Amino acid dipepetide frequency for Propionispira arboris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.651AlaAla: 8.651 ± 0.105
1.02AlaCys: 1.02 ± 0.036
4.343AlaAsp: 4.343 ± 0.063
5.134AlaGlu: 5.134 ± 0.07
3.351AlaPhe: 3.351 ± 0.064
6.39AlaGly: 6.39 ± 0.087
1.263AlaHis: 1.263 ± 0.032
6.535AlaIle: 6.535 ± 0.076
5.561AlaLys: 5.561 ± 0.077
7.459AlaLeu: 7.459 ± 0.095
2.571AlaMet: 2.571 ± 0.052
3.224AlaAsn: 3.224 ± 0.052
2.09AlaPro: 2.09 ± 0.047
2.936AlaGln: 2.936 ± 0.057
2.756AlaArg: 2.756 ± 0.05
4.241AlaSer: 4.241 ± 0.065
3.836AlaThr: 3.836 ± 0.062
6.526AlaVal: 6.526 ± 0.074
0.661AlaTrp: 0.661 ± 0.022
2.553AlaTyr: 2.553 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.879CysAla: 0.879 ± 0.027
0.214CysCys: 0.214 ± 0.016
0.665CysAsp: 0.665 ± 0.025
0.685CysGlu: 0.685 ± 0.025
0.562CysPhe: 0.562 ± 0.021
1.223CysGly: 1.223 ± 0.037
0.276CysHis: 0.276 ± 0.016
0.983CysIle: 0.983 ± 0.028
0.756CysLys: 0.756 ± 0.028
1.148CysLeu: 1.148 ± 0.033
0.377CysMet: 0.377 ± 0.016
0.521CysAsn: 0.521 ± 0.022
0.547CysPro: 0.547 ± 0.024
0.462CysGln: 0.462 ± 0.023
0.451CysArg: 0.451 ± 0.021
0.759CysSer: 0.759 ± 0.025
0.61CysThr: 0.61 ± 0.024
0.726CysVal: 0.726 ± 0.025
0.106CysTrp: 0.106 ± 0.009
0.435CysTyr: 0.435 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.809AspAla: 3.809 ± 0.058
0.655AspCys: 0.655 ± 0.023
2.505AspAsp: 2.505 ± 0.058
3.613AspGlu: 3.613 ± 0.055
2.71AspPhe: 2.71 ± 0.049
3.47AspGly: 3.47 ± 0.054
0.974AspHis: 0.974 ± 0.028
4.736AspIle: 4.736 ± 0.075
3.635AspLys: 3.635 ± 0.052
5.098AspLeu: 5.098 ± 0.068
1.587AspMet: 1.587 ± 0.037
1.993AspAsn: 1.993 ± 0.039
1.725AspPro: 1.725 ± 0.037
1.772AspGln: 1.772 ± 0.041
2.063AspArg: 2.063 ± 0.041
2.667AspSer: 2.667 ± 0.041
2.827AspThr: 2.827 ± 0.049
3.703AspVal: 3.703 ± 0.061
0.536AspTrp: 0.536 ± 0.021
2.102AspTyr: 2.102 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
4.915GluAla: 4.915 ± 0.075
0.606GluCys: 0.606 ± 0.022
2.873GluAsp: 2.873 ± 0.054
4.133GluGlu: 4.133 ± 0.062
2.435GluPhe: 2.435 ± 0.048
3.142GluGly: 3.142 ± 0.053
1.245GluHis: 1.245 ± 0.032
5.576GluIle: 5.576 ± 0.073
5.802GluLys: 5.802 ± 0.079
6.071GluLeu: 6.071 ± 0.07
1.95GluMet: 1.95 ± 0.04
3.596GluAsn: 3.596 ± 0.059
1.619GluPro: 1.619 ± 0.042
2.768GluGln: 2.768 ± 0.055
2.548GluArg: 2.548 ± 0.046
2.954GluSer: 2.954 ± 0.05
3.31GluThr: 3.31 ± 0.054
3.882GluVal: 3.882 ± 0.055
0.495GluTrp: 0.495 ± 0.022
2.327GluTyr: 2.327 ± 0.05
0.0GluXaa: 0.0 ± 0.0
Phe
3.436PheAla: 3.436 ± 0.059
0.618PheCys: 0.618 ± 0.022
2.411PheAsp: 2.411 ± 0.043
2.092PheGlu: 2.092 ± 0.039
2.336PhePhe: 2.336 ± 0.055
3.262PheGly: 3.262 ± 0.061
0.8PheHis: 0.8 ± 0.027
3.64PheIle: 3.64 ± 0.067
2.413PheLys: 2.413 ± 0.045
4.098PheLeu: 4.098 ± 0.07
1.329PheMet: 1.329 ± 0.035
1.83PheAsn: 1.83 ± 0.04
1.348PhePro: 1.348 ± 0.034
1.196PheGln: 1.196 ± 0.026
1.398PheArg: 1.398 ± 0.036
3.196PheSer: 3.196 ± 0.047
2.434PheThr: 2.434 ± 0.047
3.031PheVal: 3.031 ± 0.06
0.435PheTrp: 0.435 ± 0.021
1.609PheTyr: 1.609 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
5.269GlyAla: 5.269 ± 0.08
1.001GlyCys: 1.001 ± 0.031
3.188GlyAsp: 3.188 ± 0.056
3.773GlyGlu: 3.773 ± 0.061
3.288GlyPhe: 3.288 ± 0.051
4.841GlyGly: 4.841 ± 0.077
1.3GlyHis: 1.3 ± 0.034
6.638GlyIle: 6.638 ± 0.075
4.959GlyLys: 4.959 ± 0.064
6.432GlyLeu: 6.432 ± 0.081
2.242GlyMet: 2.242 ± 0.046
2.851GlyAsn: 2.851 ± 0.053
1.564GlyPro: 1.564 ± 0.041
2.341GlyGln: 2.341 ± 0.041
2.663GlyArg: 2.663 ± 0.046
4.074GlySer: 4.074 ± 0.068
4.053GlyThr: 4.053 ± 0.057
4.941GlyVal: 4.941 ± 0.073
0.733GlyTrp: 0.733 ± 0.031
2.666GlyTyr: 2.666 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
1.324HisAla: 1.324 ± 0.034
0.321HisCys: 0.321 ± 0.016
0.956HisAsp: 0.956 ± 0.028
1.066HisGlu: 1.066 ± 0.033
0.866HisPhe: 0.866 ± 0.026
1.374HisGly: 1.374 ± 0.034
0.49HisHis: 0.49 ± 0.022
1.631HisIle: 1.631 ± 0.037
1.189HisLys: 1.189 ± 0.031
1.815HisLeu: 1.815 ± 0.038
0.601HisMet: 0.601 ± 0.022
0.814HisAsn: 0.814 ± 0.027
0.893HisPro: 0.893 ± 0.029
0.641HisGln: 0.641 ± 0.024
0.735HisArg: 0.735 ± 0.027
1.07HisSer: 1.07 ± 0.029
1.067HisThr: 1.067 ± 0.031
1.212HisVal: 1.212 ± 0.034
0.208HisTrp: 0.208 ± 0.012
0.741HisTyr: 0.741 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
7.143IleAla: 7.143 ± 0.091
1.154IleCys: 1.154 ± 0.036
4.818IleAsp: 4.818 ± 0.064
5.454IleGlu: 5.454 ± 0.075
3.294IlePhe: 3.294 ± 0.064
6.165IleGly: 6.165 ± 0.074
1.684IleHis: 1.684 ± 0.036
6.24IleIle: 6.24 ± 0.076
5.419IleLys: 5.419 ± 0.071
8.039IleLeu: 8.039 ± 0.085
2.216IleMet: 2.216 ± 0.045
3.529IleAsn: 3.529 ± 0.067
3.373IlePro: 3.373 ± 0.052
2.943IleGln: 2.943 ± 0.048
3.077IleArg: 3.077 ± 0.056
5.223IleSer: 5.223 ± 0.066
4.69IleThr: 4.69 ± 0.059
5.809IleVal: 5.809 ± 0.07
0.669IleTrp: 0.669 ± 0.022
2.653IleTyr: 2.653 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
5.145LysAla: 5.145 ± 0.074
0.625LysCys: 0.625 ± 0.022
3.637LysAsp: 3.637 ± 0.06
5.016LysGlu: 5.016 ± 0.068
2.26LysPhe: 2.26 ± 0.044
3.609LysGly: 3.609 ± 0.06
1.185LysHis: 1.185 ± 0.033
6.464LysIle: 6.464 ± 0.08
5.909LysLys: 5.909 ± 0.085
6.031LysLeu: 6.031 ± 0.067
2.41LysMet: 2.41 ± 0.044
4.274LysAsn: 4.274 ± 0.06
2.131LysPro: 2.131 ± 0.045
2.979LysGln: 2.979 ± 0.053
2.646LysArg: 2.646 ± 0.053
3.644LysSer: 3.644 ± 0.053
4.116LysThr: 4.116 ± 0.067
4.453LysVal: 4.453 ± 0.066
0.576LysTrp: 0.576 ± 0.024
2.507LysTyr: 2.507 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
8.416LeuAla: 8.416 ± 0.086
1.294LeuCys: 1.294 ± 0.033
5.077LeuAsp: 5.077 ± 0.063
5.552LeuGlu: 5.552 ± 0.074
4.146LeuPhe: 4.146 ± 0.076
6.5LeuGly: 6.5 ± 0.088
1.802LeuHis: 1.802 ± 0.035
7.048LeuIle: 7.048 ± 0.078
6.616LeuLys: 6.616 ± 0.076
9.753LeuLeu: 9.753 ± 0.134
2.658LeuMet: 2.658 ± 0.046
4.211LeuAsn: 4.211 ± 0.062
3.925LeuPro: 3.925 ± 0.062
3.853LeuGln: 3.853 ± 0.067
3.556LeuArg: 3.556 ± 0.059
6.299LeuSer: 6.299 ± 0.085
5.573LeuThr: 5.573 ± 0.064
6.169LeuVal: 6.169 ± 0.078
0.751LeuTrp: 0.751 ± 0.029
2.995LeuTyr: 2.995 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.549MetAla: 2.549 ± 0.044
0.232MetCys: 0.232 ± 0.013
1.702MetAsp: 1.702 ± 0.035
1.931MetGlu: 1.931 ± 0.043
1.038MetPhe: 1.038 ± 0.03
2.082MetGly: 2.082 ± 0.044
0.551MetHis: 0.551 ± 0.021
2.322MetIle: 2.322 ± 0.047
2.275MetLys: 2.275 ± 0.045
2.886MetLeu: 2.886 ± 0.056
0.884MetMet: 0.884 ± 0.027
1.559MetAsn: 1.559 ± 0.033
1.23MetPro: 1.23 ± 0.035
1.328MetGln: 1.328 ± 0.035
1.162MetArg: 1.162 ± 0.03
1.733MetSer: 1.733 ± 0.043
1.618MetThr: 1.618 ± 0.04
2.05MetVal: 2.05 ± 0.041
0.19MetTrp: 0.19 ± 0.012
0.756MetTyr: 0.756 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
3.171AsnAla: 3.171 ± 0.062
0.555AsnCys: 0.555 ± 0.021
2.176AsnAsp: 2.176 ± 0.044
2.792AsnGlu: 2.792 ± 0.052
1.827AsnPhe: 1.827 ± 0.04
3.105AsnGly: 3.105 ± 0.06
0.947AsnHis: 0.947 ± 0.032
4.273AsnIle: 4.273 ± 0.064
3.039AsnLys: 3.039 ± 0.066
4.568AsnLeu: 4.568 ± 0.063
1.357AsnMet: 1.357 ± 0.033
2.073AsnAsn: 2.073 ± 0.044
2.024AsnPro: 2.024 ± 0.045
1.788AsnGln: 1.788 ± 0.044
1.825AsnArg: 1.825 ± 0.037
2.447AsnSer: 2.447 ± 0.046
2.448AsnThr: 2.448 ± 0.046
3.115AsnVal: 3.115 ± 0.061
0.493AsnTrp: 0.493 ± 0.021
1.664AsnTyr: 1.664 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
2.64ProAla: 2.64 ± 0.052
0.373ProCys: 0.373 ± 0.019
1.961ProAsp: 1.961 ± 0.043
2.648ProGlu: 2.648 ± 0.054
1.601ProPhe: 1.601 ± 0.04
2.224ProGly: 2.224 ± 0.042
0.721ProHis: 0.721 ± 0.023
2.804ProIle: 2.804 ± 0.05
2.041ProLys: 2.041 ± 0.041
3.255ProLeu: 3.255 ± 0.053
0.897ProMet: 0.897 ± 0.031
1.547ProAsn: 1.547 ± 0.036
0.917ProPro: 0.917 ± 0.025
1.318ProGln: 1.318 ± 0.032
1.026ProArg: 1.026 ± 0.031
1.756ProSer: 1.756 ± 0.04
1.855ProThr: 1.855 ± 0.041
2.776ProVal: 2.776 ± 0.053
0.349ProTrp: 0.349 ± 0.016
1.251ProTyr: 1.251 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
3.294GlnAla: 3.294 ± 0.057
0.367GlnCys: 0.367 ± 0.017
1.836GlnAsp: 1.836 ± 0.042
2.568GlnGlu: 2.568 ± 0.05
1.303GlnPhe: 1.303 ± 0.032
2.321GlnGly: 2.321 ± 0.039
0.725GlnHis: 0.725 ± 0.023
3.189GlnIle: 3.189 ± 0.054
3.019GlnLys: 3.019 ± 0.053
3.454GlnLeu: 3.454 ± 0.056
1.172GlnMet: 1.172 ± 0.034
1.892GlnAsn: 1.892 ± 0.046
1.132GlnPro: 1.132 ± 0.037
1.792GlnGln: 1.792 ± 0.043
1.479GlnArg: 1.479 ± 0.033
2.191GlnSer: 2.191 ± 0.049
2.173GlnThr: 2.173 ± 0.043
2.515GlnVal: 2.515 ± 0.046
0.324GlnTrp: 0.324 ± 0.016
1.42GlnTyr: 1.42 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.528ArgAla: 2.528 ± 0.047
0.471ArgCys: 0.471 ± 0.02
1.928ArgAsp: 1.928 ± 0.036
2.645ArgGlu: 2.645 ± 0.054
1.596ArgPhe: 1.596 ± 0.034
2.253ArgGly: 2.253 ± 0.046
0.744ArgHis: 0.744 ± 0.028
3.163ArgIle: 3.163 ± 0.049
2.66ArgLys: 2.66 ± 0.048
3.628ArgLeu: 3.628 ± 0.057
1.198ArgMet: 1.198 ± 0.029
1.745ArgAsn: 1.745 ± 0.04
1.172ArgPro: 1.172 ± 0.033
1.713ArgGln: 1.713 ± 0.039
1.74ArgArg: 1.74 ± 0.041
2.094ArgSer: 2.094 ± 0.04
1.901ArgThr: 1.901 ± 0.04
2.429ArgVal: 2.429 ± 0.046
0.355ArgTrp: 0.355 ± 0.016
1.481ArgTyr: 1.481 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
4.431SerAla: 4.431 ± 0.069
0.698SerCys: 0.698 ± 0.026
2.841SerAsp: 2.841 ± 0.048
3.269SerGlu: 3.269 ± 0.055
2.796SerPhe: 2.796 ± 0.049
4.51SerGly: 4.51 ± 0.069
1.094SerHis: 1.094 ± 0.03
4.92SerIle: 4.92 ± 0.07
3.445SerLys: 3.445 ± 0.054
5.866SerLeu: 5.866 ± 0.083
1.788SerMet: 1.788 ± 0.039
2.385SerAsn: 2.385 ± 0.041
1.899SerPro: 1.899 ± 0.041
2.174SerGln: 2.174 ± 0.046
2.163SerArg: 2.163 ± 0.048
3.672SerSer: 3.672 ± 0.072
3.068SerThr: 3.068 ± 0.055
4.063SerVal: 4.063 ± 0.05
0.637SerTrp: 0.637 ± 0.022
2.139SerTyr: 2.139 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.928ThrAla: 4.928 ± 0.064
0.62ThrCys: 0.62 ± 0.021
2.883ThrAsp: 2.883 ± 0.055
3.186ThrGlu: 3.186 ± 0.052
2.318ThrPhe: 2.318 ± 0.045
4.408ThrGly: 4.408 ± 0.056
0.947ThrHis: 0.947 ± 0.029
4.646ThrIle: 4.646 ± 0.061
3.514ThrLys: 3.514 ± 0.049
5.237ThrLeu: 5.237 ± 0.075
1.561ThrMet: 1.561 ± 0.037
2.412ThrAsn: 2.412 ± 0.052
2.122ThrPro: 2.122 ± 0.04
1.812ThrGln: 1.812 ± 0.042
1.793ThrArg: 1.793 ± 0.034
3.0ThrSer: 3.0 ± 0.048
3.198ThrThr: 3.198 ± 0.056
4.219ThrVal: 4.219 ± 0.066
0.498ThrTrp: 0.498 ± 0.022
1.834ThrTyr: 1.834 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
5.407ValAla: 5.407 ± 0.077
0.962ValCys: 0.962 ± 0.03
3.912ValAsp: 3.912 ± 0.057
4.119ValGlu: 4.119 ± 0.06
3.105ValPhe: 3.105 ± 0.056
4.768ValGly: 4.768 ± 0.068
1.246ValHis: 1.246 ± 0.031
5.402ValIle: 5.402 ± 0.063
4.516ValLys: 4.516 ± 0.071
7.044ValLeu: 7.044 ± 0.083
2.107ValMet: 2.107 ± 0.04
3.08ValAsn: 3.08 ± 0.057
2.67ValPro: 2.67 ± 0.048
2.332ValGln: 2.332 ± 0.046
2.478ValArg: 2.478 ± 0.054
4.255ValSer: 4.255 ± 0.073
3.987ValThr: 3.987 ± 0.063
5.098ValVal: 5.098 ± 0.086
0.582ValTrp: 0.582 ± 0.023
2.305ValTyr: 2.305 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.637TrpAla: 0.637 ± 0.022
0.115TrpCys: 0.115 ± 0.01
0.484TrpAsp: 0.484 ± 0.021
0.498TrpGlu: 0.498 ± 0.024
0.404TrpPhe: 0.404 ± 0.02
0.66TrpGly: 0.66 ± 0.025
0.23TrpHis: 0.23 ± 0.015
0.678TrpIle: 0.678 ± 0.024
0.555TrpLys: 0.555 ± 0.024
0.948TrpLeu: 0.948 ± 0.028
0.278TrpMet: 0.278 ± 0.015
0.513TrpAsn: 0.513 ± 0.022
0.255TrpPro: 0.255 ± 0.015
0.519TrpGln: 0.519 ± 0.021
0.379TrpArg: 0.379 ± 0.016
0.544TrpSer: 0.544 ± 0.023
0.413TrpThr: 0.413 ± 0.019
0.52TrpVal: 0.52 ± 0.021
0.124TrpTrp: 0.124 ± 0.01
0.351TrpTyr: 0.351 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.528TyrAla: 2.528 ± 0.046
0.484TyrCys: 0.484 ± 0.022
1.984TyrAsp: 1.984 ± 0.038
2.074TyrGlu: 2.074 ± 0.037
1.676TyrPhe: 1.676 ± 0.038
2.512TyrGly: 2.512 ± 0.048
0.792TyrHis: 0.792 ± 0.025
2.702TyrIle: 2.702 ± 0.053
2.296TyrLys: 2.296 ± 0.046
3.365TyrLeu: 3.365 ± 0.06
0.894TyrMet: 0.894 ± 0.026
1.637TyrAsn: 1.637 ± 0.042
1.323TyrPro: 1.323 ± 0.033
1.497TyrGln: 1.497 ± 0.037
1.506TyrArg: 1.506 ± 0.036
2.041TyrSer: 2.041 ± 0.043
1.955TyrThr: 1.955 ± 0.037
2.138TyrVal: 2.138 ± 0.043
0.382TyrTrp: 0.382 ± 0.016
1.348TyrTyr: 1.348 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3963 proteins (1224091 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski