Amino acid dipepetide frequency for Alkalihalobacillus lonarensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.051AlaAla: 7.051 ± 0.123	0.933AlaCys: 0.933 ± 0.033	3.861AlaAsp: 3.861 ± 0.089	4.994AlaGlu: 4.994 ± 0.096	3.631AlaPhe: 3.631 ± 0.07	5.703AlaGly: 5.703 ± 0.082	2.322AlaHis: 2.322 ± 0.062	5.462AlaIle: 5.462 ± 0.103	4.426AlaLys: 4.426 ± 0.103	9.273AlaLeu: 9.273 ± 0.137	2.298AlaMet: 2.298 ± 0.056	2.668AlaAsn: 2.668 ± 0.062	2.918AlaPro: 2.918 ± 0.153	3.233AlaGln: 3.233 ± 0.07	4.238AlaArg: 4.238 ± 0.09	4.431AlaSer: 4.431 ± 0.077	5.518AlaThr: 5.518 ± 0.197	6.203AlaVal: 6.203 ± 0.102	0.823AlaTrp: 0.823 ± 0.035	2.862AlaTyr: 2.862 ± 0.064	0.0AlaXaa: 0.0 ± 0.0
Cys	0.74CysAla: 0.74 ± 0.03	0.097CysCys: 0.097 ± 0.011	0.539CysAsp: 0.539 ± 0.025	0.603CysGlu: 0.603 ± 0.031	0.376CysPhe: 0.376 ± 0.022	0.777CysGly: 0.777 ± 0.04	0.306CysHis: 0.306 ± 0.023	0.576CysIle: 0.576 ± 0.031	0.361CysLys: 0.361 ± 0.023	0.885CysLeu: 0.885 ± 0.035	0.257CysMet: 0.257 ± 0.02	0.258CysAsn: 0.258 ± 0.018	0.412CysPro: 0.412 ± 0.026	0.304CysGln: 0.304 ± 0.021	0.381CysArg: 0.381 ± 0.021	0.426CysSer: 0.426 ± 0.023	0.517CysThr: 0.517 ± 0.027	0.63CysVal: 0.63 ± 0.028	0.095CysTrp: 0.095 ± 0.011	0.326CysTyr: 0.326 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.077AspAla: 4.077 ± 0.071	0.406AspCys: 0.406 ± 0.029	2.845AspAsp: 2.845 ± 0.083	4.667AspGlu: 4.667 ± 0.084	2.132AspPhe: 2.132 ± 0.05	3.676AspGly: 3.676 ± 0.083	1.49AspHis: 1.49 ± 0.044	3.428AspIle: 3.428 ± 0.069	2.507AspLys: 2.507 ± 0.071	4.595AspLeu: 4.595 ± 0.083	1.608AspMet: 1.608 ± 0.048	1.355AspAsn: 1.355 ± 0.049	2.362AspPro: 2.362 ± 0.183	1.991AspGln: 1.991 ± 0.057	2.501AspArg: 2.501 ± 0.055	1.97AspSer: 1.97 ± 0.05	2.784AspThr: 2.784 ± 0.06	4.933AspVal: 4.933 ± 0.085	0.652AspTrp: 0.652 ± 0.031	1.887AspTyr: 1.887 ± 0.055	0.0AspXaa: 0.0 ± 0.0
Glu	6.687GluAla: 6.687 ± 0.115	0.398GluCys: 0.398 ± 0.026	3.788GluAsp: 3.788 ± 0.084	6.967GluGlu: 6.967 ± 0.138	1.646GluPhe: 1.646 ± 0.05	4.433GluGly: 4.433 ± 0.087	1.498GluHis: 1.498 ± 0.042	4.099GluIle: 4.099 ± 0.086	5.777GluLys: 5.777 ± 0.109	5.789GluLeu: 5.789 ± 0.098	2.551GluMet: 2.551 ± 0.064	2.717GluAsn: 2.717 ± 0.063	2.048GluPro: 2.048 ± 0.067	3.831GluGln: 3.831 ± 0.079	4.409GluArg: 4.409 ± 0.085	3.166GluSer: 3.166 ± 0.072	4.48GluThr: 4.48 ± 0.085	5.475GluVal: 5.475 ± 0.107	0.831GluTrp: 0.831 ± 0.032	1.691GluTyr: 1.691 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	3.391PheAla: 3.391 ± 0.076	0.392PheCys: 0.392 ± 0.025	2.155PheAsp: 2.155 ± 0.057	2.445PheGlu: 2.445 ± 0.062	2.204PhePhe: 2.204 ± 0.068	2.862PheGly: 2.862 ± 0.071	1.078PheHis: 1.078 ± 0.043	3.006PheIle: 3.006 ± 0.079	1.801PheLys: 1.801 ± 0.052	4.458PheLeu: 4.458 ± 0.105	1.209PheMet: 1.209 ± 0.039	1.209PheAsn: 1.209 ± 0.045	1.626PhePro: 1.626 ± 0.049	1.528PheGln: 1.528 ± 0.048	1.675PheArg: 1.675 ± 0.05	3.14PheSer: 3.14 ± 0.072	2.592PheThr: 2.592 ± 0.059	3.447PheVal: 3.447 ± 0.075	0.442PheTrp: 0.442 ± 0.029	1.568PheTyr: 1.568 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	6.314GlyAla: 6.314 ± 0.185	0.704GlyCys: 0.704 ± 0.031	3.418GlyAsp: 3.418 ± 0.082	4.855GlyGlu: 4.855 ± 0.08	2.967GlyPhe: 2.967 ± 0.066	4.797GlyGly: 4.797 ± 0.095	1.624GlyHis: 1.624 ± 0.043	4.586GlyIle: 4.586 ± 0.084	4.339GlyLys: 4.339 ± 0.085	6.419GlyLeu: 6.419 ± 0.111	2.24GlyMet: 2.24 ± 0.06	2.169GlyAsn: 2.169 ± 0.066	2.973GlyPro: 2.973 ± 0.252	2.478GlyGln: 2.478 ± 0.051	3.149GlyArg: 3.149 ± 0.076	3.446GlySer: 3.446 ± 0.078	4.255GlyThr: 4.255 ± 0.079	6.122GlyVal: 6.122 ± 0.132	0.779GlyTrp: 0.779 ± 0.034	2.646GlyTyr: 2.646 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	2.009HisAla: 2.009 ± 0.058	0.278HisCys: 0.278 ± 0.019	1.331HisAsp: 1.331 ± 0.042	1.778HisGlu: 1.778 ± 0.05	1.221HisPhe: 1.221 ± 0.045	1.643HisGly: 1.643 ± 0.051	0.839HisHis: 0.839 ± 0.039	1.755HisIle: 1.755 ± 0.051	0.988HisLys: 0.988 ± 0.039	2.525HisLeu: 2.525 ± 0.068	0.722HisMet: 0.722 ± 0.032	0.666HisAsn: 0.666 ± 0.028	1.244HisPro: 1.244 ± 0.044	0.957HisGln: 0.957 ± 0.036	1.145HisArg: 1.145 ± 0.047	1.029HisSer: 1.029 ± 0.038	1.461HisThr: 1.461 ± 0.046	2.316HisVal: 2.316 ± 0.062	0.263HisTrp: 0.263 ± 0.019	0.963HisTyr: 0.963 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	6.112IleAla: 6.112 ± 0.087	0.679IleCys: 0.679 ± 0.032	4.152IleAsp: 4.152 ± 0.074	4.73IleGlu: 4.73 ± 0.098	2.555IlePhe: 2.555 ± 0.072	5.514IleGly: 5.514 ± 0.115	1.556IleHis: 1.556 ± 0.046	3.791IleIle: 3.791 ± 0.093	2.658IleLys: 2.658 ± 0.06	5.126IleLeu: 5.126 ± 0.102	1.351IleMet: 1.351 ± 0.048	1.994IleAsn: 1.994 ± 0.062	2.706IlePro: 2.706 ± 0.062	2.243IleGln: 2.243 ± 0.06	3.012IleArg: 3.012 ± 0.071	3.677IleSer: 3.677 ± 0.088	3.509IleThr: 3.509 ± 0.071	5.257IleVal: 5.257 ± 0.104	0.625IleTrp: 0.625 ± 0.033	1.896IleTyr: 1.896 ± 0.052	0.0IleXaa: 0.0 ± 0.0
Lys	4.367LysAla: 4.367 ± 0.085	0.348LysCys: 0.348 ± 0.022	2.934LysAsp: 2.934 ± 0.071	5.559LysGlu: 5.559 ± 0.099	1.338LysPhe: 1.338 ± 0.047	3.705LysGly: 3.705 ± 0.076	1.364LysHis: 1.364 ± 0.046	2.907LysIle: 2.907 ± 0.066	4.809LysLys: 4.809 ± 0.081	4.355LysLeu: 4.355 ± 0.085	1.97LysMet: 1.97 ± 0.049	2.118LysAsn: 2.118 ± 0.061	1.897LysPro: 1.897 ± 0.058	3.303LysGln: 3.303 ± 0.072	3.607LysArg: 3.607 ± 0.084	2.64LysSer: 2.64 ± 0.061	3.356LysThr: 3.356 ± 0.069	3.918LysVal: 3.918 ± 0.079	0.713LysTrp: 0.713 ± 0.034	1.388LysTyr: 1.388 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	8.405LeuAla: 8.405 ± 0.122	0.932LeuCys: 0.932 ± 0.036	4.827LeuAsp: 4.827 ± 0.078	6.043LeuGlu: 6.043 ± 0.093	4.816LeuPhe: 4.816 ± 0.144	6.308LeuGly: 6.308 ± 0.114	2.396LeuHis: 2.396 ± 0.069	5.728LeuIle: 5.728 ± 0.115	5.494LeuLys: 5.494 ± 0.084	10.714LeuLeu: 10.714 ± 0.18	2.562LeuMet: 2.562 ± 0.069	3.304LeuAsn: 3.304 ± 0.075	3.96LeuPro: 3.96 ± 0.082	4.217LeuGln: 4.217 ± 0.085	4.54LeuArg: 4.54 ± 0.086	6.658LeuSer: 6.658 ± 0.09	5.99LeuThr: 5.99 ± 0.095	6.744LeuVal: 6.744 ± 0.093	0.921LeuTrp: 0.921 ± 0.04	3.221LeuTyr: 3.221 ± 0.074	0.0LeuXaa: 0.0 ± 0.0
Met	2.234MetAla: 2.234 ± 0.06	0.218MetCys: 0.218 ± 0.019	1.448MetAsp: 1.448 ± 0.04	1.671MetGlu: 1.671 ± 0.047	1.1MetPhe: 1.1 ± 0.041	1.687MetGly: 1.687 ± 0.052	0.601MetHis: 0.601 ± 0.031	2.161MetIle: 2.161 ± 0.052	2.284MetLys: 2.284 ± 0.051	2.981MetLeu: 2.981 ± 0.068	1.143MetMet: 1.143 ± 0.04	1.411MetAsn: 1.411 ± 0.038	1.033MetPro: 1.033 ± 0.036	1.035MetGln: 1.035 ± 0.037	1.487MetArg: 1.487 ± 0.05	1.961MetSer: 1.961 ± 0.055	2.17MetThr: 2.17 ± 0.052	1.903MetVal: 1.903 ± 0.057	0.259MetTrp: 0.259 ± 0.018	0.877MetTyr: 0.877 ± 0.035	0.0MetXaa: 0.0 ± 0.0
Asn	2.419AsnAla: 2.419 ± 0.056	0.237AsnCys: 0.237 ± 0.018	1.989AsnAsp: 1.989 ± 0.051	2.907AsnGlu: 2.907 ± 0.069	1.154AsnPhe: 1.154 ± 0.044	2.653AsnGly: 2.653 ± 0.078	0.877AsnHis: 0.877 ± 0.037	2.407AsnIle: 2.407 ± 0.06	1.948AsnLys: 1.948 ± 0.056	2.613AsnLeu: 2.613 ± 0.062	1.065AsnMet: 1.065 ± 0.04	1.187AsnAsn: 1.187 ± 0.044	1.498AsnPro: 1.498 ± 0.055	1.33AsnGln: 1.33 ± 0.046	1.708AsnArg: 1.708 ± 0.051	1.225AsnSer: 1.225 ± 0.043	1.733AsnThr: 1.733 ± 0.046	2.912AsnVal: 2.912 ± 0.067	0.388AsnTrp: 0.388 ± 0.025	0.986AsnTyr: 0.986 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.69ProAla: 2.69 ± 0.065	0.253ProCys: 0.253 ± 0.02	2.005ProAsp: 2.005 ± 0.051	2.75ProGlu: 2.75 ± 0.065	1.952ProPhe: 1.952 ± 0.055	2.478ProGly: 2.478 ± 0.076	1.04ProHis: 1.04 ± 0.04	2.485ProIle: 2.485 ± 0.062	1.833ProLys: 1.833 ± 0.052	3.942ProLeu: 3.942 ± 0.078	0.82ProMet: 0.82 ± 0.033	1.411ProAsn: 1.411 ± 0.047	1.27ProPro: 1.27 ± 0.054	1.208ProGln: 1.208 ± 0.042	1.42ProArg: 1.42 ± 0.042	2.242ProSer: 2.242 ± 0.054	2.926ProThr: 2.926 ± 0.132	3.886ProVal: 3.886 ± 0.32	0.417ProTrp: 0.417 ± 0.02	1.407ProTyr: 1.407 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	3.778GlnAla: 3.778 ± 0.073	0.312GlnCys: 0.312 ± 0.022	1.601GlnAsp: 1.601 ± 0.044	2.829GlnGlu: 2.829 ± 0.069	1.59GlnPhe: 1.59 ± 0.047	2.331GlnGly: 2.331 ± 0.05	0.998GlnHis: 0.998 ± 0.034	1.961GlnIle: 1.961 ± 0.049	2.398GlnLys: 2.398 ± 0.062	4.678GlnLeu: 4.678 ± 0.097	1.35GlnMet: 1.35 ± 0.046	1.089GlnAsn: 1.089 ± 0.038	1.428GlnPro: 1.428 ± 0.049	2.284GlnGln: 2.284 ± 0.071	1.858GlnArg: 1.858 ± 0.054	2.289GlnSer: 2.289 ± 0.05	2.619GlnThr: 2.619 ± 0.066	2.984GlnVal: 2.984 ± 0.079	0.457GlnTrp: 0.457 ± 0.026	1.277GlnTyr: 1.277 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	3.98ArgAla: 3.98 ± 0.095	0.39ArgCys: 0.39 ± 0.024	2.575ArgAsp: 2.575 ± 0.058	3.811ArgGlu: 3.811 ± 0.081	2.199ArgPhe: 2.199 ± 0.062	2.908ArgGly: 2.908 ± 0.062	1.258ArgHis: 1.258 ± 0.042	2.979ArgIle: 2.979 ± 0.066	2.963ArgLys: 2.963 ± 0.06	5.151ArgLeu: 5.151 ± 0.091	1.628ArgMet: 1.628 ± 0.045	1.54ArgAsn: 1.54 ± 0.047	1.669ArgPro: 1.669 ± 0.056	1.944ArgGln: 1.944 ± 0.054	2.605ArgArg: 2.605 ± 0.069	2.387ArgSer: 2.387 ± 0.057	2.869ArgThr: 2.869 ± 0.07	3.477ArgVal: 3.477 ± 0.078	0.5ArgTrp: 0.5 ± 0.024	1.894ArgTyr: 1.894 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	3.903SerAla: 3.903 ± 0.076	0.511SerCys: 0.511 ± 0.028	2.576SerAsp: 2.576 ± 0.061	3.596SerGlu: 3.596 ± 0.073	3.092SerPhe: 3.092 ± 0.072	4.24SerGly: 4.24 ± 0.08	1.371SerHis: 1.371 ± 0.042	3.561SerIle: 3.561 ± 0.082	2.564SerLys: 2.564 ± 0.058	6.04SerLeu: 6.04 ± 0.107	1.671SerMet: 1.671 ± 0.044	1.711SerAsn: 1.711 ± 0.056	2.064SerPro: 2.064 ± 0.057	1.854SerGln: 1.854 ± 0.047	2.443SerArg: 2.443 ± 0.057	3.242SerSer: 3.242 ± 0.077	2.821SerThr: 2.821 ± 0.064	4.307SerVal: 4.307 ± 0.087	0.651SerTrp: 0.651 ± 0.034	2.069SerTyr: 2.069 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	4.651ThrAla: 4.651 ± 0.096	0.508ThrCys: 0.508 ± 0.025	2.957ThrAsp: 2.957 ± 0.064	3.713ThrGlu: 3.713 ± 0.085	2.965ThrPhe: 2.965 ± 0.065	6.128ThrGly: 6.128 ± 0.385	1.482ThrHis: 1.482 ± 0.048	4.126ThrIle: 4.126 ± 0.087	3.156ThrLys: 3.156 ± 0.064	6.35ThrLeu: 6.35 ± 0.08	1.622ThrMet: 1.622 ± 0.052	2.214ThrAsn: 2.214 ± 0.063	2.588ThrPro: 2.588 ± 0.085	1.663ThrGln: 1.663 ± 0.043	2.523ThrArg: 2.523 ± 0.05	3.406ThrSer: 3.406 ± 0.071	3.635ThrThr: 3.635 ± 0.083	4.689ThrVal: 4.689 ± 0.075	0.667ThrTrp: 0.667 ± 0.029	2.324ThrTyr: 2.324 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	6.717ValAla: 6.717 ± 0.165	0.844ValCys: 0.844 ± 0.032	4.289ValAsp: 4.289 ± 0.162	4.938ValGlu: 4.938 ± 0.095	3.227ValPhe: 3.227 ± 0.082	5.409ValGly: 5.409 ± 0.185	1.782ValHis: 1.782 ± 0.057	5.401ValIle: 5.401 ± 0.093	4.128ValLys: 4.128 ± 0.076	7.563ValLeu: 7.563 ± 0.119	2.226ValMet: 2.226 ± 0.056	2.779ValAsn: 2.779 ± 0.068	3.108ValPro: 3.108 ± 0.083	2.81ValGln: 2.81 ± 0.061	3.696ValArg: 3.696 ± 0.079	4.881ValSer: 4.881 ± 0.087	5.465ValThr: 5.465 ± 0.138	6.268ValVal: 6.268 ± 0.112	0.718ValTrp: 0.718 ± 0.036	2.654ValTyr: 2.654 ± 0.064	0.0ValXaa: 0.0 ± 0.0
Trp	0.668TrpAla: 0.668 ± 0.035	0.122TrpCys: 0.122 ± 0.014	0.491TrpAsp: 0.491 ± 0.03	0.615TrpGlu: 0.615 ± 0.029	0.564TrpPhe: 0.564 ± 0.028	0.602TrpGly: 0.602 ± 0.027	0.324TrpHis: 0.324 ± 0.02	0.717TrpIle: 0.717 ± 0.035	0.588TrpLys: 0.588 ± 0.032	1.474TrpLeu: 1.474 ± 0.044	0.343TrpMet: 0.343 ± 0.022	0.353TrpAsn: 0.353 ± 0.022	0.274TrpPro: 0.274 ± 0.02	0.561TrpGln: 0.561 ± 0.032	0.591TrpArg: 0.591 ± 0.027	0.585TrpSer: 0.585 ± 0.031	0.668TrpThr: 0.668 ± 0.03	0.713TrpVal: 0.713 ± 0.029	0.139TrpTrp: 0.139 ± 0.014	0.351TrpTyr: 0.351 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.656TyrAla: 2.656 ± 0.058	0.303TyrCys: 0.303 ± 0.02	2.087TyrAsp: 2.087 ± 0.064	2.81TyrGlu: 2.81 ± 0.07	1.502TyrPhe: 1.502 ± 0.051	2.427TyrGly: 2.427 ± 0.051	0.926TyrHis: 0.926 ± 0.035	2.007TyrIle: 2.007 ± 0.055	1.573TyrLys: 1.573 ± 0.055	2.849TyrLeu: 2.849 ± 0.064	1.025TyrMet: 1.025 ± 0.038	1.085TyrAsn: 1.085 ± 0.044	1.355TyrPro: 1.355 ± 0.044	1.335TyrGln: 1.335 ± 0.047	1.739TyrArg: 1.739 ± 0.047	1.486TyrSer: 1.486 ± 0.047	1.999TyrThr: 1.999 ± 0.063	2.719TyrVal: 2.719 ± 0.051	0.402TyrTrp: 0.402 ± 0.021	1.216TyrTyr: 1.216 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2581 proteins (755743 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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