Amino acid dipepetide frequency for Sulfolobales archaeon SCGC AB-777_K09

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.69AlaAla: 4.69 ± 0.394
0.286AlaCys: 0.286 ± 0.075
3.043AlaAsp: 3.043 ± 0.271
5.083AlaGlu: 5.083 ± 0.317
2.56AlaPhe: 2.56 ± 0.202
4.35AlaGly: 4.35 ± 0.299
0.931AlaHis: 0.931 ± 0.123
4.994AlaIle: 4.994 ± 0.303
4.976AlaLys: 4.976 ± 0.378
8.735AlaLeu: 8.735 ± 0.529
1.593AlaMet: 1.593 ± 0.173
2.005AlaAsn: 2.005 ± 0.216
2.166AlaPro: 2.166 ± 0.215
2.023AlaGln: 2.023 ± 0.226
4.099AlaArg: 4.099 ± 0.33
4.761AlaSer: 4.761 ± 0.324
3.132AlaThr: 3.132 ± 0.284
6.086AlaVal: 6.086 ± 0.331
0.734AlaTrp: 0.734 ± 0.131
2.935AlaTyr: 2.935 ± 0.264
0.0AlaXaa: 0.0 ± 0.0
Cys
0.268CysAla: 0.268 ± 0.065
0.036CysCys: 0.036 ± 0.025
0.447CysAsp: 0.447 ± 0.099
0.358CysGlu: 0.358 ± 0.08
0.215CysPhe: 0.215 ± 0.073
0.68CysGly: 0.68 ± 0.133
0.125CysHis: 0.125 ± 0.053
0.268CysIle: 0.268 ± 0.066
0.609CysLys: 0.609 ± 0.133
0.304CysLeu: 0.304 ± 0.065
0.107CysMet: 0.107 ± 0.039
0.304CysAsn: 0.304 ± 0.071
0.519CysPro: 0.519 ± 0.131
0.143CysGln: 0.143 ± 0.055
0.286CysArg: 0.286 ± 0.076
0.447CysSer: 0.447 ± 0.099
0.286CysThr: 0.286 ± 0.081
0.501CysVal: 0.501 ± 0.089
0.054CysTrp: 0.054 ± 0.028
0.197CysTyr: 0.197 ± 0.061
0.0CysXaa: 0.0 ± 0.0
Asp
3.007AspAla: 3.007 ± 0.233
0.268AspCys: 0.268 ± 0.067
2.041AspAsp: 2.041 ± 0.166
4.851AspGlu: 4.851 ± 0.362
2.291AspPhe: 2.291 ± 0.233
3.186AspGly: 3.186 ± 0.28
0.698AspHis: 0.698 ± 0.112
2.631AspIle: 2.631 ± 0.252
3.311AspLys: 3.311 ± 0.275
5.567AspLeu: 5.567 ± 0.36
1.038AspMet: 1.038 ± 0.134
1.754AspAsn: 1.754 ± 0.197
2.792AspPro: 2.792 ± 0.232
0.877AspGln: 0.877 ± 0.135
2.506AspArg: 2.506 ± 0.295
2.631AspSer: 2.631 ± 0.184
1.862AspThr: 1.862 ± 0.152
5.209AspVal: 5.209 ± 0.309
0.394AspTrp: 0.394 ± 0.083
2.166AspTyr: 2.166 ± 0.214
0.0AspXaa: 0.0 ± 0.0
Glu
5.817GluAla: 5.817 ± 0.376
0.465GluCys: 0.465 ± 0.125
3.293GluAsp: 3.293 ± 0.291
7.392GluGlu: 7.392 ± 0.496
2.721GluPhe: 2.721 ± 0.245
4.958GluGly: 4.958 ± 0.334
1.038GluHis: 1.038 ± 0.15
6.354GluIle: 6.354 ± 0.485
5.925GluLys: 5.925 ± 0.398
9.164GluLeu: 9.164 ± 0.539
1.504GluMet: 1.504 ± 0.157
2.9GluAsn: 2.9 ± 0.229
2.488GluPro: 2.488 ± 0.2
1.128GluGln: 1.128 ± 0.164
5.334GluArg: 5.334 ± 0.39
3.669GluSer: 3.669 ± 0.274
3.401GluThr: 3.401 ± 0.247
6.981GluVal: 6.981 ± 0.396
0.591GluTrp: 0.591 ± 0.106
3.025GluTyr: 3.025 ± 0.264
0.0GluXaa: 0.0 ± 0.0
Phe
2.846PheAla: 2.846 ± 0.199
0.394PheCys: 0.394 ± 0.1
2.237PheAsp: 2.237 ± 0.234
2.613PheGlu: 2.613 ± 0.232
1.521PhePhe: 1.521 ± 0.205
2.452PheGly: 2.452 ± 0.22
0.555PheHis: 0.555 ± 0.094
2.649PheIle: 2.649 ± 0.244
2.13PheLys: 2.13 ± 0.194
3.777PheLeu: 3.777 ± 0.306
0.734PheMet: 0.734 ± 0.123
1.879PheAsn: 1.879 ± 0.207
1.486PhePro: 1.486 ± 0.176
0.841PheGln: 0.841 ± 0.126
1.987PheArg: 1.987 ± 0.186
2.524PheSer: 2.524 ± 0.222
1.575PheThr: 1.575 ± 0.215
3.329PheVal: 3.329 ± 0.235
0.358PheTrp: 0.358 ± 0.082
1.844PheTyr: 1.844 ± 0.185
0.0PheXaa: 0.0 ± 0.0
Gly
4.546GlyAla: 4.546 ± 0.347
0.322GlyCys: 0.322 ± 0.089
3.365GlyAsp: 3.365 ± 0.26
4.976GlyGlu: 4.976 ± 0.294
2.828GlyPhe: 2.828 ± 0.226
3.974GlyGly: 3.974 ± 0.306
1.056GlyHis: 1.056 ± 0.134
5.388GlyIle: 5.388 ± 0.366
4.922GlyLys: 4.922 ± 0.299
6.265GlyLeu: 6.265 ± 0.38
1.647GlyMet: 1.647 ± 0.178
2.649GlyAsn: 2.649 ± 0.215
2.416GlyPro: 2.416 ± 0.228
1.342GlyGln: 1.342 ± 0.19
3.884GlyArg: 3.884 ± 0.313
4.099GlySer: 4.099 ± 0.309
3.813GlyThr: 3.813 ± 0.346
6.336GlyVal: 6.336 ± 0.338
0.823GlyTrp: 0.823 ± 0.13
2.882GlyTyr: 2.882 ± 0.265
0.0GlyXaa: 0.0 ± 0.0
His
0.913HisAla: 0.913 ± 0.17
0.143HisCys: 0.143 ± 0.05
0.501HisAsp: 0.501 ± 0.094
1.146HisGlu: 1.146 ± 0.177
0.752HisPhe: 0.752 ± 0.108
1.146HisGly: 1.146 ± 0.163
0.286HisHis: 0.286 ± 0.062
0.877HisIle: 0.877 ± 0.123
0.591HisLys: 0.591 ± 0.101
1.199HisLeu: 1.199 ± 0.145
0.304HisMet: 0.304 ± 0.074
0.322HisAsn: 0.322 ± 0.076
0.716HisPro: 0.716 ± 0.124
0.322HisGln: 0.322 ± 0.085
0.698HisArg: 0.698 ± 0.108
0.626HisSer: 0.626 ± 0.105
0.609HisThr: 0.609 ± 0.105
1.486HisVal: 1.486 ± 0.166
0.125HisTrp: 0.125 ± 0.046
0.752HisTyr: 0.752 ± 0.128
0.0HisXaa: 0.0 ± 0.0
Ile
5.334IleAla: 5.334 ± 0.346
0.34IleCys: 0.34 ± 0.082
4.045IleAsp: 4.045 ± 0.308
4.6IleGlu: 4.6 ± 0.272
2.041IlePhe: 2.041 ± 0.197
4.743IleGly: 4.743 ± 0.341
1.074IleHis: 1.074 ± 0.149
4.922IleIle: 4.922 ± 0.41
4.976IleLys: 4.976 ± 0.344
6.318IleLeu: 6.318 ± 0.347
1.575IleMet: 1.575 ± 0.203
3.132IleAsn: 3.132 ± 0.273
3.132IlePro: 3.132 ± 0.232
1.539IleGln: 1.539 ± 0.183
4.242IleArg: 4.242 ± 0.264
4.367IleSer: 4.367 ± 0.249
3.83IleThr: 3.83 ± 0.333
6.139IleVal: 6.139 ± 0.377
0.376IleTrp: 0.376 ± 0.092
2.685IleTyr: 2.685 ± 0.221
0.0IleXaa: 0.0 ± 0.0
Lys
5.352LysAla: 5.352 ± 0.326
0.43LysCys: 0.43 ± 0.094
3.311LysAsp: 3.311 ± 0.314
6.802LysGlu: 6.802 ± 0.457
2.058LysPhe: 2.058 ± 0.193
5.352LysGly: 5.352 ± 0.328
0.752LysHis: 0.752 ± 0.105
4.242LysIle: 4.242 ± 0.317
4.994LysLys: 4.994 ± 0.352
7.5LysLeu: 7.5 ± 0.408
1.486LysMet: 1.486 ± 0.17
1.7LysAsn: 1.7 ± 0.201
2.399LysPro: 2.399 ± 0.201
1.307LysGln: 1.307 ± 0.172
4.421LysArg: 4.421 ± 0.322
3.705LysSer: 3.705 ± 0.296
3.347LysThr: 3.347 ± 0.278
7.267LysVal: 7.267 ± 0.392
0.805LysTrp: 0.805 ± 0.139
2.631LysTyr: 2.631 ± 0.207
0.0LysXaa: 0.0 ± 0.0
Leu
8.287LeuAla: 8.287 ± 0.483
0.537LeuCys: 0.537 ± 0.113
4.851LeuAsp: 4.851 ± 0.305
8.52LeuGlu: 8.52 ± 0.601
3.598LeuPhe: 3.598 ± 0.305
7.124LeuGly: 7.124 ± 0.437
1.36LeuHis: 1.36 ± 0.139
7.052LeuIle: 7.052 ± 0.399
7.392LeuLys: 7.392 ± 0.402
9.361LeuLeu: 9.361 ± 0.42
2.506LeuMet: 2.506 ± 0.194
4.153LeuAsn: 4.153 ± 0.279
4.278LeuPro: 4.278 ± 0.277
2.148LeuGln: 2.148 ± 0.226
6.372LeuArg: 6.372 ± 0.514
7.482LeuSer: 7.482 ± 0.409
5.406LeuThr: 5.406 ± 0.37
7.894LeuVal: 7.894 ± 0.402
0.752LeuTrp: 0.752 ± 0.126
3.759LeuTyr: 3.759 ± 0.301
0.0LeuXaa: 0.0 ± 0.0
Met
1.665MetAla: 1.665 ± 0.208
0.143MetCys: 0.143 ± 0.06
1.092MetAsp: 1.092 ± 0.147
1.611MetGlu: 1.611 ± 0.166
0.358MetPhe: 0.358 ± 0.089
1.45MetGly: 1.45 ± 0.166
0.215MetHis: 0.215 ± 0.052
1.593MetIle: 1.593 ± 0.171
1.7MetLys: 1.7 ± 0.18
1.808MetLeu: 1.808 ± 0.18
0.68MetMet: 0.68 ± 0.136
0.716MetAsn: 0.716 ± 0.108
0.949MetPro: 0.949 ± 0.145
0.322MetGln: 0.322 ± 0.074
1.915MetArg: 1.915 ± 0.172
1.521MetSer: 1.521 ± 0.153
1.199MetThr: 1.199 ± 0.139
1.665MetVal: 1.665 ± 0.179
0.322MetTrp: 0.322 ± 0.072
0.626MetTyr: 0.626 ± 0.098
0.0MetXaa: 0.0 ± 0.0
Asn
2.56AsnAla: 2.56 ± 0.245
0.34AsnCys: 0.34 ± 0.099
1.862AsnAsp: 1.862 ± 0.168
2.828AsnGlu: 2.828 ± 0.236
1.521AsnPhe: 1.521 ± 0.185
3.025AsnGly: 3.025 ± 0.371
0.304AsnHis: 0.304 ± 0.072
2.237AsnIle: 2.237 ± 0.202
2.327AsnLys: 2.327 ± 0.23
3.813AsnLeu: 3.813 ± 0.287
0.841AsnMet: 0.841 ± 0.119
1.378AsnAsn: 1.378 ± 0.164
2.291AsnPro: 2.291 ± 0.182
1.056AsnGln: 1.056 ± 0.171
1.879AsnArg: 1.879 ± 0.2
2.47AsnSer: 2.47 ± 0.259
1.396AsnThr: 1.396 ± 0.247
4.135AsnVal: 4.135 ± 0.26
0.501AsnTrp: 0.501 ± 0.09
1.933AsnTyr: 1.933 ± 0.224
0.0AsnXaa: 0.0 ± 0.0
Pro
2.291ProAla: 2.291 ± 0.273
0.125ProCys: 0.125 ± 0.043
2.327ProAsp: 2.327 ± 0.25
3.114ProGlu: 3.114 ± 0.291
1.826ProPhe: 1.826 ± 0.19
3.204ProGly: 3.204 ± 0.302
0.788ProHis: 0.788 ± 0.116
3.114ProIle: 3.114 ± 0.209
2.953ProLys: 2.953 ± 0.239
3.992ProLeu: 3.992 ± 0.262
0.734ProMet: 0.734 ± 0.128
2.058ProAsn: 2.058 ± 0.234
1.718ProPro: 1.718 ± 0.21
1.163ProGln: 1.163 ± 0.166
2.148ProArg: 2.148 ± 0.203
2.882ProSer: 2.882 ± 0.249
2.058ProThr: 2.058 ± 0.236
3.848ProVal: 3.848 ± 0.348
0.662ProTrp: 0.662 ± 0.112
1.897ProTyr: 1.897 ± 0.182
0.0ProXaa: 0.0 ± 0.0
Gln
2.058GlnAla: 2.058 ± 0.234
0.018GlnCys: 0.018 ± 0.019
0.859GlnAsp: 0.859 ± 0.135
1.933GlnGlu: 1.933 ± 0.248
0.734GlnPhe: 0.734 ± 0.103
1.647GlnGly: 1.647 ± 0.17
0.251GlnHis: 0.251 ± 0.063
1.539GlnIle: 1.539 ± 0.216
1.468GlnLys: 1.468 ± 0.154
2.542GlnLeu: 2.542 ± 0.248
0.376GlnMet: 0.376 ± 0.084
0.662GlnAsn: 0.662 ± 0.149
0.698GlnPro: 0.698 ± 0.158
0.68GlnGln: 0.68 ± 0.122
1.253GlnArg: 1.253 ± 0.143
1.235GlnSer: 1.235 ± 0.148
1.038GlnThr: 1.038 ± 0.168
1.844GlnVal: 1.844 ± 0.211
0.233GlnTrp: 0.233 ± 0.06
0.841GlnTyr: 0.841 ± 0.141
0.0GlnXaa: 0.0 ± 0.0
Arg
3.472ArgAla: 3.472 ± 0.291
0.412ArgCys: 0.412 ± 0.087
3.061ArgAsp: 3.061 ± 0.222
5.119ArgGlu: 5.119 ± 0.407
2.255ArgPhe: 2.255 ± 0.226
3.741ArgGly: 3.741 ± 0.295
0.698ArgHis: 0.698 ± 0.105
3.687ArgIle: 3.687 ± 0.273
4.976ArgLys: 4.976 ± 0.331
6.712ArgLeu: 6.712 ± 0.456
0.967ArgMet: 0.967 ± 0.148
2.255ArgAsn: 2.255 ± 0.166
2.363ArgPro: 2.363 ± 0.249
1.146ArgGln: 1.146 ± 0.117
4.063ArgArg: 4.063 ± 0.357
2.828ArgSer: 2.828 ± 0.205
3.079ArgThr: 3.079 ± 0.283
5.388ArgVal: 5.388 ± 0.332
0.447ArgTrp: 0.447 ± 0.103
2.023ArgTyr: 2.023 ± 0.224
0.0ArgXaa: 0.0 ± 0.0
Ser
3.902SerAla: 3.902 ± 0.282
0.412SerCys: 0.412 ± 0.083
3.025SerAsp: 3.025 ± 0.228
4.385SerGlu: 4.385 ± 0.339
2.237SerPhe: 2.237 ± 0.201
4.009SerGly: 4.009 ± 0.301
0.877SerHis: 0.877 ± 0.116
3.884SerIle: 3.884 ± 0.271
4.188SerLys: 4.188 ± 0.358
6.838SerLeu: 6.838 ± 0.362
1.611SerMet: 1.611 ± 0.16
2.255SerAsn: 2.255 ± 0.214
3.204SerPro: 3.204 ± 0.207
1.754SerGln: 1.754 ± 0.194
3.347SerArg: 3.347 ± 0.287
4.761SerSer: 4.761 ± 0.318
3.204SerThr: 3.204 ± 0.274
5.423SerVal: 5.423 ± 0.334
0.698SerTrp: 0.698 ± 0.128
2.058SerTyr: 2.058 ± 0.191
0.0SerXaa: 0.0 ± 0.0
Thr
3.168ThrAla: 3.168 ± 0.241
0.465ThrCys: 0.465 ± 0.097
2.148ThrAsp: 2.148 ± 0.183
3.204ThrGlu: 3.204 ± 0.268
2.416ThrPhe: 2.416 ± 0.202
3.705ThrGly: 3.705 ± 0.325
0.609ThrHis: 0.609 ± 0.107
3.616ThrIle: 3.616 ± 0.302
2.774ThrLys: 2.774 ± 0.229
5.227ThrLeu: 5.227 ± 0.348
1.11ThrMet: 1.11 ± 0.123
1.987ThrAsn: 1.987 ± 0.278
2.47ThrPro: 2.47 ± 0.31
1.074ThrGln: 1.074 ± 0.16
2.363ThrArg: 2.363 ± 0.203
3.419ThrSer: 3.419 ± 0.287
2.739ThrThr: 2.739 ± 0.454
4.69ThrVal: 4.69 ± 0.385
0.43ThrTrp: 0.43 ± 0.102
2.112ThrTyr: 2.112 ± 0.29
0.0ThrXaa: 0.0 ± 0.0
Val
5.764ValAla: 5.764 ± 0.351
0.68ValCys: 0.68 ± 0.124
4.976ValAsp: 4.976 ± 0.272
6.354ValGlu: 6.354 ± 0.367
3.58ValPhe: 3.58 ± 0.243
5.495ValGly: 5.495 ± 0.361
0.967ValHis: 0.967 ± 0.126
6.927ValIle: 6.927 ± 0.368
6.999ValLys: 6.999 ± 0.397
8.592ValLeu: 8.592 ± 0.467
1.718ValMet: 1.718 ± 0.208
4.367ValAsn: 4.367 ± 0.349
4.242ValPro: 4.242 ± 0.287
1.7ValGln: 1.7 ± 0.182
5.585ValArg: 5.585 ± 0.321
5.37ValSer: 5.37 ± 0.323
5.155ValThr: 5.155 ± 0.38
8.09ValVal: 8.09 ± 0.468
0.609ValTrp: 0.609 ± 0.119
3.598ValTyr: 3.598 ± 0.291
0.0ValXaa: 0.0 ± 0.0
Trp
0.43TrpAla: 0.43 ± 0.106
0.089TrpCys: 0.089 ± 0.039
0.465TrpAsp: 0.465 ± 0.102
0.823TrpGlu: 0.823 ± 0.137
0.483TrpPhe: 0.483 ± 0.085
0.519TrpGly: 0.519 ± 0.092
0.268TrpHis: 0.268 ± 0.078
0.841TrpIle: 0.841 ± 0.124
0.698TrpLys: 0.698 ± 0.1
0.877TrpLeu: 0.877 ± 0.146
0.233TrpMet: 0.233 ± 0.078
0.447TrpAsn: 0.447 ± 0.087
0.34TrpPro: 0.34 ± 0.079
0.197TrpGln: 0.197 ± 0.064
0.447TrpArg: 0.447 ± 0.087
0.447TrpSer: 0.447 ± 0.085
0.43TrpThr: 0.43 ± 0.081
0.805TrpVal: 0.805 ± 0.109
0.072TrpTrp: 0.072 ± 0.035
0.483TrpTyr: 0.483 ± 0.095
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.828TyrAla: 2.828 ± 0.227
0.251TyrCys: 0.251 ± 0.064
2.13TyrAsp: 2.13 ± 0.2
2.434TyrGlu: 2.434 ± 0.184
1.736TyrPhe: 1.736 ± 0.203
2.774TyrGly: 2.774 ± 0.217
0.662TyrHis: 0.662 ± 0.105
2.595TyrIle: 2.595 ± 0.249
1.951TyrLys: 1.951 ± 0.187
4.242TyrLeu: 4.242 ± 0.295
0.77TyrMet: 0.77 ± 0.114
1.772TyrAsn: 1.772 ± 0.219
2.237TyrPro: 2.237 ± 0.195
1.146TyrGln: 1.146 ± 0.189
1.862TyrArg: 1.862 ± 0.214
2.828TyrSer: 2.828 ± 0.24
2.166TyrThr: 2.166 ± 0.26
3.651TyrVal: 3.651 ± 0.267
0.412TyrTrp: 0.412 ± 0.087
2.381TyrTyr: 2.381 ± 0.306
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 206 proteins (55869 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski