Amino acid dipepetide frequency for Sulfitobacter sp. S4J41

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.862AlaAla: 16.862 ± 0.174	1.127AlaCys: 1.127 ± 0.029	6.789AlaAsp: 6.789 ± 0.08	7.822AlaGlu: 7.822 ± 0.082	4.055AlaPhe: 4.055 ± 0.055	10.681AlaGly: 10.681 ± 0.1	2.33AlaHis: 2.33 ± 0.042	5.671AlaIle: 5.671 ± 0.066	3.727AlaLys: 3.727 ± 0.072	14.43AlaLeu: 14.43 ± 0.149	3.88AlaMet: 3.88 ± 0.056	2.515AlaAsn: 2.515 ± 0.041	6.162AlaPro: 6.162 ± 0.085	4.845AlaGln: 4.845 ± 0.061	9.175AlaArg: 9.175 ± 0.108	5.341AlaSer: 5.341 ± 0.065	5.989AlaThr: 5.989 ± 0.068	8.524AlaVal: 8.524 ± 0.087	1.345AlaTrp: 1.345 ± 0.04	2.573AlaTyr: 2.573 ± 0.047	0.001AlaXaa: 0.001 ± 0.001
Cys	1.187CysAla: 1.187 ± 0.033	0.109CysCys: 0.109 ± 0.01	0.665CysAsp: 0.665 ± 0.023	0.434CysGlu: 0.434 ± 0.016	0.323CysPhe: 0.323 ± 0.015	0.969CysGly: 0.969 ± 0.028	0.271CysHis: 0.271 ± 0.016	0.395CysIle: 0.395 ± 0.017	0.226CysLys: 0.226 ± 0.012	0.847CysLeu: 0.847 ± 0.026	0.163CysMet: 0.163 ± 0.012	0.21CysAsn: 0.21 ± 0.012	0.513CysPro: 0.513 ± 0.02	0.214CysGln: 0.214 ± 0.014	0.553CysArg: 0.553 ± 0.02	0.472CysSer: 0.472 ± 0.016	0.488CysThr: 0.488 ± 0.017	0.613CysVal: 0.613 ± 0.024	0.118CysTrp: 0.118 ± 0.01	0.205CysTyr: 0.205 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.834AspAla: 6.834 ± 0.087	0.558AspCys: 0.558 ± 0.022	3.174AspAsp: 3.174 ± 0.069	3.334AspGlu: 3.334 ± 0.056	2.298AspPhe: 2.298 ± 0.046	5.298AspGly: 5.298 ± 0.08	1.423AspHis: 1.423 ± 0.036	3.011AspIle: 3.011 ± 0.05	1.789AspLys: 1.789 ± 0.039	6.871AspLeu: 6.871 ± 0.082	1.745AspMet: 1.745 ± 0.038	1.219AspAsn: 1.219 ± 0.039	3.814AspPro: 3.814 ± 0.057	1.922AspGln: 1.922 ± 0.041	4.224AspArg: 4.224 ± 0.055	2.435AspSer: 2.435 ± 0.045	3.035AspThr: 3.035 ± 0.05	4.103AspVal: 4.103 ± 0.068	1.172AspTrp: 1.172 ± 0.033	1.466AspTyr: 1.466 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	7.792GluAla: 7.792 ± 0.09	0.338GluCys: 0.338 ± 0.017	3.25GluAsp: 3.25 ± 0.054	3.2GluGlu: 3.2 ± 0.057	1.739GluPhe: 1.739 ± 0.037	4.614GluGly: 4.614 ± 0.065	1.133GluHis: 1.133 ± 0.031	3.756GluIle: 3.756 ± 0.064	2.079GluLys: 2.079 ± 0.047	5.06GluLeu: 5.06 ± 0.068	1.838GluMet: 1.838 ± 0.04	1.562GluAsn: 1.562 ± 0.043	2.41GluPro: 2.41 ± 0.044	2.17GluGln: 2.17 ± 0.042	4.199GluArg: 4.199 ± 0.061	2.244GluSer: 2.244 ± 0.042	3.819GluThr: 3.819 ± 0.064	4.259GluVal: 4.259 ± 0.061	0.627GluTrp: 0.627 ± 0.02	1.025GluTyr: 1.025 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.35PheAla: 4.35 ± 0.058	0.428PheCys: 0.428 ± 0.017	2.885PheAsp: 2.885 ± 0.043	2.122PheGlu: 2.122 ± 0.04	1.388PhePhe: 1.388 ± 0.039	3.585PheGly: 3.585 ± 0.058	0.751PheHis: 0.751 ± 0.024	1.576PheIle: 1.576 ± 0.033	0.932PheLys: 0.932 ± 0.027	3.492PheLeu: 3.492 ± 0.065	0.85PheMet: 0.85 ± 0.026	1.056PheAsn: 1.056 ± 0.026	1.506PhePro: 1.506 ± 0.033	1.032PheGln: 1.032 ± 0.029	2.109PheArg: 2.109 ± 0.037	2.245PheSer: 2.245 ± 0.041	2.11PheThr: 2.11 ± 0.041	2.617PheVal: 2.617 ± 0.046	0.542PheTrp: 0.542 ± 0.02	0.896PheTyr: 0.896 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.328GlyAla: 10.328 ± 0.091	0.908GlyCys: 0.908 ± 0.026	4.806GlyAsp: 4.806 ± 0.081	4.756GlyGlu: 4.756 ± 0.069	3.666GlyPhe: 3.666 ± 0.067	7.641GlyGly: 7.641 ± 0.113	1.9GlyHis: 1.9 ± 0.04	4.448GlyIle: 4.448 ± 0.06	3.229GlyLys: 3.229 ± 0.056	9.399GlyLeu: 9.399 ± 0.102	2.721GlyMet: 2.721 ± 0.053	2.037GlyAsn: 2.037 ± 0.051	3.797GlyPro: 3.797 ± 0.063	3.202GlyGln: 3.202 ± 0.057	5.772GlyArg: 5.772 ± 0.077	4.147GlySer: 4.147 ± 0.059	4.698GlyThr: 4.698 ± 0.057	6.524GlyVal: 6.524 ± 0.084	1.494GlyTrp: 1.494 ± 0.036	2.356GlyTyr: 2.356 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	2.255HisAla: 2.255 ± 0.048	0.224HisCys: 0.224 ± 0.014	1.315HisAsp: 1.315 ± 0.031	1.029HisGlu: 1.029 ± 0.027	0.817HisPhe: 0.817 ± 0.028	1.944HisGly: 1.944 ± 0.039	0.562HisHis: 0.562 ± 0.021	0.929HisIle: 0.929 ± 0.026	0.526HisLys: 0.526 ± 0.02	2.217HisLeu: 2.217 ± 0.052	0.563HisMet: 0.563 ± 0.018	0.48HisAsn: 0.48 ± 0.019	1.392HisPro: 1.392 ± 0.033	0.585HisGln: 0.585 ± 0.02	1.39HisArg: 1.39 ± 0.033	0.98HisSer: 0.98 ± 0.026	0.829HisThr: 0.829 ± 0.022	1.533HisVal: 1.533 ± 0.034	0.358HisTrp: 0.358 ± 0.018	0.538HisTyr: 0.538 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.028IleAla: 7.028 ± 0.081	0.641IleCys: 0.641 ± 0.024	3.307IleAsp: 3.307 ± 0.054	3.553IleGlu: 3.553 ± 0.053	1.724IlePhe: 1.724 ± 0.039	4.72IleGly: 4.72 ± 0.075	0.944IleHis: 0.944 ± 0.027	2.062IleIle: 2.062 ± 0.043	1.483IleLys: 1.483 ± 0.035	4.904IleLeu: 4.904 ± 0.068	1.044IleMet: 1.044 ± 0.031	1.378IleAsn: 1.378 ± 0.033	2.391IlePro: 2.391 ± 0.042	1.21IleGln: 1.21 ± 0.028	3.131IleArg: 3.131 ± 0.048	2.87IleSer: 2.87 ± 0.046	3.061IleThr: 3.061 ± 0.053	3.653IleVal: 3.653 ± 0.052	0.745IleTrp: 0.745 ± 0.022	1.217IleTyr: 1.217 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.759LysAla: 3.759 ± 0.062	0.187LysCys: 0.187 ± 0.012	1.702LysAsp: 1.702 ± 0.04	1.401LysGlu: 1.401 ± 0.037	0.928LysPhe: 0.928 ± 0.03	2.797LysGly: 2.797 ± 0.045	0.575LysHis: 0.575 ± 0.023	1.765LysIle: 1.765 ± 0.037	1.169LysLys: 1.169 ± 0.036	3.033LysLeu: 3.033 ± 0.05	0.927LysMet: 0.927 ± 0.029	0.764LysAsn: 0.764 ± 0.024	1.844LysPro: 1.844 ± 0.046	1.006LysGln: 1.006 ± 0.029	2.196LysArg: 2.196 ± 0.049	1.85LysSer: 1.85 ± 0.039	2.074LysThr: 2.074 ± 0.039	2.243LysVal: 2.243 ± 0.048	0.383LysTrp: 0.383 ± 0.017	0.688LysTyr: 0.688 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.112LeuAla: 13.112 ± 0.128	1.015LeuCys: 1.015 ± 0.028	6.241LeuAsp: 6.241 ± 0.075	5.508LeuGlu: 5.508 ± 0.07	3.613LeuPhe: 3.613 ± 0.065	8.78LeuGly: 8.78 ± 0.097	1.929LeuHis: 1.929 ± 0.041	5.381LeuIle: 5.381 ± 0.072	3.245LeuLys: 3.245 ± 0.051	9.396LeuLeu: 9.396 ± 0.127	2.743LeuMet: 2.743 ± 0.043	2.715LeuAsn: 2.715 ± 0.048	5.702LeuPro: 5.702 ± 0.075	2.708LeuGln: 2.708 ± 0.052	7.587LeuArg: 7.587 ± 0.086	7.112LeuSer: 7.112 ± 0.083	6.008LeuThr: 6.008 ± 0.077	7.005LeuVal: 7.005 ± 0.088	1.28LeuTrp: 1.28 ± 0.043	2.031LeuTyr: 2.031 ± 0.038	0.0LeuXaa: 0.0 ± 0.0
Met	3.495MetAla: 3.495 ± 0.044	0.192MetCys: 0.192 ± 0.012	1.407MetAsp: 1.407 ± 0.032	1.322MetGlu: 1.322 ± 0.03	0.782MetPhe: 0.782 ± 0.025	2.367MetGly: 2.367 ± 0.047	0.487MetHis: 0.487 ± 0.019	1.629MetIle: 1.629 ± 0.033	1.043MetLys: 1.043 ± 0.028	2.76MetLeu: 2.76 ± 0.048	0.829MetMet: 0.829 ± 0.028	0.831MetAsn: 0.831 ± 0.027	1.529MetPro: 1.529 ± 0.034	1.052MetGln: 1.052 ± 0.029	1.994MetArg: 1.994 ± 0.042	1.84MetSer: 1.84 ± 0.036	2.14MetThr: 2.14 ± 0.035	1.946MetVal: 1.946 ± 0.041	0.24MetTrp: 0.24 ± 0.014	0.363MetTyr: 0.363 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.977AsnAla: 2.977 ± 0.046	0.248AsnCys: 0.248 ± 0.015	1.4AsnAsp: 1.4 ± 0.046	1.11AsnGlu: 1.11 ± 0.032	0.918AsnPhe: 0.918 ± 0.03	2.281AsnGly: 2.281 ± 0.049	0.468AsnHis: 0.468 ± 0.016	1.319AsnIle: 1.319 ± 0.03	0.686AsnLys: 0.686 ± 0.022	2.545AsnLeu: 2.545 ± 0.052	0.688AsnMet: 0.688 ± 0.024	0.621AsnAsn: 0.621 ± 0.025	1.785AsnPro: 1.785 ± 0.042	0.676AsnGln: 0.676 ± 0.022	1.701AsnArg: 1.701 ± 0.038	1.127AsnSer: 1.127 ± 0.028	1.33AsnThr: 1.33 ± 0.035	1.763AsnVal: 1.763 ± 0.041	0.421AsnTrp: 0.421 ± 0.018	0.578AsnTyr: 0.578 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.856ProAla: 5.856 ± 0.076	0.363ProCys: 0.363 ± 0.016	3.972ProAsp: 3.972 ± 0.06	4.37ProGlu: 4.37 ± 0.056	1.936ProPhe: 1.936 ± 0.038	4.755ProGly: 4.755 ± 0.067	1.064ProHis: 1.064 ± 0.028	2.278ProIle: 2.278 ± 0.041	1.664ProLys: 1.664 ± 0.035	4.906ProLeu: 4.906 ± 0.069	1.348ProMet: 1.348 ± 0.032	1.256ProAsn: 1.256 ± 0.034	2.381ProPro: 2.381 ± 0.048	1.761ProGln: 1.761 ± 0.037	2.955ProArg: 2.955 ± 0.052	2.429ProSer: 2.429 ± 0.035	2.413ProThr: 2.413 ± 0.041	4.356ProVal: 4.356 ± 0.058	0.647ProTrp: 0.647 ± 0.02	1.193ProTyr: 1.193 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	4.19GlnAla: 4.19 ± 0.058	0.208GlnCys: 0.208 ± 0.012	1.754GlnAsp: 1.754 ± 0.032	1.573GlnGlu: 1.573 ± 0.038	1.066GlnPhe: 1.066 ± 0.026	2.758GlnGly: 2.758 ± 0.044	0.622GlnHis: 0.622 ± 0.023	2.146GlnIle: 2.146 ± 0.044	1.089GlnLys: 1.089 ± 0.03	2.925GlnLeu: 2.925 ± 0.05	1.145GlnMet: 1.145 ± 0.035	0.869GlnAsn: 0.869 ± 0.023	1.653GlnPro: 1.653 ± 0.036	1.214GlnGln: 1.214 ± 0.037	2.214GlnArg: 2.214 ± 0.042	1.803GlnSer: 1.803 ± 0.039	1.877GlnThr: 1.877 ± 0.043	2.513GlnVal: 2.513 ± 0.04	0.382GlnTrp: 0.382 ± 0.017	0.594GlnTyr: 0.594 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.787ArgAla: 8.787 ± 0.106	0.504ArgCys: 0.504 ± 0.021	4.434ArgAsp: 4.434 ± 0.06	3.61ArgGlu: 3.61 ± 0.05	2.727ArgPhe: 2.727 ± 0.043	4.841ArgGly: 4.841 ± 0.067	1.609ArgHis: 1.609 ± 0.04	3.861ArgIle: 3.861 ± 0.048	2.327ArgLys: 2.327 ± 0.046	7.431ArgLeu: 7.431 ± 0.092	2.017ArgMet: 2.017 ± 0.038	1.708ArgAsn: 1.708 ± 0.038	3.439ArgPro: 3.439 ± 0.061	2.316ArgGln: 2.316 ± 0.051	5.1ArgArg: 5.1 ± 0.081	3.268ArgSer: 3.268 ± 0.056	3.019ArgThr: 3.019 ± 0.052	4.69ArgVal: 4.69 ± 0.063	0.906ArgTrp: 0.906 ± 0.027	1.562ArgTyr: 1.562 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.964SerAla: 5.964 ± 0.076	0.47SerCys: 0.47 ± 0.018	3.299SerAsp: 3.299 ± 0.055	2.907SerGlu: 2.907 ± 0.048	2.269SerPhe: 2.269 ± 0.044	5.631SerGly: 5.631 ± 0.072	1.08SerHis: 1.08 ± 0.027	2.424SerIle: 2.424 ± 0.046	1.564SerLys: 1.564 ± 0.033	4.888SerLeu: 4.888 ± 0.073	1.344SerMet: 1.344 ± 0.032	1.331SerAsn: 1.331 ± 0.034	2.565SerPro: 2.565 ± 0.04	1.537SerGln: 1.537 ± 0.038	3.165SerArg: 3.165 ± 0.053	2.684SerSer: 2.684 ± 0.05	2.595SerThr: 2.595 ± 0.05	3.793SerVal: 3.793 ± 0.056	0.754SerTrp: 0.754 ± 0.023	1.334SerTyr: 1.334 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.403ThrAla: 6.403 ± 0.084	0.462ThrCys: 0.462 ± 0.018	3.036ThrAsp: 3.036 ± 0.052	2.879ThrGlu: 2.879 ± 0.044	1.898ThrPhe: 1.898 ± 0.039	5.582ThrGly: 5.582 ± 0.064	1.127ThrHis: 1.127 ± 0.024	2.583ThrIle: 2.583 ± 0.045	1.462ThrLys: 1.462 ± 0.038	6.275ThrLeu: 6.275 ± 0.076	1.277ThrMet: 1.277 ± 0.032	1.219ThrAsn: 1.219 ± 0.029	3.636ThrPro: 3.636 ± 0.053	1.642ThrGln: 1.642 ± 0.033	3.706ThrArg: 3.706 ± 0.057	2.588ThrSer: 2.588 ± 0.043	2.847ThrThr: 2.847 ± 0.054	4.204ThrVal: 4.204 ± 0.052	0.674ThrTrp: 0.674 ± 0.025	1.262ThrTyr: 1.262 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.787ValAla: 8.787 ± 0.088	0.612ValCys: 0.612 ± 0.022	3.923ValAsp: 3.923 ± 0.049	4.338ValGlu: 4.338 ± 0.062	2.876ValPhe: 2.876 ± 0.052	5.364ValGly: 5.364 ± 0.061	1.315ValHis: 1.315 ± 0.032	4.225ValIle: 4.225 ± 0.063	2.028ValLys: 2.028 ± 0.043	7.814ValLeu: 7.814 ± 0.096	2.214ValMet: 2.214 ± 0.046	1.94ValAsn: 1.94 ± 0.044	3.619ValPro: 3.619 ± 0.052	2.29ValGln: 2.29 ± 0.044	4.288ValArg: 4.288 ± 0.062	4.216ValSer: 4.216 ± 0.055	4.546ValThr: 4.546 ± 0.053	5.617ValVal: 5.617 ± 0.08	0.949ValTrp: 0.949 ± 0.027	1.449ValTyr: 1.449 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.415TrpAla: 1.415 ± 0.034	0.135TrpCys: 0.135 ± 0.01	0.78TrpAsp: 0.78 ± 0.029	0.61TrpGlu: 0.61 ± 0.022	0.53TrpPhe: 0.53 ± 0.022	1.007TrpGly: 1.007 ± 0.032	0.332TrpHis: 0.332 ± 0.017	0.691TrpIle: 0.691 ± 0.022	0.421TrpLys: 0.421 ± 0.017	1.651TrpLeu: 1.651 ± 0.04	0.412TrpMet: 0.412 ± 0.018	0.371TrpAsn: 0.371 ± 0.017	0.714TrpPro: 0.714 ± 0.023	0.514TrpGln: 0.514 ± 0.02	1.101TrpArg: 1.101 ± 0.028	0.782TrpSer: 0.782 ± 0.026	0.742TrpThr: 0.742 ± 0.024	0.906TrpVal: 0.906 ± 0.028	0.2TrpTrp: 0.2 ± 0.012	0.286TrpTyr: 0.286 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.461TyrAla: 2.461 ± 0.041	0.248TyrCys: 0.248 ± 0.013	1.586TyrAsp: 1.586 ± 0.037	1.237TyrGlu: 1.237 ± 0.032	0.917TyrPhe: 0.917 ± 0.028	2.215TyrGly: 2.215 ± 0.048	0.544TyrHis: 0.544 ± 0.02	0.918TyrIle: 0.918 ± 0.03	0.601TyrLys: 0.601 ± 0.023	2.268TyrLeu: 2.268 ± 0.04	0.498TyrMet: 0.498 ± 0.022	0.562TyrAsn: 0.562 ± 0.023	1.051TyrPro: 1.051 ± 0.033	0.698TyrGln: 0.698 ± 0.023	1.595TyrArg: 1.595 ± 0.032	1.164TyrSer: 1.164 ± 0.031	1.141TyrThr: 1.141 ± 0.026	1.546TyrVal: 1.546 ± 0.035	0.365TyrTrp: 0.365 ± 0.016	0.57TyrTyr: 0.57 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.001XaaTrp: 0.001 ± 0.001	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4217 proteins (1348334 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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