	0.345SerCys: 0.345 ± 0.017	2.691SerAsp: 2.691 ± 0.042	2.728SerGlu: 2.728 ± 0.046	1.565SerPhe: 1.565 ± 0.031	5.716SerGly: 5.716 ± 0.067	0.884SerHis: 0.884 ± 0.026	1.832SerIle: 1.832 ± 0.036	0.983SerLys: 0.983 ± 0.028	4.581SerLeu: 4.581 ± 0.057	1.089SerMet: 1.089 ± 0.027	1.013SerAsn: 1.013 ± 0.028	2.782SerPro: 2.782 ± 0.048	1.283SerGln: 1.283 ± 0.029	3.263SerArg: 3.263 ± 0.041	2.535SerSer: 2.535 ± 0.047	2.87SerThr: 2.87 ± 0.043	3.903SerVal: 3.903 ± 0.049	0.944SerTrp: 0.944 ± 0.023	1.139SerTyr: 1.139 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	9.219ThrAla: 9.219 ± 0.091	0.409ThrCys: 0.409 ± 0.015	3.663ThrAsp: 3.663 ± 0.057	3.496ThrGlu: 3.496 ± 0.06	1.627ThrPhe: 1.627 ± 0.031	6.767ThrGly: 6.767 ± 0.079	0.924ThrHis: 0.924 ± 0.023	2.009ThrIle: 2.009 ± 0.037	0.978ThrLys: 0.978 ± 0.024	5.059ThrLeu: 5.059 ± 0.058	0.991ThrMet: 0.991 ± 0.024	1.039ThrAsn: 1.039 ± 0.028	3.262ThrPro: 3.262 ± 0.047	1.162ThrGln: 1.162 ± 0.027	3.344ThrArg: 3.344 ± 0.049	2.745ThrSer: 2.745 ± 0.051	3.509ThrThr: 3.509 ± 0.06	6.008ThrVal: 6.008 ± 0.065	1.067ThrTrp: 1.067 ± 0.028	1.272ThrTyr: 1.272 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	11.344ValAla: 11.344 ± 0.108	0.664ValCys: 0.664 ± 0.022	5.459ValAsp: 5.459 ± 0.058	5.175ValGlu: 5.175 ± 0.062	2.881ValPhe: 2.881 ± 0.047	6.165ValGly: 6.165 ± 0.071	1.772ValHis: 1.772 ± 0.038	3.082ValIle: 3.082 ± 0.047	1.764ValLys: 1.764 ± 0.032	9.129ValLeu: 9.129 ± 0.09	1.45ValMet: 1.45 ± 0.036	1.929ValAsn: 1.929 ± 0.041	4.74ValPro: 4.74 ± 0.061	1.97ValGln: 1.97 ± 0.039	5.683ValArg: 5.683 ± 0.063	4.115ValSer: 4.115 ± 0.053	5.026ValThr: 5.026 ± 0.063	7.586ValVal: 7.586 ± 0.094	1.258ValTrp: 1.258 ± 0.026	1.847ValTyr: 1.847 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.863TrpAla: 1.863 ± 0.034	0.144TrpCys: 0.144 ± 0.009	0.985TrpAsp: 0.985 ± 0.026	0.836TrpGlu: 0.836 ± 0.02	0.592TrpPhe: 0.592 ± 0.017	1.219TrpGly: 1.219 ± 0.031	0.373TrpHis: 0.373 ± 0.016	0.772TrpIle: 0.772 ± 0.021	0.387TrpLys: 0.387 ± 0.018	1.755TrpLeu: 1.755 ± 0.036	0.346TrpMet: 0.346 ± 0.014	0.566TrpAsn: 0.566 ± 0.02	0.821TrpPro: 0.821 ± 0.025	0.56TrpGln: 0.56 ± 0.017	1.353TrpArg: 1.353 ± 0.024	1.008TrpSer: 1.008 ± 0.025	1.304TrpThr: 1.304 ± 0.03	1.075TrpVal: 1.075 ± 0.026	0.389TrpTrp: 0.389 ± 0.016	0.379TrpTyr: 0.379 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.731TyrAla: 2.731 ± 0.039	0.176TyrCys: 0.176 ± 0.01	1.469TyrAsp: 1.469 ± 0.035	1.327TyrGlu: 1.327 ± 0.028	0.806TyrPhe: 0.806 ± 0.019	2.191TyrGly: 2.191 ± 0.04	0.406TyrHis: 0.406 ± 0.018	0.623TyrIle: 0.623 ± 0.022	0.368TyrLys: 0.368 ± 0.014	2.352TyrLeu: 2.352 ± 0.039	0.315TyrMet: 0.315 ± 0.014	0.504TyrAsn: 0.504 ± 0.018	1.158TyrPro: 1.158 ± 0.031	0.638TyrGln: 0.638 ± 0.019	1.87TyrArg: 1.87 ± 0.035	1.069TyrSer: 1.069 ± 0.028	1.389TyrThr: 1.389 ± 0.034	1.555TyrVal: 1.555 ± 0.032	0.409TyrTrp: 0.409 ± 0.016	0.53TyrTyr: 0.53 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5037 proteins (1656086 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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